> top > docs > PMC:7128678 > spans > 24138-25005 > annotations

PMC:7128678 / 24138-25005 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
671 23-41 Chemical denotes hydroxychloroquine MESH:D006886
672 43-49 Chemical denotes CLQ-OH
673 89-92 Chemical denotes GM1 MESH:D005677
674 113-116 Chemical denotes GM1 MESH:D005677
675 141-147 Chemical denotes CLQ-OH
676 197-203 Chemical denotes CLQ-OH
677 219-222 Chemical denotes GM1 MESH:D005677
678 310-317 Chemical denotes glucose MESH:D005947
679 327-330 Chemical denotes GM1 MESH:D005677
680 354-360 Chemical denotes CLQ-OH
681 397-400 Chemical denotes GM1 MESH:D005677
682 436-441 Chemical denotes N-137 MESH:C022084
683 480-501 Chemical denotes N-acetylgalactosamine MESH:D000116
684 513-516 Chemical denotes GM1 MESH:D005677
685 571-577 Chemical denotes CLQ-OH
686 594-597 Chemical denotes GM1 MESH:D005677
687 693-699 Chemical denotes CLQ-OH
688 719-722 Chemical denotes GM1 MESH:D005677
689 791-794 Chemical denotes GM1 MESH:D005677
690 805-811 Chemical denotes CLQ-OH
691 855-866 Chemical denotes ganglioside MESH:D005732

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T535 23-41 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T536 67-73 SO:0000417 denotes domain
T537 148-157 CHEBI:36357;CHEBI:36357 denotes molecules
T538 204-213 CHEBI:36357;CHEBI:36357 denotes molecules
T539 310-317 CHEBI:17234;CHEBI:17234 denotes glucose
T540 480-501 CHEBI:28800;CHEBI:28800 denotes N-acetylgalactosamine
T541 623-627 CHEBI:23888;CHEBI:23888 denotes drug
T542 700-709 CHEBI:36357;CHEBI:36357 denotes molecules
T543 812-821 CHEBI:36357;CHEBI:36357 denotes molecules
T544 855-866 CHEBI:5386;CHEBI:5386 denotes ganglioside

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T161 310-317 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T162 480-501 Body_part denotes N-acetylgalactosamine http://purl.org/sig/ont/fma/fma82786
T163 855-866 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T111 75-78 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T113 184-187 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T115 457-460 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T117 656-659 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T119 776-779 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T190 246-247 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 248-249 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T192 405-406 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T579 23-41 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T580 89-92 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T583 113-116 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T586 148-157 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T587 204-213 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T588 219-222 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T591 310-317 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T593 327-330 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T596 397-400 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T599 480-501 Chemical denotes N-acetylgalactosamine http://purl.obolibrary.org/obo/CHEBI_28800
T600 513-516 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T603 594-597 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T606 623-627 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T607 700-709 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T608 719-722 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T611 791-794 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T614 812-821 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T615 855-866 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T34 89-92 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T35 113-116 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T36 219-222 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T37 327-330 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T38 397-400 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T39 513-516 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T40 594-597 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T41 719-722 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T42 791-794 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T199 52-158 Sentence denotes The N-terminal domain (NTD) bound to GM1 was superposed onto GM1 in interaction with two CLQ-OH molecules.
T200 159-431 Sentence denotes The models only show the NTD and both CLQ-OH molecules (not GM1, to improve clarity). (a,b) The aromatic ring of F-135 (in red), which stacks onto the glucose cycle of GM1, overlaps the aromatic CLQ-OH rings (in green) which also bind to GM1 via a CH-π stacking mechanism.
T201 432-867 Sentence denotes The N-137 residue of the NTD interacts with the N-acetylgalactosamine residue of GM1, but this interaction cannot occur in the presence of CLQ-OH as this part of GM1 is totally masked by the drug. (c,d) Superposition of the NTD surface (in purple) with the two CLQ-OH molecules bound to GM1, illustrating the steric impossibility that prevents NTD binding to GM1 when both CLQ-OH molecules are already interacting with the ganglioside.