PMC:7127386 / 13968-15262
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 492 | 229-234 | Gene | denotes | Mcl-1 | Gene:4170 |
| 493 | 239-244 | Gene | denotes | c-Myc | Gene:4609 |
| 494 | 550-572 | Species | denotes | varicella-zoster virus | Tax:10335 |
| 495 | 574-596 | Species | denotes | herpes simplex virus-1 | Tax:10298 |
| 496 | 598-616 | Species | denotes | pseudorabies virus | Tax:10345 |
| 497 | 619-632 | Species | denotes | coronaviruses | Tax:11118 |
| 498 | 634-665 | Species | denotes | porcine epidemic diarrhea virus | Tax:28295 |
| 499 | 670-692 | Species | denotes | murine hepatitis virus | Tax:11138 |
| 500 | 718-730 | Species | denotes | rabies virus | Tax:11292 |
| 501 | 771-794 | Species | denotes | Newcastle disease virus | Tax:11176 |
| 502 | 800-811 | Species | denotes | echovirus 1 | Tax:46633 |
| 503 | 902-912 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 504 | 1000-1008 | Species | denotes | patients | Tax:9606 |
| 505 | 1268-1278 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 506 | 0-17 | Chemical | denotes | Homoharringtonine | MESH:D000077863 |
| 507 | 329-340 | Chemical | denotes | Omacetaxine | MESH:D000077863 |
| 508 | 367-384 | Chemical | denotes | homoharringtonine | MESH:D000077863 |
| 509 | 448-465 | Chemical | denotes | Homoharringtonine | MESH:D000077863 |
| 510 | 875-892 | Chemical | denotes | homoharringtonine | MESH:D000077863 |
| 511 | 1033-1044 | Chemical | denotes | omacetaxine | MESH:D000077863 |
| 512 | 51-72 | Disease | denotes | Cephalotoxus fortunei | |
| 513 | 91-96 | Disease | denotes | tumor | MESH:D009369 |
| 514 | 274-282 | Disease | denotes | leukemia | MESH:D007938 |
| 515 | 422-446 | Disease | denotes | chronic myeloid leukemia | MESH:D015464 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T43 | 124-135 | Body_part | denotes | ribosomal A | http://purl.org/sig/ont/fma/fma66867 |
| T44 | 152-159 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T45 | 210-218 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T46 | 229-232 | Body_part | denotes | Mcl | http://purl.org/sig/ont/fma/fma305650 |
| T47 | 283-288 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T48 | 1104-1110 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T92 | 91-96 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T93 | 274-282 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T94 | 422-446 | Disease | denotes | chronic myeloid leukemia | http://purl.obolibrary.org/obo/MONDO_0011996 |
| T95 | 430-446 | Disease | denotes | myeloid leukemia | http://purl.obolibrary.org/obo/MONDO_0004643 |
| T96 | 438-446 | Disease | denotes | leukemia | http://purl.obolibrary.org/obo/MONDO_0005059 |
| T97 | 550-559 | Disease | denotes | varicella | http://purl.obolibrary.org/obo/MONDO_0005700 |
| T98 | 560-566 | Disease | denotes | zoster | http://purl.obolibrary.org/obo/MONDO_0005609 |
| T99 | 574-588 | Disease | denotes | herpes simplex | http://purl.obolibrary.org/obo/MONDO_0004609 |
| T100 | 598-610 | Disease | denotes | pseudorabies | http://purl.obolibrary.org/obo/MONDO_0005932 |
| T101 | 651-659 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T102 | 677-686 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T103 | 718-724 | Disease | denotes | rabies | http://purl.obolibrary.org/obo/MONDO_0019173 |
| T104 | 752-763 | Disease | denotes | hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
| T105 | 752-761 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T106 | 771-788 | Disease | denotes | Newcastle disease | http://purl.obolibrary.org/obo/MONDO_0005875 |
| T107 | 902-910 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T108 | 1268-1276 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T87 | 21-22 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T88 | 97-105 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T89 | 134-135 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T90 | 283-288 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T91 | 303-307 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T92 | 342-343 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T93 | 466-469 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T94 | 518-526 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T95 | 567-572 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T96 | 589-594 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T97 | 611-616 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T98 | 660-665 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T99 | 687-692 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T100 | 725-730 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T101 | 743-750 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T102 | 762-763 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T103 | 764-769 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T104 | 789-794 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T105 | 827-831 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T106 | 1104-1110 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T107 | 1190-1192 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T108 | 1279-1284 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T217 | 0-17 | Chemical | denotes | Homoharringtonine | http://purl.obolibrary.org/obo/CHEBI_71019 |
| T218 | 29-37 | Chemical | denotes | alkaloid | http://purl.obolibrary.org/obo/CHEBI_22315 |
| T219 | 152-159 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T220 | 210-218 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T221 | 309-311 | Chemical | denotes | Lu | http://purl.obolibrary.org/obo/CHEBI_33382 |
| T222 | 448-465 | Chemical | denotes | Homoharringtonine | http://purl.obolibrary.org/obo/CHEBI_71019 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T13 | 152-171 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | protein translation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T95 | 0-73 | Sentence | denotes | Homoharringtonine is a plant alkaloid derived from Cephalotoxus fortunei. |
| T96 | 74-328 | Sentence | denotes | It exhibits anti-tumor activity by binding to the ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014). |
| T97 | 329-447 | Sentence | denotes | Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia. |
| T98 | 448-856 | Sentence | denotes | Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), coronaviruses (porcine epidemic diarrhea virus and murine hepatitis virus), rhabdoviruses (VSV and rabies virus), and other viruses (hepatitis B virus, Newcastle disease virus, and echovirus 1) (Dong et al., 2018; Andersen et al., 2019). |
| T99 | 857-956 | Sentence | denotes | Here, we observed homoharringtonine inhibits SARS-CoV-2 with EC50 at 2.10 μM (Fig. 1C and Table 1). |
| T100 | 957-1294 | Sentence | denotes | Previous pharmacokinetic study showed that patients treated with 1.25 mg/m2 omacetaxine every 12 h by subcutaneous injection may reach the maximal plasma concentration at 25.1 ng/mL (0.046 μM) and 36.2 ng/mL (0.066 μM) on days 1 and 11, respectively (Nemunaitis et al., 2013), which were below the EC50 against SARS-CoV-2 virus in vitro. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T10 | 91-96 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
| T11 | 274-282 | Phenotype | denotes | leukemia | http://purl.obolibrary.org/obo/HP_0001909 |
| T12 | 422-446 | Phenotype | denotes | chronic myeloid leukemia | http://purl.obolibrary.org/obo/HP_0005506 |
| T13 | 651-659 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T14 | 677-686 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T15 | 752-761 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T335 | 23-28 | NCBITaxon:3193 | denotes | plant |
| T336 | 29-37 | CHEBI:22315;CHEBI:22315 | denotes | alkaloid |
| T337 | 51-63 | NCBITaxon:6073 | denotes | Cephalotoxus |
| T338 | 124-133 | GO:0005840 | denotes | ribosomal |
| T339 | 160-171 | GO:0006412 | denotes | translation |
| T340 | 229-232 | PR:000010240 | denotes | Mcl |
| T341 | 329-340 | CHEBI:25675;CHEBI:25675 | denotes | Omacetaxine |
| T342 | 430-437 | CL:0000763 | denotes | myeloid |
| T343 | 512-517 | NCBITaxon:10239 | denotes | viral |
| T344 | 535-548 | NCBITaxon:10376 | denotes | herpesviruses |
| T345 | 550-559 | NCBITaxon:10633 | denotes | varicella |
| T346 | 560-566 | NCBITaxon:7955 | denotes | zoster |
| T347 | 567-572 | NCBITaxon:10239 | denotes | virus |
| T348 | 574-580 | NCBITaxon:10376 | denotes | herpes |
| T349 | 581-594 | NCBITaxon:10633 | denotes | simplex virus |
| T350 | 594-595 | NCBITaxon:10376 | denotes | - |
| T351 | 598-610 | NCBITaxon:9258 | denotes | pseudorabies |
| T352 | 611-616 | NCBITaxon:10239 | denotes | virus |
| T353 | 619-632 | NCBITaxon:11118 | denotes | coronaviruses |
| T354 | 634-641 | NCBITaxon:9258 | denotes | porcine |
| T355 | 642-659 | NCBITaxon:28295 | denotes | epidemic diarrhea |
| T356 | 660-665 | NCBITaxon:10239 | denotes | virus |
| T357 | 670-676 | NCBITaxon:39107 | denotes | murine |
| T358 | 677-686 | NCBITaxon:5690 | denotes | hepatitis |
| T359 | 687-692 | NCBITaxon:10376 | denotes | virus |
| T360 | 695-708 | NCBITaxon:7729 | denotes | rhabdoviruses |
| T361 | 710-713 | NCBITaxon:10298 | denotes | VSV |
| T362 | 718-724 | NCBITaxon:9654 | denotes | rabies |
| T363 | 725-730 | NCBITaxon:10376 | denotes | virus |
| T364 | 743-750 | NCBITaxon:10239 | denotes | viruses |
| T365 | 752-761 | NCBITaxon:5690 | denotes | hepatitis |
| T366 | 762-769 | NCBITaxon:10376 | denotes | B virus |
| T367 | 771-780 | NCBITaxon:6231 | denotes | Newcastle |
| T368 | 781-788 | NCBITaxon:10376 | denotes | disease |
| T369 | 789-794 | NCBITaxon:10239 | denotes | virus |
| T370 | 800-809 | NCBITaxon:33758 | denotes | echovirus |
| T371 | 902-912 | SP_7 | denotes | SARS-CoV-2 |
| T372 | 1033-1044 | CHEBI:25675;CHEBI:25675 | denotes | omacetaxine |
| T373 | 1104-1110 | UBERON:0001969 | denotes | plasma |
| T374 | 1268-1278 | SP_7 | denotes | SARS-CoV-2 |
| T375 | 1279-1284 | NCBITaxon:10239 | denotes | virus |
| T77556 | 6-11 | NCBITaxon:10239 | denotes | rring |
| T29223 | 17-26 | NCBITaxon:33758 | denotes | is a pla |
| T31283 | 119-129 | SP_7 | denotes | the ribos |
| T93027 | 251-259 | CHEBI:25675;CHEBI:25675 | denotes | romote t |
| T87372 | 318-324 | UBERON:0001969 | denotes | ng, 20 |
| T51725 | 484-494 | SP_7 | denotes | rted to ex |
| T24739 | 495-500 | NCBITaxon:10239 | denotes | ibit |
| T90567 | 524-541 | GO:0006412 | denotes | ty against herpes |
| T93899 | 542-551 | CHEBI:48001;CHEBI:48001 | denotes | iruses (v |
| T72886 | 574-583 | NCBITaxon:33317 | denotes | herpes si |
| T45099 | 610-620 | NCBITaxon:5774 | denotes | virus), c |
| T23080 | 666-676 | GO:0005840 | denotes | and murine |
| T62379 | 687-708 | NCBITaxon:5833 | denotes | virus), rhabdoviruses |
| T45335 | 916-923 | NCBITaxon:10376 | denotes | h EC50 |
| T16969 | 935-939 | NCBITaxon:7955 | denotes | Fig. |
| T42624 | 940-945 | NCBITaxon:10376 | denotes | 1C an |
| T19146 | 947-957 | NCBITaxon:10376 | denotes | Table 1). |
| T1785 | 959-970 | NCBITaxon:6073 | denotes | evious phar |
| T71027 | 972-978 | NCBITaxon:9654 | denotes | cokine |
| T80641 | 979-984 | NCBITaxon:10376 | denotes | ic st |
| T1065 | 993-1002 | NCBITaxon:33758 | denotes | d that pa |
| T80588 | 1006-1013 | NCBITaxon:9940 | denotes | ts trea |
| T69278 | 1014-1022 | NCBITaxon:9258 | denotes | ed with |
| T72172 | 1024-1030 | NCBITaxon:27592 | denotes | 25 mg/ |
| T2968 | 1031-1045 | NCBITaxon:5690 | denotes | 2 omacetaxine |
| T54511 | 1049-1054 | NCBITaxon:9258 | denotes | y 12 |
| T78740 | 1059-1065 | NCBITaxon:7656 | denotes | subcut |
| T6403 | 1066-1075 | NCBITaxon:7729 | denotes | neous inj |
| T46358 | 1076-1081 | NCBITaxon:10239 | denotes | ction |
| T13633 | 1083-1092 | NCBITaxon:6231 | denotes | ay reach |
| T23133 | 1093-1107 | NCBITaxon:10376 | denotes | he maximal pla |
| T36362 | 1109-1115 | NCBITaxon:5690 | denotes | a conc |
| T95862 | 1116-1123 | NCBITaxon:10633 | denotes | ntratio |
| T61572 | 1124-1129 | NCBITaxon:10376 | denotes | at 2 |
| T32709 | 1133-1146 | NCBITaxon:7737 | denotes | ng/mL (0.046 |
| T13406 | 1148-1165 | NCBITaxon:11588 | denotes | ) and 36.2 ng/mL |
| T29449 | 1166-1171 | NCBITaxon:10239 | denotes | 0.066 |