PMC:7152911 / 87114-88327 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T21","span":{"begin":271,"end":276},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"}],"text":"Detection in the presence of flow fields requires high stability of immobilized biorecognition elements (Bard and Faulkner, 2000). The effect of flow characteristics on biosensor collection rates is an important consideration, especially when considering micro- and nano-scale transducers with microfluidic formats (Squires et al. 2008). For example, emerging nanostructured electrodes, such as functionalized nanoporous membranes, have been shown to achieve high stability in microfluidic devices (Joung et al. 2013; Tan et al. 2011). A detailed discussion on the relationship between device dimensions, flow characteristics, achievable target collection rates, and equilibrium measurement times has been provided elsewhere (Squires et al. 2008). It is paramount for interpreting biosensor response that users understand the interplay between mass transport of target molecules (both diffusive and convective mechanisms) and reaction at the biosensor surface (i.e., binding of target species to immobilized biorecognition elements). Such fundamental understanding can also be employed in biosensor and experiment design to create improved assay outcomes, such as reducing TTR or improving measurement confidence."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T580","span":{"begin":34,"end":40},"obj":"http://purl.obolibrary.org/obo/UBERON_0007688"},{"id":"T581","span":{"begin":421,"end":430},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T582","span":{"begin":490,"end":497},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T583","span":{"begin":536,"end":537},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T584","span":{"begin":586,"end":592},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T585","span":{"begin":697,"end":700},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"Detection in the presence of flow fields requires high stability of immobilized biorecognition elements (Bard and Faulkner, 2000). The effect of flow characteristics on biosensor collection rates is an important consideration, especially when considering micro- and nano-scale transducers with microfluidic formats (Squires et al. 2008). For example, emerging nanostructured electrodes, such as functionalized nanoporous membranes, have been shown to achieve high stability in microfluidic devices (Joung et al. 2013; Tan et al. 2011). A detailed discussion on the relationship between device dimensions, flow characteristics, achievable target collection rates, and equilibrium measurement times has been provided elsewhere (Squires et al. 2008). It is paramount for interpreting biosensor response that users understand the interplay between mass transport of target molecules (both diffusive and convective mechanisms) and reaction at the biosensor surface (i.e., binding of target species to immobilized biorecognition elements). Such fundamental understanding can also be employed in biosensor and experiment design to create improved assay outcomes, such as reducing TTR or improving measurement confidence."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T83685","span":{"begin":869,"end":878},"obj":"Chemical"}],"attributes":[{"id":"A42084","pred":"chebi_id","subj":"T83685","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"}],"text":"Detection in the presence of flow fields requires high stability of immobilized biorecognition elements (Bard and Faulkner, 2000). The effect of flow characteristics on biosensor collection rates is an important consideration, especially when considering micro- and nano-scale transducers with microfluidic formats (Squires et al. 2008). For example, emerging nanostructured electrodes, such as functionalized nanoporous membranes, have been shown to achieve high stability in microfluidic devices (Joung et al. 2013; Tan et al. 2011). A detailed discussion on the relationship between device dimensions, flow characteristics, achievable target collection rates, and equilibrium measurement times has been provided elsewhere (Squires et al. 2008). It is paramount for interpreting biosensor response that users understand the interplay between mass transport of target molecules (both diffusive and convective mechanisms) and reaction at the biosensor surface (i.e., binding of target species to immobilized biorecognition elements). Such fundamental understanding can also be employed in biosensor and experiment design to create improved assay outcomes, such as reducing TTR or improving measurement confidence."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T36","span":{"begin":849,"end":858},"obj":"http://purl.obolibrary.org/obo/GO_0006810"}],"text":"Detection in the presence of flow fields requires high stability of immobilized biorecognition elements (Bard and Faulkner, 2000). The effect of flow characteristics on biosensor collection rates is an important consideration, especially when considering micro- and nano-scale transducers with microfluidic formats (Squires et al. 2008). For example, emerging nanostructured electrodes, such as functionalized nanoporous membranes, have been shown to achieve high stability in microfluidic devices (Joung et al. 2013; Tan et al. 2011). A detailed discussion on the relationship between device dimensions, flow characteristics, achievable target collection rates, and equilibrium measurement times has been provided elsewhere (Squires et al. 2008). It is paramount for interpreting biosensor response that users understand the interplay between mass transport of target molecules (both diffusive and convective mechanisms) and reaction at the biosensor surface (i.e., binding of target species to immobilized biorecognition elements). Such fundamental understanding can also be employed in biosensor and experiment design to create improved assay outcomes, such as reducing TTR or improving measurement confidence."}

{"project":"LitCovid-sentences","denotations":[{"id":"T710","span":{"begin":0,"end":130},"obj":"Sentence"},{"id":"T711","span":{"begin":131,"end":330},"obj":"Sentence"},{"id":"T712","span":{"begin":331,"end":337},"obj":"Sentence"},{"id":"T713","span":{"begin":338,"end":511},"obj":"Sentence"},{"id":"T714","span":{"begin":512,"end":528},"obj":"Sentence"},{"id":"T715","span":{"begin":529,"end":535},"obj":"Sentence"},{"id":"T716","span":{"begin":536,"end":740},"obj":"Sentence"},{"id":"T717","span":{"begin":741,"end":747},"obj":"Sentence"},{"id":"T718","span":{"begin":748,"end":1033},"obj":"Sentence"},{"id":"T719","span":{"begin":1034,"end":1213},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Detection in the presence of flow fields requires high stability of immobilized biorecognition elements (Bard and Faulkner, 2000). The effect of flow characteristics on biosensor collection rates is an important consideration, especially when considering micro- and nano-scale transducers with microfluidic formats (Squires et al. 2008). For example, emerging nanostructured electrodes, such as functionalized nanoporous membranes, have been shown to achieve high stability in microfluidic devices (Joung et al. 2013; Tan et al. 2011). A detailed discussion on the relationship between device dimensions, flow characteristics, achievable target collection rates, and equilibrium measurement times has been provided elsewhere (Squires et al. 2008). It is paramount for interpreting biosensor response that users understand the interplay between mass transport of target molecules (both diffusive and convective mechanisms) and reaction at the biosensor surface (i.e., binding of target species to immobilized biorecognition elements). Such fundamental understanding can also be employed in biosensor and experiment design to create improved assay outcomes, such as reducing TTR or improving measurement confidence."}

{"project":"2_test","denotations":[{"id":"32364936-18392027-7713114","span":{"begin":331,"end":335},"obj":"18392027"},{"id":"32364936-23428735-7713115","span":{"begin":512,"end":516},"obj":"23428735"},{"id":"32364936-18392027-7713116","span":{"begin":741,"end":745},"obj":"18392027"}],"text":"Detection in the presence of flow fields requires high stability of immobilized biorecognition elements (Bard and Faulkner, 2000). The effect of flow characteristics on biosensor collection rates is an important consideration, especially when considering micro- and nano-scale transducers with microfluidic formats (Squires et al. 2008). For example, emerging nanostructured electrodes, such as functionalized nanoporous membranes, have been shown to achieve high stability in microfluidic devices (Joung et al. 2013; Tan et al. 2011). A detailed discussion on the relationship between device dimensions, flow characteristics, achievable target collection rates, and equilibrium measurement times has been provided elsewhere (Squires et al. 2008). It is paramount for interpreting biosensor response that users understand the interplay between mass transport of target molecules (both diffusive and convective mechanisms) and reaction at the biosensor surface (i.e., binding of target species to immobilized biorecognition elements). Such fundamental understanding can also be employed in biosensor and experiment design to create improved assay outcomes, such as reducing TTR or improving measurement confidence."}