PMC:7144273 / 19872-20652 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T168","span":{"begin":432,"end":436},"obj":"Body_part"},{"id":"T169","span":{"begin":592,"end":596},"obj":"Body_part"},{"id":"T170","span":{"begin":664,"end":668},"obj":"Body_part"}],"attributes":[{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T56","span":{"begin":432,"end":436},"obj":"Body_part"},{"id":"T57","span":{"begin":592,"end":596},"obj":"Body_part"},{"id":"T58","span":{"begin":664,"end":668},"obj":"Body_part"}],"attributes":[{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A58","pred":"uberon_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}

{"project":"LitCovid_AGAC","denotations":[{"id":"p108659s12","span":{"begin":419,"end":428},"obj":"NegReg"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T158","span":{"begin":52,"end":61},"obj":"Disease"},{"id":"T159","span":{"begin":63,"end":72},"obj":"Disease"},{"id":"T160","span":{"begin":267,"end":276},"obj":"Disease"},{"id":"T161","span":{"begin":299,"end":308},"obj":"Disease"},{"id":"T162","span":{"begin":366,"end":375},"obj":"Disease"},{"id":"T163","span":{"begin":384,"end":398},"obj":"Disease"},{"id":"T164","span":{"begin":628,"end":640},"obj":"Disease"}],"attributes":[{"id":"A158","pred":"mondo_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A159","pred":"mondo_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A160","pred":"mondo_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A161","pred":"mondo_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A162","pred":"mondo_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A163","pred":"mondo_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/MONDO_0002249"},{"id":"A164","pred":"mondo_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T283","span":{"begin":73,"end":74},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T284","span":{"begin":89,"end":91},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T285","span":{"begin":93,"end":98},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T286","span":{"begin":113,"end":118},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T287","span":{"begin":119,"end":121},"obj":"http://purl.obolibrary.org/obo/CLO_0001997"},{"id":"T288","span":{"begin":136,"end":141},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T289","span":{"begin":142,"end":144},"obj":"http://purl.obolibrary.org/obo/CLO_0001997"},{"id":"T290","span":{"begin":339,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0009899"},{"id":"T291","span":{"begin":345,"end":350},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T292","span":{"begin":410,"end":411},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T293","span":{"begin":432,"end":436},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T294","span":{"begin":432,"end":436},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T295","span":{"begin":592,"end":596},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T296","span":{"begin":592,"end":596},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T297","span":{"begin":664,"end":668},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T298","span":{"begin":664,"end":668},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T108","span":{"begin":597,"end":602},"obj":"Chemical"}],"attributes":[{"id":"A108","pred":"chebi_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T61","span":{"begin":628,"end":640},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T25","span":{"begin":384,"end":398},"obj":"Phenotype"},{"id":"T26","span":{"begin":560,"end":571},"obj":"Phenotype"}],"attributes":[{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0001894"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0001824"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}

{"project":"LitCovid-sentences","denotations":[{"id":"T98","span":{"begin":0,"end":245},"obj":"Sentence"},{"id":"T99","span":{"begin":246,"end":780},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}

{"project":"LitCovid-PubTator","denotations":[{"id":"745","span":{"begin":93,"end":98},"obj":"Species"},{"id":"746","span":{"begin":107,"end":111},"obj":"Species"},{"id":"747","span":{"begin":113,"end":118},"obj":"Species"},{"id":"749","span":{"begin":345,"end":350},"obj":"Species"},{"id":"770","span":{"begin":366,"end":375},"obj":"Species"},{"id":"775","span":{"begin":597,"end":602},"obj":"Chemical"},{"id":"782","span":{"begin":267,"end":276},"obj":"Disease"},{"id":"783","span":{"begin":299,"end":308},"obj":"Disease"},{"id":"784","span":{"begin":384,"end":398},"obj":"Disease"},{"id":"785","span":{"begin":560,"end":571},"obj":"Disease"},{"id":"786","span":{"begin":623,"end":640},"obj":"Disease"}],"attributes":[{"id":"A745","pred":"tao:has_database_id","subj":"745","obj":"Tax:10090"},{"id":"A746","pred":"tao:has_database_id","subj":"746","obj":"Tax:114727"},{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"Tax:10090"},{"id":"A749","pred":"tao:has_database_id","subj":"749","obj":"Tax:10090"},{"id":"A770","pred":"tao:has_database_id","subj":"770","obj":"Tax:11320"},{"id":"A775","pred":"tao:has_database_id","subj":"775","obj":"MESH:D014867"},{"id":"A782","pred":"tao:has_database_id","subj":"782","obj":"MESH:D007239"},{"id":"A783","pred":"tao:has_database_id","subj":"783","obj":"MESH:D007239"},{"id":"A784","pred":"tao:has_database_id","subj":"784","obj":"MESH:D013922"},{"id":"A785","pred":"tao:has_database_id","subj":"785","obj":"MESH:D015431"},{"id":"A786","pred":"tao:has_database_id","subj":"786","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Gotts, 2014 [38] C57BL/6 mice aged 7–10 weeks, i.n. infection, influenza A/Puerto Rico/8/34 (mouse-adapted H1N1) Mouse BM-MSCs (≤P7) or human BM-MSCs (≤P7), 5×105 cells·mouse−1, i.v. (retro-orbital injection) or i.t. (data not shown); two doses: 1) days 5 and 6 post infection, 2) days 2 and 3 post infection (data not shown) Days 7, 9 or 11 No Mouse MSCs prevented influenza-induced thrombocytosis and caused a modest reduction in lung viral load on day 7; early (data not shown) and late syngeneic and xenogeneic i.v. administration of MSCs failed to affect weight loss, failed to decrease lung water, failed to decrease BALF inflammation, and failed to improve lung histology; i.t. administration increased severity of model (data not shown) Nonspecified (soluble mediators) No"}