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PMC:7128678 / 21330-22204 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
618 44-75 Gene denotes angiotensin-converting enzyme-2 Gene:59272
619 77-82 Gene denotes ACE-2 Gene:59272
620 564-565 Gene denotes S Gene:43740568
621 87-97 Species denotes SARS-CoV-2 Tax:2697049
622 27-39 Chemical denotes gangliosides MESH:D005732
623 336-347 Chemical denotes ganglioside MESH:D005732
624 384-389 Chemical denotes Lipid MESH:D008055
625 436-448 Chemical denotes gangliosides MESH:D005732
626 465-476 Chemical denotes cholesterol MESH:D002784
627 737-748 Chemical denotes ganglioside MESH:D005732
628 795-800 Chemical denotes lipid MESH:D008055
629 839-850 Chemical denotes chloroquine MESH:D002738
630 855-873 Chemical denotes hydroxychloroquine MESH:D006886
631 599-608 Disease denotes infection MESH:D007239

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T453 27-39 CHEBI:5386;CHEBI:5386 denotes gangliosides
T454 44-75 PG_10;PR:000003622 denotes angiotensin-converting enzyme-2
T455 77-82 G_3;PG_10;PR:000003622 denotes ACE-2
T456 87-91 PR:000014459;SP_7 denotes SARS
T457 91-97 SP_7 denotes -CoV-2
T458 121-126 NCBITaxon:10239 denotes viral
T459 157-164 SO:0000417 denotes domains
T460 255-261 SO:0000417 denotes domain
T461 275-280 G_3;PG_10;PR:000003622 denotes ACE-2
T462 310-316 SO:0000417 denotes domain
T463 336-347 CHEBI:16856;CHEBI:16856 denotes ganglioside
T464 353-359 SO:0000417 denotes domain
T465 367-382 GO:0005886 denotes plasma membrane
T466 384-389 CHEBI:18059;CHEBI:18059;GO:0045121 denotes Lipid
T467 390-395 GO:0045121 denotes rafts
T468 407-415 GO:0016020 denotes membrane
T469 416-423 GO:0044425 denotes domains
T470 436-448 CHEBI:5386;CHEBI:5386 denotes gangliosides
T471 465-476 CHEBI:16113;CHEBI:16113 denotes cholesterol
T472 558-563 NCBITaxon:10239 denotes viral
T473 564-573 PG_1 denotes S protein
T474 737-748 CHEBI:5386;CHEBI:5386 denotes ganglioside
T475 757-763 SO:0000417 denotes domain
T476 795-800 CHEBI:18059;CHEBI:18059;GO:0045121 denotes lipid
T477 801-806 GO:0045121 denotes rafts
T478 839-850 CHEBI:3638;CHEBI:3638;DG_10 denotes chloroquine
T479 855-873 CHEBI:5801;CHEBI:5801;DG_20 denotes hydroxychloroquine

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T131 27-39 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T132 108-115 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T133 127-134 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T134 336-347 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T135 367-382 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T136 384-389 Body_part denotes Lipid http://purl.org/sig/ont/fma/fma67264
T137 436-448 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T138 566-573 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T139 680-690 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T140 737-748 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T141 795-800 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T92 87-95 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 318-321 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T95 599-608 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T96 715-718 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T167 367-373 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T168 374-382 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T169 407-415 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T170 496-497 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 680-699 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T172 680-699 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T173 704-707 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T174 724-725 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T498 27-39 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T499 44-55 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T500 108-115 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T501 127-134 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T502 336-347 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T503 384-389 Chemical denotes Lipid http://purl.obolibrary.org/obo/CHEBI_18059
T504 436-448 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T505 465-476 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T506 566-573 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T507 680-690 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T508 680-685 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T509 686-690 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T510 737-748 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T511 795-800 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T512 839-850 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T513 855-873 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T179 0-116 Sentence denotes Fig. 8 Dual recognition of gangliosides and angiotensin-converting enzyme-2 (ACE-2) by SARS-CoV-2 spike (S) protein.
T180 117-233 Sentence denotes The viral protein displays two distinct domains, the tips of which are available for distinct types of interactions.
T181 234-383 Sentence denotes The receptor-binding domain binds to the ACE-2 receptor, and the N-terminal domain (NTD) binds to the ganglioside-rich domain of the plasma membrane.
T182 384-617 Sentence denotes Lipid rafts, which are membrane domains enriched in gangliosides (in yellow) and cholesterol (in blue), provide a perfect attractive interface for adequately positioning the viral S protein at the first step of the infection process.
T183 618-874 Sentence denotes These structural and molecular modelling studies suggest that amino acid residues 111–162 of the NTD form a functional ganglioside-binding domain, the interaction of which with lipid rafts can be efficiently prevented by chloroquine and hydroxychloroquine.