PMC:7128678 / 13410-13860 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"355","span":{"begin":39,"end":42},"obj":"Chemical"},{"id":"356","span":{"begin":106,"end":114},"obj":"Chemical"},{"id":"357","span":{"begin":208,"end":219},"obj":"Chemical"},{"id":"358","span":{"begin":231,"end":241},"obj":"Chemical"},{"id":"359","span":{"begin":292,"end":304},"obj":"Chemical"},{"id":"360","span":{"begin":315,"end":318},"obj":"Chemical"},{"id":"361","span":{"begin":347,"end":362},"obj":"Chemical"}],"attributes":[{"id":"A355","pred":"tao:has_database_id","subj":"355","obj":"MESH:D005677"},{"id":"A356","pred":"tao:has_database_id","subj":"356","obj":"MESH:D002518"},{"id":"A357","pred":"tao:has_database_id","subj":"357","obj":"MESH:D019158"},{"id":"A358","pred":"tao:has_database_id","subj":"358","obj":"MESH:D002241"},{"id":"A359","pred":"tao:has_database_id","subj":"359","obj":"MESH:D002241"},{"id":"A360","pred":"tao:has_database_id","subj":"360","obj":"MESH:D005677"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The surface electrostatic potential of GM1 indicates a non-polar, membrane-embedded part corresponding to ceramide (white areas), and an acidic part protruding in the extracellular space corresponding to the sialic-acid-containing saccharide part (red areas). (a) CLQ bound to the tip of the carbohydrate moiety of GM1. (b) Molecular mechanism of CLQ–ganglioside interactions. (c) Molecular dynamics simulations revealed a second site of interaction."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T281","span":{"begin":66,"end":74},"obj":"GO:0016020"},{"id":"T282","span":{"begin":106,"end":114},"obj":"CHEBI:17761;CHEBI:17761"},{"id":"T283","span":{"begin":137,"end":143},"obj":"CHEBI:37527;CHEBI:37527"},{"id":"T284","span":{"begin":167,"end":186},"obj":"GO:0005615"},{"id":"T285","span":{"begin":208,"end":219},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T286","span":{"begin":231,"end":241},"obj":"CHEBI:32111;CHEBI:32111"},{"id":"T287","span":{"begin":292,"end":304},"obj":"CHEBI:16646;CHEBI:16646"},{"id":"T288","span":{"begin":351,"end":362},"obj":"CHEBI:5386;CHEBI:5386"}],"text":"The surface electrostatic potential of GM1 indicates a non-polar, membrane-embedded part corresponding to ceramide (white areas), and an acidic part protruding in the extracellular space corresponding to the sialic-acid-containing saccharide part (red areas). (a) CLQ bound to the tip of the carbohydrate moiety of GM1. (b) Molecular mechanism of CLQ–ganglioside interactions. (c) Molecular dynamics simulations revealed a second site of interaction."}

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{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T6","span":{"begin":281,"end":284},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_2001840"}],"text":"The surface electrostatic potential of GM1 indicates a non-polar, membrane-embedded part corresponding to ceramide (white areas), and an acidic part protruding in the extracellular space corresponding to the sialic-acid-containing saccharide part (red areas). (a) CLQ bound to the tip of the carbohydrate moiety of GM1. (b) Molecular mechanism of CLQ–ganglioside interactions. (c) Molecular dynamics simulations revealed a second site of interaction."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T89","span":{"begin":53,"end":54},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T90","span":{"begin":66,"end":74},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T91","span":{"begin":261,"end":262},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T92","span":{"begin":321,"end":322},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T93","span":{"begin":421,"end":422},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The surface electrostatic potential of GM1 indicates a non-polar, membrane-embedded part corresponding to ceramide (white areas), and an acidic part protruding in the extracellular space corresponding to the sialic-acid-containing saccharide part (red areas). (a) CLQ bound to the tip of the carbohydrate moiety of GM1. (b) Molecular mechanism of CLQ–ganglioside interactions. (c) Molecular dynamics simulations revealed a second site of interaction."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T243","span":{"begin":39,"end":42},"obj":"Chemical"},{"id":"T246","span":{"begin":106,"end":114},"obj":"Chemical"},{"id":"T248","span":{"begin":215,"end":219},"obj":"Chemical"},{"id":"T249","span":{"begin":231,"end":241},"obj":"Chemical"},{"id":"T250","span":{"begin":292,"end":304},"obj":"Chemical"},{"id":"T251","span":{"begin":315,"end":318},"obj":"Chemical"},{"id":"T254","span":{"begin":351,"end":362},"obj":"Chemical"}],"attributes":[{"id":"A243","pred":"chebi_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A244","pred":"chebi_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A245","pred":"chebi_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A246","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_17761"},{"id":"A247","pred":"chebi_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/CHEBI_52639"},{"id":"A248","pred":"chebi_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A249","pred":"chebi_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_16646"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A252","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A253","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A254","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"}],"text":"The surface electrostatic potential of GM1 indicates a non-polar, membrane-embedded part corresponding to ceramide (white areas), and an acidic part protruding in the extracellular space corresponding to the sialic-acid-containing saccharide part (red areas). (a) CLQ bound to the tip of the carbohydrate moiety of GM1. (b) Molecular mechanism of CLQ–ganglioside interactions. (c) Molecular dynamics simulations revealed a second site of interaction."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T9","span":{"begin":39,"end":42},"obj":"GlycoEpitope"},{"id":"T10","span":{"begin":315,"end":318},"obj":"GlycoEpitope"}],"attributes":[{"id":"A9","pred":"glyco_epitope_db_id","subj":"T9","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A10","pred":"glyco_epitope_db_id","subj":"T10","obj":"http://www.glycoepitope.jp/epitopes/EP0050"}],"text":"The surface electrostatic potential of GM1 indicates a non-polar, membrane-embedded part corresponding to ceramide (white areas), and an acidic part protruding in the extracellular space corresponding to the sialic-acid-containing saccharide part (red areas). (a) CLQ bound to the tip of the carbohydrate moiety of GM1. (b) Molecular mechanism of CLQ–ganglioside interactions. (c) Molecular dynamics simulations revealed a second site of interaction."}

{"project":"LitCovid-sentences","denotations":[{"id":"T102","span":{"begin":0,"end":450},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The surface electrostatic potential of GM1 indicates a non-polar, membrane-embedded part corresponding to ceramide (white areas), and an acidic part protruding in the extracellular space corresponding to the sialic-acid-containing saccharide part (red areas). (a) CLQ bound to the tip of the carbohydrate moiety of GM1. (b) Molecular mechanism of CLQ–ganglioside interactions. (c) Molecular dynamics simulations revealed a second site of interaction."}