PMC:7128678 / 2199-3603
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
87 | 1035-1066 | Gene | denotes | angiotensin-converting enzyme-2 | Gene:59272 |
88 | 1068-1073 | Gene | denotes | ACE-2 | Gene:59272 |
89 | 45-63 | Species | denotes | SARS-coronavirus 2 | Tax:2697049 |
90 | 65-75 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
91 | 310-318 | Species | denotes | patients | Tax:9606 |
92 | 636-646 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
93 | 1130-1138 | Species | denotes | SARS-CoV | Tax:694009 |
94 | 1147-1157 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
95 | 1205-1216 | Species | denotes | coronavirus | Tax:11118 |
96 | 392-403 | Chemical | denotes | chloroquine | MESH:D002738 |
97 | 301-309 | Disease | denotes | infected | MESH:D007239 |
98 | 526-534 | Disease | denotes | COVID-19 | MESH:C000657245 |
99 | 546-555 | Disease | denotes | pneumonia | MESH:D011014 |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T58 | 45-49 | SP_10 | denotes | SARS |
T59 | 50-61 | NCBITaxon:11118 | denotes | coronavirus |
T60 | 65-75 | SP_7 | denotes | SARS-CoV-2 |
T61 | 219-223 | CHEBI:23888;CHEBI:23888 | denotes | drug |
T62 | 348-353 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
T63 | 392-403 | CHEBI:3638;CHEBI:3638;DG_10 | denotes | chloroquine |
T64 | 424-436 | CHEBI:35718;CHEBI:35718 | denotes | antimalarial |
T65 | 437-441 | CHEBI:23888;CHEBI:23888 | denotes | drug |
T66 | 526-534 | SP_7 | denotes | COVID-19 |
T67 | 636-646 | SP_7 | denotes | SARS-CoV-2 |
T68 | 665-669 | CHEBI:23888;CHEBI:23888 | denotes | drug |
T69 | 791-800 | CHEBI:35222;CHEBI:35222 | denotes | inhibitor |
T70 | 804-813 | GO:0006897 | denotes | endocytic |
T71 | 844-853 | GO:0005768 | denotes | endosomal |
T72 | 921-929 | CHEBI:36357;CHEBI:36357 | denotes | compound |
T73 | 1035-1066 | PG_10;PR:000003622 | denotes | angiotensin-converting enzyme-2 |
T74 | 1068-1073 | G_3;PG_10;PR:000003622 | denotes | ACE-2 |
T75 | 1096-1111 | GO:0005886 | denotes | plasma membrane |
T76 | 1130-1138 | SP_10 | denotes | SARS-CoV |
T77 | 1147-1157 | SP_7 | denotes | SARS-CoV-2 |
T78 | 1205-1216 | NCBITaxon:11118 | denotes | coronavirus |
T79 | 1217-1228 | GO:0006260 | denotes | replication |
T80 | 1332-1337 | NCBITaxon:10239 | denotes | viral |
T81 | 1381-1393 | GO:0044228 | denotes | cell surface |
T82 | 1394-1403 | CHEBI:36357;CHEBI:36357 | denotes | molecules |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T13 | 844-853 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
T14 | 1096-1102 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
T15 | 1103-1120 | Body_part | denotes | membrane receptor | http://purl.org/sig/ont/fma/fma0326969 |
T16 | 1381-1393 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
T17 | 1381-1385 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid_AGAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
p88102s10 | 1009-1031 | MPA | denotes | terminal glycosylation |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T11 | 45-61 | Disease | denotes | SARS-coronavirus | http://purl.obolibrary.org/obo/MONDO_0005091 |
T12 | 65-73 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T13 | 526-534 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T14 | 546-555 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
T15 | 636-644 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T16 | 1130-1138 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T17 | 1147-1155 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11 | 96-97 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T12 | 159-165 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
T13 | 372-378 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T14 | 411-412 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T15 | 478-481 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T16 | 685-686 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T17 | 972-975 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T18 | 1094-1095 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T19 | 1096-1102 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
T20 | 1103-1111 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T21 | 1357-1358 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T22 | 1381-1385 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T27 | 166-182 | Chemical | denotes | antiviral agents | http://purl.obolibrary.org/obo/CHEBI_22587 |
T28 | 219-223 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T29 | 348-353 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T30 | 392-403 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T31 | 424-436 | Chemical | denotes | antimalarial | http://purl.obolibrary.org/obo/CHEBI_38068 |
T32 | 437-441 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T33 | 665-669 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T34 | 712-721 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T35 | 791-800 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
T36 | 911-920 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T37 | 1035-1046 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T38 | 1394-1403 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3 | 1009-1031 | http://purl.obolibrary.org/obo/GO_0033578 | denotes | terminal glycosylation |
T4 | 1018-1031 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 546-555 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21 | 0-183 | Sentence | denotes | The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic [1], and there is an urgent need to identify active antiviral agents. |
T22 | 184-339 | Sentence | denotes | Given the global health emergency, drug repositioning is the most reliable option to design an efficient therapy for infected patients without delay [2,3]. |
T23 | 340-587 | Sentence | denotes | Several drugs have already been tested, among which chloroquine (CLQ), a well-known antimalarial drug, is one of the most promising as it has shown apparent efficacy in the treatment of COVID-19-associated pneumonia in recent clinical studies [4]. |
T24 | 588-734 | Sentence | denotes | However, the mechanism of action of CLQ against SARS-CoV-2 is unclear as the drug seems to exert a broad range of potential antiviral effects [5]. |
T25 | 735-952 | Sentence | denotes | Therefore, although CLQ is classically considered as an inhibitor of endocytic pathways through elevation of endosomal pH [6], its detailed molecular mechanism of action as an antiviral compound remains unclear [3,5]. |
T26 | 953-1239 | Sentence | denotes | Interestingly, CLQ has been shown to interfere with the terminal glycosylation of angiotensin-converting enzyme-2 (ACE-2) [7], which acts as a plasma membrane receptor for both SARS-CoV [8] and SARS-CoV-2 [9], and CLQ could act at several steps of the coronavirus replication cycle [7]. |
T27 | 1240-1404 | Sentence | denotes | These data suggest the interesting and mostly unexplored possibility that CLQ could prevent viral attachment through a direct effect on host cell surface molecules. |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32251731-32015507-48149932 | 115-116 | 32015507 | denotes | 1 |
32251731-22743966-48149933 | 334-335 | 22743966 | denotes | 2 |
32251731-16439323-48149934 | 731-732 | 16439323 | denotes | 5 |
32251731-29940786-48149935 | 858-859 | 29940786 | denotes | 6 |
32251731-16439323-48149936 | 949-950 | 16439323 | denotes | 5 |
32251731-16115318-48149937 | 1076-1077 | 16115318 | denotes | 7 |
32251731-14647384-48149938 | 1140-1141 | 14647384 | denotes | 8 |
32251731-16115318-48149939 | 1236-1237 | 16115318 | denotes | 7 |
T52786 | 115-116 | 32015507 | denotes | 1 |
T82566 | 334-335 | 22743966 | denotes | 2 |
T79534 | 731-732 | 16439323 | denotes | 5 |
T31422 | 858-859 | 29940786 | denotes | 6 |
T11075 | 949-950 | 16439323 | denotes | 5 |
T4317 | 1076-1077 | 16115318 | denotes | 7 |
T96387 | 1140-1141 | 14647384 | denotes | 8 |
T9534 | 1236-1237 | 16115318 | denotes | 7 |