PMC:7152911 / 100180-102285 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7152911","sourcedb":"PMC","sourceid":"7152911","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7152911","text":"In EIS the impedance and phase angle of the system are measured as a function of the frequency of the applied electrical potential. EIS is a diverse electrochemical method, which can be done as a faradaic or non-faradaic process, and enables the study of intrinsic material properties, experiment-specific processes, or biorecognition events at the electrode surface. EIS is often performed using an applied low-amplitude sinusoidal electrical potential and a three-electrode configuration. Equivalent circuit models are commonly fit to experimental impedance and phase angle data to interpret the electrochemical process in terms of passive circuit elements, such as resistors and capacitors. For example, the electric double layer is typically modeled as a capacitive element, while the resistance to faradaic charge transfer at the electrode-electrolyte interface is represented as a resistor, often referred to as the charge transfer resistance. Additional circuit elements, such as constant-phase or Warburg elements, can also be included to represent other features of the electrochemical cell and process, such transport characteristics of the species at the electrode-electrolyte interface. The Randles model is a commonly used equivalent circuit for interpretation of biosensor EIS data. The circuit consists of an electrolyte resistance in series with a parallel combination of the double-layer capacitance with the charge transfer resistance and the Warburg impedance element (Randles, 1947). Variations of this model have been formulated for a variety of biosensing studies. For example, the equivalent circuit model and associated Nyquist plot for electrochemical detection of S. typhimurium using EIS with a poly(pyrrole-co-3-carboxyl-pyrrole) copolymer supported aptamer can be found in Fig. 5c (Sheikhzadeh et al. 2016). The equivalent circuit model consists of the solution resistance, charge transfer resistance at the copolymer-aptamer/electrolyte interface, and constant phase element for the charge capacitance at the copolymer-aptamer/electrolyte interface (Sheikhzadeh et al. 2016).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1666","span":{"begin":1690,"end":1704},"obj":"Species"},{"id":"1667","span":{"begin":1722,"end":1757},"obj":"Chemical"},{"id":"1668","span":{"begin":1937,"end":1946},"obj":"Chemical"},{"id":"1669","span":{"begin":2039,"end":2048},"obj":"Chemical"}],"attributes":[{"id":"A1666","pred":"tao:has_database_id","subj":"1666","obj":"Tax:90371"},{"subj":"1666","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1667","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1668","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1669","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":422,"end":432},"obj":"Body_part"},{"id":"T2","span":{"begin":1095,"end":1099},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma63131"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T5","span":{"begin":67,"end":68},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":139,"end":140},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":194,"end":195},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":458,"end":459},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9","span":{"begin":757,"end":758},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T10","span":{"begin":885,"end":886},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T11","span":{"begin":1095,"end":1099},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T12","span":{"begin":1220,"end":1221},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T13","span":{"begin":1362,"end":1363},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":1554,"end":1555},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T15","span":{"begin":1720,"end":1721},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T99195","span":{"begin":3,"end":6},"obj":"Chemical"},{"id":"T78349","span":{"begin":132,"end":135},"obj":"Chemical"},{"id":"T79190","span":{"begin":368,"end":371},"obj":"Chemical"},{"id":"T24405","span":{"begin":1287,"end":1290},"obj":"Chemical"},{"id":"T65446","span":{"begin":1711,"end":1714},"obj":"Chemical"},{"id":"T51139","span":{"begin":1727,"end":1734},"obj":"Chemical"},{"id":"T47305","span":{"begin":1749,"end":1756},"obj":"Chemical"},{"id":"T99055","span":{"begin":1758,"end":1767},"obj":"Chemical"},{"id":"T92711","span":{"begin":1778,"end":1785},"obj":"Chemical"},{"id":"T55108","span":{"begin":1882,"end":1890},"obj":"Chemical"},{"id":"T49199","span":{"begin":1937,"end":1946},"obj":"Chemical"},{"id":"T57991","span":{"begin":1947,"end":1954},"obj":"Chemical"},{"id":"T97641","span":{"begin":2039,"end":2048},"obj":"Chemical"},{"id":"T52161","span":{"begin":2049,"end":2056},"obj":"Chemical"}],"attributes":[{"id":"A59983","pred":"chebi_id","subj":"T99195","obj":"http://purl.obolibrary.org/obo/CHEBI_73498"},{"id":"A82932","pred":"chebi_id","subj":"T78349","obj":"http://purl.obolibrary.org/obo/CHEBI_73498"},{"id":"A51446","pred":"chebi_id","subj":"T79190","obj":"http://purl.obolibrary.org/obo/CHEBI_73498"},{"id":"A22941","pred":"chebi_id","subj":"T24405","obj":"http://purl.obolibrary.org/obo/CHEBI_73498"},{"id":"A23891","pred":"chebi_id","subj":"T65446","obj":"http://purl.obolibrary.org/obo/CHEBI_73498"},{"id":"A6563","pred":"chebi_id","subj":"T51139","obj":"http://purl.obolibrary.org/obo/CHEBI_19203"},{"id":"A68113","pred":"chebi_id","subj":"T51139","obj":"http://purl.obolibrary.org/obo/CHEBI_35556"},{"id":"A37992","pred":"chebi_id","subj":"T47305","obj":"http://purl.obolibrary.org/obo/CHEBI_19203"},{"id":"A67487","pred":"chebi_id","subj":"T47305","obj":"http://purl.obolibrary.org/obo/CHEBI_35556"},{"id":"A6151","pred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