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LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"145","span":{"begin":178,"end":187},"obj":"Chemical"},{"id":"146","span":{"begin":232,"end":250},"obj":"Chemical"},{"id":"147","span":{"begin":252,"end":262},"obj":"Chemical"},{"id":"148","span":{"begin":308,"end":314},"obj":"Chemical"},{"id":"149","span":{"begin":562,"end":572},"obj":"Chemical"},{"id":"150","span":{"begin":1484,"end":1495},"obj":"Chemical"},{"id":"151","span":{"begin":716,"end":730},"obj":"Disease"}],"attributes":[{"id":"A146","pred":"tao:has_database_id","subj":"146","obj":"MESH:D006844"},{"id":"A147","pred":"tao:has_database_id","subj":"147","obj":"MESH:C046060"},{"id":"A148","pred":"tao:has_database_id","subj":"148","obj":"MESH:C036216"},{"id":"A149","pred":"tao:has_database_id","subj":"149","obj":"MESH:C046060"},{"id":"A150","pred":"tao:has_database_id","subj":"150","obj":"MESH:C506365"},{"id":"A151","pred":"tao:has_database_id","subj":"151","obj":"MESH:D006333"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"COC [42] is chosen as polymeric substrate because of its biocompatibility, optical transparency, physical resistance, chemical resistance, electrical insulation, and price. This copolymer consists of two monomers, an apolar bridged cyclic hydrocarbon (norbornene) monomer and a linear, lesser apolar, linear ethene monomers. Injection molded COC plates (10 cm by 10 cm and 1.5 mm thickness) of the grade TOPAS 6017 (see Figure 4a) are obtained via Kunststoff-Zentrum Leipzig (Kunststoff-Zentrum gGmbH, Leipzig, Germany). This grade is chosen because of its high norbornene content, giving it a relatively high Tg of 170 °C. This minimizes the chance of melting during the milling process and decreases the chance of heater failure due to a deforming substrate during operation of the heater [28]. The microfluidic structure explained in Section 2.1 is CNC-milled using a Mikron WF 21C milling machine (Mikron SA Agno, Agno, Switzerland), as can be seen in Figure 4b. Milling is a very fast prototyping technique and chosen because of its flexibility [41]. The milling creates a surface roughness, which increases the surface-area-to-volume ratio. This roughness increases the chance of inhibition during the amplification due to the interaction of the used chemicals with the surface [44]. It also causes a considerable loss of optical transparency, which could obstruct the potential use of in situ fluorescence detection in future devices. Therefore, a chemical post-treatment with cyclohexane vapor is done (see Figure 4c). Such treatment dissolves a thin outer layer of the COC substrate and causes reflowing of the surface roughness due to the surface tension of the material, restoring the optical transparency and reducing the surface roughness [59]."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T24","span":{"begin":852,"end":855},"obj":"Disease"}],"attributes":[{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0015285"},{"id":"A25","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0019134"}],"text":"COC [42] is chosen as polymeric substrate because of its biocompatibility, optical transparency, physical resistance, chemical resistance, electrical insulation, and price. This copolymer consists of two monomers, an apolar bridged cyclic hydrocarbon (norbornene) monomer and a linear, lesser apolar, linear ethene monomers. Injection molded COC plates (10 cm by 10 cm and 1.5 mm thickness) of the grade TOPAS 6017 (see Figure 4a) are obtained via Kunststoff-Zentrum Leipzig (Kunststoff-Zentrum gGmbH, Leipzig, Germany). This grade is chosen because of its high norbornene content, giving it a relatively high Tg of 170 °C. This minimizes the chance of melting during the milling process and decreases the chance of heater failure due to a deforming substrate during operation of the heater [28]. The microfluidic structure explained in Section 2.1 is CNC-milled using a Mikron WF 21C milling machine (Mikron SA Agno, Agno, Switzerland), as can be seen in Figure 4b. Milling is a very fast prototyping technique and chosen because of its flexibility [41]. The milling creates a surface roughness, which increases the surface-area-to-volume ratio. This roughness increases the chance of inhibition during the amplification due to the interaction of the used chemicals with the surface [44]. It also causes a considerable loss of optical transparency, which could obstruct the potential use of in situ fluorescence detection in future devices. Therefore, a chemical post-treatment with cyclohexane vapor is done (see Figure 4c). Such treatment dissolves a thin outer layer of the COC substrate and causes reflowing of the surface roughness due to the surface tension of the material, restoring the optical transparency and reducing the surface roughness [59]."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T150","span":{"begin":276,"end":277},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T151","span":{"begin":592,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T152","span":{"begin":738,"end":739},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T153","span":{"begin":852,"end":855},"obj":"http://purl.obolibrary.org/obo/UBERON_0003099"},{"id":"T154","span":{"begin":869,"end":870},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T155","span":{"begin":978,"end":979},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T156","span":{"begin":1051,"end":1053},"obj":"http://purl.obolibrary.org/obo/CLO_0053794"},{"id":"T157","span":{"begin":1076,"end":1077},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T158","span":{"begin":1305,"end":1306},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T159","span":{"begin":1433,"end":1440},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T160","span":{"begin":1453,"end":1454},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T161","span":{"begin":1522,"end":1524},"obj":"http://purl.obolibrary.org/obo/CLO_0001387"},{"id":"T162","span":{"begin":1552,"end":1553},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"COC [42] is chosen as polymeric substrate because of its biocompatibility, optical transparency, physical resistance, chemical resistance, electrical insulation, and price. This copolymer consists of two monomers, an apolar bridged cyclic hydrocarbon (norbornene) monomer and a linear, lesser apolar, linear ethene monomers. Injection molded COC plates (10 cm by 10 cm and 1.5 mm thickness) of the grade TOPAS 6017 (see Figure 4a) are obtained via Kunststoff-Zentrum Leipzig (Kunststoff-Zentrum gGmbH, Leipzig, Germany). This grade is chosen because of its high norbornene content, giving it a relatively high Tg of 170 °C. This minimizes the chance of melting during the milling process and decreases the chance of heater failure due to a deforming substrate during operation of the heater [28]. The microfluidic structure explained in Section 2.1 is CNC-milled using a Mikron WF 21C milling machine (Mikron SA Agno, Agno, Switzerland), as can be seen in Figure 4b. Milling is a very fast prototyping technique and chosen because of its flexibility [41]. The milling creates a surface roughness, which increases the surface-area-to-volume ratio. This roughness increases the chance of inhibition during the amplification due to the interaction of the used chemicals with the surface [44]. It also causes a considerable loss of optical transparency, which could obstruct the potential use of in situ fluorescence detection in future devices. Therefore, a chemical post-treatment with cyclohexane vapor is done (see Figure 4c). Such treatment dissolves a thin outer layer of the COC substrate and causes reflowing of the surface roughness due to the surface tension of the material, restoring the optical transparency and reducing the surface roughness [59]."}

LitCovid-PD-CHEBI

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T171","span":{"begin":0,"end":172},"obj":"Sentence"},{"id":"T172","span":{"begin":173,"end":324},"obj":"Sentence"},{"id":"T173","span":{"begin":325,"end":520},"obj":"Sentence"},{"id":"T174","span":{"begin":521,"end":623},"obj":"Sentence"},{"id":"T175","span":{"begin":624,"end":796},"obj":"Sentence"},{"id":"T176","span":{"begin":797,"end":966},"obj":"Sentence"},{"id":"T177","span":{"begin":967,"end":1055},"obj":"Sentence"},{"id":"T178","span":{"begin":1056,"end":1146},"obj":"Sentence"},{"id":"T179","span":{"begin":1147,"end":1289},"obj":"Sentence"},{"id":"T180","span":{"begin":1290,"end":1441},"obj":"Sentence"},{"id":"T181","span":{"begin":1442,"end":1526},"obj":"Sentence"},{"id":"T182","span":{"begin":1527,"end":1757},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"COC [42] is chosen as polymeric substrate because of its biocompatibility, optical transparency, physical resistance, chemical resistance, electrical insulation, and price. This copolymer consists of two monomers, an apolar bridged cyclic hydrocarbon (norbornene) monomer and a linear, lesser apolar, linear ethene monomers. Injection molded COC plates (10 cm by 10 cm and 1.5 mm thickness) of the grade TOPAS 6017 (see Figure 4a) are obtained via Kunststoff-Zentrum Leipzig (Kunststoff-Zentrum gGmbH, Leipzig, Germany). This grade is chosen because of its high norbornene content, giving it a relatively high Tg of 170 °C. This minimizes the chance of melting during the milling process and decreases the chance of heater failure due to a deforming substrate during operation of the heater [28]. The microfluidic structure explained in Section 2.1 is CNC-milled using a Mikron WF 21C milling machine (Mikron SA Agno, Agno, Switzerland), as can be seen in Figure 4b. Milling is a very fast prototyping technique and chosen because of its flexibility [41]. The milling creates a surface roughness, which increases the surface-area-to-volume ratio. This roughness increases the chance of inhibition during the amplification due to the interaction of the used chemicals with the surface [44]. It also causes a considerable loss of optical transparency, which could obstruct the potential use of in situ fluorescence detection in future devices. Therefore, a chemical post-treatment with cyclohexane vapor is done (see Figure 4c). Such treatment dissolves a thin outer layer of the COC substrate and causes reflowing of the surface roughness due to the surface tension of the material, restoring the optical transparency and reducing the surface roughness [59]."}

2_test

{"project":"2_test","denotations":[{"id":"32106462-25906246-69893319","span":{"begin":1051,"end":1053},"obj":"25906246"}],"text":"COC [42] is chosen as polymeric substrate because of its biocompatibility, optical transparency, physical resistance, chemical resistance, electrical insulation, and price. This copolymer consists of two monomers, an apolar bridged cyclic hydrocarbon (norbornene) monomer and a linear, lesser apolar, linear ethene monomers. Injection molded COC plates (10 cm by 10 cm and 1.5 mm thickness) of the grade TOPAS 6017 (see Figure 4a) are obtained via Kunststoff-Zentrum Leipzig (Kunststoff-Zentrum gGmbH, Leipzig, Germany). This grade is chosen because of its high norbornene content, giving it a relatively high Tg of 170 °C. This minimizes the chance of melting during the milling process and decreases the chance of heater failure due to a deforming substrate during operation of the heater [28]. The microfluidic structure explained in Section 2.1 is CNC-milled using a Mikron WF 21C milling machine (Mikron SA Agno, Agno, Switzerland), as can be seen in Figure 4b. Milling is a very fast prototyping technique and chosen because of its flexibility [41]. The milling creates a surface roughness, which increases the surface-area-to-volume ratio. This roughness increases the chance of inhibition during the amplification due to the interaction of the used chemicals with the surface [44]. It also causes a considerable loss of optical transparency, which could obstruct the potential use of in situ fluorescence detection in future devices. Therefore, a chemical post-treatment with cyclohexane vapor is done (see Figure 4c). Such treatment dissolves a thin outer layer of the COC substrate and causes reflowing of the surface roughness due to the surface tension of the material, restoring the optical transparency and reducing the surface roughness [59]."}