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PMC:7128678 / 13290-14484 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
349 1059-1072 Gene denotes CLQ-OH/CLQ-OH
350 42-53 Chemical denotes chloroquine MESH:D002738
351 64-82 Chemical denotes hydroxychloroquine MESH:D006886
352 84-90 Chemical denotes CLQ-OH
353 103-114 Chemical denotes ganglioside MESH:D005732
354 115-118 Chemical denotes GM1 MESH:D005677
355 159-162 Chemical denotes GM1 MESH:D005677
356 226-234 Chemical denotes ceramide MESH:D002518
357 328-339 Chemical denotes sialic-acid MESH:D019158
358 351-361 Chemical denotes saccharide MESH:D002241
359 412-424 Chemical denotes carbohydrate MESH:D002241
360 435-438 Chemical denotes GM1 MESH:D005677
361 467-482 Chemical denotes CLQ–ganglioside
362 634-642 Chemical denotes ceramide MESH:D002518
363 643-648 Chemical denotes sugar MESH:D000073893
364 671-679 Chemical denotes nitrogen MESH:D009584
365 723-734 Chemical denotes ganglioside MESH:D005732
366 777-780 Chemical denotes GM1 MESH:D005677
367 891-894 Chemical denotes GM1 MESH:D005677
368 922-925 Chemical denotes GM1 MESH:D005677
369 969-975 Chemical denotes CLQ-OH
370 1107-1113 Chemical denotes CLQ-OH
371 1133-1136 Chemical denotes GM1 MESH:D005677

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T278 42-53 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T279 64-82 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T280 103-114 CHEBI:16856;CHEBI:16856 denotes ganglioside
T281 186-194 GO:0016020 denotes membrane
T282 226-234 CHEBI:17761;CHEBI:17761 denotes ceramide
T283 257-263 CHEBI:37527;CHEBI:37527 denotes acidic
T284 287-306 GO:0005615 denotes extracellular space
T285 328-339 CHEBI:26667;CHEBI:26667 denotes sialic-acid
T286 351-361 CHEBI:32111;CHEBI:32111 denotes saccharide
T287 412-424 CHEBI:16646;CHEBI:16646 denotes carbohydrate
T288 471-482 CHEBI:5386;CHEBI:5386 denotes ganglioside
T289 634-642 CHEBI:17761;CHEBI:17761 denotes ceramide
T290 680-685 CHEBI:33250;CHEBI:33250 denotes atoms
T291 704-710 CHEBI:37527;CHEBI:37527 denotes acidic
T292 723-734 CHEBI:5386;CHEBI:5386 denotes ganglioside
T293 781-790 GO:0032991 denotes complexed
T294 819-828 CHEBI:36357;CHEBI:36357 denotes molecules
T295 903-912 CHEBI:36357;CHEBI:36357 denotes molecules
T296 926-934 CHEBI:36357;CHEBI:36357 denotes molecule
T297 976-985 CHEBI:36357;CHEBI:36357 denotes molecules
T298 1114-1123 CHEBI:36357;CHEBI:36357 denotes molecules

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T59 103-114 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T60 287-306 Body_part denotes extracellular space http://purl.org/sig/ont/fma/fma70022
T61 412-424 Body_part denotes carbohydrate http://purl.org/sig/ont/fma/fma82737
T62 471-482 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T63 643-648 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T64 723-734 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 401-404 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T89 173-174 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 186-194 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T91 381-382 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 441-442 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T93 541-542 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 649-657 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T237 42-53 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T238 64-82 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T239 103-118 Chemical denotes ganglioside GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048
T241 103-114 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T242 115-118 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_73110
T243 159-162 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T246 226-234 Chemical denotes ceramide http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639
T248 335-339 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T249 351-361 Chemical denotes saccharide http://purl.obolibrary.org/obo/CHEBI_16646
T250 412-424 Chemical denotes carbohydrate http://purl.obolibrary.org/obo/CHEBI_16646
T251 435-438 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T254 471-482 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T255 634-642 Chemical denotes ceramide http://purl.obolibrary.org/obo/CHEBI_17761|http://purl.obolibrary.org/obo/CHEBI_52639
T257 671-679 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T258 680-685 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T259 723-734 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T260 777-780 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T263 819-828 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T264 891-894 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T267 903-912 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T268 922-925 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110
T271 926-934 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T272 976-985 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T273 1114-1123 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T274 1133-1136 Chemical denotes GM1 http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T8 115-118 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T9 159-162 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T10 435-438 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T11 777-780 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T12 891-894 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T13 922-925 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T14 1133-1136 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T101 0-119 Sentence denotes Fig. 4 Molecular modelling simulations of chloroquine (CLQ) and hydroxychloroquine (CLQ-OH) binding to ganglioside GM1.
T102 120-570 Sentence denotes The surface electrostatic potential of GM1 indicates a non-polar, membrane-embedded part corresponding to ceramide (white areas), and an acidic part protruding in the extracellular space corresponding to the sialic-acid-containing saccharide part (red areas). (a) CLQ bound to the tip of the carbohydrate moiety of GM1. (b) Molecular mechanism of CLQ–ganglioside interactions. (c) Molecular dynamics simulations revealed a second site of interaction.
T103 571-1086 Sentence denotes In this case, the aromatic cycles of CLQ are positioned at the ceramide–sugar junction, whereas the nitrogen atoms interact with the acidic part of the ganglioside (not illustrated). (d,e) Surface views of GM1 complexed with one (d) or two (e) CLQ molecules (both in blue), illustrating the geometric complementarity of GM1 and CLQ molecules. (f) One GM1 molecule can also accommodate two distinct CLQ-OH molecules simultaneously, after slight rearrangement allowing increased fit due to CLQ-OH/CLQ-OH interactions.
T104 1087-1194 Sentence denotes To improve clarity, CLQ-OH molecules bound to GM1 are represented in two distinct colours (blue and green).