PMC:7152911 / 80591-82009 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1501","span":{"begin":1129,"end":1136},"obj":"Species"},{"id":"1502","span":{"begin":1161,"end":1179},"obj":"Species"},{"id":"1503","span":{"begin":1181,"end":1193},"obj":"Species"},{"id":"1504","span":{"begin":1242,"end":1269},"obj":"Species"},{"id":"1505","span":{"begin":1292,"end":1315},"obj":"Species"}],"attributes":[{"id":"A1501","pred":"tao:has_database_id","subj":"1501","obj":"Tax:562"},{"id":"A1502","pred":"tao:has_database_id","subj":"1502","obj":"Tax:1392"},{"id":"A1503","pred":"tao:has_database_id","subj":"1503","obj":"Tax:1392"},{"id":"A1504","pred":"tao:has_database_id","subj":"1504","obj":"Tax:11099"},{"id":"A1505","pred":"tao:has_database_id","subj":"1505","obj":"Tax:11320"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"3.1.4 Magnetic separation\nThe separation of the target species from a sample using magnetic beads has become a commonly used sample preparation approach in pathogen detection applications. Target pre-concentration via magnetic bead-based separation processes typically involves the binding of antibody-functionalized magnetic beads to the target species. The bead-target complexes are subsequently separated from the solution by externally-applied magnetic fields. Magnetic-assisted separation processes are useful when the target species exhibits similar properties to other analytes or background species in the sample, such as those with similar size, density, or chemical properties (Chen et al. 2017). The bead-target complexes are then introduced directly to the biosensor to enable quantification of the target pathogen that was present in the initial sample. As shown in Table 2, magnetic bead-based separation processes have been extensively used for pathogen detection as well as general substrates for traditional immunoassays. Such assays have been used to detect a variety of pathogens, including bacteria, such as E. coli (Chan et al. 2013 ) and Bacillus anthracis (B. anthracis) (Pal and Alocilja, 2009), and viruses, such as bovine viral diarrhea virus (Luo et al. 2010) and human influenza A virus (Shen et al. 2012). In addition to serving as a separation agent, magnetic beads also serve as labels."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T175","span":{"begin":294,"end":302},"obj":"Body_part"}],"attributes":[{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"3.1.4 Magnetic separation\nThe separation of the target species from a sample using magnetic beads has become a commonly used sample preparation approach in pathogen detection applications. Target pre-concentration via magnetic bead-based separation processes typically involves the binding of antibody-functionalized magnetic beads to the target species. The bead-target complexes are subsequently separated from the solution by externally-applied magnetic fields. Magnetic-assisted separation processes are useful when the target species exhibits similar properties to other analytes or background species in the sample, such as those with similar size, density, or chemical properties (Chen et al. 2017). The bead-target complexes are then introduced directly to the biosensor to enable quantification of the target pathogen that was present in the initial sample. As shown in Table 2, magnetic bead-based separation processes have been extensively used for pathogen detection as well as general substrates for traditional immunoassays. Such assays have been used to detect a variety of pathogens, including bacteria, such as E. coli (Chan et al. 2013 ) and Bacillus anthracis (B. anthracis) (Pal and Alocilja, 2009), and viruses, such as bovine viral diarrhea virus (Luo et al. 2010) and human influenza A virus (Shen et al. 2012). In addition to serving as a separation agent, magnetic beads also serve as labels."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T69","span":{"begin":1255,"end":1263},"obj":"Disease"},{"id":"T70","span":{"begin":1298,"end":1307},"obj":"Disease"}],"attributes":[{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"3.1.4 Magnetic separation\nThe separation of the target species from a sample using magnetic beads has become a commonly used sample preparation approach in pathogen detection applications. Target pre-concentration via magnetic bead-based separation processes typically involves the binding of antibody-functionalized magnetic beads to the target species. The bead-target complexes are subsequently separated from the solution by externally-applied magnetic fields. Magnetic-assisted separation processes are useful when the target species exhibits similar properties to other analytes or background species in the sample, such as those with similar size, density, or chemical properties (Chen et al. 2017). The bead-target complexes are then introduced directly to the biosensor to enable quantification of the target pathogen that was present in the initial sample. As shown in Table 2, magnetic bead-based separation processes have been extensively used for pathogen detection as well as general substrates for traditional immunoassays. Such assays have been used to detect a variety of pathogens, including bacteria, such as E. coli (Chan et al. 2013 ) and Bacillus anthracis (B. anthracis) (Pal and Alocilja, 2009), and viruses, such as bovine viral diarrhea virus (Luo et al. 2010) and human influenza A virus (Shen et al. 2012). In addition to serving as a separation agent, magnetic beads also serve as labels."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T533","span":{"begin":69,"end":70},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T534","span":{"begin":99,"end":102},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T535","span":{"begin":110,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T536","span":{"begin":458,"end":464},"obj":"http://purl.obolibrary.org/obo/UBERON_0007688"},{"id":"T537","span":{"begin":1077,"end":1078},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T538","span":{"begin":1111,"end":1119},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T539","span":{"begin":1181,"end":1182},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T540","span":{"begin":1225,"end":1232},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T541","span":{"begin":1264,"end":1269},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T542","span":{"begin":1292,"end":1297},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T543","span":{"begin":1308,"end":1309},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T544","span":{"begin":1310,"end":1315},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T545","span":{"begin":1362,"end":1363},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T546","span":{"begin":1411,"end":1417},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"}],"text":"3.1.4 Magnetic separation\nThe separation of the target species from a sample using magnetic beads has become a commonly used sample preparation approach in pathogen detection applications. Target pre-concentration via magnetic bead-based separation processes typically involves the binding of antibody-functionalized magnetic beads to the target species. The bead-target complexes are subsequently separated from the solution by externally-applied magnetic fields. Magnetic-assisted separation processes are useful when the target species exhibits similar properties to other analytes or background species in the sample, such as those with similar size, density, or chemical properties (Chen et al. 2017). The bead-target complexes are then introduced directly to the biosensor to enable quantification of the target pathogen that was present in the initial sample. As shown in Table 2, magnetic bead-based separation processes have been extensively used for pathogen detection as well as general substrates for traditional immunoassays. Such assays have been used to detect a variety of pathogens, including bacteria, such as E. coli (Chan et al. 2013 ) and Bacillus anthracis (B. anthracis) (Pal and Alocilja, 2009), and viruses, such as bovine viral diarrhea virus (Luo et al. 2010) and human influenza A virus (Shen et al. 2012). In addition to serving as a separation agent, magnetic beads also serve as labels."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T124","span":{"begin":418,"end":426},"obj":"Chemical"}],"attributes":[{"id":"A9503","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_75958"}],"text":"3.1.4 Magnetic separation\nThe separation of the target species from a sample using magnetic beads has become a commonly used sample preparation approach in pathogen detection applications. Target pre-concentration via magnetic bead-based separation processes typically involves the binding of antibody-functionalized magnetic beads to the target species. The bead-target complexes are subsequently separated from the solution by externally-applied magnetic fields. Magnetic-assisted separation processes are useful when the target species exhibits similar properties to other analytes or background species in the sample, such as those with similar size, density, or chemical properties (Chen et al. 2017). The bead-target complexes are then introduced directly to the biosensor to enable quantification of the target pathogen that was present in the initial sample. As shown in Table 2, magnetic bead-based separation processes have been extensively used for pathogen detection as well as general substrates for traditional immunoassays. Such assays have been used to detect a variety of pathogens, including bacteria, such as E. coli (Chan et al. 2013 ) and Bacillus anthracis (B. anthracis) (Pal and Alocilja, 2009), and viruses, such as bovine viral diarrhea virus (Luo et al. 2010) and human influenza A virus (Shen et al. 2012). In addition to serving as a separation agent, magnetic beads also serve as labels."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T10","span":{"begin":1255,"end":1263},"obj":"Phenotype"}],"attributes":[{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0002014"}],"text":"3.1.4 Magnetic separation\nThe separation of the target species from a sample using magnetic beads has become a commonly used sample preparation approach in pathogen detection applications. Target pre-concentration via magnetic bead-based separation processes typically involves the binding of antibody-functionalized magnetic beads to the target species. The bead-target complexes are subsequently separated from the solution by externally-applied magnetic fields. Magnetic-assisted separation processes are useful when the target species exhibits similar properties to other analytes or background species in the sample, such as those with similar size, density, or chemical properties (Chen et al. 2017). The bead-target complexes are then introduced directly to the biosensor to enable quantification of the target pathogen that was present in the initial sample. As shown in Table 2, magnetic bead-based separation processes have been extensively used for pathogen detection as well as general substrates for traditional immunoassays. Such assays have been used to detect a variety of pathogens, including bacteria, such as E. coli (Chan et al. 2013 ) and Bacillus anthracis (B. anthracis) (Pal and Alocilja, 2009), and viruses, such as bovine viral diarrhea virus (Luo et al. 2010) and human influenza A virus (Shen et al. 2012). In addition to serving as a separation agent, magnetic beads also serve as labels."}

{"project":"LitCovid-sentences","denotations":[{"id":"T658","span":{"begin":0,"end":26},"obj":"Sentence"},{"id":"T659","span":{"begin":27,"end":189},"obj":"Sentence"},{"id":"T660","span":{"begin":190,"end":355},"obj":"Sentence"},{"id":"T661","span":{"begin":356,"end":465},"obj":"Sentence"},{"id":"T662","span":{"begin":466,"end":700},"obj":"Sentence"},{"id":"T663","span":{"begin":701,"end":707},"obj":"Sentence"},{"id":"T664","span":{"begin":708,"end":867},"obj":"Sentence"},{"id":"T665","span":{"begin":868,"end":1039},"obj":"Sentence"},{"id":"T666","span":{"begin":1040,"end":1149},"obj":"Sentence"},{"id":"T667","span":{"begin":1150,"end":1281},"obj":"Sentence"},{"id":"T668","span":{"begin":1282,"end":1328},"obj":"Sentence"},{"id":"T669","span":{"begin":1329,"end":1335},"obj":"Sentence"},{"id":"T670","span":{"begin":1336,"end":1418},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"3.1.4 Magnetic separation\nThe separation of the target species from a sample using magnetic beads has become a commonly used sample preparation approach in pathogen detection applications. Target pre-concentration via magnetic bead-based separation processes typically involves the binding of antibody-functionalized magnetic beads to the target species. The bead-target complexes are subsequently separated from the solution by externally-applied magnetic fields. Magnetic-assisted separation processes are useful when the target species exhibits similar properties to other analytes or background species in the sample, such as those with similar size, density, or chemical properties (Chen et al. 2017). The bead-target complexes are then introduced directly to the biosensor to enable quantification of the target pathogen that was present in the initial sample. As shown in Table 2, magnetic bead-based separation processes have been extensively used for pathogen detection as well as general substrates for traditional immunoassays. Such assays have been used to detect a variety of pathogens, including bacteria, such as E. coli (Chan et al. 2013 ) and Bacillus anthracis (B. anthracis) (Pal and Alocilja, 2009), and viruses, such as bovine viral diarrhea virus (Luo et al. 2010) and human influenza A virus (Shen et al. 2012). In addition to serving as a separation agent, magnetic beads also serve as labels."}

{"project":"2_test","denotations":[{"id":"32364936-23058659-7713107","span":{"begin":1150,"end":1154},"obj":"23058659"},{"id":"32364936-18823768-7713108","span":{"begin":1214,"end":1218},"obj":"18823768"},{"id":"32364936-20833013-7713109","span":{"begin":1282,"end":1286},"obj":"20833013"},{"id":"32364936-22731392-7713110","span":{"begin":1329,"end":1333},"obj":"22731392"}],"text":"3.1.4 Magnetic separation\nThe separation of the target species from a sample using magnetic beads has become a commonly used sample preparation approach in pathogen detection applications. Target pre-concentration via magnetic bead-based separation processes typically involves the binding of antibody-functionalized magnetic beads to the target species. The bead-target complexes are subsequently separated from the solution by externally-applied magnetic fields. Magnetic-assisted separation processes are useful when the target species exhibits similar properties to other analytes or background species in the sample, such as those with similar size, density, or chemical properties (Chen et al. 2017). The bead-target complexes are then introduced directly to the biosensor to enable quantification of the target pathogen that was present in the initial sample. As shown in Table 2, magnetic bead-based separation processes have been extensively used for pathogen detection as well as general substrates for traditional immunoassays. Such assays have been used to detect a variety of pathogens, including bacteria, such as E. coli (Chan et al. 2013 ) and Bacillus anthracis (B. anthracis) (Pal and Alocilja, 2009), and viruses, such as bovine viral diarrhea virus (Luo et al. 2010) and human influenza A virus (Shen et al. 2012). In addition to serving as a separation agent, magnetic beads also serve as labels."}