PMC:7127386 / 12001-12302 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"417","span":{"begin":44,"end":63},"obj":"Gene"},{"id":"420","span":{"begin":9,"end":14},"obj":"Species"},{"id":"421","span":{"begin":282,"end":290},"obj":"Species"},{"id":"422","span":{"begin":292,"end":300},"obj":"Species"},{"id":"442","span":{"begin":88,"end":97},"obj":"Chemical"},{"id":"443","span":{"begin":120,"end":139},"obj":"Chemical"},{"id":"444","span":{"begin":183,"end":192},"obj":"Chemical"},{"id":"445","span":{"begin":222,"end":231},"obj":"Chemical"},{"id":"446","span":{"begin":240,"end":249},"obj":"Chemical"}],"attributes":[{"id":"A417","pred":"tao:has_database_id","subj":"417","obj":"Gene:1576"},{"id":"A420","pred":"tao:has_database_id","subj":"420","obj":"Tax:11676"},{"id":"A421","pred":"tao:has_database_id","subj":"421","obj":"Tax:694009"},{"id":"A422","pred":"tao:has_database_id","subj":"422","obj":"Tax:1335626"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"MESH:D061466"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"MESH:C558899"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"MESH:D061466"},{"id":"A445","pred":"tao:has_database_id","subj":"445","obj":"MESH:D061466"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"MESH:D019438"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"not only HIV-1 protease but also the host's cytochrome P450 3A4 enzyme that metabolizes lopinavir (Kempf et al., 1997). Lopinavir/ritonavir in combination prolongs bioavailability of lopinavir in vivo (Sham et al., 1998). Lopinavir but not ritonavir showed antiviral effect against SARS-CoV, MERS-CoV,"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T40","span":{"begin":9,"end":12},"obj":"Body_part"}],"attributes":[{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma278683"}],"text":"not only HIV-1 protease but also the host's cytochrome P450 3A4 enzyme that metabolizes lopinavir (Kempf et al., 1997). Lopinavir/ritonavir in combination prolongs bioavailability of lopinavir in vivo (Sham et al., 1998). Lopinavir but not ritonavir showed antiviral effect against SARS-CoV, MERS-CoV,"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T82","span":{"begin":282,"end":290},"obj":"Disease"}],"attributes":[{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"not only HIV-1 protease but also the host's cytochrome P450 3A4 enzyme that metabolizes lopinavir (Kempf et al., 1997). Lopinavir/ritonavir in combination prolongs bioavailability of lopinavir in vivo (Sham et al., 1998). Lopinavir but not ritonavir showed antiviral effect against SARS-CoV, MERS-CoV,"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T180","span":{"begin":44,"end":59},"obj":"Chemical"},{"id":"T181","span":{"begin":44,"end":54},"obj":"Chemical"},{"id":"T182","span":{"begin":88,"end":97},"obj":"Chemical"},{"id":"T183","span":{"begin":120,"end":129},"obj":"Chemical"},{"id":"T184","span":{"begin":130,"end":139},"obj":"Chemical"},{"id":"T185","span":{"begin":183,"end":192},"obj":"Chemical"},{"id":"T186","span":{"begin":222,"end":231},"obj":"Chemical"},{"id":"T187","span":{"begin":240,"end":249},"obj":"Chemical"},{"id":"T188","span":{"begin":257,"end":266},"obj":"Chemical"}],"attributes":[{"id":"A180","pred":"chebi_id","subj":"T180","obj":"http://purl.obolibrary.org/obo/CHEBI_38559"},{"id":"A181","pred":"chebi_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/CHEBI_4056"},{"id":"A182","pred":"chebi_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A183","pred":"chebi_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A184","pred":"chebi_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"},{"id":"A185","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A186","pred":"chebi_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A187","pred":"chebi_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"},{"id":"A188","pred":"chebi_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"}],"text":"not only HIV-1 protease but also the host's cytochrome P450 3A4 enzyme that metabolizes lopinavir (Kempf et al., 1997). Lopinavir/ritonavir in combination prolongs bioavailability of lopinavir in vivo (Sham et al., 1998). Lopinavir but not ritonavir showed antiviral effect against SARS-CoV, MERS-CoV,"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T9","span":{"begin":44,"end":54},"obj":"http://purl.obolibrary.org/obo/GO_0045158"},{"id":"T10","span":{"begin":44,"end":54},"obj":"http://purl.obolibrary.org/obo/GO_0045157"},{"id":"T11","span":{"begin":44,"end":54},"obj":"http://purl.obolibrary.org/obo/GO_0045156"},{"id":"T12","span":{"begin":44,"end":54},"obj":"http://purl.obolibrary.org/obo/GO_0008121"}],"text":"not only HIV-1 protease but also the host's cytochrome P450 3A4 enzyme that metabolizes lopinavir (Kempf et al., 1997). Lopinavir/ritonavir in combination prolongs bioavailability of lopinavir in vivo (Sham et al., 1998). Lopinavir but not ritonavir showed antiviral effect against SARS-CoV, MERS-CoV,"}

{"project":"LitCovid-sentences","denotations":[{"id":"T85","span":{"begin":120,"end":221},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"not only HIV-1 protease but also the host's cytochrome P450 3A4 enzyme that metabolizes lopinavir (Kempf et al., 1997). Lopinavir/ritonavir in combination prolongs bioavailability of lopinavir in vivo (Sham et al., 1998). Lopinavir but not ritonavir showed antiviral effect against SARS-CoV, MERS-CoV,"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T286","span":{"begin":44,"end":54},"obj":"CHEBI:38559;CHEBI:38559"},{"id":"T287","span":{"begin":55,"end":63},"obj":"PR:000006130"},{"id":"T288","span":{"begin":76,"end":87},"obj":"GO:0008152"},{"id":"T289","span":{"begin":88,"end":97},"obj":"DG_23;CHEBI:31781;CHEBI:31781"},{"id":"T290","span":{"begin":120,"end":129},"obj":"CHEBI:31781;DG_23;CHEBI:31781"},{"id":"T291","span":{"begin":130,"end":139},"obj":"CHEBI:45409;DG_30;CHEBI:45409"},{"id":"T292","span":{"begin":183,"end":192},"obj":"CHEBI:31781;DG_23;CHEBI:31781"},{"id":"T293","span":{"begin":222,"end":231},"obj":"DG_23"},{"id":"T294","span":{"begin":240,"end":249},"obj":"DG_30"},{"id":"T295","span":{"begin":282,"end":290},"obj":"SP_10"},{"id":"T296","span":{"begin":292,"end":300},"obj":"SP_9"},{"id":"T42","span":{"begin":222,"end":231},"obj":"DG_23"},{"id":"T43","span":{"begin":240,"end":249},"obj":"DG_30"},{"id":"T73155","span":{"begin":34,"end":44},"obj":"SP_7"},{"id":"T30112","span":{"begin":159,"end":167},"obj":"CHEBI:31781;DG_23;CHEBI:31781"},{"id":"T8788","span":{"begin":195,"end":204},"obj":"DG_30"},{"id":"T45388","span":{"begin":213,"end":223},"obj":"SP_7"}],"text":"not only HIV-1 protease but also the host's cytochrome P450 3A4 enzyme that metabolizes lopinavir (Kempf et al., 1997). Lopinavir/ritonavir in combination prolongs bioavailability of lopinavir in vivo (Sham et al., 1998). Lopinavir but not ritonavir showed antiviral effect against SARS-CoV, MERS-CoV,"}