PMC:7128678 / 19820-20600
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7128678","sourcedb":"PMC","sourceid":"7128678","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7128678","text":"Fig. 7 Molecular complex between the N-terminal domain (NTD) of SARS-CoV-2 spike protein and a dimer of GM1. In (a), (c) and (d), the NTD is represented as in Fig. 4. In (b), the surface of the NTD is shown without any transparency. The amino acid residues Q-134 to S-162 belonging to the ganglioside-binding domain (GBD) are represented as green spheres. Compared with a single GM1 molecule, the dimer of gangliosides forms a larger attractive surface for the NTD. In the above view of (d), the anchorage of the NTD to the gangliosides is particularly obvious. As chloroquine also interacts with the saccharide part of GM1, its presence would clearly mask most of the landing surface available for the NTD, preventing attachment of the virus to the plasma membrane of host cells.","divisions":[{"label":"label","span":{"begin":0,"end":6}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"539","span":{"begin":75,"end":80},"obj":"Gene"},{"id":"540","span":{"begin":266,"end":267},"obj":"Gene"},{"id":"541","span":{"begin":64,"end":74},"obj":"Species"},{"id":"542","span":{"begin":104,"end":107},"obj":"Chemical"},{"id":"543","span":{"begin":289,"end":300},"obj":"Chemical"},{"id":"544","span":{"begin":379,"end":382},"obj":"Chemical"},{"id":"545","span":{"begin":406,"end":418},"obj":"Chemical"},{"id":"546","span":{"begin":524,"end":536},"obj":"Chemical"},{"id":"547","span":{"begin":565,"end":576},"obj":"Chemical"},{"id":"548","span":{"begin":601,"end":611},"obj":"Chemical"},{"id":"549","span":{"begin":620,"end":623},"obj":"Chemical"}],"attributes":[{"id":"A539","pred":"tao:has_database_id","subj":"539","obj":"Gene:43740568"},{"id":"A540","pred":"tao:has_database_id","subj":"540","obj":"Gene:43740568"},{"id":"A541","pred":"tao:has_database_id","subj":"541","obj":"Tax:2697049"},{"id":"A542","pred":"tao:has_database_id","subj":"542","obj":"MESH:D005677"},{"id":"A543","pred":"tao:has_database_id","subj":"543","obj":"MESH:D005732"},{"id":"A544","pred":"tao:has_database_id","subj":"544","obj":"MESH:D005677"},{"id":"A545","pred":"tao:has_database_id","subj":"545","obj":"MESH:D005732"},{"id":"A546","pred":"tao:has_database_id","subj":"546","obj":"MESH:D005732"},{"id":"A547","pred":"tao:has_database_id","subj":"547","obj":"MESH:D002738"},{"id":"A548","pred":"tao:has_database_id","subj":"548","obj":"MESH:D002241"},{"id":"A549","pred":"tao:has_database_id","subj":"549","obj":"MESH:D005677"},{"subj":"539","pred":"source","obj":"LitCovid-PubTator"},{"subj":"540","pred":"source","obj":"LitCovid-PubTator"},{"subj":"541","pred":"source","obj":"LitCovid-PubTator"},{"subj":"542","pred":"source","obj":"LitCovid-PubTator"},{"subj":"543","pred":"source","obj":"LitCovid-PubTator"},{"subj":"544","pred":"source","obj":"LitCovid-PubTator"},{"subj":"545","pred":"source","obj":"LitCovid-PubTator"},{"subj":"546","pred":"source","obj":"LitCovid-PubTator"},{"subj":"547","pred":"source","obj":"LitCovid-PubTator"},{"subj":"548","pred":"source","obj":"LitCovid-PubTator"},{"subj":"549","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T425","span":{"begin":7,"end":24},"obj":"GO:0043234"},{"id":"T426","span":{"begin":48,"end":54},"obj":"SO:0000417"},{"id":"T427","span":{"begin":64,"end":74},"obj":"SP_7"},{"id":"T428","span":{"begin":289,"end":300},"obj":"CHEBI:28892;CHEBI:28892"},{"id":"T429","span":{"begin":309,"end":315},"obj":"SO:0000417"},{"id":"T430","span":{"begin":383,"end":391},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T431","span":{"begin":406,"end":418},"obj":"CHEBI:5386;CHEBI:5386"},{"id":"T432","span":{"begin":524,"end":536},"obj":"CHEBI:5386;CHEBI:5386"},{"id":"T433","span":{"begin":565,"end":576},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T434","span":{"begin":601,"end":611},"obj":"CHEBI:32111;CHEBI:32111"},{"id":"T435","span":{"begin":737,"end":742},"obj":"NCBITaxon:10239"},{"id":"T436","span":{"begin":750,"end":765},"obj":"GO:0005886"}],"attributes":[{"subj":"T425","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T426","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T427","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T428","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T429","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T430","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T431","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T432","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T433","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T434","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T435","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T436","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T114","span":{"begin":81,"end":88},"obj":"Body_part"},{"id":"T115","span":{"begin":237,"end":247},"obj":"Body_part"},{"id":"T116","span":{"begin":289,"end":300},"obj":"Body_part"},{"id":"T117","span":{"begin":406,"end":418},"obj":"Body_part"},{"id":"T118","span":{"begin":524,"end":536},"obj":"Body_part"},{"id":"T119","span":{"begin":750,"end":765},"obj":"Body_part"},{"id":"T120","span":{"begin":774,"end":779},"obj":"Body_part"}],"attributes":[{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T74","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T76","span":{"begin":64,"end":72},"obj":"Disease"},{"id":"T77","span":{"begin":134,"end":137},"obj":"Disease"},{"id":"T79","span":{"begin":194,"end":197},"obj":"Disease"},{"id":"T81","span":{"begin":461,"end":464},"obj":"Disease"},{"id":"T83","span":{"begin":513,"end":516},"obj":"Disease"},{"id":"T85","span":{"begin":703,"end":706},"obj":"Disease"}],"attributes":[{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A75","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A76","pred":"mondo_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A77","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A78","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A80","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A82","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A83","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A84","pred":"mondo_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A86","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T146","span":{"begin":93,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T147","span":{"begin":113,"end":114},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T148","span":{"begin":171,"end":172},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T149","span":{"begin":237,"end":256},"obj":"http://purl.obolibrary.org/obo/CHEBI_33708"},{"id":"T150","span":{"begin":237,"end":256},"obj":"http://purl.obolibrary.org/obo/PR_000036907"},{"id":"T151","span":{"begin":268,"end":271},"obj":"http://purl.obolibrary.org/obo/CLO_0001002"},{"id":"T152","span":{"begin":370,"end":371},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T153","span":{"begin":425,"end":426},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T154","span":{"begin":737,"end":742},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T155","span":{"begin":750,"end":756},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T156","span":{"begin":757,"end":765},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T157","span":{"begin":774,"end":779},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T146","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T147","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T148","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T471","span":{"begin":81,"end":88},"obj":"Chemical"},{"id":"T472","span":{"begin":104,"end":107},"obj":"Chemical"},{"id":"T475","span":{"begin":237,"end":247},"obj":"Chemical"},{"id":"T476","span":{"begin":237,"end":242},"obj":"Chemical"},{"id":"T477","span":{"begin":243,"end":247},"obj":"Chemical"},{"id":"T478","span":{"begin":289,"end":300},"obj":"Chemical"},{"id":"T479","span":{"begin":379,"end":382},"obj":"Chemical"},{"id":"T482","span":{"begin":383,"end":391},"obj":"Chemical"},{"id":"T483","span":{"begin":406,"end":418},"obj":"Chemical"},{"id":"T484","span":{"begin":524,"end":536},"obj":"Chemical"},{"id":"T485","span":{"begin":565,"end":576},"obj":"Chemical"},{"id":"T486","span":{"begin":601,"end":611},"obj":"Chemical"},{"id":"T487","span":{"begin":620,"end":623},"obj":"Chemical"}],"attributes":[{"id":"A471","pred":"chebi_id","subj":"T471","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A472","pred":"chebi_id","subj":"T472","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A473","pred":"chebi_id","subj":"T472","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A474","pred":"chebi_id","subj":"T472","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A475","pred":"chebi_id","subj":"T475","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A476","pred":"chebi_id","subj":"T476","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A477","pred":"chebi_id","subj":"T477","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A478","pred":"chebi_id","subj":"T478","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A479","pred":"chebi_id","subj":"T479","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A480","pred":"chebi_id","subj":"T479","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A481","pred":"chebi_id","subj":"T479","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A482","pred":"chebi_id","subj":"T482","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A483","pred":"chebi_id","subj":"T483","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A484","pred":"chebi_id","subj":"T484","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A485","pred":"chebi_id","subj":"T485","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A486","pred":"chebi_id","subj":"T486","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A487","pred":"chebi_id","subj":"T487","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A488","pred":"chebi_id","subj":"T487","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A489","pred":"chebi_id","subj":"T487","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"subj":"T471","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T472","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T475","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T476","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T477","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T478","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T479","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T482","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T483","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T484","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T485","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T486","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T487","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T24","span":{"begin":104,"end":107},"obj":"GlycoEpitope"},{"id":"T25","span":{"begin":379,"end":382},"obj":"GlycoEpitope"},{"id":"T26","span":{"begin":620,"end":623},"obj":"GlycoEpitope"}],"attributes":[{"id":"A24","pred":"glyco_epitope_db_id","subj":"T24","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A25","pred":"glyco_epitope_db_id","subj":"T25","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A26","pred":"glyco_epitope_db_id","subj":"T26","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T168","span":{"begin":0,"end":108},"obj":"Sentence"},{"id":"T169","span":{"begin":109,"end":166},"obj":"Sentence"},{"id":"T170","span":{"begin":167,"end":232},"obj":"Sentence"},{"id":"T171","span":{"begin":233,"end":355},"obj":"Sentence"},{"id":"T172","span":{"begin":356,"end":465},"obj":"Sentence"},{"id":"T173","span":{"begin":466,"end":561},"obj":"Sentence"},{"id":"T174","span":{"begin":562,"end":780},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T168","pred":"source","obj":"LitCovid-sentences"},{"subj":"T169","pred":"source","obj":"LitCovid-sentences"},{"subj":"T170","pred":"source","obj":"LitCovid-sentences"},{"subj":"T171","pred":"source","obj":"LitCovid-sentences"},{"subj":"T172","pred":"source","obj":"LitCovid-sentences"},{"subj":"T173","pred":"source","obj":"LitCovid-sentences"},{"subj":"T174","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93e9","default":true},{"id":"LitCovid-PMC-OGER-BB","color":"#93ecd4"},{"id":"LitCovid-PD-FMA-UBERON","color":"#ecba93"},{"id":"LitCovid-PD-MONDO","color":"#a093ec"},{"id":"LitCovid-PD-CLO","color":"#9fec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93b9"},{"id":"LitCovid-PD-GlycoEpitope","color":"#93d3ec"},{"id":"LitCovid-sentences","color":"#eceb93"}]}]}}