PMC:7152911 / 60222-61271 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7152911","sourcedb":"PMC","sourceid":"7152911","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7152911","text":"Biorecognition elements for electrochemical biosensors can be defined as (1) biocatalytic or (2) biocomplexing. In the case of biocatalytic biorecognition elements, the biosensor response is based on a reaction catalyzed by macromolecules. Enzymes, whole cells, and tissues are the most commonly used biocatalytic biorecognition element. While enzyzmes provide biorecognition elements in various chemical sensing applications, they are often used as labels for pathogen detection applications and most commonly introduced via secondary binding steps. In the case of biocomplexing biorecognition elements, the biosensor response is based on the interaction of analytes with macromolecules or organized molecular assemblies. As shown in Table 1, Table 2, antibodies, peptides, and phages are the most commonly used biocomplexing biorecognition elements for pathogen detection. In addition to biomacromolecules, imprinted polymers have also been examined as biocomplexing biorecognition elements for pathogen detection using electrochemical biosensors.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1363","span":{"begin":919,"end":927},"obj":"Chemical"}],"attributes":[{"id":"A1363","pred":"tao:has_database_id","subj":"1363","obj":"MESH:D011108"},{"subj":"1363","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T121","span":{"begin":255,"end":260},"obj":"Body_part"},{"id":"T122","span":{"begin":266,"end":273},"obj":"Body_part"}],"attributes":[{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma9637"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T416","span":{"begin":200,"end":201},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T417","span":{"begin":255,"end":260},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T418","span":{"begin":450,"end":456},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"},{"id":"T419","span":{"begin":691,"end":700},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T420","span":{"begin":765,"end":773},"obj":"http://purl.obolibrary.org/obo/PR_000018263"}],"attributes":[{"subj":"T416","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T417","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T418","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T419","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T420","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T8714","span":{"begin":224,"end":238},"obj":"Chemical"},{"id":"T82184","span":{"begin":673,"end":687},"obj":"Chemical"},{"id":"T43","span":{"begin":765,"end":773},"obj":"Chemical"},{"id":"T43840","span":{"begin":890,"end":907},"obj":"Chemical"},{"id":"T45","span":{"begin":919,"end":927},"obj":"Chemical"}],"attributes":[{"id":"A46631","pred":"chebi_id","subj":"T8714","obj":"http://purl.obolibrary.org/obo/CHEBI_33839"},{"id":"A4538","pred":"chebi_id","subj":"T82184","obj":"http://purl.obolibrary.org/obo/CHEBI_33839"},{"id":"A42643","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A55385","pred":"chebi_id","subj":"T43840","obj":"http://purl.obolibrary.org/obo/CHEBI_33694"},{"id":"A47118","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_33839"},{"subj":"T8714","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T82184","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T43840","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T480","span":{"begin":0,"end":111},"obj":"Sentence"},{"id":"T481","span":{"begin":112,"end":239},"obj":"Sentence"},{"id":"T482","span":{"begin":240,"end":337},"obj":"Sentence"},{"id":"T483","span":{"begin":338,"end":550},"obj":"Sentence"},{"id":"T484","span":{"begin":551,"end":722},"obj":"Sentence"},{"id":"T485","span":{"begin":723,"end":874},"obj":"Sentence"},{"id":"T486","span":{"begin":875,"end":1049},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T480","pred":"source","obj":"LitCovid-sentences"},{"subj":"T481","pred":"source","obj":"LitCovid-sentences"},{"subj":"T482","pred":"source","obj":"LitCovid-sentences"},{"subj":"T483","pred":"source","obj":"LitCovid-sentences"},{"subj":"T484","pred":"source","obj":"LitCovid-sentences"},{"subj":"T485","pred":"source","obj":"LitCovid-sentences"},{"subj":"T486","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93c7","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93e1ec"},{"id":"LitCovid-PD-CLO","color":"#ecdc93"},{"id":"LitCovid-PD-CHEBI","color":"#c293ec"},{"id":"LitCovid-sentences","color":"#93eca8"}]}]}}