PMC:7152911 / 53220-54230 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7152911","sourcedb":"PMC","sourceid":"7152911","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7152911","text":"While studies have reported improved biosensor performance using electrode nanostructuring, such as improved sensitivity and LOD, it is prudent to consider the effect of nanostructuring on biorecognition element immobilization and target binding. For example, nanostructured electrodes that exhibit high-aspect-ratio structures and other three-dimensional structures have also been shown to enhance biomolecular steric hindrance effects, which may have implications for pathogen detection applications (Hong et al. 2015; Lam et al. 2012; Mahshid et al. 2017). There also remains a need to understand device-to-device and batch-to-batch variation in electrode nanostructuring quality. For example, it is presently unclear how the structure (e.g., topography, crystal structure) and material properties (e.g., electrical properties) of nanostructured surfaces vary among mass-produced electrodes. It is also unclear how such variance in nanostructuring quality affects the repeatability of biosensor performance.","tracks":[{"project":"LitCovid-PD-CLO","denotations":[{"id":"T374","span":{"begin":579,"end":580},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T375","span":{"begin":600,"end":606},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T376","span":{"begin":610,"end":616},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"}],"attributes":[{"subj":"T374","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T375","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T376","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T427","span":{"begin":0,"end":246},"obj":"Sentence"},{"id":"T428","span":{"begin":247,"end":514},"obj":"Sentence"},{"id":"T429","span":{"begin":515,"end":531},"obj":"Sentence"},{"id":"T430","span":{"begin":532,"end":552},"obj":"Sentence"},{"id":"T431","span":{"begin":553,"end":559},"obj":"Sentence"},{"id":"T432","span":{"begin":560,"end":683},"obj":"Sentence"},{"id":"T433","span":{"begin":684,"end":894},"obj":"Sentence"},{"id":"T434","span":{"begin":895,"end":1010},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T427","pred":"source","obj":"LitCovid-sentences"},{"subj":"T428","pred":"source","obj":"LitCovid-sentences"},{"subj":"T429","pred":"source","obj":"LitCovid-sentences"},{"subj":"T430","pred":"source","obj":"LitCovid-sentences"},{"subj":"T431","pred":"source","obj":"LitCovid-sentences"},{"subj":"T432","pred":"source","obj":"LitCovid-sentences"},{"subj":"T433","pred":"source","obj":"LitCovid-sentences"},{"subj":"T434","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32364936-25254625-7713052","span":{"begin":515,"end":519},"obj":"25254625"},{"id":"32364936-22142422-7713053","span":{"begin":532,"end":536},"obj":"22142422"},{"id":"32364936-28829912-7713054","span":{"begin":553,"end":557},"obj":"28829912"}],"attributes":[{"subj":"32364936-25254625-7713052","pred":"source","obj":"2_test"},{"subj":"32364936-22142422-7713053","pred":"source","obj":"2_test"},{"subj":"32364936-28829912-7713054","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-CLO","color":"#c893ec","default":true},{"id":"LitCovid-sentences","color":"#93ecae"},{"id":"2_test","color":"#ec9493"}]}]}}