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PMC:7128678 / 2199-3603 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
87 1035-1066 Gene denotes angiotensin-converting enzyme-2 Gene:59272
88 1068-1073 Gene denotes ACE-2 Gene:59272
89 45-63 Species denotes SARS-coronavirus 2 Tax:2697049
90 65-75 Species denotes SARS-CoV-2 Tax:2697049
91 310-318 Species denotes patients Tax:9606
92 636-646 Species denotes SARS-CoV-2 Tax:2697049
93 1130-1138 Species denotes SARS-CoV Tax:694009
94 1147-1157 Species denotes SARS-CoV-2 Tax:2697049
95 1205-1216 Species denotes coronavirus Tax:11118
96 392-403 Chemical denotes chloroquine MESH:D002738
97 301-309 Disease denotes infected MESH:D007239
98 526-534 Disease denotes COVID-19 MESH:C000657245
99 546-555 Disease denotes pneumonia MESH:D011014

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T58 45-49 SP_10 denotes SARS
T59 50-61 NCBITaxon:11118 denotes coronavirus
T60 65-75 SP_7 denotes SARS-CoV-2
T61 219-223 CHEBI:23888;CHEBI:23888 denotes drug
T62 348-353 CHEBI:23888;CHEBI:23888 denotes drugs
T63 392-403 CHEBI:3638;CHEBI:3638;DG_10 denotes chloroquine
T64 424-436 CHEBI:35718;CHEBI:35718 denotes antimalarial
T65 437-441 CHEBI:23888;CHEBI:23888 denotes drug
T66 526-534 SP_7 denotes COVID-19
T67 636-646 SP_7 denotes SARS-CoV-2
T68 665-669 CHEBI:23888;CHEBI:23888 denotes drug
T69 791-800 CHEBI:35222;CHEBI:35222 denotes inhibitor
T70 804-813 GO:0006897 denotes endocytic
T71 844-853 GO:0005768 denotes endosomal
T72 921-929 CHEBI:36357;CHEBI:36357 denotes compound
T73 1035-1066 PG_10;PR:000003622 denotes angiotensin-converting enzyme-2
T74 1068-1073 G_3;PG_10;PR:000003622 denotes ACE-2
T75 1096-1111 GO:0005886 denotes plasma membrane
T76 1130-1138 SP_10 denotes SARS-CoV
T77 1147-1157 SP_7 denotes SARS-CoV-2
T78 1205-1216 NCBITaxon:11118 denotes coronavirus
T79 1217-1228 GO:0006260 denotes replication
T80 1332-1337 NCBITaxon:10239 denotes viral
T81 1381-1393 GO:0044228 denotes cell surface
T82 1394-1403 CHEBI:36357;CHEBI:36357 denotes molecules

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T13 844-853 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T14 1096-1102 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T15 1103-1120 Body_part denotes membrane receptor http://purl.org/sig/ont/fma/fma0326969
T16 1381-1393 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T17 1381-1385 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p88102s10 1009-1031 MPA denotes terminal glycosylation

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T11 45-61 Disease denotes SARS-coronavirus http://purl.obolibrary.org/obo/MONDO_0005091
T12 65-73 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 526-534 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 546-555 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T15 636-644 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1130-1138 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 1147-1155 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T11 96-97 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 159-165 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T13 372-378 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T14 411-412 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 478-481 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T16 685-686 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 972-975 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T18 1094-1095 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 1096-1102 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T20 1103-1111 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T21 1357-1358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 1381-1385 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T27 166-182 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T28 219-223 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T29 348-353 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T30 392-403 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T31 424-436 Chemical denotes antimalarial http://purl.obolibrary.org/obo/CHEBI_38068
T32 437-441 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T33 665-669 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T34 712-721 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T35 791-800 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T36 911-920 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T37 1035-1046 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T38 1394-1403 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 1009-1031 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T4 1018-1031 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 546-555 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T21 0-183 Sentence denotes The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic [1], and there is an urgent need to identify active antiviral agents.
T22 184-339 Sentence denotes Given the global health emergency, drug repositioning is the most reliable option to design an efficient therapy for infected patients without delay [2,3].
T23 340-587 Sentence denotes Several drugs have already been tested, among which chloroquine (CLQ), a well-known antimalarial drug, is one of the most promising as it has shown apparent efficacy in the treatment of COVID-19-associated pneumonia in recent clinical studies [4].
T24 588-734 Sentence denotes However, the mechanism of action of CLQ against SARS-CoV-2 is unclear as the drug seems to exert a broad range of potential antiviral effects [5].
T25 735-952 Sentence denotes Therefore, although CLQ is classically considered as an inhibitor of endocytic pathways through elevation of endosomal pH [6], its detailed molecular mechanism of action as an antiviral compound remains unclear [3,5].
T26 953-1239 Sentence denotes Interestingly, CLQ has been shown to interfere with the terminal glycosylation of angiotensin-converting enzyme-2 (ACE-2) [7], which acts as a plasma membrane receptor for both SARS-CoV [8] and SARS-CoV-2 [9], and CLQ could act at several steps of the coronavirus replication cycle [7].
T27 1240-1404 Sentence denotes These data suggest the interesting and mostly unexplored possibility that CLQ could prevent viral attachment through a direct effect on host cell surface molecules.

2_test

Id Subject Object Predicate Lexical cue
32251731-32015507-48149932 115-116 32015507 denotes 1
32251731-22743966-48149933 334-335 22743966 denotes 2
32251731-16439323-48149934 731-732 16439323 denotes 5
32251731-29940786-48149935 858-859 29940786 denotes 6
32251731-16439323-48149936 949-950 16439323 denotes 5
32251731-16115318-48149937 1076-1077 16115318 denotes 7
32251731-14647384-48149938 1140-1141 14647384 denotes 8
32251731-16115318-48149939 1236-1237 16115318 denotes 7
T52786 115-116 32015507 denotes 1
T82566 334-335 22743966 denotes 2
T79534 731-732 16439323 denotes 5
T31422 858-859 29940786 denotes 6
T11075 949-950 16439323 denotes 5
T4317 1076-1077 16115318 denotes 7
T96387 1140-1141 14647384 denotes 8
T9534 1236-1237 16115318 denotes 7