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PMC:7128678 / 20602-22204 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
593 48-58 Species denotes SARS-CoV-2 Tax:2697049
594 111-123 Chemical denotes gangliosides MESH:D005732
595 127-132 Chemical denotes lipid MESH:D008055
600 285-290 Gene denotes ACE-2 Gene:59272
601 235-245 Species denotes SARS-CoV-2 Tax:2697049
602 361-372 Chemical denotes ganglioside MESH:D005732
603 392-397 Chemical denotes lipid MESH:D008055
618 772-803 Gene denotes angiotensin-converting enzyme-2 Gene:59272
619 805-810 Gene denotes ACE-2 Gene:59272
620 1292-1293 Gene denotes S Gene:43740568
621 815-825 Species denotes SARS-CoV-2 Tax:2697049
622 755-767 Chemical denotes gangliosides MESH:D005732
623 1064-1075 Chemical denotes ganglioside MESH:D005732
624 1112-1117 Chemical denotes Lipid MESH:D008055
625 1164-1176 Chemical denotes gangliosides MESH:D005732
626 1193-1204 Chemical denotes cholesterol MESH:D002784
627 1465-1476 Chemical denotes ganglioside MESH:D005732
628 1523-1528 Chemical denotes lipid MESH:D008055
629 1567-1578 Chemical denotes chloroquine MESH:D002738
630 1583-1601 Chemical denotes hydroxychloroquine MESH:D006886
631 1327-1336 Disease denotes infection MESH:D007239
637 500-501 Gene denotes S Gene:43740568
638 489-499 Species denotes SARS-CoV-2 Tax:2697049
639 593-599 Chemical denotes CLQ-OH
640 697-709 Chemical denotes sialic acids MESH:D012794
641 714-726 Chemical denotes gangliosides MESH:D005732

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T437 48-58 SP_7 denotes SARS-CoV-2
T438 67-82 GO:0005886 denotes plasma membrane
T439 111-123 CHEBI:16856;CHEBI:16856 denotes gangliosides
T440 127-132 CHEBI:18059;CHEBI:18059;GO:0045121 denotes lipid
T441 133-138 GO:0045121 denotes rafts
T442 235-245 SP_7 denotes SARS-CoV-2
T443 260-266 SO:0000417 denotes domain
T444 285-290 G_3;PG_10;PR:000003622 denotes ACE-2
T445 361-372 CHEBI:28892;CHEBI:28892 denotes ganglioside
T446 392-397 CHEBI:18059;CHEBI:18059;GO:0045121 denotes lipid
T447 398-402 GO:0045121 denotes raft
T448 411-423 GO:0009986 denotes cell surface
T449 489-499 SP_7 denotes SARS-CoV-2
T450 500-509 PG_1 denotes S protein
T451 697-709 CHEBI:26667;CHEBI:26667 denotes sialic acids
T452 714-726 CHEBI:30563;CHEBI:30563 denotes gangliosides
T453 755-767 CHEBI:5386;CHEBI:5386 denotes gangliosides
T454 772-803 PG_10;PR:000003622 denotes angiotensin-converting enzyme-2
T455 805-810 G_3;PG_10;PR:000003622 denotes ACE-2
T456 815-819 PR:000014459;SP_7 denotes SARS
T457 819-825 SP_7 denotes -CoV-2
T458 849-854 NCBITaxon:10239 denotes viral
T459 885-892 SO:0000417 denotes domains
T460 983-989 SO:0000417 denotes domain
T461 1003-1008 G_3;PG_10;PR:000003622 denotes ACE-2
T462 1038-1044 SO:0000417 denotes domain
T463 1064-1075 CHEBI:16856;CHEBI:16856 denotes ganglioside
T464 1081-1087 SO:0000417 denotes domain
T465 1095-1110 GO:0005886 denotes plasma membrane
T466 1112-1117 CHEBI:18059;CHEBI:18059;GO:0045121 denotes Lipid
T467 1118-1123 GO:0045121 denotes rafts
T468 1135-1143 GO:0016020 denotes membrane
T469 1144-1151 GO:0044425 denotes domains
T470 1164-1176 CHEBI:5386;CHEBI:5386 denotes gangliosides
T471 1193-1204 CHEBI:16113;CHEBI:16113 denotes cholesterol
T472 1286-1291 NCBITaxon:10239 denotes viral
T473 1292-1301 PG_1 denotes S protein
T474 1465-1476 CHEBI:5386;CHEBI:5386 denotes ganglioside
T475 1485-1491 SO:0000417 denotes domain
T476 1523-1528 CHEBI:18059;CHEBI:18059;GO:0045121 denotes lipid
T477 1529-1534 GO:0045121 denotes rafts
T478 1567-1578 CHEBI:3638;CHEBI:3638;DG_10 denotes chloroquine
T479 1583-1601 CHEBI:5801;CHEBI:5801;DG_20 denotes hydroxychloroquine

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T121 67-82 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T122 93-97 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T123 111-123 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T124 127-132 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T125 361-372 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T126 392-397 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T127 411-423 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T128 411-415 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T129 502-509 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T130 714-726 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T131 755-767 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T132 836-843 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T133 855-862 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T134 1064-1075 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T135 1095-1110 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T136 1112-1117 Body_part denotes Lipid http://purl.org/sig/ont/fma/fma67264
T137 1164-1176 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T138 1294-1301 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T139 1408-1418 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T140 1465-1476 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T141 1523-1528 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T87 48-56 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 235-243 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T89 321-324 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T91 489-497 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 815-823 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 1046-1049 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T95 1327-1336 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T96 1443-1446 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T158 67-73 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T159 74-82 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T160 86-87 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T161 93-97 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T162 198-199 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T163 359-360 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 411-415 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T165 430-431 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T166 677-678 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T167 1095-1101 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T168 1102-1110 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T169 1135-1143 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T170 1224-1225 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 1408-1427 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T172 1408-1427 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T173 1432-1435 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T174 1452-1453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T490 111-123 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T491 127-132 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T492 361-372 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T493 392-397 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T494 502-509 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T495 697-709 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T496 704-709 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T497 714-726 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T498 755-767 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T499 772-783 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T500 836-843 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T501 855-862 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T502 1064-1075 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T503 1112-1117 Chemical denotes Lipid http://purl.obolibrary.org/obo/CHEBI_18059
T504 1164-1176 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T505 1193-1204 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T506 1294-1301 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T507 1408-1418 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T508 1408-1413 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T509 1414-1418 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T510 1465-1476 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T511 1523-1528 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T512 1567-1578 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T513 1583-1601 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T175 0-138 Sentence denotes 3.6 Potential coordinated interactions between SARS-CoV-2 and the plasma membrane of a host cell: key role of gangliosides in lipid rafts
T176 139-424 Sentence denotes Taken together, these data strongly support the concept of a dual receptor/attachment model for SARS-CoV-2, with the RBD domain being involved in ACE-2 receptor recognition, and the NTD interface responsible for finding a ganglioside-rich landing area (lipid raft) at the cell surface.
T177 425-534 Sentence denotes Such a dual receptor model, consistent with the topology of the SARS-CoV-2 S protein, is proposed in Fig. 8 .
T178 535-727 Sentence denotes With this model in mind, the potential effects of CLQ and CLQ-OH were studied, both of which, according to the molecular modelling data, have a high affinity for sialic acids and gangliosides.
T179 728-844 Sentence denotes Fig. 8 Dual recognition of gangliosides and angiotensin-converting enzyme-2 (ACE-2) by SARS-CoV-2 spike (S) protein.
T180 845-961 Sentence denotes The viral protein displays two distinct domains, the tips of which are available for distinct types of interactions.
T181 962-1111 Sentence denotes The receptor-binding domain binds to the ACE-2 receptor, and the N-terminal domain (NTD) binds to the ganglioside-rich domain of the plasma membrane.
T182 1112-1345 Sentence denotes Lipid rafts, which are membrane domains enriched in gangliosides (in yellow) and cholesterol (in blue), provide a perfect attractive interface for adequately positioning the viral S protein at the first step of the infection process.
T183 1346-1602 Sentence denotes These structural and molecular modelling studies suggest that amino acid residues 111–162 of the NTD form a functional ganglioside-binding domain, the interaction of which with lipid rafts can be efficiently prevented by chloroquine and hydroxychloroquine.