PMC:7128678 / 22335-25005
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 671 | 1826-1844 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 672 | 1846-1852 | Chemical | denotes | CLQ-OH | |
| 673 | 1892-1895 | Chemical | denotes | GM1 | MESH:D005677 |
| 674 | 1916-1919 | Chemical | denotes | GM1 | MESH:D005677 |
| 675 | 1944-1950 | Chemical | denotes | CLQ-OH | |
| 676 | 2000-2006 | Chemical | denotes | CLQ-OH | |
| 677 | 2022-2025 | Chemical | denotes | GM1 | MESH:D005677 |
| 678 | 2113-2120 | Chemical | denotes | glucose | MESH:D005947 |
| 679 | 2130-2133 | Chemical | denotes | GM1 | MESH:D005677 |
| 680 | 2157-2163 | Chemical | denotes | CLQ-OH | |
| 681 | 2200-2203 | Chemical | denotes | GM1 | MESH:D005677 |
| 682 | 2239-2244 | Chemical | denotes | N-137 | MESH:C022084 |
| 683 | 2283-2304 | Chemical | denotes | N-acetylgalactosamine | MESH:D000116 |
| 684 | 2316-2319 | Chemical | denotes | GM1 | MESH:D005677 |
| 685 | 2374-2380 | Chemical | denotes | CLQ-OH | |
| 686 | 2397-2400 | Chemical | denotes | GM1 | MESH:D005677 |
| 687 | 2496-2502 | Chemical | denotes | CLQ-OH | |
| 688 | 2522-2525 | Chemical | denotes | GM1 | MESH:D005677 |
| 689 | 2594-2597 | Chemical | denotes | GM1 | MESH:D005677 |
| 690 | 2608-2614 | Chemical | denotes | CLQ-OH | |
| 691 | 2658-2669 | Chemical | denotes | ganglioside | MESH:D005732 |
| 730 | 1603-1604 | Gene | denotes | S | Gene:43740568 |
| 731 | 84-94 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 732 | 1592-1602 | Species | denotes | SARS-Cov-2 | Tax:2697049 |
| 733 | 45-51 | Chemical | denotes | CLQ-OH | |
| 734 | 114-126 | Chemical | denotes | gangliosides | MESH:D005732 |
| 735 | 144-147 | Chemical | denotes | GM1 | MESH:D005677 |
| 736 | 183-186 | Chemical | denotes | GM1 | MESH:D005677 |
| 737 | 230-241 | Chemical | denotes | ganglioside | MESH:D005732 |
| 738 | 322-328 | Chemical | denotes | CLQ-OH | |
| 739 | 389-392 | Chemical | denotes | GM1 | MESH:D005677 |
| 740 | 397-400 | Chemical | denotes | GM1 | MESH:D005677 |
| 741 | 520-526 | Chemical | denotes | CLQ-OH | |
| 742 | 536-539 | Chemical | denotes | GM1 | MESH:D005677 |
| 743 | 616-624 | Chemical | denotes | hydrogen | MESH:D006859 |
| 744 | 713-721 | Chemical | denotes | hydrogen | MESH:D006859 |
| 745 | 736-739 | Chemical | denotes | Asn | MESH:D001216 |
| 746 | 803-806 | Chemical | denotes | Phe | MESH:D010649 |
| 747 | 835-838 | Chemical | denotes | Asn | MESH:D001216 |
| 748 | 868-876 | Chemical | denotes | hydrogen | MESH:D006859 |
| 749 | 892-898 | Chemical | denotes | GalNAc | |
| 750 | 910-913 | Chemical | denotes | GM1 | MESH:D005677 |
| 751 | 960-963 | Chemical | denotes | Phe | MESH:D010649 |
| 752 | 998-1001 | Chemical | denotes | Glc | MESH:D005947 |
| 753 | 1013-1016 | Chemical | denotes | GM1 | MESH:D005677 |
| 754 | 1041-1047 | Chemical | denotes | CLQ-OH | |
| 755 | 1059-1067 | Chemical | denotes | nitrogen | MESH:D009584 |
| 756 | 1118-1121 | Chemical | denotes | Glc | MESH:D005947 |
| 757 | 1157-1160 | Chemical | denotes | Phe | MESH:D010649 |
| 758 | 1178-1184 | Chemical | denotes | CLQ-OH | |
| 759 | 1255-1261 | Chemical | denotes | CLQ-OH | |
| 760 | 1300-1305 | Chemical | denotes | sugar | MESH:D000073893 |
| 761 | 1318-1329 | Chemical | denotes | ganglioside | MESH:D005732 |
| 762 | 1350-1368 | Chemical | denotes | GalNAc ganglioside | |
| 763 | 1409-1420 | Chemical | denotes | ganglioside | MESH:D005732 |
| 764 | 1440-1447 | Chemical | denotes | Asn-137 | |
| 765 | 1505-1511 | Chemical | denotes | CLQ-OH | |
| 766 | 1550-1561 | Chemical | denotes | ganglioside | MESH:D005732 |
| 767 | 1625-1636 | Chemical | denotes | ganglioside | MESH:D005732 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T510 | 84-94 | SP_7 | denotes | SARS-CoV-2 |
| T511 | 98-113 | GO:0005886 | denotes | plasma membrane |
| T512 | 114-126 | CHEBI:16856;CHEBI:16856 | denotes | gangliosides |
| T513 | 148-155 | GO:0032991 | denotes | complex |
| T514 | 178-182 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T515 | 187-194 | GO:0032991 | denotes | complex |
| T516 | 230-241 | CHEBI:5386;CHEBI:5386 | denotes | ganglioside |
| T517 | 316-320 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T518 | 417-422 | NCBITaxon:10239 | denotes | viral |
| T519 | 439-443 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T520 | 505-510 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
| T521 | 565-575 | GO:0065007 | denotes | controlled |
| T522 | 786-794 | GO:0045177 | denotes | aromatic |
| T523 | 998-1001 | PR:000022772 | denotes | Glc |
| T524 | 1091-1095 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T525 | 1262-1270 | CHEBI:36357;CHEBI:36357 | denotes | molecule |
| T526 | 1318-1329 | CHEBI:5386;CHEBI:5386 | denotes | ganglioside |
| T527 | 1357-1368 | CHEBI:16856;CHEBI:16856 | denotes | ganglioside |
| T528 | 1409-1420 | CHEBI:5386;CHEBI:5386 | denotes | ganglioside |
| T529 | 1426-1436 | CHEBI:50325;CHEBI:50325 | denotes | side chain |
| T530 | 1525-1534 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T531 | 1550-1561 | CHEBI:16856;CHEBI:16856 | denotes | ganglioside |
| T532 | 1592-1602 | SP_7 | denotes | SARS-Cov-2 |
| T533 | 1603-1612 | PG_1 | denotes | S protein |
| T534 | 1625-1636 | CHEBI:28892;CHEBI:28892 | denotes | ganglioside |
| T535 | 1826-1844 | CHEBI:5801;DG_20;CHEBI:5801 | denotes | hydroxychloroquine |
| T536 | 1870-1876 | SO:0000417 | denotes | domain |
| T537 | 1951-1960 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T538 | 2007-2016 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T539 | 2113-2120 | CHEBI:17234;CHEBI:17234 | denotes | glucose |
| T540 | 2283-2304 | CHEBI:28800;CHEBI:28800 | denotes | N-acetylgalactosamine |
| T541 | 2426-2430 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T542 | 2503-2512 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T543 | 2615-2624 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
| T544 | 2658-2669 | CHEBI:5386;CHEBI:5386 | denotes | ganglioside |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T146 | 98-113 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T147 | 114-126 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T148 | 230-241 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T149 | 423-430 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T150 | 829-833 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T151 | 928-932 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
| T152 | 998-1001 | Body_part | denotes | Glc | http://purl.org/sig/ont/fma/fma82743 |
| T153 | 1118-1121 | Body_part | denotes | Glc | http://purl.org/sig/ont/fma/fma82743 |
| T154 | 1300-1305 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T155 | 1318-1329 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T156 | 1357-1368 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T157 | 1409-1420 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T158 | 1550-1561 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T159 | 1605-1612 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T160 | 1625-1636 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T161 | 2113-2120 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T162 | 2283-2304 | Body_part | denotes | N-acetylgalactosamine | http://purl.org/sig/ont/fma/fma82786 |
| T163 | 2658-2669 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T13 | 829-833 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T14 | 928-932 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T15 | 1289-1292 | Body_part | denotes | tip | http://purl.obolibrary.org/obo/UBERON_2001840 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T99 | 84-92 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T100 | 140-143 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T102 | 304-307 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T104 | 493-496 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T106 | 704-707 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T108 | 1389-1392 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T110 | 1592-1596 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T111 | 1878-1881 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T113 | 1987-1990 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T115 | 2260-2263 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T117 | 2459-2462 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T119 | 2579-2582 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T176 | 9-12 | http://purl.obolibrary.org/obo/PR_000001343 | denotes | aim |
| T177 | 98-104 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T178 | 105-113 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T179 | 176-177 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T180 | 545-546 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T181 | 579-580 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T182 | 614-615 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T183 | 634-635 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T184 | 817-828 | http://purl.obolibrary.org/obo/UBERON_0002481 | denotes | (b). On one |
| T185 | 855-856 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T186 | 1132-1136 | http://purl.obolibrary.org/obo/CLO_0001387 | denotes | 4(c) |
| T187 | 1376-1377 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T188 | 1548-1549 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T189 | 1590-1591 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T190 | 2049-2050 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T191 | 2051-2052 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T192 | 2208-2209 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T517 | 114-126 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T518 | 144-147 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T521 | 178-182 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T522 | 183-186 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T525 | 230-241 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T526 | 316-320 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T527 | 389-392 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T530 | 397-400 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T533 | 423-430 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T534 | 439-443 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T535 | 505-510 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T536 | 536-539 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T539 | 616-624 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T540 | 713-721 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T541 | 736-739 | Chemical | denotes | Asn | http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347 |
| T544 | 803-806 | Chemical | denotes | Phe | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997 |
| T546 | 835-838 | Chemical | denotes | Asn | http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347 |
| T549 | 868-876 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T550 | 892-898 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T552 | 910-913 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T555 | 960-963 | Chemical | denotes | Phe | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997 |
| T557 | 998-1001 | Chemical | denotes | Glc | http://purl.obolibrary.org/obo/CHEBI_17234 |
| T558 | 1013-1016 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T561 | 1059-1067 | Chemical | denotes | nitrogen | http://purl.obolibrary.org/obo/CHEBI_25555 |
| T562 | 1091-1095 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T563 | 1118-1121 | Chemical | denotes | Glc | http://purl.obolibrary.org/obo/CHEBI_17234 |
| T564 | 1157-1160 | Chemical | denotes | Phe | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997 |
| T566 | 1262-1270 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T567 | 1318-1329 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T568 | 1350-1356 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T570 | 1357-1368 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T571 | 1409-1420 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T572 | 1440-1443 | Chemical | denotes | Asn | http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347 |
| T575 | 1525-1534 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T576 | 1550-1561 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T577 | 1605-1612 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T578 | 1625-1636 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T579 | 1826-1844 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T580 | 1892-1895 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T583 | 1916-1919 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T586 | 1951-1960 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T587 | 2007-2016 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T588 | 2022-2025 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T591 | 2113-2120 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T593 | 2130-2133 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T596 | 2200-2203 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T599 | 2283-2304 | Chemical | denotes | N-acetylgalactosamine | http://purl.obolibrary.org/obo/CHEBI_28800 |
| T600 | 2316-2319 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T603 | 2397-2400 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T606 | 2426-2430 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T607 | 2503-2512 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T608 | 2522-2525 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T611 | 2594-2597 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T614 | 2615-2624 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T615 | 2658-2669 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T27 | 144-147 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T28 | 183-186 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T29 | 389-392 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T30 | 397-400 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T31 | 536-539 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T32 | 910-913 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T33 | 1013-1016 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T34 | 1892-1895 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T35 | 1916-1919 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T36 | 2022-2025 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T37 | 2130-2133 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T38 | 2200-2203 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T39 | 2316-2319 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T40 | 2397-2400 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T41 | 2522-2525 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T42 | 2594-2597 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T185 | 0-205 | Sentence | denotes | With the aim of establishing whether CLQ and CLQ-OH could prevent the attachment of SARS-CoV-2 to plasma membrane gangliosides, the initial NTD–GM1 complex was superposed with a drug–GM1 complex (Fig. 9 ). |
| T186 | 206-269 | Sentence | denotes | To improve clarity, the ganglioside is not presented in Fig. 9. |
| T187 | 270-459 | Sentence | denotes | This superposition shows that the NTD and the drug (CLQ-OH in this case) share the same spatial position when bound to GM1, so GM1 cannot bind the viral protein and the drug simultaneously. |
| T188 | 460-684 | Sentence | denotes | This is due to the fact that the NTD and the drugs (CLQ and CLQ-OH) bind to GM1 with a similar mechanism controlled by a dyad of functional interactions: a hydrogen bond and a geometrically perfect CH-π stacking interaction. |
| T189 | 685-821 | Sentence | denotes | In the case of the NTD, the hydrogen bond involves Asn-167, whereas CH-π stacking is mediated by the aromatic ring of Phe-135 Fig. 6(b). |
| T190 | 822-914 | Sentence | denotes | On one hand, Asn-167 establishes a network of hydrogen bonds with the GalNAc residue of GM1. |
| T191 | 915-1017 | Sentence | denotes | On the other hand, the flat aromatic ring of Phe-135 stacks on to the cycle of the Glc residue of GM1. |
| T192 | 1018-1137 | Sentence | denotes | In the case of CLQ and CLQ-OH, it is the nitrogen-containing ring of the drug that stacks on to the Glc ring Fig. 4(c). |
| T193 | 1138-1244 | Sentence | denotes | Note that both the Phe-135 (in red) and CLQ-OH (in green) rings are located in the same position (Fig. 9). |
| T194 | 1245-1379 | Sentence | denotes | The other CLQ-OH molecule, which covers the tip of the sugar part of the ganglioside, interacts with the GalNAc ganglioside Fig. 4(b). |
| T195 | 1380-1489 | Sentence | denotes | When the NTD is bound to the ganglioside, the side chain of Asn-137 is found in this exact position (Fig. 9). |
| T196 | 1490-1658 | Sentence | denotes | Thus, once two CLQ-OH (or two CLQ) molecules are bound to a ganglioside Fig. 4(e,f), any binding of a SARS-Cov-2 S protein to the same ganglioside is totally prevented. |
| T197 | 1659-1795 | Sentence | denotes | The energy required to overcome this steric incompatibility is estimated to be several hundred kJ.mol−1, which is far too high to occur. |
| T198 | 1796-1854 | Sentence | denotes | Fig. 9 Mechanism of action of hydroxychloroquine (CLQ-OH). |
| T199 | 1855-1961 | Sentence | denotes | The N-terminal domain (NTD) bound to GM1 was superposed onto GM1 in interaction with two CLQ-OH molecules. |
| T200 | 1962-2234 | Sentence | denotes | The models only show the NTD and both CLQ-OH molecules (not GM1, to improve clarity). (a,b) The aromatic ring of F-135 (in red), which stacks onto the glucose cycle of GM1, overlaps the aromatic CLQ-OH rings (in green) which also bind to GM1 via a CH-π stacking mechanism. |
| T201 | 2235-2670 | Sentence | denotes | The N-137 residue of the NTD interacts with the N-acetylgalactosamine residue of GM1, but this interaction cannot occur in the presence of CLQ-OH as this part of GM1 is totally masked by the drug. (c,d) Superposition of the NTD surface (in purple) with the two CLQ-OH molecules bound to GM1, illustrating the steric impossibility that prevents NTD binding to GM1 when both CLQ-OH molecules are already interacting with the ganglioside. |