PMC:7151644 / 28393-29533 JSONTXT

{"project":"2_test","denotations":[{"id":"32296543-204240-144433921","span":{"begin":244,"end":248},"obj":"204240"},{"id":"32296543-16318717-144433922","span":{"begin":264,"end":268},"obj":"16318717"},{"id":"32296543-27158509-144433923","span":{"begin":373,"end":377},"obj":"27158509"},{"id":"32296543-27158509-144433924","span":{"begin":593,"end":597},"obj":"27158509"},{"id":"32296543-28923111-144433925","span":{"begin":612,"end":616},"obj":"28923111"},{"id":"32296543-30939106-144433926","span":{"begin":636,"end":640},"obj":"30939106"}],"text":"Coltiviruses are well-known tick-borne pathogens that can cause human disease. For example, CTFV causes mild febrile illness or more severe disease including infection of the central nervous system, and/or hemorrhagic fever (Goodpasture et al. 1978; Attoui et al. 2005). Additionally, EYAV infections have been associated with human neurological disease (Moutailler et al. 2016). Notably, although some coltiviruses (e.g. CTFV, EYAV, TFRV) have been detected in wildlife (such as bats and rodents), there is no clear evidence that these viruses can cause disease in animals (Moutailler et al. 2016; Weiss et al. 2017; Williamson et al. 2019). In this study, a novel coltivirus, named LSPV, was identified in one of the sick pangolins [2-Lishui (M. javanica)]. Given the high abundance of LSPV in the meta-transcriptomic data, combined with the clinical features and pathologic changes appeared in the pangolin (2-Lishui), as well as the detection of LSPV in several organs, our data suggest that LSPV may have caused systemic infection and the death of the pangolin in question, although this will need to be confirmed with additional data."}