PMC:7128678 / 8080-9989 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7128678","sourcedb":"PMC","sourceid":"7128678","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7128678","text":"Neu5Ac is the predominant sialic acid found in human glycoproteins and gangliosides. When CLQ was merged with Neu5Ac, a quasi-instantaneous fit occurred between the two molecules, whose global shapes in water are geometrically complementary Fig. 2 (a). This is particularly obvious in the views of the CLQ–Neu5Ac complex in mixed surface/balls and sticks rendition Fig. 2(a,b). The interaction was driven by the positioning of the negative charge of the carboxylate group of Neu5Ac and one of the two cationic charges of CLQ (pKa 10.2) Fig. 2(c). The energy of interaction of this complex was estimated to be -47 kJ.mol−1. As coronaviruses preferentially interact with 9-O-acetyl-N-acetylneuraminic acid (9-O-SIA) [10], this study used a similar molecular modelling approach to assess whether CLQ could also interact with this specific sialic acid. A good fit between CLQ and 9-O-SIA was obtained Fig. 2(d–f), with an energy of interaction of -45 kJ.mol−1. In this case, the carboxylate group of the sialic acid interacted with the cationic group of the nitrogen-containing ring of CLQ (pKa 8.1) Fig. 2(d). The complex was further stabilized by OH-π and van der Waals interactions.\nFig. 2 Molecular modelling of chloroquine (CLQ) interaction with sialic acids. (a,b) Surface representation of the CLQ–sialic acid (Neu5Ac) complex. Two opposite views of the complex are shown. Note the geometric complementarity between the L-shape conformer of CLQ dissolved in water (in blue) and Neu5Ac (in red). (c) Neu5Ac bound to CLQ via a combination of CH-π and electrostatic interactions with one of the cationic groups of CLQ (+). (d) Molecular modelling of CLQ bound to N-acetyl-9-O-acetylneuraminic acid (9-O-SIA). From right to left, the dashed lines indicate a series of van der Waals, OH-π and electrostatic contacts with both cationic groups of CLQ (+). (e,f) Surface representations of the CLQ–9-O-SIA complex.","divisions":[{"label":"label","span":{"begin":1182,"end":1188}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"248","span":{"begin":1212,"end":1223},"obj":"Chemical"},{"id":"249","span":{"begin":1247,"end":1259},"obj":"Chemical"},{"id":"250","span":{"begin":1301,"end":1312},"obj":"Chemical"},{"id":"251","span":{"begin":1314,"end":1320},"obj":"Chemical"},{"id":"252","span":{"begin":1461,"end":1466},"obj":"Chemical"},{"id":"253","span":{"begin":1481,"end":1487},"obj":"Chemical"},{"id":"254","span":{"begin":1502,"end":1508},"obj":"Chemical"},{"id":"255","span":{"begin":1543,"end":1547},"obj":"Chemical"},{"id":"256","span":{"begin":1663,"end":1697},"obj":"Chemical"},{"id":"257","span":{"begin":1782,"end":1786},"obj":"Chemical"},{"id":"275","span":{"begin":47,"end":52},"obj":"Species"},{"id":"276","span":{"begin":626,"end":639},"obj":"Species"},{"id":"277","span":{"begin":0,"end":6},"obj":"Chemical"},{"id":"278","span":{"begin":26,"end":37},"obj":"Chemical"},{"id":"279","span":{"begin":71,"end":83},"obj":"Chemical"},{"id":"280","span":{"begin":110,"end":116},"obj":"Chemical"},{"id":"281","span":{"begin":203,"end":208},"obj":"Chemical"},{"id":"282","span":{"begin":306,"end":312},"obj":"Chemical"},{"id":"283","span":{"begin":454,"end":465},"obj":"Chemical"},{"id":"284","span":{"begin":475,"end":481},"obj":"Chemical"},{"id":"285","span":{"begin":669,"end":703},"obj":"Chemical"},{"id":"286","span":{"begin":836,"end":847},"obj":"Chemical"},{"id":"287","span":{"begin":975,"end":986},"obj":"Chemical"},{"id":"288","span":{"begin":1000,"end":1011},"obj":"Chemical"},{"id":"289","span":{"begin":1054,"end":1062},"obj":"Chemical"},{"id":"290","span":{"begin":1145,"end":1149},"obj":"Chemical"},{"id":"291","span":{"begin":120,"end":143},"obj":"Disease"}],"attributes":[{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"MESH:D002738"},{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"MESH:D012794"},{"id":"A250","pred":"tao:has_database_id","subj":"250","obj":"MESH:D019158"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"MESH:D014867"},{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"MESH:C025676"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"Tax:9606"},{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"Tax:11118"},{"id":"A278","pred":"tao:has_database_id","subj":"278","obj":"MESH:D019158"},{"id":"A279","pred":"tao:has_database_id","subj":"279","obj":"MESH:D005732"},{"id":"A281","pred":"tao:has_database_id","subj":"281","obj":"MESH:D014867"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"MESH:C025676"},{"id":"A286","pred":"tao:has_database_id","subj":"286","obj":"MESH:D019158"},{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"MESH:D019158"},{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"MESH:D009584"},{"id":"A291","pred":"tao:has_database_id","subj":"291","obj":"MESH:D012640"},{"subj":"248","pred":"source","obj":"LitCovid-PubTator"},{"subj":"249","pred":"source","obj":"LitCovid-PubTator"},{"subj":"250","pred":"source","obj":"LitCovid-PubTator"},{"subj":"251","pred":"source","obj":"LitCovid-PubTator"},{"subj":"252","pred":"source","obj":"LitCovid-PubTator"},{"subj":"253","pred":"source","obj":"LitCovid-PubTator"},{"subj":"254","pred":"source","obj":"LitCovid-PubTator"},{"subj":"255","pred":"source","obj":"LitCovid-PubTator"},{"subj":"256","pred":"source","obj":"LitCovid-PubTator"},{"subj":"257","pred":"source","obj":"LitCovid-PubTator"},{"subj":"275","pred":"source","obj":"LitCovid-PubTator"},{"subj":"276","pred":"source","obj":"LitCovid-PubTator"},{"subj":"277","pred":"source","obj":"LitCovid-PubTator"},{"subj":"278","pred":"source","obj":"LitCovid-PubTator"},{"subj":"279","pred":"source","obj":"LitCovid-PubTator"},{"subj":"280","pred":"source","obj":"LitCovid-PubTator"},{"subj":"281","pred":"source","obj":"LitCovid-PubTator"},{"subj":"282","pred":"source","obj":"LitCovid-PubTator"},{"subj":"283","pred":"source","obj":"LitCovid-PubTator"},{"subj":"284","pred":"source","obj":"LitCovid-PubTator"},{"subj":"285","pred":"source","obj":"LitCovid-PubTator"},{"subj":"286","pred":"source","obj":"LitCovid-PubTator"},{"subj":"287","pred":"source","obj":"LitCovid-PubTator"},{"subj":"288","pred":"source","obj":"LitCovid-PubTator"},{"subj":"289","pred":"source","obj":"LitCovid-PubTator"},{"subj":"290","pred":"source","obj":"LitCovid-PubTator"},{"subj":"291","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T179","span":{"begin":0,"end":6},"obj":"PR:000002082"},{"id":"T180","span":{"begin":26,"end":32},"obj":"CHEBI:30563;CHEBI:30563"},{"id":"T181","span":{"begin":33,"end":37},"obj":"CHEBI:24195;CHEBI:24195"},{"id":"T182","span":{"begin":47,"end":52},"obj":"SP_6;NCBITaxon:9606"},{"id":"T183","span":{"begin":53,"end":66},"obj":"CHEBI:17089;CHEBI:17089;BV_11"},{"id":"T184","span":{"begin":71,"end":83},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T185","span":{"begin":110,"end":116},"obj":"PR:000002082"},{"id":"T186","span":{"begin":169,"end":178},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T187","span":{"begin":203,"end":208},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T188","span":{"begin":306,"end":312},"obj":"PR:000002082"},{"id":"T189","span":{"begin":313,"end":320},"obj":"GO:0032991"},{"id":"T190","span":{"begin":475,"end":481},"obj":"PR:000002082"},{"id":"T191","span":{"begin":501,"end":509},"obj":"CHEBI:36916;CHEBI:36916"},{"id":"T192","span":{"begin":581,"end":588},"obj":"GO:0032991"},{"id":"T193","span":{"begin":626,"end":639},"obj":"NCBITaxon:11118"},{"id":"T194","span":{"begin":669,"end":670},"obj":"CHEBI:16066;CHEBI:16066"},{"id":"T195","span":{"begin":673,"end":679},"obj":"CHEBI:40574;CHEBI:40574"},{"id":"T196","span":{"begin":680,"end":703},"obj":"CHEBI:17012;CHEBI:17012"},{"id":"T197","span":{"begin":836,"end":847},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T198","span":{"begin":987,"end":992},"obj":"CHEBI:24433;CHEBI:24433"},{"id":"T199","span":{"begin":1000,"end":1011},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T200","span":{"begin":1032,"end":1046},"obj":"CHEBI:64766;CHEBI:64766"},{"id":"T201","span":{"begin":1111,"end":1118},"obj":"GO:0032991"},{"id":"T202","span":{"begin":1212,"end":1223},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T203","span":{"begin":1247,"end":1259},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T204","span":{"begin":1301,"end":1307},"obj":"CHEBI:30563;CHEBI:30563"},{"id":"T205","span":{"begin":1308,"end":1312},"obj":"CHEBI:41865;CHEBI:41865"},{"id":"T206","span":{"begin":1314,"end":1320},"obj":"PR:000002082"},{"id":"T207","span":{"begin":1322,"end":1329},"obj":"GO:0032991"},{"id":"T208","span":{"begin":1357,"end":1364},"obj":"GO:0032991"},{"id":"T209","span":{"begin":1461,"end":1466},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T210","span":{"begin":1481,"end":1487},"obj":"PR:000002082"},{"id":"T211","span":{"begin":1502,"end":1508},"obj":"PR:000002082"},{"id":"T212","span":{"begin":1595,"end":1610},"obj":"CHEBI:64766;CHEBI:64766"},{"id":"T213","span":{"begin":1663,"end":1697},"obj":"CHEBI:21500;CHEBI:21500"},{"id":"T214","span":{"begin":1824,"end":1839},"obj":"CHEBI:64766;CHEBI:64766"},{"id":"T215","span":{"begin":1901,"end":1908},"obj":"GO:0032991"}],"attributes":[{"subj":"T179","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T180","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T181","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T182","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T183","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T184","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T185","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T186","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T187","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T188","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T189","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T190","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T191","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T192","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T193","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T194","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T195","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T196","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T197","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T198","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T199","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T200","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T201","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T202","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T203","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T204","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T205","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T206","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T207","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T208","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T209","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T210","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T211","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T212","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T213","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T214","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T215","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T39","span":{"begin":53,"end":66},"obj":"Body_part"},{"id":"T40","span":{"begin":71,"end":83},"obj":"Body_part"},{"id":"T41","span":{"begin":680,"end":703},"obj":"Body_part"}],"attributes":[{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma82788"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T51","span":{"begin":47,"end":52},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T52","span":{"begin":118,"end":119},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T53","span":{"begin":246,"end":251},"obj":"http://purl.obolibrary.org/obo/CLO_0001236"},{"id":"T54","span":{"begin":372,"end":373},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T55","span":{"begin":374,"end":375},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T56","span":{"begin":736,"end":737},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T57","span":{"begin":849,"end":850},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T58","span":{"begin":904,"end":907},"obj":"http://purl.obolibrary.org/obo/CLO_0002755"},{"id":"T59","span":{"begin":944,"end":946},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T60","span":{"begin":1262,"end":1263},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T61","span":{"begin":1264,"end":1265},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T62","span":{"begin":1526,"end":1527},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T63","span":{"begin":1755,"end":1756},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T51","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T122","span":{"begin":0,"end":6},"obj":"Chemical"},{"id":"T124","span":{"begin":26,"end":37},"obj":"Chemical"},{"id":"T125","span":{"begin":33,"end":37},"obj":"Chemical"},{"id":"T126","span":{"begin":53,"end":66},"obj":"Chemical"},{"id":"T127","span":{"begin":71,"end":83},"obj":"Chemical"},{"id":"T128","span":{"begin":110,"end":116},"obj":"Chemical"},{"id":"T130","span":{"begin":169,"end":178},"obj":"Chemical"},{"id":"T131","span":{"begin":203,"end":208},"obj":"Chemical"},{"id":"T132","span":{"begin":306,"end":312},"obj":"Chemical"},{"id":"T134","span":{"begin":466,"end":471},"obj":"Chemical"},{"id":"T135","span":{"begin":475,"end":481},"obj":"Chemical"},{"id":"T137","span":{"begin":673,"end":679},"obj":"Chemical"},{"id":"T139","span":{"begin":680,"end":703},"obj":"Chemical"},{"id":"T140","span":{"begin":699,"end":703},"obj":"Chemical"},{"id":"T141","span":{"begin":836,"end":847},"obj":"Chemical"},{"id":"T142","span":{"begin":843,"end":847},"obj":"Chemical"},{"id":"T143","span":{"begin":987,"end":992},"obj":"Chemical"},{"id":"T144","span":{"begin":1000,"end":1011},"obj":"Chemical"},{"id":"T145","span":{"begin":1007,"end":1011},"obj":"Chemical"},{"id":"T146","span":{"begin":1032,"end":1046},"obj":"Chemical"},{"id":"T147","span":{"begin":1041,"end":1046},"obj":"Chemical"},{"id":"T148","span":{"begin":1054,"end":1062},"obj":"Chemical"},{"id":"T149","span":{"begin":1212,"end":1223},"obj":"Chemical"},{"id":"T150","span":{"begin":1247,"end":1259},"obj":"Chemical"},{"id":"T151","span":{"begin":1254,"end":1259},"obj":"Chemical"},{"id":"T152","span":{"begin":1301,"end":1312},"obj":"Chemical"},{"id":"T153","span":{"begin":1308,"end":1312},"obj":"Chemical"},{"id":"T154","span":{"begin":1314,"end":1320},"obj":"Chemical"},{"id":"T156","span":{"begin":1461,"end":1466},"obj":"Chemical"},{"id":"T157","span":{"begin":1481,"end":1487},"obj":"Chemical"},{"id":"T159","span":{"begin":1502,"end":1508},"obj":"Chemical"},{"id":"T161","span":{"begin":1595,"end":1610},"obj":"Chemical"},{"id":"T162","span":{"begin":1663,"end":1697},"obj":"Chemical"},{"id":"T163","span":{"begin":1665,"end":1671},"obj":"Chemical"},{"id":"T165","span":{"begin":1693,"end":1697},"obj":"Chemical"},{"id":"T166","span":{"begin":1824,"end":1839},"obj":"Chemical"}],"attributes":[{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A123","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A129","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A132","pred":"chebi_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A133","pred":"chebi_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A136","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A138","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A145","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A146","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_64766"},{"id":"A147","pred":"chebi_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A151","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A152","pred":"chebi_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A155","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A156","pred":"chebi_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A157","pred":"chebi_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A158","pred":"chebi_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A159","pred":"chebi_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A160","pred":"chebi_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A161","pred":"chebi_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/CHEBI_64766"},{"id":"A162","pred":"chebi_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/CHEBI_21500"},{"id":"A163","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A164","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A165","pred":"chebi_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A166","pred":"chebi_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/CHEBI_64766"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T130","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T131","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T132","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T135","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T139","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T140","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T141","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T142","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T145","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T146","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T147","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T148","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T63","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"T64","span":{"begin":85,"end":252},"obj":"Sentence"},{"id":"T65","span":{"begin":253,"end":377},"obj":"Sentence"},{"id":"T66","span":{"begin":378,"end":546},"obj":"Sentence"},{"id":"T67","span":{"begin":547,"end":622},"obj":"Sentence"},{"id":"T68","span":{"begin":623,"end":848},"obj":"Sentence"},{"id":"T69","span":{"begin":849,"end":956},"obj":"Sentence"},{"id":"T70","span":{"begin":957,"end":1106},"obj":"Sentence"},{"id":"T71","span":{"begin":1107,"end":1181},"obj":"Sentence"},{"id":"T72","span":{"begin":1182,"end":1330},"obj":"Sentence"},{"id":"T73","span":{"begin":1331,"end":1375},"obj":"Sentence"},{"id":"T74","span":{"begin":1376,"end":1708},"obj":"Sentence"},{"id":"T75","span":{"begin":1709,"end":1909},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T63","pred":"source","obj":"LitCovid-sentences"},{"subj":"T64","pred":"source","obj":"LitCovid-sentences"},{"subj":"T65","pred":"source","obj":"LitCovid-sentences"},{"subj":"T66","pred":"source","obj":"LitCovid-sentences"},{"subj":"T67","pred":"source","obj":"LitCovid-sentences"},{"subj":"T68","pred":"source","obj":"LitCovid-sentences"},{"subj":"T69","pred":"source","obj":"LitCovid-sentences"},{"subj":"T70","pred":"source","obj":"LitCovid-sentences"},{"subj":"T71","pred":"source","obj":"LitCovid-sentences"},{"subj":"T72","pred":"source","obj":"LitCovid-sentences"},{"subj":"T73","pred":"source","obj":"LitCovid-sentences"},{"subj":"T74","pred":"source","obj":"LitCovid-sentences"},{"subj":"T75","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32251731-23873408-48149952","span":{"begin":715,"end":717},"obj":"23873408"},{"id":"T46400","span":{"begin":715,"end":717},"obj":"23873408"}],"attributes":[{"subj":"32251731-23873408-48149952","pred":"source","obj":"2_test"},{"subj":"T46400","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93bd","default":true},{"id":"LitCovid-PMC-OGER-BB","color":"#93d7ec"},{"id":"LitCovid-PD-FMA-UBERON","color":"#ece693"},{"id":"LitCovid-PD-CLO","color":"#cc93ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ecb2"},{"id":"LitCovid-sentences","color":"#ec9893"},{"id":"2_test","color":"#93a7ec"}]}]}}