PMC:7127386 / 14092-14593 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"492","span":{"begin":105,"end":110},"obj":"Gene"},{"id":"493","span":{"begin":115,"end":120},"obj":"Gene"},{"id":"494","span":{"begin":426,"end":448},"obj":"Species"},{"id":"495","span":{"begin":450,"end":472},"obj":"Species"},{"id":"496","span":{"begin":474,"end":492},"obj":"Species"},{"id":"507","span":{"begin":205,"end":216},"obj":"Chemical"},{"id":"508","span":{"begin":243,"end":260},"obj":"Chemical"},{"id":"509","span":{"begin":324,"end":341},"obj":"Chemical"},{"id":"514","span":{"begin":150,"end":158},"obj":"Disease"},{"id":"515","span":{"begin":298,"end":322},"obj":"Disease"}],"attributes":[{"id":"A492","pred":"tao:has_database_id","subj":"492","obj":"Gene:4170"},{"id":"A493","pred":"tao:has_database_id","subj":"493","obj":"Gene:4609"},{"id":"A494","pred":"tao:has_database_id","subj":"494","obj":"Tax:10335"},{"id":"A495","pred":"tao:has_database_id","subj":"495","obj":"Tax:10298"},{"id":"A496","pred":"tao:has_database_id","subj":"496","obj":"Tax:10345"},{"id":"A507","pred":"tao:has_database_id","subj":"507","obj":"MESH:D000077863"},{"id":"A508","pred":"tao:has_database_id","subj":"508","obj":"MESH:D000077863"},{"id":"A509","pred":"tao:has_database_id","subj":"509","obj":"MESH:D000077863"},{"id":"A514","pred":"tao:has_database_id","subj":"514","obj":"MESH:D007938"},{"id":"A515","pred":"tao:has_database_id","subj":"515","obj":"MESH:D015464"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), corona"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T43","span":{"begin":0,"end":11},"obj":"Body_part"},{"id":"T44","span":{"begin":28,"end":35},"obj":"Body_part"},{"id":"T45","span":{"begin":86,"end":94},"obj":"Body_part"},{"id":"T46","span":{"begin":105,"end":108},"obj":"Body_part"},{"id":"T47","span":{"begin":159,"end":164},"obj":"Body_part"}],"attributes":[{"id":"A43","pred":"fma_id","subj":"T43","obj":"http://purl.org/sig/ont/fma/fma66867"},{"id":"A44","pred":"fma_id","subj":"T44","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A45","pred":"fma_id","subj":"T45","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A46","pred":"fma_id","subj":"T46","obj":"http://purl.org/sig/ont/fma/fma305650"},{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), corona"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T93","span":{"begin":150,"end":158},"obj":"Disease"},{"id":"T94","span":{"begin":298,"end":322},"obj":"Disease"},{"id":"T95","span":{"begin":306,"end":322},"obj":"Disease"},{"id":"T96","span":{"begin":314,"end":322},"obj":"Disease"},{"id":"T97","span":{"begin":426,"end":435},"obj":"Disease"},{"id":"T98","span":{"begin":436,"end":442},"obj":"Disease"},{"id":"T99","span":{"begin":450,"end":464},"obj":"Disease"},{"id":"T100","span":{"begin":474,"end":486},"obj":"Disease"}],"attributes":[{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0005059"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0011996"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0004643"},{"id":"A96","pred":"mondo_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/MONDO_0005059"},{"id":"A97","pred":"mondo_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/MONDO_0005700"},{"id":"A98","pred":"mondo_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/MONDO_0005609"},{"id":"A99","pred":"mondo_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/MONDO_0004609"},{"id":"A100","pred":"mondo_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/MONDO_0005932"}],"text":"ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), corona"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T89","span":{"begin":10,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T90","span":{"begin":159,"end":164},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T91","span":{"begin":179,"end":183},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T92","span":{"begin":218,"end":219},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T93","span":{"begin":342,"end":345},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T94","span":{"begin":394,"end":402},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T95","span":{"begin":443,"end":448},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T96","span":{"begin":465,"end":470},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T97","span":{"begin":487,"end":492},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), corona"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T219","span":{"begin":28,"end":35},"obj":"Chemical"},{"id":"T220","span":{"begin":86,"end":94},"obj":"Chemical"},{"id":"T221","span":{"begin":185,"end":187},"obj":"Chemical"},{"id":"T222","span":{"begin":324,"end":341},"obj":"Chemical"}],"attributes":[{"id":"A219","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A220","pred":"chebi_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A221","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_33382"},{"id":"A222","pred":"chebi_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/CHEBI_71019"}],"text":"ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), corona"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T13","span":{"begin":28,"end":47},"obj":"http://purl.obolibrary.org/obo/GO_0006412"}],"text":"ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), corona"}

{"project":"LitCovid-sentences","denotations":[{"id":"T97","span":{"begin":205,"end":323},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), corona"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T11","span":{"begin":150,"end":158},"obj":"Phenotype"},{"id":"T12","span":{"begin":298,"end":322},"obj":"Phenotype"}],"attributes":[{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0001909"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0005506"}],"text":"ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), corona"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T338","span":{"begin":0,"end":9},"obj":"GO:0005840"},{"id":"T339","span":{"begin":36,"end":47},"obj":"GO:0006412"},{"id":"T340","span":{"begin":105,"end":108},"obj":"PR:000010240"},{"id":"T341","span":{"begin":205,"end":216},"obj":"CHEBI:25675;CHEBI:25675"},{"id":"T342","span":{"begin":306,"end":313},"obj":"CL:0000763"},{"id":"T343","span":{"begin":388,"end":393},"obj":"NCBITaxon:10239"},{"id":"T344","span":{"begin":411,"end":424},"obj":"NCBITaxon:10376"},{"id":"T345","span":{"begin":426,"end":435},"obj":"NCBITaxon:10633"},{"id":"T346","span":{"begin":436,"end":442},"obj":"NCBITaxon:7955"},{"id":"T347","span":{"begin":443,"end":448},"obj":"NCBITaxon:10239"},{"id":"T348","span":{"begin":450,"end":456},"obj":"NCBITaxon:10376"},{"id":"T349","span":{"begin":457,"end":470},"obj":"NCBITaxon:10633"},{"id":"T350","span":{"begin":470,"end":471},"obj":"NCBITaxon:10376"},{"id":"T351","span":{"begin":474,"end":486},"obj":"NCBITaxon:9258"},{"id":"T352","span":{"begin":487,"end":492},"obj":"NCBITaxon:10239"},{"id":"T93027","span":{"begin":127,"end":135},"obj":"CHEBI:25675;CHEBI:25675"},{"id":"T87372","span":{"begin":194,"end":200},"obj":"UBERON:0001969"},{"id":"T51725","span":{"begin":360,"end":370},"obj":"SP_7"},{"id":"T24739","span":{"begin":371,"end":376},"obj":"NCBITaxon:10239"},{"id":"T90567","span":{"begin":400,"end":417},"obj":"GO:0006412"},{"id":"T93899","span":{"begin":418,"end":427},"obj":"CHEBI:48001;CHEBI:48001"},{"id":"T72886","span":{"begin":450,"end":459},"obj":"NCBITaxon:33317"},{"id":"T45099","span":{"begin":486,"end":496},"obj":"NCBITaxon:5774"}],"text":"ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), corona"}