> top > docs > PMC:7148425 > spans > 8567-10829 > annotations

PMC:7148425 / 8567-10829 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
97 87-92 Disease denotes COVID MESH:C000657245
106 1493-1499 Species denotes people Tax:9606
107 239-244 Disease denotes COVID MESH:C000657245
108 415-424 Disease denotes infection MESH:D007239
109 553-562 Disease denotes infection MESH:D007239
110 861-870 Disease denotes infection MESH:D007239
111 956-969 Disease denotes hematopoiesis MESH:C536227
112 1011-1032 Disease denotes dysfunctional myeloid MESH:D007951
113 1244-1256 Disease denotes inflammation MESH:D007249
116 2158-2168 Species denotes SARS-CoV-2 Tax:2697049
117 2191-2196 Disease denotes COVID MESH:C000657245

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T131 195-200 UBERON:0007023 denotes adult
T132 267-273 UBERON:0007023 denotes adults
T133 523-538 CHEBI:52217;CHEBI:52217 denotes Pharmacological
T134 629-634 NCBITaxon:10239 denotes viral
T135 658-667 CHEBI:36357;CHEBI:36357 denotes molecules
T136 748-754 UBERON:0002405 denotes immune
T137 842-848 UBERON:0002405;GO:0006955 denotes immune
T138 849-857 GO:0006955 denotes response
T139 956-969 GO:0030097 denotes hematopoiesis
T140 1025-1038 CL:0000763 denotes myeloid cells
T141 1091-1095 UBERON:0002048 denotes lung
T142 1114-1120 CL:0000084 denotes T cell
T143 1165-1171 UBERON:0002370 denotes thymus
T144 1197-1204 CL:0000084 denotes T cells
T145 1217-1227 GO:0065007;CL:0000815 denotes regulatory
T146 1228-1235 CL:0000815 denotes T cells
T147 1260-1265 GO:0000075 denotes check
T148 1285-1292 CHEBI:59132;CHEBI:59132 denotes antigen
T149 1322-1333 UBERON:0000029 denotes lymph nodes
T150 1354-1355 CL:0000236 denotes T
T151 1356-1362 CL:0000236 denotes B cell
T152 1493-1499 NCBITaxon:9606 denotes people
T153 1594-1601 NCBITaxon:10239 denotes viruses
T154 1623-1628 NCBITaxon:10239 denotes virus
T155 1868-1873 NCBITaxon:10239 denotes virus
T156 1916-1922 UBERON:0002405 denotes immune
T157 1923-1929 GO:0007613 denotes memory
T158 2141-2147 UBERON:0002405;GO:0045087 denotes immune
T159 2148-2157 GO:0045087 denotes responses
T160 2158-2168 SP_7 denotes SARS-CoV-2
T161 2255-2261 UBERON:0007023 denotes adults
T88471 195-200 UBERON:0007023 denotes adult
T69140 267-273 UBERON:0007023 denotes adults
T99077 523-538 CHEBI:52217;CHEBI:52217 denotes Pharmacological
T52993 629-634 NCBITaxon:10239 denotes viral
T19904 658-667 CHEBI:36357;CHEBI:36357 denotes molecules
T34929 748-754 UBERON:0002405 denotes immune
T29544 842-848 UBERON:0002405;GO:0006955 denotes immune
T87061 849-857 GO:0006955 denotes response
T80178 956-969 GO:0030097 denotes hematopoiesis
T98847 1025-1038 CL:0000763 denotes myeloid cells
T51000 1091-1095 UBERON:0002048 denotes lung
T67065 1114-1120 CL:0000084 denotes T cell
T21403 1165-1171 UBERON:0002370 denotes thymus
T1426 1197-1204 CL:0000084 denotes T cells
T78479 1217-1227 GO:0065007;CL:0000815 denotes regulatory
T29874 1228-1235 CL:0000815 denotes T cells
T64682 1260-1265 GO:0000075 denotes check
T64287 1285-1292 CHEBI:59132;CHEBI:59132 denotes antigen
T40891 1322-1333 UBERON:0000029 denotes lymph nodes
T27403 1354-1355 CL:0000236 denotes T
T51932 1356-1362 CL:0000236 denotes B cell
T33921 1493-1499 NCBITaxon:9606 denotes people
T83204 1594-1601 NCBITaxon:10239 denotes viruses
T59755 1623-1628 NCBITaxon:10239 denotes virus
T59738 1868-1873 NCBITaxon:10239 denotes virus
T76554 1916-1922 UBERON:0002405 denotes immune
T1318 1923-1929 GO:0007613 denotes memory
T29495 2141-2147 UBERON:0002405;GO:0045087 denotes immune
T41257 2148-2157 GO:0045087 denotes responses
T44798 2158-2168 SP_7 denotes SARS-CoV-2
T54015 2255-2261 UBERON:0007023 denotes adults

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T47 635-643 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T48 653-657 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T49 1025-1038 Body_part denotes myeloid cells http://purl.org/sig/ont/fma/fma70339
T50 1033-1038 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T51 1091-1095 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T52 1116-1120 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T53 1165-1171 Body_part denotes thymus http://purl.org/sig/ont/fma/fma9607
T54 1199-1204 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T55 1217-1235 Body_part denotes regulatory T cells http://purl.org/sig/ont/fma/fma84070
T56 1230-1235 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T57 1322-1333 Body_part denotes lymph nodes http://purl.org/sig/ont/fma/fma5034
T58 1322-1327 Body_part denotes lymph http://purl.org/sig/ont/fma/fma9671
T59 1358-1362 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T14 1091-1095 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T15 1165-1171 Body_part denotes thymus http://purl.obolibrary.org/obo/UBERON_0002370
T16 1322-1333 Body_part denotes lymph nodes http://purl.obolibrary.org/obo/UBERON_0000029
T17 1322-1327 Body_part denotes lymph http://purl.obolibrary.org/obo/UBERON_0002391

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T33 415-424 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 553-562 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T35 861-870 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T36 1244-1256 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T37 2158-2166 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T74 157-158 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 459-460 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 653-657 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T77 1033-1038 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T78 1091-1095 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T79 1091-1095 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T80 1114-1120 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T81 1165-1171 http://purl.obolibrary.org/obo/UBERON_0002370 denotes thymus
T82 1197-1204 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T83 1217-1235 http://purl.obolibrary.org/obo/CL_0000815 denotes regulatory T cells
T84 1322-1333 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
T85 1356-1362 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T86 1594-1601 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T87 1623-1628 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T88 1782-1783 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 1868-1873 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T90 1895-1896 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91 2042-2046 http://purl.obolibrary.org/obo/CLO_0008416 denotes peer
T92 2042-2046 http://purl.obolibrary.org/obo/CLO_0050081 denotes peer
T93 2065-2066 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T12 635-643 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T13 658-667 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T14 1285-1292 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T16 842-857 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T17 956-969 http://purl.obolibrary.org/obo/GO_0030097 denotes hematopoiesis
T18 1055-1083 http://purl.obolibrary.org/obo/GO_0002526 denotes acute inflammatory responses
T19 1244-1256 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T20 1285-1305 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T21 1923-1929 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T22 2141-2157 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T51 0-93 Sentence denotes How can current immunological knowledge be leveraged to protect the oldest old against COVID?
T52 94-391 Sentence denotes According to the above arguments, we consider it unlikely that a conventional vaccine based on young adult responses will be highly effective in COVID prophylaxis for older adults, but should be rigorously applied to everyone else to achieve herd immunity that will indirectly protect the elderly.
T53 392-522 Sentence denotes The ability to prevent infection by adoptive immunotherapy remains a possibility, albeit logistically and financially challenging.
T54 523-702 Sentence denotes Pharmacological prevention of infection by other means, for example, by blocking the interactions between viral proteins and host cell molecules acting as receptors may be useful.
T55 703-894 Sentence denotes Finally, various ways to improve the general immune functions in the older population should be considered and developed to strengthen the immune response to infection and vaccine in general.
T56 895-1394 Sentence denotes These approaches could include interventions at the level of hematopoiesis to correct the skewing of output towards dysfunctional myeloid cells responsible for acute inflammatory responses in the lung, normalisation of T cell progenitor output and reconstitution of the thymus for correct selection of T cells, especially regulatory T cells to keep inflammation in check, reconstitution of antigen presentation function in the lymph nodes and re-alignment of T-B cell interactions and functionality.
T57 1395-1500 Sentence denotes In the meantime, the major benefit of vaccination will be seen at the population level in younger people.
T58 1501-1830 Sentence denotes Once herd immunity is established, the well-known effect of diluting out new hosts for acute viruses should result in the virus disappearing, with the proviso that protective immunity is retained for long enough (this is not yet established) and reinfection is not introduced from a location where new hosts were still available.
T59 1831-1945 Sentence denotes And with the linked proviso that the virus does not mutate into a form against which immune memory is not present.
T60 1946-2262 Sentence denotes We welcome papers addressing any of the issues discussed above and will endeavour to fast-track peer-review to provide a platform exclusively for discussions of individual and age differences in immune responses SARS-CoV-2 and susceptibility to COVID and how to prevent or reduce severity of disease in older adults.