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PMC:7128678 / 24131-25005 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
671 30-48 Chemical denotes hydroxychloroquine MESH:D006886
672 50-56 Chemical denotes CLQ-OH
673 96-99 Chemical denotes GM1 MESH:D005677
674 120-123 Chemical denotes GM1 MESH:D005677
675 148-154 Chemical denotes CLQ-OH
676 204-210 Chemical denotes CLQ-OH
677 226-229 Chemical denotes GM1 MESH:D005677
678 317-324 Chemical denotes glucose MESH:D005947
679 334-337 Chemical denotes GM1 MESH:D005677
680 361-367 Chemical denotes CLQ-OH
681 404-407 Chemical denotes GM1 MESH:D005677
682 443-448 Chemical denotes N-137 MESH:C022084
683 487-508 Chemical denotes N-acetylgalactosamine MESH:D000116
684 520-523 Chemical denotes GM1 MESH:D005677
685 578-584 Chemical denotes CLQ-OH
686 601-604 Chemical denotes GM1 MESH:D005677
687 700-706 Chemical denotes CLQ-OH
688 726-729 Chemical denotes GM1 MESH:D005677
689 798-801 Chemical denotes GM1 MESH:D005677
690 812-818 Chemical denotes CLQ-OH
691 862-873 Chemical denotes ganglioside MESH:D005732

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T535 30-48 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T536 74-80 SO:0000417 denotes domain
T537 155-164 CHEBI:36357;CHEBI:36357 denotes molecules
T538 211-220 CHEBI:36357;CHEBI:36357 denotes molecules
T539 317-324 CHEBI:17234;CHEBI:17234 denotes glucose
T540 487-508 CHEBI:28800;CHEBI:28800 denotes N-acetylgalactosamine
T541 630-634 CHEBI:23888;CHEBI:23888 denotes drug
T542 707-716 CHEBI:36357;CHEBI:36357 denotes molecules
T543 819-828 CHEBI:36357;CHEBI:36357 denotes molecules
T544 862-873 CHEBI:5386;CHEBI:5386 denotes ganglioside

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T161 317-324 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T162 487-508 Body_part denotes N-acetylgalactosamine http://purl.org/sig/ont/fma/fma82786
T163 862-873 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T111 82-85 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T113 191-194 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T115 464-467 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T117 663-666 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T119 783-786 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T190 253-254 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 255-256 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T192 412-413 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T579 30-48 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T580 96-99 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T583 120-123 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T586 155-164 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T587 211-220 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T588 226-229 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T591 317-324 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T593 334-337 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T596 404-407 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T599 487-508 Chemical denotes N-acetylgalactosamine http://purl.obolibrary.org/obo/CHEBI_28800
T600 520-523 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T603 601-604 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T606 630-634 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T607 707-716 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T608 726-729 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T611 798-801 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T614 819-828 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T615 862-873 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T34 96-99 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T35 120-123 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T36 226-229 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T37 334-337 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T38 404-407 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T39 520-523 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T40 601-604 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T41 726-729 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T42 798-801 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T198 0-58 Sentence denotes Fig. 9 Mechanism of action of hydroxychloroquine (CLQ-OH).
T199 59-165 Sentence denotes The N-terminal domain (NTD) bound to GM1 was superposed onto GM1 in interaction with two CLQ-OH molecules.
T200 166-438 Sentence denotes The models only show the NTD and both CLQ-OH molecules (not GM1, to improve clarity). (a,b) The aromatic ring of F-135 (in red), which stacks onto the glucose cycle of GM1, overlaps the aromatic CLQ-OH rings (in green) which also bind to GM1 via a CH-π stacking mechanism.
T201 439-874 Sentence denotes The N-137 residue of the NTD interacts with the N-acetylgalactosamine residue of GM1, but this interaction cannot occur in the presence of CLQ-OH as this part of GM1 is totally masked by the drug. (c,d) Superposition of the NTD surface (in purple) with the two CLQ-OH molecules bound to GM1, illustrating the steric impossibility that prevents NTD binding to GM1 when both CLQ-OH molecules are already interacting with the ganglioside.