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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
5 62-72 Species denotes SARS-CoV-2 Tax:2697049
6 0-10 Chemical denotes Remdesivir MESH:C000606551
7 12-21 Chemical denotes lopinavir MESH:D061466
8 23-30 Chemical denotes emetine MESH:D004640
9 36-53 Chemical denotes homoharringtonine MESH:D000077863
26 140-150 Species denotes SARS-CoV-2 Tax:2697049
27 336-347 Species denotes coronavirus Tax:11118
28 433-443 Species denotes SARS-CoV-2 Tax:2697049
29 444-452 Species denotes patients Tax:9606
30 548-558 Species denotes SARS-CoV-2 Tax:2697049
31 488-498 Chemical denotes remdesivir MESH:C000606551
32 500-509 Chemical denotes lopinavir MESH:D061466
33 511-526 Chemical denotes homorringtonine
34 532-539 Chemical denotes emetine MESH:D004640
35 687-696 Chemical denotes Ribavirin MESH:D012254
36 700-711 Chemical denotes favipiravir MESH:C462182
37 811-821 Chemical denotes remdesivir MESH:C000606551
38 826-833 Chemical denotes emetine MESH:D004640
39 852-862 Chemical denotes remdesivir MESH:C000606551
40 894-901 Chemical denotes emetine MESH:D004640
41 568-575 CellLine denotes Vero E6 CVCL:0574
45 1158-1168 Species denotes SARS-CoV-2 Tax:2697049
46 1138-1148 Chemical denotes Remdesivir MESH:C000606551
47 1184-1191 CellLine denotes Vero-E6 CVCL:0574
51 1261-1271 Species denotes SARS-CoV-2 Tax:2697049
52 1224-1233 Chemical denotes Lopinavir MESH:D061466
53 1242-1251 Chemical denotes ritonavir MESH:D019438
57 1349-1359 Species denotes SARS-CoV-2 Tax:2697049
58 1310-1327 Chemical denotes Homoharringtonine MESH:D000077863
59 1332-1339 Chemical denotes emetine MESH:D004640
62 1435-1445 Chemical denotes remdesivir MESH:C000606551
63 1450-1457 Chemical denotes emetine MESH:D004640
73 1546-1556 Species denotes SARS-CoV-2 Tax:2697049
74 1749-1759 Species denotes SARS-CoV-2 Tax:2697049
75 2521-2526 Species denotes human Tax:9606
76 2527-2540 Species denotes coronaviruses Tax:11118
77 2544-2554 Species denotes SARS-CoV-2 Tax:2697049
78 1724-1733 Disease denotes Infection MESH:D007239
79 1835-1844 Disease denotes infection MESH:D007239
80 1911-1921 Disease denotes infections MESH:D007239
81 2148-2157 Disease denotes infection MESH:D007239
113 3903-3907 Gene denotes PD-1 Gene:6622
114 3926-3930 Gene denotes IL-6 Gene:3569
115 2560-2570 Species denotes SARS-CoV-2 Tax:2697049
116 2614-2622 Species denotes SARS-CoV Tax:694009
117 2655-2668 Species denotes coronaviruses Tax:11118
118 2786-2794 Species denotes SARS-CoV Tax:694009
119 2804-2817 Species denotes coronaviruses Tax:11118
120 2843-2853 Species denotes SARS-CoV-2 Tax:2697049
121 3102-3115 Species denotes coronaviruses Tax:11118
122 3215-3224 Species denotes 2019-nCoV Tax:2697049
123 3291-3308 Species denotes novel coronavirus Tax:2697049
124 3386-3392 Species denotes People Tax:9606
125 4164-4175 Species denotes coronavirus Tax:11118
126 4243-4251 Species denotes patients Tax:9606
127 3996-4006 Species denotes SARS-CoV-2 Tax:2697049
128 2967-2977 Chemical denotes remdesivir MESH:C000606551
129 2979-2986 Chemical denotes GS-5734 MESH:C000606551
130 3002-3011 Chemical denotes adenosine MESH:D000241
131 3478-3497 Chemical denotes lopinavir/ritonavir MESH:C558899
132 3499-3508 Chemical denotes ribavirin MESH:D012254
133 3529-3548 Chemical denotes lopinavir/ritonavir MESH:C558899
134 3550-3571 Chemical denotes chloroquine phosphate MESH:C023676
135 3576-3583 Chemical denotes Arbidol MESH:C086979
136 3681-3691 Chemical denotes remdesivir MESH:C000606551
137 3730-3749 Chemical denotes lopinavir/ritonavir MESH:C558899
138 3751-3766 Chemical denotes ASC09/ritonavir
139 3768-3777 Chemical denotes darunavir MESH:D000069454
140 3813-3821 Chemical denotes Azvudine MESH:C540945
141 3932-3943 Chemical denotes Tocilizumab MESH:C502936
142 4257-4276 Disease denotes coronavirus disease MESH:D018352
143 4278-4286 Disease denotes COVID-19 MESH:C000657245
169 4289-4299 Species denotes SARS-CoV-2 Tax:2697049
170 4307-4314 Species denotes BetaCoV Tax:694002
171 4425-4432 Species denotes patient Tax:9606
172 4792-4798 Species denotes stocks Tax:3724
173 5407-5417 Species denotes SARS-CoV-2 Tax:2697049
174 4592-4596 Chemical denotes DMEM
175 4625-4632 Chemical denotes glucose MESH:D005947
176 4643-4658 Chemical denotes sodium pyruvate
177 4680-4690 Chemical denotes Penicillin MESH:D010406
178 4691-4703 Chemical denotes Streptomycin MESH:D013307
179 4715-4720 Chemical denotes HEPES MESH:D006531
180 4830-4840 Chemical denotes remdesivir MESH:C000606551
181 5038-5047 Chemical denotes lopinavir MESH:D061466
182 5074-5079 Chemical denotes water MESH:D014867
183 5194-5217 Chemical denotes Oseltamivir carboxylate MESH:C535162
184 5228-5233 Chemical denotes water MESH:D014867
185 4416-4424 Disease denotes COVID-19 MESH:C000657245
186 4575-4584 Disease denotes infection MESH:D007239
187 5361-5370 Disease denotes infection MESH:D007239
188 5394-5403 Disease denotes infection MESH:D007239
189 5609-5618 Disease denotes infection MESH:D007239
190 4457-4459 CellLine denotes E6 CVCL:4582
191 4563-4565 CellLine denotes E6 CVCL:4582
192 5309-5311 CellLine denotes E6 CVCL:4582
193 6132-6134 CellLine denotes E6 CVCL:4582
220 10255-10268 Gene denotes neuraminidase Gene:4758
221 8413-8423 Species denotes SARS-CoV-2 Tax:2697049
222 8645-8650 Species denotes Ebola Tax:1570291
223 8654-8664 Species denotes SARS-CoV-2 Tax:2697049
224 9220-9225 Species denotes HIV-1 Tax:11676
225 8583-8593 Chemical denotes Remdesivir MESH:C000606551
226 8594-8603 Chemical denotes adenosine MESH:D000241
227 8954-8963 Chemical denotes adenosine MESH:D000241
228 9171-9180 Chemical denotes adenosine MESH:D000241
229 9288-9297 Chemical denotes adenosine MESH:D000241
230 9404-9413 Chemical denotes Lopinavir MESH:D061466
231 8781-8790 Disease denotes infection MESH:D007239
232 8882-8911 Disease denotes chronic hepatitis C infection MESH:D019698
233 8998-9019 Disease denotes fever virus infection MESH:D005334
234 9113-9128 Disease denotes virus infection MESH:D001102
235 9352-9372 Disease denotes lymphocytic leukemia MESH:D007945
236 9463-9478 Disease denotes HIV-1 infection MESH:D015658
237 9601-9616 Disease denotes HIV-1 infection MESH:D015658
238 9764-9783 Disease denotes invasive amoebiasis MESH:D000562
239 9879-9893 Disease denotes skin infection MESH:D007239
240 10024-10038 Disease denotes skin infection MESH:D007239
241 10128-10134 Disease denotes cancer MESH:D009369
242 10162-10186 Disease denotes chronic myeloid leukemia MESH:D015464
243 10316-10325 Disease denotes infection MESH:D007239
244 10444-10453 Disease denotes infection MESH:D007239
245 10583-10596 Disease denotes schizophrenia MESH:D012559
248 8360-8370 Species denotes SARS-CoV-2 Tax:2697049
249 8379-8381 CellLine denotes E6 CVCL:4582
251 10709-10711 CellLine denotes E6 CVCL:4582
257 10945-10955 Species denotes SARS-CoV-2 Tax:2697049
258 10878-10887 Chemical denotes ribavirin MESH:D012254
259 11054-11063 Disease denotes infection MESH:D007239
260 11169-11177 Disease denotes infected MESH:D007239
261 10965-10972 CellLine denotes Vero E6 CVCL:0574
263 11281-11290 Disease denotes infection MESH:D007239
265 11389-11398 Disease denotes infection MESH:D007239
274 11542-11552 Species denotes SARS-CoV-2 Tax:2697049
275 11451-11461 Chemical denotes remdesivir MESH:C000606551
276 11467-11476 Chemical denotes lopinavir MESH:D061466
277 11482-11497 Chemical denotes homorringtonine
278 11506-11529 Chemical denotes emetine dihydrochloride MESH:D004640
279 11654-11657 Chemical denotes ATP MESH:D000255
280 11700-11709 Disease denotes infection MESH:D007239
281 11671-11678 CellLine denotes Vero E6 CVCL:0574
324 6336-6346 Species denotes SARS-CoV-2 Tax:2697049
325 6606-6616 Species denotes SARS-CoV-2 Tax:2697049
326 6761-6766 Species denotes human Tax:9606
327 6767-6780 Species denotes coronaviruses Tax:11118
328 6782-6791 Species denotes hCoV-OC43 Tax:31631
329 6796-6805 Species denotes hCoV-229E Tax:11137
330 6807-6815 Species denotes SARS-CoV Tax:694009
331 6817-6825 Species denotes MERS-CoV Tax:1335626
332 6831-6841 Species denotes SARS-CoV-2 Tax:2697049
333 6964-6974 Species denotes SARS-CoV-2 Tax:2697049
334 7128-7138 Species denotes SARS-CoV-2 Tax:2697049
335 7471-7493 Species denotes murine hepatitis virus Tax:11138
336 7690-7700 Species denotes SARS-CoV-2 Tax:2697049
337 8227-8232 Species denotes human Tax:9606
338 6244-6254 Chemical denotes remdesivir MESH:C000606551
339 6256-6265 Chemical denotes lopinavir MESH:D061466
340 6267-6284 Chemical denotes homoharringtonine MESH:D000077863
341 6290-6313 Chemical denotes emetine dihydrochloride MESH:D004640
342 6508-6517 Chemical denotes ribavirin MESH:D012254
343 6519-6530 Chemical denotes favipiravir MESH:C462182
344 6532-6543 Chemical denotes oseltamivir MESH:D053139
345 6548-6557 Chemical denotes baloxavir MESH:C000628402
346 6674-6684 Chemical denotes Remdesivir MESH:C000606551
347 6711-6720 Chemical denotes adenosine MESH:D000241
348 7095-7105 Chemical denotes remdesivir MESH:C000606551
349 7298-7308 Chemical denotes remdesivir MESH:C000606551
350 7548-7558 Chemical denotes remdesivir MESH:C000606551
351 7794-7804 Chemical denotes remdesivir MESH:C000606551
352 7812-7821 Chemical denotes adenosine MESH:D000241
353 7833-7844 Chemical denotes galidesivir MESH:C517546
354 7846-7855 Chemical denotes tenofovor
355 7860-7881 Chemical denotes fludarabine phosphate MESH:C042382
356 7886-7896 Chemical denotes nucleoside MESH:D009705
357 7908-7919 Chemical denotes favipiravir MESH:C462182
358 7921-7930 Chemical denotes ribavirin MESH:D012254
359 7932-7938 Chemical denotes R-1479 MESH:C508950
360 8007-8017 Chemical denotes nucleoside MESH:D009705
361 8068-8080 Chemical denotes triphosphate MESH:C005692
362 8195-8205 Chemical denotes nucleoside MESH:D009705
363 6362-6369 CellLine denotes Vero E6 CVCL:0574
364 7407-7412 Mutation denotes F476L p.F476L
365 7417-7422 Mutation denotes V553L p.V553L
417 12045-12064 Gene denotes cytochrome P450 3A4 Gene:1576
418 11844-11849 Species denotes HIV-1 Tax:11676
419 11911-11916 Species denotes HIV-1 Tax:11676
420 12010-12015 Species denotes HIV-1 Tax:11676
421 12283-12291 Species denotes SARS-CoV Tax:694009
422 12293-12301 Species denotes MERS-CoV Tax:1335626
423 12307-12316 Species denotes hCoV-229E Tax:11137
424 12474-12482 Species denotes SARS-CoV Tax:694009
425 12483-12491 Species denotes patients Tax:9606
426 12541-12549 Species denotes patients Tax:9606
427 12821-12831 Species denotes SARS-CoV-2 Tax:2697049
428 12832-12840 Species denotes patients Tax:9606
429 12996-13006 Species denotes SARS-CoV-2 Tax:2697049
430 13039-13044 Species denotes HIV-1 Tax:11676
431 13045-13053 Species denotes patients Tax:9606
432 13236-13246 Species denotes SARS-CoV-2 Tax:2697049
433 13436-13444 Species denotes patients Tax:9606
434 13601-13611 Species denotes SARS-CoV-2 Tax:2697049
435 13612-13620 Species denotes patients Tax:9606
436 13876-13886 Species denotes SARS-CoV-2 Tax:2697049
437 11787-11796 Chemical denotes Lopinavir MESH:D061466
438 11817-11826 Chemical denotes ritonavir MESH:D019438
439 11871-11880 Chemical denotes Lopinavir MESH:D061466
440 11922-11931 Chemical denotes ritonavir MESH:D019438
441 11982-11991 Chemical denotes Ritonavir MESH:D019438
442 12089-12098 Chemical denotes lopinavir MESH:D061466
443 12121-12140 Chemical denotes Lopinavir/ritonavir MESH:C558899
444 12184-12193 Chemical denotes lopinavir MESH:D061466
445 12223-12232 Chemical denotes Lopinavir MESH:D061466
446 12241-12250 Chemical denotes ritonavir MESH:D019438
447 12394-12413 Chemical denotes Lopinavir/ritonavir MESH:C558899
448 12434-12443 Chemical denotes ribavirin MESH:D012254
449 12614-12633 Chemical denotes lopinavir/ritonavir MESH:C558899
450 12639-12648 Chemical denotes ribavirin MESH:D012254
451 12687-12696 Chemical denotes ribavirin MESH:D012254
452 12749-12768 Chemical denotes lopinavir/ritonavir MESH:C558899
453 12785-12794 Chemical denotes ribavirin MESH:D012254
454 12942-12951 Chemical denotes lopinavir MESH:D061466
455 12978-12987 Chemical denotes ritonavir MESH:D019438
456 13077-13086 Chemical denotes lopinavir MESH:D061466
457 13101-13110 Chemical denotes ritonavir MESH:D019438
458 13145-13154 Chemical denotes lopinavir MESH:D061466
459 13302-13321 Chemical denotes lopinavir/ritonavir MESH:C558899
460 13366-13375 Chemical denotes ribavirin MESH:D012254
461 13565-13584 Chemical denotes lopinavir-ritonavir MESH:C558899
462 13823-13832 Chemical denotes lopinavir MESH:D061466
463 13957-13966 Chemical denotes lopinavir MESH:D061466
464 12565-12569 Disease denotes ARDS MESH:D012128
465 12573-12578 Disease denotes death MESH:D003643
466 13427-13435 Disease denotes COVID-19 MESH:C000657245
467 13678-13687 Disease denotes mortality MESH:D003643
492 14197-14202 Gene denotes Mcl-1 Gene:4170
493 14207-14212 Gene denotes c-Myc Gene:4609
494 14518-14540 Species denotes varicella-zoster virus Tax:10335
495 14542-14564 Species denotes herpes simplex virus-1 Tax:10298
496 14566-14584 Species denotes pseudorabies virus Tax:10345
497 14587-14600 Species denotes coronaviruses Tax:11118
498 14602-14633 Species denotes porcine epidemic diarrhea virus Tax:28295
499 14638-14660 Species denotes murine hepatitis virus Tax:11138
500 14686-14698 Species denotes rabies virus Tax:11292
501 14739-14762 Species denotes Newcastle disease virus Tax:11176
502 14768-14779 Species denotes echovirus 1 Tax:46633
503 14870-14880 Species denotes SARS-CoV-2 Tax:2697049
504 14968-14976 Species denotes patients Tax:9606
505 15236-15246 Species denotes SARS-CoV-2 Tax:2697049
506 13968-13985 Chemical denotes Homoharringtonine MESH:D000077863
507 14297-14308 Chemical denotes Omacetaxine MESH:D000077863
508 14335-14352 Chemical denotes homoharringtonine MESH:D000077863
509 14416-14433 Chemical denotes Homoharringtonine MESH:D000077863
510 14843-14860 Chemical denotes homoharringtonine MESH:D000077863
511 15001-15012 Chemical denotes omacetaxine MESH:D000077863
512 14019-14040 Disease denotes Cephalotoxus fortunei
513 14059-14064 Disease denotes tumor MESH:D009369
514 14242-14250 Disease denotes leukemia MESH:D007938
515 14390-14414 Disease denotes chronic myeloid leukemia MESH:D015464
540 15437-15458 Species denotes Plasmodium falciparum Tax:5833
541 15663-15674 Species denotes DNA viruses Tax:2080735
542 15686-15696 Species denotes Zika virus Tax:64320
543 15727-15739 Species denotes rabies virus Tax:11292
544 15741-15746 Species denotes HIV-1 Tax:11676
545 15748-15759 Species denotes echovirus 1 Tax:46633
546 15779-15799 Species denotes bovine herpesvirus 1 Tax:10320
547 15801-15833 Species denotes peste des petits ruminants virus Tax:31604
548 15835-15858 Species denotes Newcastle disease virus Tax:11176
549 15860-15882 Species denotes herpes simplex virus-2 Tax:10310
550 15901-15924 Species denotes Rift Valley fever virus Tax:11588
551 16128-16137 Species denotes hCoV-OC43 Tax:31631
552 16150-16158 Species denotes SARS-CoV Tax:694009
553 16160-16168 Species denotes MERS-CoV Tax:1335626
554 16336-16346 Species denotes SARS-CoV-2 Tax:2697049
555 16527-16537 Species denotes SARS-CoV-2 Tax:2697049
556 15698-15708 Species denotes Ebolavirus Tax:1570291
557 15263-15270 Chemical denotes Emetine MESH:D004640
558 16089-16096 Chemical denotes Emetine MESH:D004640
559 16287-16294 Chemical denotes emetine MESH:D004640
560 16428-16435 Chemical denotes emetine MESH:D004640
561 15391-15398 Disease denotes malaria MESH:D008288
562 15519-15533 Disease denotes cardiotoxicity MESH:D066126
563 15710-15725 Disease denotes Cytomegalovirus MESH:D003586
573 17523-17533 Species denotes SARS-CoV-2 Tax:2697049
574 17476-17486 Chemical denotes remdesivir MESH:C000606551
575 17491-17514 Chemical denotes emetine dihydrochloride MESH:D004640
576 17602-17612 Chemical denotes remdesivir MESH:C000606551
577 17627-17634 Chemical denotes emetine MESH:D004640
578 17898-17908 Chemical denotes remdesivir MESH:C000606551
579 17976-17986 Chemical denotes remdesivir MESH:C000606551
580 17991-17998 Chemical denotes emetine MESH:D004640
581 17656-17658 CellLine denotes E6 CVCL:4582
590 16787-16797 Chemical denotes remdesivir MESH:C000606551
591 16802-16809 Chemical denotes emetine MESH:D004640
592 16909-16919 Chemical denotes remdesivir MESH:C000606551
593 16934-16941 Chemical denotes emetine MESH:D004640
594 16971-16981 Chemical denotes Remdesivir MESH:C000606551
595 17013-17020 Chemical denotes emetine MESH:D004640
596 17311-17321 Chemical denotes Remdesivir MESH:C000606551
597 17326-17333 Chemical denotes emetine MESH:D004640
602 18315-18326 Species denotes coronavirus Tax:11118
603 18330-18340 Species denotes SARS-CoV-2 Tax:2697049
604 18465-18475 Species denotes SARS-CoV-2 Tax:2697049
605 18633-18643 Species denotes SARS-CoV-2 Tax:2697049

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 576-581 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T2 1063-1069 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T3 1192-1197 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T4 3705-3708 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T5 3884-3892 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T6 4364-4375 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T7 4389-4395 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T8 4460-4465 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T9 4566-4571 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T10 4625-4632 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T11 5312-5317 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T12 5584-5589 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T13 6135-6140 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14 6178-6182 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T15 6370-6375 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T16 7249-7252 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T17 7431-7434 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T18 7445-7448 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T19 8147-8151 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T20 8240-8256 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T21 8251-8256 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22 8382-8387 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T23 8566-8569 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T24 9220-9223 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T25 9339-9343 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 9352-9363 Body_part denotes lymphocytic http://purl.org/sig/ont/fma/fma62863
T27 9463-9466 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T28 9601-9604 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T29 9879-9883 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T30 10024-10028 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T31 10712-10717 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 10775-10779 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T33 10973-10978 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T34 11337-11340 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T35 11406-11409 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T36 11615-11619 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T37 11679-11684 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T38 11844-11847 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T39 11911-11914 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T40 12010-12013 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T41 13039-13042 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T42 13155-13160 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T43 14092-14103 Body_part denotes ribosomal A http://purl.org/sig/ont/fma/fma66867
T44 14120-14127 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T45 14178-14186 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T46 14197-14200 Body_part denotes Mcl http://purl.org/sig/ont/fma/fma305650
T47 14251-14256 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T48 15072-15078 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T49 15276-15283 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T50 15417-15426 Body_part denotes ribosomal http://purl.org/sig/ont/fma/fma66867
T51 15655-15658 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T52 15663-15666 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T53 15741-15744 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T54 16404-16410 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T55 16564-16570 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T56 16725-16731 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T57 17659-17664 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T58 17801-17804 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T59 17867-17870 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T60 18506-18512 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 4364-4375 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T2 4389-4395 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T3 7019-7024 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T4 7211-7216 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T5 9879-9883 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T6 10024-10028 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T7 13155-13160 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T8 17749-17754 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p85318s26 7534-7558 MPA denotes resistance to remdesivir
p85411s18 13906-13913 MPA denotes synergy
p85411s22 13929-13953 MPA denotes inhibitory concentration

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 62-70 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 140-148 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 433-441 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 548-556 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 1158-1166 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 1261-1269 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 1349-1357 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1546-1554 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1724-1733 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 1749-1757 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 1835-1844 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 1911-1924 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T13 2148-2157 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T14 2544-2552 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 2560-2568 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 2614-2622 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 2786-2794 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 2843-2851 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T19 2979-2981 Disease denotes GS http://purl.obolibrary.org/obo/MONDO_0005773
T20 3829-3838 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T21 3996-4004 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 4278-4286 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T23 4289-4297 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 4416-4424 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 4575-4584 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T26 5361-5370 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 5394-5403 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T28 5407-5415 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 5609-5618 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T30 6336-6344 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 6606-6614 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 6807-6815 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 6831-6839 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 6964-6972 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 7128-7136 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 7478-7487 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T37 7690-7698 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 8360-8368 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 8413-8421 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 8522-8532 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T41 8645-8650 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T42 8654-8662 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 8771-8790 Disease denotes influenza infection http://purl.obolibrary.org/obo/MONDO_0005812
T44 8781-8790 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T45 8882-8901 Disease denotes chronic hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231|http://purl.obolibrary.org/obo/MONDO_0005354
T47 8882-8899 Disease denotes chronic hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T48 8902-8911 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 8991-9003 Disease denotes yellow fever http://purl.obolibrary.org/obo/MONDO_0020502
T50 9004-9019 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T51 9010-9019 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T52 9106-9128 Disease denotes dengue virus infection http://purl.obolibrary.org/obo/MONDO_0005502
T53 9113-9128 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T54 9119-9128 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T55 9337-9372 Disease denotes B-cell chronic lymphocytic leukemia http://purl.obolibrary.org/obo/MONDO_0004948
T56 9352-9372 Disease denotes lymphocytic leukemia http://purl.obolibrary.org/obo/MONDO_0005402
T57 9364-9372 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T58 9469-9478 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 9607-9616 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 9773-9783 Disease denotes amoebiasis http://purl.obolibrary.org/obo/MONDO_0005644
T61 9879-9893 Disease denotes skin infection http://purl.obolibrary.org/obo/MONDO_0021201
T62 9884-9893 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T63 10024-10038 Disease denotes skin infection http://purl.obolibrary.org/obo/MONDO_0021201
T64 10029-10038 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T65 10128-10134 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T66 10162-10186 Disease denotes chronic myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0011996
T67 10170-10186 Disease denotes myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0004643
T68 10178-10186 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T69 10306-10325 Disease denotes influenza infection http://purl.obolibrary.org/obo/MONDO_0005812
T70 10316-10325 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T71 10434-10453 Disease denotes influenza infection http://purl.obolibrary.org/obo/MONDO_0005812
T72 10444-10453 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T73 10583-10596 Disease denotes schizophrenia http://purl.obolibrary.org/obo/MONDO_0005090
T74 10945-10953 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 11054-11063 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T76 11223-11233 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T77 11281-11290 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T78 11389-11398 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T79 11542-11550 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 11569-11579 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T81 11700-11709 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T82 12283-12291 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 12474-12482 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T84 12536-12540 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T85 12565-12569 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T86 12821-12829 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T87 12996-13004 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 13236-13244 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T89 13427-13435 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T90 13601-13609 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 13876-13884 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 14059-14064 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T93 14242-14250 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T94 14390-14414 Disease denotes chronic myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0011996
T95 14398-14414 Disease denotes myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0004643
T96 14406-14414 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T97 14518-14527 Disease denotes varicella http://purl.obolibrary.org/obo/MONDO_0005700
T98 14528-14534 Disease denotes zoster http://purl.obolibrary.org/obo/MONDO_0005609
T99 14542-14556 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T100 14566-14578 Disease denotes pseudorabies http://purl.obolibrary.org/obo/MONDO_0005932
T101 14619-14627 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T102 14645-14654 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T103 14686-14692 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T104 14720-14731 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T105 14720-14729 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T106 14739-14756 Disease denotes Newcastle disease http://purl.obolibrary.org/obo/MONDO_0005875
T107 14870-14878 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T108 15236-15244 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T109 15391-15398 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T110 15686-15690 Disease denotes Zika http://purl.obolibrary.org/obo/MONDO_0018661
T111 15727-15733 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T112 15801-15827 Disease denotes peste des petits ruminants http://purl.obolibrary.org/obo/MONDO_0005908
T113 15835-15852 Disease denotes Newcastle disease http://purl.obolibrary.org/obo/MONDO_0005875
T114 15860-15874 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T115 15901-15918 Disease denotes Rift Valley fever http://purl.obolibrary.org/obo/MONDO_0017880
T116 15906-15918 Disease denotes Valley fever http://purl.obolibrary.org/obo/MONDO_0005706
T117 15930-15939 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T118 16150-16158 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T119 16336-16344 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T120 16527-16535 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T121 17523-17531 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T122 18330-18338 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T123 18465-18473 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T124 18633-18641 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T125 18801-18808 Disease denotes Allergy http://purl.obolibrary.org/obo/MONDO_0005271
T126 18813-18823 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 151-156 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T2 559-564 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T3 568-581 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T4 1063-1069 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T5 1184-1197 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero-E6 cells
T6 1557-1562 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T7 1609-1615 http://purl.obolibrary.org/obo/UBERON_0001456 denotes facing
T8 1760-1765 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 1778-1779 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 2275-2277 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T11 2275-2277 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T12 2297-2302 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T13 2521-2526 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T14 2571-2576 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 2651-2654 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T16 2989-2990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 3024-3025 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 3051-3059 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T19 4300-4305 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T20 4404-4405 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 4452-4465 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T22 4489-4494 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T23 4558-4571 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T24 5304-5317 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T25 5418-5423 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26 5484-5489 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T27 5584-5589 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28 5661-5663 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T29 5802-5807 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T30 6127-6140 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T31 6178-6182 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T32 6236-6242 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T33 6362-6375 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T34 6617-6622 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T35 6688-6689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 6735-6738 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T37 6761-6766 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T38 6976-6977 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T39 7139-7144 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T40 7376-7377 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T41 7469-7470 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T42 7488-7493 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T43 7577-7581 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T44 7669-7673 http://purl.obolibrary.org/obo/CLO_0002980 denotes F480
T45 8046-8056 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T46 8147-8157 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T47 8227-8232 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T48 8233-8239 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T49 8240-8250 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T50 8251-8256 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T51 8327-8335 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T52 8374-8387 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T53 9004-9009 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T54 9113-9118 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T55 9337-9343 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cell
T56 9879-9883 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T57 9879-9883 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T58 9879-9883 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T59 9879-9883 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T60 9879-9883 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T61 9918-9926 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T62 10024-10028 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T63 10024-10028 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T64 10024-10028 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T65 10024-10028 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T66 10024-10028 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T67 10063-10071 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T68 10333-10335 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T69 10647-10648 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T70 10704-10717 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T71 10721-10723 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T72 10775-10779 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T73 10807-10808 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T74 10956-10961 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T75 10965-10978 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T76 11044-11046 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T77 11234-11239 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T78 11439-11447 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T79 11463-11464 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T80 11478-11479 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T81 11553-11558 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T82 11671-11684 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T83 12498-12499 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 13247-13252 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T85 13496-13497 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T86 13887-13892 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T87 13989-13990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 14065-14073 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T89 14102-14103 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T90 14251-14256 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T91 14271-14275 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T92 14310-14311 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 14434-14437 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T94 14486-14494 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T95 14535-14540 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T96 14557-14562 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T97 14579-14584 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T98 14628-14633 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T99 14655-14660 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T100 14693-14698 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T101 14711-14718 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T102 14730-14731 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T103 14732-14737 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T104 14757-14762 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T105 14795-14799 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T106 15072-15078 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T107 15158-15160 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T108 15247-15252 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T109 15274-15275 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 15534-15537 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T111 15621-15629 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T112 15638-15639 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T113 15667-15674 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T114 15691-15696 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T115 15734-15739 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T116 15828-15833 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T117 15853-15858 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T118 15875-15880 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T119 15919-15924 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 16036-16040 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T121 16082-16086 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T122 16347-16352 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T123 16404-16410 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T124 16538-16543 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T125 16564-16570 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T126 16725-16731 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T127 17099-17105 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T128 17120-17123 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2 A
T129 17357-17358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 17402-17403 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 17534-17539 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T132 17551-17552 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T133 17651-17664 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T134 17925-17926 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T135 18065-18066 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T136 18247-18255 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T137 18506-18512 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T138 18644-18649 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 12-21 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T2 23-30 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T3 265-274 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T4 468-477 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T5 488-498 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T6 500-509 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T7 532-539 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T8 700-711 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T9 811-821 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T10 826-833 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T11 852-862 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T12 894-901 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T13 1224-1233 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T14 1242-1251 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T15 1310-1327 Chemical denotes Homoharringtonine http://purl.obolibrary.org/obo/CHEBI_71019
T16 1332-1339 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T17 1435-1445 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T18 1450-1457 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T19 2275-2277 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T20 2467-2476 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T21 2967-2977 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T22 2979-2986 Chemical denotes GS-5734 http://purl.obolibrary.org/obo/CHEBI_145994
T23 2979-2981 Chemical denotes GS http://purl.obolibrary.org/obo/CHEBI_73516
T24 2991-2998 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T25 3002-3011 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T26 3041-3050 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T27 3426-3435 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T28 3466-3476 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T29 3478-3497 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T30 3478-3487 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T31 3488-3497 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T32 3499-3508 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T33 3529-3548 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T34 3529-3538 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T35 3539-3548 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T36 3550-3561 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T37 3562-3571 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T41 3681-3691 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T42 3705-3728 Chemical denotes HIV-protease inhibitors http://purl.obolibrary.org/obo/CHEBI_35660
T43 3709-3728 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T45 3718-3728 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T46 3730-3749 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T47 3730-3739 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T48 3740-3749 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T49 3757-3766 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T50 3768-3777 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T51 3780-3811 Chemical denotes reverse transcriptase inhibitor http://purl.obolibrary.org/obo/CHEBI_53756|http://purl.obolibrary.org/obo/CHEBI_59897
T53 3788-3811 Chemical denotes transcriptase inhibitor http://purl.obolibrary.org/obo/CHEBI_37416
T54 3802-3811 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T55 3850-3860 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T56 3903-3905 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T57 3926-3928 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T59 3969-3971 Chemical denotes Re http://purl.obolibrary.org/obo/CHEBI_49882
T60 4623-4632 Chemical denotes D-glucose http://purl.obolibrary.org/obo/CHEBI_17634|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_42758
T63 4625-4632 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234
T64 4643-4658 Chemical denotes sodium pyruvate http://purl.obolibrary.org/obo/CHEBI_50144
T65 4643-4649 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T66 4650-4658 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T67 4680-4690 Chemical denotes Penicillin http://purl.obolibrary.org/obo/CHEBI_17334
T68 4715-4720 Chemical denotes HEPES http://purl.obolibrary.org/obo/CHEBI_46756
T69 4818-4822 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T70 4830-4840 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T71 4849-4860 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T72 4882-4891 Chemical denotes tenofovir http://purl.obolibrary.org/obo/CHEBI_134504|http://purl.obolibrary.org/obo/CHEBI_63625|http://purl.obolibrary.org/obo/CHEBI_63716
T75 4899-4920 Chemical denotes fludarabine phosphate http://purl.obolibrary.org/obo/CHEBI_63599
T76 4911-4920 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T80 4945-4973 Chemical denotes chlorpromazine hydrochloride http://purl.obolibrary.org/obo/CHEBI_3649
T81 4945-4959 Chemical denotes chlorpromazine http://purl.obolibrary.org/obo/CHEBI_3647
T82 4960-4973 Chemical denotes hydrochloride http://purl.obolibrary.org/obo/CHEBI_36807
T83 4980-4991 Chemical denotes dalbavancin http://purl.obolibrary.org/obo/CHEBI_82721
T84 4992-5005 Chemical denotes hydrochloride http://purl.obolibrary.org/obo/CHEBI_36807
T85 5038-5047 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T86 5055-5064 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T87 5074-5079 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T88 5086-5093 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T89 5129-5142 Chemical denotes hydrochloride http://purl.obolibrary.org/obo/CHEBI_36807
T90 5150-5159 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T91 5168-5191 Chemical denotes oritavancin diphosphate http://purl.obolibrary.org/obo/CHEBI_83305
T92 5168-5179 Chemical denotes oritavancin http://purl.obolibrary.org/obo/CHEBI_82699
T93 5180-5191 Chemical denotes diphosphate http://purl.obolibrary.org/obo/CHEBI_18361|http://purl.obolibrary.org/obo/CHEBI_33019
T95 5194-5217 Chemical denotes Oseltamivir carboxylate http://purl.obolibrary.org/obo/CHEBI_73139
T96 5194-5205 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T97 5228-5233 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T98 6244-6254 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T99 6256-6265 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T100 6290-6297 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T101 6508-6517 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T102 6519-6530 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T103 6532-6543 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T104 6577-6586 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T105 6693-6698 Chemical denotes cyano http://purl.obolibrary.org/obo/CHEBI_48819
T106 6711-6720 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T107 7095-7105 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T108 7298-7308 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T109 7548-7558 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T110 7794-7804 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T111 7812-7821 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T112 7860-7881 Chemical denotes fludarabine phosphate http://purl.obolibrary.org/obo/CHEBI_63599
T113 7872-7881 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T117 7886-7906 Chemical denotes nucleoside analogues http://purl.obolibrary.org/obo/CHEBI_60783
T118 7886-7896 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T119 7908-7919 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T120 7921-7930 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T121 8007-8027 Chemical denotes nucleoside analogues http://purl.obolibrary.org/obo/CHEBI_60783
T122 8007-8017 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T123 8068-8080 Chemical denotes triphosphate http://purl.obolibrary.org/obo/CHEBI_18036
T124 8104-8114 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T125 8195-8215 Chemical denotes nucleoside analogues http://purl.obolibrary.org/obo/CHEBI_60783
T126 8195-8205 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T127 8463-8474 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T128 8594-8603 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T129 8833-8842 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T130 8954-8963 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T131 9171-9180 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T132 9278-9287 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T136 9288-9297 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T137 9404-9413 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T138 9414-9432 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T140 9423-9432 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T141 9499-9508 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T142 9552-9570 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T144 9561-9570 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T145 9698-9705 Chemical denotes Emetine http://purl.obolibrary.org/obo/CHEBI_4781
T146 9706-9719 Chemical denotes hydrochloride http://purl.obolibrary.org/obo/CHEBI_36807
T147 9816-9839 Chemical denotes Oritavancin diphosphate http://purl.obolibrary.org/obo/CHEBI_83305
T148 9828-9839 Chemical denotes diphosphate http://purl.obolibrary.org/obo/CHEBI_18361|http://purl.obolibrary.org/obo/CHEBI_33019
T150 9840-9851 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T151 9971-9984 Chemical denotes hydrochloride http://purl.obolibrary.org/obo/CHEBI_36807
T152 9985-9996 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T153 10105-10122 Chemical denotes Homoharringtonine http://purl.obolibrary.org/obo/CHEBI_71019
T154 10220-10243 Chemical denotes Oseltamivir carboxylate http://purl.obolibrary.org/obo/CHEBI_73139
T155 10220-10231 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T156 10244-10253 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T157 10255-10278 Chemical denotes neuraminidase inhibitor http://purl.obolibrary.org/obo/CHEBI_52425
T158 10269-10278 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T159 10368-10372 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T160 10373-10382 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T161 10397-10406 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T162 10488-10516 Chemical denotes Chlorpromazine hydrochloride http://purl.obolibrary.org/obo/CHEBI_3649
T163 10488-10502 Chemical denotes Chlorpromazine http://purl.obolibrary.org/obo/CHEBI_3647
T164 10503-10516 Chemical denotes hydrochloride http://purl.obolibrary.org/obo/CHEBI_36807
T165 10517-10527 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T166 10878-10887 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T167 11451-11461 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T168 11467-11476 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T169 11506-11513 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T170 11654-11657 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T172 11756-11765 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T173 11787-11796 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T174 11817-11826 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T175 11850-11869 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T177 11859-11869 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T178 11871-11880 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T179 11922-11931 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T180 12045-12060 Chemical denotes cytochrome P450 http://purl.obolibrary.org/obo/CHEBI_38559
T181 12045-12055 Chemical denotes cytochrome http://purl.obolibrary.org/obo/CHEBI_4056
T182 12089-12098 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T183 12121-12130 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T184 12131-12140 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T185 12184-12193 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T186 12223-12232 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T187 12241-12250 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T188 12258-12267 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T189 12394-12403 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T190 12404-12413 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T191 12434-12443 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T192 12614-12633 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T193 12614-12623 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T194 12624-12633 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T195 12639-12648 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T196 12687-12696 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T197 12701-12716 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T198 12749-12768 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T199 12749-12758 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T200 12759-12768 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T201 12785-12794 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T202 12922-12931 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T203 12942-12951 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T204 12978-12987 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T205 13077-13086 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T206 13101-13110 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T207 13145-13154 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T208 13302-13321 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T209 13302-13311 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T210 13312-13321 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T211 13366-13375 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T212 13565-13584 Chemical denotes lopinavir-ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T213 13565-13574 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T214 13575-13584 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T215 13823-13832 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T216 13957-13966 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T217 13968-13985 Chemical denotes Homoharringtonine http://purl.obolibrary.org/obo/CHEBI_71019
T218 13997-14005 Chemical denotes alkaloid http://purl.obolibrary.org/obo/CHEBI_22315
T219 14120-14127 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T220 14178-14186 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T221 14277-14279 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T222 14416-14433 Chemical denotes Homoharringtonine http://purl.obolibrary.org/obo/CHEBI_71019
T223 15263-15270 Chemical denotes Emetine http://purl.obolibrary.org/obo/CHEBI_4781
T224 15276-15303 Chemical denotes protein synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_48001
T225 15276-15283 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T226 15294-15303 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T227 15611-15620 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T228 15663-15666 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T229 16089-16096 Chemical denotes Emetine http://purl.obolibrary.org/obo/CHEBI_4781
T230 16287-16294 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T231 16428-16435 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T232 16787-16797 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T233 16802-16809 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T234 16909-16919 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T235 16934-16941 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T236 17013-17020 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T237 17326-17333 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T238 17476-17486 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T239 17491-17498 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T240 17602-17612 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T241 17627-17634 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T242 17820-17824 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T243 17898-17908 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T244 17976-17986 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T245 17991-17998 Chemical denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781
T246 18215-18220 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T247 18237-18246 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 3788-3801 http://purl.obolibrary.org/obo/GO_0003968 denotes transcriptase
T2 3788-3801 http://purl.obolibrary.org/obo/GO_0003899 denotes transcriptase
T3 6049-6074 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T4 6057-6074 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T5 6057-6074 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T6 7948-7973 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T7 7956-7973 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T8 7956-7973 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T9 12045-12055 http://purl.obolibrary.org/obo/GO_0045158 denotes cytochrome
T10 12045-12055 http://purl.obolibrary.org/obo/GO_0045157 denotes cytochrome
T11 12045-12055 http://purl.obolibrary.org/obo/GO_0045156 denotes cytochrome
T12 12045-12055 http://purl.obolibrary.org/obo/GO_0008121 denotes cytochrome
T13 14120-14139 http://purl.obolibrary.org/obo/GO_0006412 denotes protein translation
T14 15276-15293 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T15 15284-15293 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
T2 95-103 Sentence denotes Abstract
T3 104-238 Sentence denotes An escalating pandemic by the novel SARS-CoV-2 virus is impacting global health and effective therapeutic options are urgently needed.
T4 239-453 Sentence denotes We evaluated the in vitro antiviral effect of compounds that were previously reported to inhibit coronavirus replication and compounds that are currently under evaluation in clinical trials for SARS-CoV-2 patients.
T5 454-686 Sentence denotes We report the antiviral effect of remdesivir, lopinavir, homorringtonine, and emetine against SARS-CoV-2 virus in Vero E6 cells with the estimated 50% effective concentration at 23.15 μM, 26.63 μM, 2.55 μM and 0.46 μM, respectively.
T6 687-794 Sentence denotes Ribavirin or favipiravir that are currently evaluated under clinical trials showed no inhibition at 100 μM.
T7 795-958 Sentence denotes Synergy between remdesivir and emetine was observed, and remdesivir at 6.25 μM in combination with emetine at 0.195 μM may achieve 64.9% inhibition in viral yield.
T8 959-1122 Sentence denotes Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits.
T9 1124-1134 Sentence denotes Highlights
T10 1135-1220 Sentence denotes • Remdesivir inhibits SARS-CoV-2 replication in Vero-E6 cells with EC50 at 23.15 μM.
T11 1221-1306 Sentence denotes • Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC50 at 26.63 μM.
T12 1307-1416 Sentence denotes • Homoharringtonine and emetine inhibits SARS-CoV-2 replication with EC50 at 2.55 and 0.46 μM, respectively.
T13 1417-1493 Sentence denotes • Combination of remdesivir and emetine showed synergistic effect in vitro.
T14 1495-1723 Sentence denotes Within three months of the first identification of SARS-CoV-2 virus in Wuhan, Hubei Province, China, the world is facing an escalating pandemic that will have significant impacts on global health systems and economy (WHO, 2019).
T15 1724-2001 Sentence denotes Infection with the novel SARS-CoV-2 virus may lead to a wide range of clinical presentations from asymptomatic infection in 1% of laboratory confirmed cases to mild, severe, and critical infections in 81%, 14%, and 5% of symptomatic cases, respectively (Wu and McGoogan, 2020).
T16 2002-2204 Sentence denotes The estimated symptomatic case-fatality risk (sCFR) among cases in Wuhan was 1.4%, and those aged above 59 were 5.1 times more likely to die from infection than those aged 30–59 years (Wu et al., 2020).
T17 2205-2434 Sentence denotes With an estimated basic reproductive number of 2.2 (95% CI, 1.4–3.9) (Li et al., 2020), the virus will continue to spread and infect 55% of the global population over time if no effective vaccine is developed (Fine et al., 2011).
T18 2435-2555 Sentence denotes There is currently no effective antiviral compound licensed for the treatment against human coronaviruses or SARS-CoV-2.
T19 2556-2722 Sentence denotes The SARS-CoV-2 virus shared 79.5% genetic homology to the SARS-CoV and both are descendants of bat coronaviruses within the Betacoronavirus genus (Zhou et al., 2020).
T20 2723-2953 Sentence denotes Antiviral compounds previously reported to show effect against SARS-CoV or other coronaviruses may be effective against SARS-CoV-2 (Chu et al., 2004; de Wilde et al., 2014; Dyall et al., 2014; Shen et al., 2019; Cao et al., 2015).
T21 2954-3254 Sentence denotes In addition, remdesivir (GS-5734), a prodrug of adenosine analog with a broad-spectrum antiviral activity against filoviruses, paramyxoviruses, and coronaviruses (Brown et al., 2019; Sheahan et al., 2017; de Wit et al., 2020), was recently confirmed to inhibit 2019-nCoV in vitro (Wang et al., 2020).
T22 3255-3625 Sentence denotes According to the 7th edition of the novel coronavirus diagnosis and treatment plan issued by the National Health Commission of the People's Republic of China, options for antiviral therapy include aerosolized α-interferon, lopinavir/ritonavir, ribavirin in combination with lopinavir/ritonavir, chloroquine phosphate, or Arbidol (China National Health Commission, 2020).
T23 3626-3973 Sentence denotes Ongoing clinical trials are evaluating the efficacy of remdesivir, and various HIV-protease inhibitors (lopinavir/ritonavir, ASC09/ritonavir, darunavir), reverse transcriptase inhibitor (Azvudine), anti-influenza compounds, interferon alfa-2b, or monoclonal antibody targeting PD-1 (Camrelizumab) or IL-6 (Tocilizumab) (Chinese Clinical Trial Re).
T24 3974-4288 Sentence denotes We evaluated the anti-SARS-CoV-2 effect of compounds that have been under development or already approved for other clinical applications; some compounds were previously reported to inhibit coronavirus replication in vitro, and some are evaluated in clinical trials in patients with coronavirus disease (COVID-19).
T25 4289-4482 Sentence denotes SARS-CoV-2 virus, BetaCoV/Hong Kong/VM20001061/2020, was isolated from the nasopharynx aspirate and throat swab of a confirmed COVID-19 patient in Hong Kong using Vero E6 cells (ATCC CRL-1586).
T26 4483-4722 Sentence denotes Stock virus (107.25 TCID50/mL) was prepared after three serial passages in Vero E6 cells in infection media (DMEM supplemented with 4.5 g/L D-glucose, 100 mg/L sodium pyruvate, 2% FBS, 100,000 U/L Penicillin-Streptomycin, and 25 mM HEPES).
T27 4723-5193 Sentence denotes Compounds were sourced from MedChemExpress and Sigma-Aldrich and the stocks were prepared with DMSO (50 mM remdesivir, 100 mM favipiravir, 10 mM R-1479, 10 mM tenofovir, 10 mM fludarabine phosphate, 10 mM baloxavir, 10 mM chlorpromazine hydrochloride, 5 mM dalbavancin hydrochloride, 10 mM homoharringtonine, 10 mM lopinavir, 10 mM ritonavir) or with water (5 mM emetine dihydrochloride, 10 mM galidesivir hydrochloride, 50 mM ribavirin, 2.5 mM oritavancin diphosphate).
T28 5194-5257 Sentence denotes Oseltamivir carboxylate (10 mM in water) was provided by Roche.
T29 5258-5438 Sentence denotes To evaluate the effect of compounds in vitro, Vero E6 cells were pre-treated with compounds diluted in infection media for 1 h prior to infection by SARS-CoV-2 virus at MOI = 0.02.
T30 5439-5532 Sentence denotes Antiviral compounds were maintained with the virus inoculum during the 2-h incubation period.
T31 5533-5654 Sentence denotes The inoculum was removed after incubation, and the cells were overlaid with infection media containing diluted compounds.
T32 5655-5878 Sentence denotes After 48 h incubation at 37 °C, supernatants were collected to quantify viral loads by TCID50 assay or quantitative real-time RT-PCR (TaqMan™ Fast Virus 1-Step Master Mix) following the methods described (Chu et al., 2020).
T33 5879-6075 Sentence denotes Four-parameter logistic regression (GraphPad Prism) was used to fit the dose-response curves and determined the 50% effective concentrations (EC50) of the compounds that inhibit viral replication.
T34 6076-6209 Sentence denotes Cytotoxicty of selected compounds was evaluated in Vero E6 cells using the CellTiter-Glo® Luminescent Cell Viability Assay (Promega).
T35 6210-6410 Sentence denotes Among the 16 compounds we tested, remdesivir, lopinavir, homoharringtonine, and emetine dihydrochloride were found to inhibit SARS-CoV-2 replication in Vero E6 cells with EC50 under 100 μM (Table 1 ).
T36 6411-6673 Sentence denotes Importantly, we observed that some of the compounds currently undergoing clinical trials such as ribavirin, favipiravir, oseltamivir, or baloxavir showed no apparent antiviral effect against the SARS-CoV-2 virus in vitro at concentrations under 100 μM (Table 1).
T37 6674-6906 Sentence denotes Remdesivir is a 1′-cyano-substituted adenosine analogue that has been shown to inhibit human coronaviruses (hCoV-OC43 and hCoV-229E) SARS-CoV, MERS-CoV, and SARS-CoV-2 (Brown et al., 2019; Sheahan et al., 2017; de Wit et al., 2020).
T38 6907-6975 Sentence denotes It is currently evaluated in phase 4 clinical trials for SARS-CoV-2.
T39 6976-7176 Sentence denotes A recent study fitted viral load in linear scale (eg. the percentage of inhibition) under increasing concentrations of remdesivir reported EC50 against SARS-CoV-2 virus at 0.77 μM (Wang et al., 2020).
T40 7177-7391 Sentence denotes We fitted viral load in logarithm scale (log10TCID50/mL and log10 viral RNA copies/mL) under increasing concentration of remdesivir and determined EC50 at 23.15 μM and 26.90 μM, respectively (Fig. 1 A and Table 1).
T41 7392-7583 Sentence denotes Two mutations (F476L and V553L) in the RNA-dependent RNA polymerase nsp12 of a murine hepatitis virus have been previously reported to confer resistance to remdesivir (Agostini et al., 2018).
T42 7584-7805 Sentence denotes Due to insertions and deletions in nsp12, these two conserved residues are mapped at F480 and V557 in the SARS-CoV-2 isolate (GISAID# EPI_ISL_412028) used for the experiments, which should remain sensitive for remdesivir.
T43 7806-7997 Sentence denotes Other adenosine analogues (galidesivir, tenofovor, or fludarabine phosphate) or nucleoside analogues (favipiravir, ribavirin, R-1479) did not inhibit viral replication under 100 μM (Table 1).
T44 7998-8158 Sentence denotes However, nucleoside analogues require metabolic activation into their triphosphate forms by host cellular nucleoside kinases, which may differ among cell types.
T45 8159-8308 Sentence denotes Further evaluation of the effect of nucleoside analogues in primary human airway epithelial cells would facilitate the interpretation of the results.
T46 8309-8388 Sentence denotes Table 1 Antiviral activity of 16 compounds against SARS-CoV-2 in Vero E6 cells.
T47 8389-8436 Sentence denotes Compounds Inhibition of SARS-CoV-2 in vitro, μM
T48 8437-8482 Sentence denotes Name Bioactivity Clinical application CAS No.
T49 8483-8582 Sentence denotes CC50, μMa CPE inhibitionb Reduction in infectious virusc (EC50) Reduction in viral RNA copyd (EC50)
T50 8583-8697 Sentence denotes Remdesivir adenosine analogue Phase 4 trials for treatment of Ebola or SARS-CoV-2 1809249-37-3 >100 25 23.15 26.90
T51 8698-8822 Sentence denotes Favipiravir guanineanalogue Approved in Japan and China for treatment of influenza infection 259793-96-9 >100 >100 >100 >100
T52 8823-8941 Sentence denotes Ribavirin guanosine analogue FDA approved for treatment of chronic hepatitis C infection 36791-04-5 >100 500 >500 >500
T53 8942-9050 Sentence denotes Galidesivir adenosine analogue Phase 2 trial for yellow fever virus infection 222631-44-9 >100 100 >100 >100
T54 9051-9155 Sentence denotes R-1479 cytidineanalogue Phase 2 trial for treatment of dengue virus infection 478182-28-4 >100 >100 N.D.
T55 9156-9160 Sentence denotes N.D.
T56 9161-9260 Sentence denotes Tenofovor adenosine analogue FDA approved for treatment of HIV-1 and HBV 147127-20-6 >100 >100 N.D.
T57 9261-9265 Sentence denotes N.D.
T58 9266-9398 Sentence denotes Fludarabine phosphate adenosine analogue FDA approved for treatment of B-cell chronic lymphocytic leukemia 75607-67-9 >100 >100 N.D.
T59 9399-9403 Sentence denotes N.D.
T60 9404-9541 Sentence denotes Lopinavir protease inhibitor FDA approved for treatment of HIV-1 infection in combination with ritonavir 192725-17-0 49.75 25 26.63 26.10
T61 9542-9697 Sentence denotes Ritonavir protease inhibitor FDA approved for treatment of HIV-1 infection in combination with other antiretroviral agents 155213-67-5 48.91 >100 >100 >100
T62 9698-9815 Sentence denotes Emetine hydrochloride anti-protozoal Approved in China for severe invasive amoebiasis 316-42-7 56.46 1.5625 0.46 0.50
T63 9816-9953 Sentence denotes Oritavancin diphosphate antibiotics FDA approved treatment for skin infection caused by Gram positive bacteria 192564-14-0 N.D. >100 N.D.
T64 9954-9958 Sentence denotes N.D.
T65 9959-10099 Sentence denotes Dalbavancin hydrochloride antibiotics FDA approved treatment for skin infection caused by Gram positive bacteria 2227366-51-8 N.D. >100 N.D.
T66 10100-10104 Sentence denotes N.D.
T67 10105-10219 Sentence denotes Homoharringtonine anti-cancer FDA approved treatment for chronic myeloid leukemia 26833-87-4 59.75 3.125 2.55 2.14
T68 10220-10357 Sentence denotes Oseltamivir carboxylate antiviral, neuraminidase inhibitor FDA approved treatment for influenza infection 187227-45-8 >100 >100 >100 >100
T69 10358-10487 Sentence denotes Baloxivir acid antiviral, endonuclease inhibitor FDA approved treatment for influenza infection 1985605-59-1 85.90 >100 >100 >100
T70 10488-10620 Sentence denotes Chlorpromazine hydrochloride antagonist for post-synaptic receptors FDA approved treatment for schizophrenia 69-09-0 21.29 >100 N.D.
T71 10621-10625 Sentence denotes N.D.
T72 10626-10630 Sentence denotes N.D.
T73 10631-10646 Sentence denotes Not determined.
T74 10647-10806 Sentence denotes a CC50 was determined with serially-diluted compounds in Vero E6 cells at 48 h post-incubation using CellTiter-Glow Luminescent Cell Viability Assay (Promega).
T75 10807-10916 Sentence denotes b Compounds were serially 2-fold or 4-fold diluted from 100 μM, except ribavirin which was started at 500 μM.
T76 10917-11064 Sentence denotes Cytopathic effects (CPE) of SARS-CoV-2 virus in Vero E6 cells under increasing concentration of the compounds were observed at 48 h post-infection.
T77 11065-11201 Sentence denotes The lowest concentration of the compound with 100% CPE inhibition (eg. exhibiting comparable CPE of non-infected controls) was recorded.
T78 11202-11309 Sentence denotes c EC50 determined by infectious virus yield in culture supernatant at 48h post-infection (log10 TCID50/mL).
T79 11310-11421 Sentence denotes d EC50 determined by viral RNA copy numbers in culture supernatant at 48h post-infection (log10 RNA copies/mL).
T80 11422-11568 Sentence denotes Fig. 1 Antiviral activity of remdesivir (A), lopinavir (B), homorringtonine (C) and emetine dihydrochloride (D) against SARS-CoV-2 virus in vitro.
T81 11569-11786 Sentence denotes Infectious viral loads (log10TCID50/mL left Y axis) and viability (normalized to the ATP level of the Vero E6 cells incubated with infection media) under increasing concentrations of the antiviral compounds are shown.
T82 11787-11870 Sentence denotes Lopinavir in combination with ritonavir are FDA approved HIV-1 protease inhibitors.
T83 11871-11981 Sentence denotes Lopinavir was more potent in inhibiting HIV-1 than ritonavir in vitro but showed poor bioavailability in vivo.
T84 11982-12120 Sentence denotes Ritonavir inhibits not only HIV-1 protease but also the host's cytochrome P450 3A4 enzyme that metabolizes lopinavir (Kempf et al., 1997).
T85 12121-12222 Sentence denotes Lopinavir/ritonavir in combination prolongs bioavailability of lopinavir in vivo (Sham et al., 1998).
T86 12223-12393 Sentence denotes Lopinavir but not ritonavir showed antiviral effect against SARS-CoV, MERS-CoV, and hCoV-229E in vitro, with mean EC50 ranged from 6.6 to 17.1 μM (de Wilde et al., 2014).
T87 12394-12530 Sentence denotes Lopinavir/ritonavir in combination with ribavirin were used previously to treat SARS-CoV patients under a non-randomized clinical trial.
T88 12531-12736 Sentence denotes Less SARS patients developed into ARDS or death after receiving the combination of lopinavir/ritonavir with ribavirin than historical controls who received ribavirin and corticosteroids (Chu et al., 2004).
T89 12737-12873 Sentence denotes Efficacy of lopinavir/ritonavir with or without ribavirin is currently evaluated in SARS-CoV-2 patients under randomized control trials.
T90 12874-13038 Sentence denotes In agreement with previous reports, we observed antiviral effect of lopinavir (EC50 at 26.1 μM) but not ritonavir against SARS-CoV-2 in vitro (Fig. 1B and Table 1).
T91 13039-13290 Sentence denotes HIV-1 patients treated with 400 mg of lopinavir and 100 mg of ritonavir twice daily may reach the minimal lopinavir serum concentration at 9.4 μM (IQR 7.2–12.1 μM), which is below the EC50 against SARS-CoV-2 virus in vitro (Lopez-Cortes et al., 2013).
T92 13291-13495 Sentence denotes Currently, lopinavir/ritonavir at 400mg/100 mg twice daily with or without ribavirin are part of the recommended treatment for managing COVID-19 patients in China (China National Health Commission, 2020).
T93 13496-13797 Sentence denotes A recent randomized control trial reported no significant benefit of lopinavir-ritonavir in hospitalized SARS-CoV-2 patients than standard care, as the time to clinical improvement, mortality at 28 days, and viral loads at various time points were comparable between the two groups (Cao et al., 2020).
T94 13798-13967 Sentence denotes Combinational therapy of lopinavir with the other effective compounds against SARS-CoV-2 virus may increase synergy and reduce the inhibitory concentration of lopinavir.
T95 13968-14041 Sentence denotes Homoharringtonine is a plant alkaloid derived from Cephalotoxus fortunei.
T96 14042-14296 Sentence denotes It exhibits anti-tumor activity by binding to the ribosomal A site to inhibit protein translation, leading to rapid loss of short-lived proteins including Mcl-1 and c-Myc that promote the survival of leukemia cells (Dong et al., 2018; Lu and Wang, 2014).
T97 14297-14415 Sentence denotes Omacetaxine, a semi-synthetic form of homoharringtonine, is approved by FDA for treatment of chronic myeloid leukemia.
T98 14416-14824 Sentence denotes Homoharringtonine has also been reported to exhibit potent anti-viral activity against herpesviruses (varicella-zoster virus, herpes simplex virus-1, pseudorabies virus), coronaviruses (porcine epidemic diarrhea virus and murine hepatitis virus), rhabdoviruses (VSV and rabies virus), and other viruses (hepatitis B virus, Newcastle disease virus, and echovirus 1) (Dong et al., 2018; Andersen et al., 2019).
T99 14825-14924 Sentence denotes Here, we observed homoharringtonine inhibits SARS-CoV-2 with EC50 at 2.10 μM (Fig. 1C and Table 1).
T100 14925-15262 Sentence denotes Previous pharmacokinetic study showed that patients treated with 1.25 mg/m2 omacetaxine every 12 h by subcutaneous injection may reach the maximal plasma concentration at 25.1 ng/mL (0.046 μM) and 36.2 ng/mL (0.066 μM) on days 1 and 11, respectively (Nemunaitis et al., 2013), which were below the EC50 against SARS-CoV-2 virus in vitro.
T101 15263-15495 Sentence denotes Emetine is a protein synthesis inhibitor that was used as anti-protozoan approved for treatment of ameobiasis; it also inhibits malaria by binding to the ribosomal E site of Plasmodium falciparum (Grollman, 1966; Wong et al., 2014).
T102 15496-15586 Sentence denotes However, its potential cardiotoxicity has restricted its clinical use in the recent years.
T103 15587-16088 Sentence denotes It was found to process antiviral activity against a broad range of RNA and DNA viruses, including Zika virus, Ebolavirus, Cytomegalovirus, rabies virus, HIV-1, echovirus 1, buffalo poxvirus, bovine herpesvirus 1, peste des petits ruminants virus, Newcastle disease virus, herpes simplex virus-2, metapneumovirus, Rift Valley fever virus, and influenza (Andersen et al., 2019; Chaves Valadao et al., 2015; Khandelwal et al., 2017; MacGibeny et al., 2018; Mukhopadhyay et al., 2016; Yang et al., 2018).
T104 16089-16274 Sentence denotes Emetine was also identified to inhibit hCoV-OC43, hCoV-NL43, SARS-CoV, MERS-CoV, and MHV-A59 in vitro with EC50 reported at low micromolar range (Dyall et al., 2014; Shen et al., 2019).
T105 16275-16387 Sentence denotes We observed emetine at around 0.5 μM may effectively inhibit SARS-CoV-2 virus replication (Fig. 1D and Table 1).
T106 16388-16553 Sentence denotes The therapeutic plasma concentration of emetine may reach 0.075 μg/mL (0.156 μM) (Regenthal et al., 1999), which is below the EC50 against SARS-CoV-2 virus in vitro.
T107 16554-16633 Sentence denotes The toxic plasma concentration is 0.5 μg/mL (1.04 μM) (Regenthal et al., 1999).
T108 16634-16819 Sentence denotes To reduce the effective concentration of individual compound below the maximal therapeutic plasma concentration, we explored the combinational effect of remdesivir and emetine in vitro.
T109 16820-16970 Sentence denotes Drug interaction was evaluated using the checkerboard assay with serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in combination.
T110 16971-17125 Sentence denotes Remdesivir at 6.25 μM in combination with emetine at 0.195 μM may achieve 64.9% inhibition of viral yield, which can be further tested in vivo (Fig. 2 A).
T111 17126-17310 Sentence denotes The Loewe additive model and the Bliss independent model (Malyutina et al., 2019) were used to analyse the interaction of the two compounds using SynergyFinder (Ianevski et al., 2017).
T112 17311-17444 Sentence denotes Remdesivir and emetine in combination yielded a Loewe synergy score of 0.306 (Fig. 2B) and a Bliss synergy score of 20.234 (Fig. 2C).
T113 17445-17665 Sentence denotes Fig. 2 Combinational effect of remdesivir and emetine dihydrochloride against SARS-CoV-2 virus in vitro. (A) Dose response matrix of serially 2-fold diluted remdesivir (0–50 μM) and emetine (0–0.781 μM) in Vero E6 cells.
T114 17666-18130 Sentence denotes The percentage of viral inhibition was normalized based on viral load in logarithm scale (log10RNA copies/mL), using the maximal viral RNA copies with no drug controls as 0% inhibition and the minimal RNA copies determined at 50 μM remdesivir as references. (B) The three-dimensional interaction landscapes of remdesivir and emetine were generated by SynergyFinder (Ianevski et al., 2017) based on (B) the Loewe additive model and (C) the Bliss independence model.
T115 18131-18221 Sentence denotes Red colour indicates synergy while the green colour indicates antagonism of the two drugs.
T116 18222-18362 Sentence denotes We confirm the antiviral activity of four compounds that have been reported to inhibit other coronavirus or SARS-CoV-2 replication in vitro.
T117 18363-18527 Sentence denotes Our results suggest that combinational therapy may help to reduce the effective concentration against SARS-CoV-2 under the maximal therapeutic plasma concentration.
T118 18528-18678 Sentence denotes There is an urgent research need to identify optimal dose combination of effective compounds against the SARS-CoV-2 virus for better clinical benefit.
T119 18680-18696 Sentence denotes Acknowledgements
T120 18697-19020 Sentence denotes This study was supported by Contract HHSN272201400006C from the 10.13039/100000060National Institute of Allergy and Infectious Diseases of the 10.13039/100000002National Institutes of Health, USA, and the Theme-Based Research Scheme (T11-705/14N) from the 10.13039/501100002920Research Grants Council, Hong Kong SAR, China.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 7478-7487 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T2 8882-8899 Phenotype denotes chronic hepatitis http://purl.obolibrary.org/obo/HP_0200123
T3 8998-9003 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T4 9344-9372 Phenotype denotes chronic lymphocytic leukemia http://purl.obolibrary.org/obo/HP_0005550
T5 9879-9893 Phenotype denotes skin infection http://purl.obolibrary.org/obo/HP_0100658
T6 10024-10038 Phenotype denotes skin infection http://purl.obolibrary.org/obo/HP_0100658
T7 10128-10134 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T8 10162-10186 Phenotype denotes chronic myeloid leukemia http://purl.obolibrary.org/obo/HP_0005506
T9 10583-10596 Phenotype denotes schizophrenia http://purl.obolibrary.org/obo/HP_0100753
T10 14059-14064 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T11 14242-14250 Phenotype denotes leukemia http://purl.obolibrary.org/obo/HP_0001909
T12 14390-14414 Phenotype denotes chronic myeloid leukemia http://purl.obolibrary.org/obo/HP_0005506
T13 14619-14627 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T14 14645-14654 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T15 14720-14729 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T16 15906-15918 Phenotype denotes Valley fever http://purl.obolibrary.org/obo/HP_0032249
T17 18801-18808 Phenotype denotes Allergy http://purl.obolibrary.org/obo/HP_0012393

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1 0-10 DG_28 denotes Remdesivir
T2 12-21 DG_23 denotes lopinavir
T3 23-30 CHEBI:4781;CHEBI:4781 denotes emetine
T4 62-72 SP_7 denotes SARS-CoV-2
T5 73-84 GO:0006260 denotes replication
T6 140-150 SP_7 denotes SARS-CoV-2
T7 151-156 NCBITaxon:10239 denotes virus
T8 285-294 CHEBI:36357;CHEBI:36357 denotes compounds
T9 336-347 NCBITaxon:11118 denotes coronavirus
T10 348-359 GO:0006260 denotes replication
T11 364-373 CHEBI:36357;CHEBI:36357 denotes compounds
T12 433-443 SP_7 denotes SARS-CoV-2
T13 488-498 DG_28 denotes remdesivir
T14 500-509 DG_23;NCBITaxon:11646 denotes lopinavir
T15 548-558 SP_7 denotes SARS-CoV-2
T16 559-564 NCBITaxon:10239 denotes virus
T17 568-572 CL_6 denotes Vero
T18 687-696 CHEBI:85129;DG_29;CHEBI:85129 denotes Ribavirin
T19 700-711 DG_17;NCBITaxon:31032 denotes favipiravir
T20 811-821 DG_28 denotes remdesivir
T21 852-862 DG_28 denotes remdesivir
T22 894-901 CHEBI:6121;CHEBI:6121 denotes emetine
T23 946-951 NCBITaxon:10239 denotes viral
T24 1031-1040 CHEBI:36357;CHEBI:36357 denotes compounds
T25 1063-1069 UBERON:0001969 denotes plasma
T26 1138-1148 DG_28 denotes Remdesivir
T27 1158-1168 SP_7 denotes SARS-CoV-2
T28 1169-1180 GO:0006260 denotes replication
T29 1184-1188 CL_6 denotes Vero
T30 1224-1233 DG_23 denotes Lopinavir
T31 1242-1251 DG_30 denotes ritonavir
T32 1261-1271 SP_7 denotes SARS-CoV-2
T33 1272-1283 GO:0006260 denotes replication
T34 1332-1339 CHEBI:4781;CHEBI:4781 denotes emetine
T35 1349-1359 SP_7 denotes SARS-CoV-2
T36 1360-1371 GO:0006260 denotes replication
T37 1435-1445 DG_28 denotes remdesivir
T50 1546-1556 SP_7 denotes SARS-CoV-2
T51 1557-1562 NCBITaxon:10239 denotes virus
T52 1684-1698 UBERON:0000467 denotes health systems
T53 1749-1759 SP_7 denotes SARS-CoV-2
T54 1760-1765 NCBITaxon:10239 denotes virus
T55 2139-2142 GO:0016265 denotes die
T56 2229-2241 GO:0000003 denotes reproductive
T57 2297-2302 NCBITaxon:10239 denotes virus
T58 2477-2485 CHEBI:36357;CHEBI:36357 denotes compound
T59 2521-2526 SP_6;NCBITaxon:9606 denotes human
T60 2527-2540 NCBITaxon:11118 denotes coronaviruses
T61 2544-2554 SP_7 denotes SARS-CoV-2
T62 2560-2570 SP_7 denotes SARS-CoV-2
T63 2571-2576 NCBITaxon:10239 denotes virus
T64 2590-2597 SO:0000704 denotes genetic
T65 2598-2606 SO:0000853 denotes homology
T66 2614-2622 SP_10 denotes SARS-CoV
T67 2651-2654 SP_2 denotes bat
T68 2655-2668 NCBITaxon:11118 denotes coronaviruses
T69 2680-2695 SP_8;NCBITaxon:694002 denotes Betacoronavirus
T70 2733-2742 CHEBI:36357;CHEBI:36357 denotes compounds
T71 2786-2794 SP_10 denotes SARS-CoV
T72 2804-2817 NCBITaxon:11118 denotes coronaviruses
T73 2843-2853 SP_7 denotes SARS-CoV-2
T74 2967-2977 DG_28 denotes remdesivir
T75 2979-2986 DG_28 denotes GS-5734
T76 2991-2998 CHEBI:50266;CHEBI:50266 denotes prodrug
T77 3002-3011 CHEBI:22260;CHEBI:22260 denotes adenosine
T78 3068-3079 NCBITaxon:4894 denotes filoviruses
T79 3081-3096 NCBITaxon:7656 denotes paramyxoviruses
T80 3102-3115 NCBITaxon:11118 denotes coronaviruses
T81 3215-3224 SP_7 denotes 2019-nCoV
T82 3297-3308 NCBITaxon:11118 denotes coronavirus
T83 3478-3487 DG_23 denotes lopinavir
T84 3488-3497 DG_30 denotes ritonavir
T85 3499-3508 DG_29 denotes ribavirin
T86 3529-3538 DG_23 denotes lopinavir
T87 3539-3548 DG_30 denotes ritonavir
T88 3550-3561 DG_10;CHEBI:3638;CHEBI:3638 denotes chloroquine
T89 3576-3583 DG_49 denotes Arbidol
T90 3681-3691 DG_28 denotes remdesivir
T91 3718-3728 CHEBI:35660;CHEBI:35660 denotes inhibitors
T92 3730-3739 DG_23 denotes lopinavir
T93 3740-3749 DG_30 denotes ritonavir
T94 3757-3766 DG_30 denotes ritonavir
T95 3768-3777 DG_13 denotes darunavir
T96 3802-3811 CHEBI:35222;CHEBI:35222 denotes inhibitor
T97 3839-3848 CHEBI:36357;CHEBI:36357 denotes compounds
T98 3884-3892 GO:0042571 denotes antibody
T99 3903-3907 PR:000001919 denotes PD-1
T100 3926-3930 PR:000001393 denotes IL-6
T101 3932-3943 DG_35 denotes Tocilizumab
T102 3996-4006 SP_7 denotes SARS-CoV-2
T103 4017-4026 CHEBI:36357;CHEBI:36357 denotes compounds
T104 4118-4127 CHEBI:36357;CHEBI:36357 denotes compounds
T105 4164-4175 NCBITaxon:11118 denotes coronavirus
T106 4176-4187 GO:0006260 denotes replication
T107 4257-4268 NCBITaxon:11118 denotes coronavirus
T108 4278-4286 SP_7 denotes COVID-19
T109 4289-4299 SP_7 denotes SARS-CoV-2
T110 4300-4305 NCBITaxon:10239 denotes virus
T111 4364-4375 UBERON:0001728 denotes nasopharynx
T112 4389-4395 UBERON:0000341 denotes throat
T113 4416-4424 SP_7 denotes COVID-19
T114 4452-4456 CL_6 denotes Vero
T115 4489-4494 NCBITaxon:10239 denotes virus
T116 4558-4562 CL_6 denotes Vero
T117 4623-4632 CHEBI:17634;CHEBI:17634 denotes D-glucose
T118 4643-4658 CHEBI:50144;CHEBI:50144 denotes sodium pyruvate
T119 4680-4690 CHEBI:17334;CHEBI:17334 denotes Penicillin
T120 4691-4703 CHEBI:17076;CHEBI:17076 denotes Streptomycin
T121 4715-4720 CHEBI:46756;CHEBI:46756 denotes HEPES
T122 4818-4822 CHEBI:51231;CHEBI:51231 denotes DMSO
T123 4830-4840 DG_28 denotes remdesivir
T124 4849-4860 CHEBI:119915;CHEBI:119915;DG_17;NCBITaxon:31032 denotes favipiravir
T125 4882-4891 CHEBI:50694;CHEBI:50694 denotes tenofovir
T126 4899-4920 CHEBI:63599;CHEBI:63599 denotes fludarabine phosphate
T127 4928-4937 CHEBI:3213;CHEBI:3213;NCBITaxon:10442 denotes baloxavir
T128 4945-4973 CHEBI:3649;CHEBI:3649 denotes chlorpromazine hydrochloride
T129 4980-4991 CHEBI:82721;CHEBI:82721 denotes dalbavancin
T130 4992-5005 CHEBI:36807;CHEBI:36807 denotes hydrochloride
T131 5038-5047 CHEBI:31781;CHEBI:31781;DG_23 denotes lopinavir
T132 5055-5064 CHEBI:45409;CHEBI:45409;DG_30 denotes ritonavir
T133 5074-5079 CHEBI:15377;CHEBI:15377 denotes water
T134 5086-5093 CHEBI:4781;CHEBI:4781 denotes emetine
T135 5094-5109 CHEBI:50488;CHEBI:50488 denotes dihydrochloride
T136 5117-5128 DG_19 denotes galidesivir
T137 5129-5142 CHEBI:36807;CHEBI:36807 denotes hydrochloride
T138 5150-5159 CHEBI:63580;CHEBI:63580;DG_29 denotes ribavirin
T139 5168-5179 CHEBI:82699;CHEBI:82699 denotes oritavancin
T140 5194-5205 CHEBI:7798;CHEBI:7798 denotes Oseltamivir
T141 5228-5233 CHEBI:15377;CHEBI:15377 denotes water
T142 5284-5293 CHEBI:36357;CHEBI:36357 denotes compounds
T143 5304-5308 CL_6 denotes Vero
T144 5340-5349 CHEBI:36357;CHEBI:36357 denotes compounds
T145 5407-5417 SP_7 denotes SARS-CoV-2
T146 5418-5423 NCBITaxon:10239 denotes virus
T147 5449-5458 CHEBI:36357;CHEBI:36357 denotes compounds
T148 5484-5489 NCBITaxon:10239 denotes virus
T149 5644-5653 CHEBI:36357;CHEBI:36357 denotes compounds
T150 5727-5732 NCBITaxon:10239 denotes viral
T151 5822-5825 CHEBI:60004;CHEBI:60004 denotes Mix
T152 6034-6043 CHEBI:36357;CHEBI:36357 denotes compounds
T153 6057-6062 NCBITaxon:10239;GO:0006260 denotes viral
T154 6063-6074 GO:0006260 denotes replication
T155 6100-6109 CHEBI:36357;CHEBI:36357 denotes compounds
T156 6127-6131 CL_6 denotes Vero
T157 6223-6232 CHEBI:36357;CHEBI:36357 denotes compounds
T158 6244-6254 DG_28 denotes remdesivir
T159 6256-6265 CHEBI:31781;CHEBI:31781;DG_23 denotes lopinavir
T160 6290-6297 CHEBI:4781;CHEBI:4781 denotes emetine
T161 6298-6313 CHEBI:50488;CHEBI:50488 denotes dihydrochloride
T162 6336-6346 SP_7 denotes SARS-CoV-2
T163 6347-6358 GO:0006260 denotes replication
T164 6362-6366 CL_6 denotes Vero
T165 6453-6462 CHEBI:36357;CHEBI:36357 denotes compounds
T166 6508-6517 CHEBI:63580;CHEBI:63580;DG_29 denotes ribavirin
T167 6519-6530 CHEBI:119915;CHEBI:119915;DG_17;NCBITaxon:31032 denotes favipiravir
T168 6532-6543 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T169 6548-6557 CHEBI:3213;CHEBI:3213;NCBITaxon:10442 denotes baloxavir
T170 6606-6616 SP_7 denotes SARS-CoV-2
T171 6617-6622 NCBITaxon:10239 denotes virus
T172 6674-6684 DG_28 denotes Remdesivir
T173 6691-6692 CHEBI:17865;CHEBI:17865 denotes ′
T174 6692-6693 CHEBI:50217;CHEBI:50217 denotes -
T175 6693-6698 CHEBI:48819;CHEBI:48819 denotes cyano
T176 6711-6720 CHEBI:22260;CHEBI:22260;NCBITaxon:10508 denotes adenosine
T177 6761-6766 SP_6;NCBITaxon:9606 denotes human
T178 6767-6780 NCBITaxon:11118 denotes coronaviruses
T179 6782-6786 NCBITaxon:10359 denotes hCoV
T180 6796-6800 NCBITaxon:10359 denotes hCoV
T181 6807-6815 SP_10 denotes SARS-CoV
T182 6817-6825 SP_9 denotes MERS-CoV
T183 6831-6841 SP_7 denotes SARS-CoV-2
T184 6964-6974 SP_7 denotes SARS-CoV-2
T185 6998-7003 NCBITaxon:10239 denotes viral
T186 7095-7105 DG_28 denotes remdesivir
T187 7128-7138 SP_7 denotes SARS-CoV-2
T188 7139-7144 NCBITaxon:10239 denotes virus
T189 7187-7192 NCBITaxon:10239 denotes viral
T190 7243-7248 NCBITaxon:10239 denotes viral
T191 7298-7308 DG_28 denotes remdesivir
T192 7460-7465 PR:000000125 denotes nsp12
T193 7471-7477 NCBITaxon:39107 denotes murine
T194 7478-7487 NCBITaxon:9606 denotes hepatitis
T195 7488-7493 NCBITaxon:10239 denotes virus
T196 7548-7558 DG_28 denotes remdesivir
T197 7690-7700 SP_7 denotes SARS-CoV-2
T198 7794-7804 DG_28 denotes remdesivir
T199 7812-7821 CHEBI:22260;CHEBI:22260 denotes adenosine
T200 7833-7844 DG_19 denotes galidesivir
T201 7860-7881 CHEBI:63599;CHEBI:63599 denotes fludarabine phosphate
T202 7886-7896 CHEBI:60783;CHEBI:60783 denotes nucleoside
T203 7908-7919 DG_17;NCBITaxon:31032 denotes favipiravir
T204 7921-7930 DG_29 denotes ribavirin
T205 7956-7961 NCBITaxon:10239;GO:0006260 denotes viral
T206 7962-7973 GO:0006260 denotes replication
T207 8007-8017 CHEBI:60783;CHEBI:60783 denotes nucleoside
T208 8036-8045 GO:0008152 denotes metabolic
T209 8104-8114 CHEBI:23447;CHEBI:23447 denotes nucleoside
T210 8195-8205 CHEBI:23447;CHEBI:23447 denotes nucleoside
T211 8227-8232 SP_6;NCBITaxon:9606 denotes human
T212 8233-8239 CL:0002368;UBERON:0001005 denotes airway
T213 8240-8250 UBERON:0000483;CL:0002368 denotes epithelial
T214 8251-8256 CL:0002368 denotes cells
T258 8342-8351 CHEBI:36357;CHEBI:36357 denotes compounds
T259 8360-8370 SP_7 denotes SARS-CoV-2
T260 8374-8378 CL_6 denotes Vero
T261 10691-10700 CHEBI:36357;CHEBI:36357 denotes compounds
T262 10704-10708 CL_6 denotes Vero
T263 10878-10887 CHEBI:63580;DG_29;CHEBI:63580 denotes ribavirin
T264 10945-10955 SP_7 denotes SARS-CoV-2
T265 10956-10961 NCBITaxon:10239 denotes virus
T266 10965-10969 NCBITaxon:10633;CL_6 denotes Vero
T267 11017-11026 CHEBI:36357;CHEBI:36357 denotes compounds
T268 11097-11105 CHEBI:36357;CHEBI:36357 denotes compound
T269 11234-11239 NCBITaxon:10239 denotes virus
T270 11331-11336 NCBITaxon:10239 denotes viral
T271 11451-11461 DG_28 denotes remdesivir
T272 11467-11476 DG_23 denotes lopinavir
T273 11506-11513 CHEBI:4781;CHEBI:4781 denotes emetine
T274 11514-11529 CHEBI:50488;CHEBI:50488 denotes dihydrochloride
T275 11542-11552 SP_7 denotes SARS-CoV-2
T276 11553-11558 NCBITaxon:10239 denotes virus
T277 11580-11585 NCBITaxon:10239 denotes viral
T278 11671-11675 CL_6 denotes Vero
T279 11766-11775 CHEBI:36357;CHEBI:36357 denotes compounds
T280 11787-11796 CHEBI:31781;DG_23;CHEBI:31781 denotes Lopinavir
T281 11817-11826 DG_30 denotes ritonavir
T282 11859-11869 CHEBI:37670;CHEBI:37670 denotes inhibitors
T283 11871-11880 CHEBI:31781;DG_23;CHEBI:31781 denotes Lopinavir
T284 11922-11931 CHEBI:45409;DG_30;CHEBI:45409 denotes ritonavir
T285 11982-11991 DG_30 denotes Ritonavir
T286 12045-12055 CHEBI:38559;CHEBI:38559 denotes cytochrome
T287 12056-12064 PR:000006130 denotes P450 3A4
T288 12077-12088 GO:0008152 denotes metabolizes
T289 12089-12098 DG_23;CHEBI:31781;CHEBI:31781 denotes lopinavir
T290 12121-12130 CHEBI:31781;DG_23;CHEBI:31781 denotes Lopinavir
T291 12131-12140 CHEBI:45409;DG_30;CHEBI:45409 denotes ritonavir
T292 12184-12193 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T293 12223-12232 DG_23 denotes Lopinavir
T294 12241-12250 DG_30 denotes ritonavir
T295 12283-12291 SP_10 denotes SARS-CoV
T296 12293-12301 SP_9 denotes MERS-CoV
T297 12307-12311 NCBITaxon:10359 denotes hCoV
T298 12394-12403 DG_23 denotes Lopinavir
T299 12404-12413 DG_30 denotes ritonavir
T300 12434-12443 DG_29 denotes ribavirin
T301 12474-12482 SP_10 denotes SARS-CoV
T302 12536-12540 SP_10 denotes SARS
T303 12573-12578 GO:0016265 denotes death
T304 12614-12623 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T305 12624-12633 DG_30 denotes ritonavir
T306 12639-12648 CHEBI:28201;DG_29;CHEBI:28201 denotes ribavirin
T307 12687-12696 CHEBI:63580;DG_29;CHEBI:63580 denotes ribavirin
T308 12701-12716 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T309 12749-12758 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T310 12759-12768 DG_30 denotes ritonavir
T311 12785-12794 CHEBI:28201;DG_29;CHEBI:28201 denotes ribavirin
T312 12821-12831 SP_7 denotes SARS-CoV-2
T313 12942-12951 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T314 12978-12987 DG_30 denotes ritonavir
T315 12996-13006 SP_7 denotes SARS-CoV-2
T316 13077-13086 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T317 13101-13110 CHEBI:45409;DG_30;CHEBI:45409 denotes ritonavir
T318 13145-13154 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T319 13155-13160 UBERON:0001977 denotes serum
T320 13236-13246 SP_7 denotes SARS-CoV-2
T321 13247-13252 NCBITaxon:10239 denotes virus
T322 13302-13311 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T323 13312-13321 DG_30 denotes ritonavir
T324 13366-13375 CHEBI:63580;DG_29;CHEBI:63580 denotes ribavirin
T325 13427-13435 SP_7 denotes COVID-19
T326 13565-13574 DG_23 denotes lopinavir
T327 13575-13584 DG_30 denotes ritonavir
T328 13601-13611 SP_7 denotes SARS-CoV-2
T329 13704-13709 NCBITaxon:10239 denotes viral
T330 13823-13832 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T331 13858-13867 CHEBI:36357;CHEBI:36357 denotes compounds
T332 13876-13886 SP_7 denotes SARS-CoV-2
T333 13887-13892 NCBITaxon:10239 denotes virus
T334 13957-13966 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T335 13991-13996 NCBITaxon:3193 denotes plant
T336 13997-14005 CHEBI:22315;CHEBI:22315 denotes alkaloid
T337 14019-14031 NCBITaxon:6073 denotes Cephalotoxus
T338 14092-14101 GO:0005840 denotes ribosomal
T339 14128-14139 GO:0006412 denotes translation
T340 14197-14200 PR:000010240 denotes Mcl
T341 14297-14308 CHEBI:25675;CHEBI:25675 denotes Omacetaxine
T342 14398-14405 CL:0000763 denotes myeloid
T343 14480-14485 NCBITaxon:10239 denotes viral
T344 14503-14516 NCBITaxon:10376 denotes herpesviruses
T345 14518-14527 NCBITaxon:10633 denotes varicella
T346 14528-14534 NCBITaxon:7955 denotes zoster
T347 14535-14540 NCBITaxon:10239 denotes virus
T348 14542-14548 NCBITaxon:10376 denotes herpes
T349 14549-14562 NCBITaxon:10633 denotes simplex virus
T350 14562-14563 NCBITaxon:10376 denotes -
T351 14566-14578 NCBITaxon:9258 denotes pseudorabies
T352 14579-14584 NCBITaxon:10239 denotes virus
T353 14587-14600 NCBITaxon:11118 denotes coronaviruses
T354 14602-14609 NCBITaxon:9258 denotes porcine
T355 14610-14627 NCBITaxon:28295 denotes epidemic diarrhea
T356 14628-14633 NCBITaxon:10239 denotes virus
T357 14638-14644 NCBITaxon:39107 denotes murine
T358 14645-14654 NCBITaxon:5690 denotes hepatitis
T359 14655-14660 NCBITaxon:10376 denotes virus
T360 14663-14676 NCBITaxon:7729 denotes rhabdoviruses
T361 14678-14681 NCBITaxon:10298 denotes VSV
T362 14686-14692 NCBITaxon:9654 denotes rabies
T363 14693-14698 NCBITaxon:10376 denotes virus
T364 14711-14718 NCBITaxon:10239 denotes viruses
T365 14720-14729 NCBITaxon:5690 denotes hepatitis
T366 14730-14737 NCBITaxon:10376 denotes B virus
T367 14739-14748 NCBITaxon:6231 denotes Newcastle
T368 14749-14756 NCBITaxon:10376 denotes disease
T369 14757-14762 NCBITaxon:10239 denotes virus
T370 14768-14777 NCBITaxon:33758 denotes echovirus
T371 14870-14880 SP_7 denotes SARS-CoV-2
T372 15001-15012 CHEBI:25675;CHEBI:25675 denotes omacetaxine
T373 15072-15078 UBERON:0001969 denotes plasma
T374 15236-15246 SP_7 denotes SARS-CoV-2
T375 15247-15252 NCBITaxon:10239 denotes virus
T376 15276-15293 GO:0006412 denotes protein synthesis
T377 15294-15303 CHEBI:48001;CHEBI:48001 denotes inhibitor
T378 15326-15335 NCBITaxon:33317 denotes protozoan
T379 15362-15372 NCBITaxon:5774 denotes ameobiasis
T380 15417-15426 GO:0005840 denotes ribosomal
T381 15437-15458 NCBITaxon:5833 denotes Plasmodium falciparum
T382 15667-15674 NCBITaxon:10376 denotes viruses
T383 15686-15690 NCBITaxon:7955 denotes Zika
T384 15691-15696 NCBITaxon:10376 denotes virus
T385 15698-15708 NCBITaxon:10376 denotes Ebolavirus
T386 15710-15725 NCBITaxon:6073 denotes Cytomegalovirus
T387 15727-15733 NCBITaxon:9654 denotes rabies
T388 15734-15739 NCBITaxon:10376 denotes virus
T389 15748-15757 NCBITaxon:33758 denotes echovirus
T390 15761-15768 NCBITaxon:9940 denotes buffalo
T391 15769-15777 NCBITaxon:9258 denotes poxvirus
T392 15779-15785 NCBITaxon:27592 denotes bovine
T393 15786-15797 NCBITaxon:5690 denotes herpesvirus
T394 15801-15806 NCBITaxon:9258 denotes peste
T395 15811-15817 NCBITaxon:7656 denotes petits
T396 15818-15827 NCBITaxon:7729 denotes ruminants
T397 15828-15833 NCBITaxon:10239 denotes virus
T398 15835-15844 NCBITaxon:6231 denotes Newcastle
T399 15845-15858 NCBITaxon:10376 denotes disease virus
T400 15860-15866 NCBITaxon:5690 denotes herpes
T401 15867-15874 NCBITaxon:10633 denotes simplex
T402 15875-15880 NCBITaxon:10376 denotes virus
T403 15884-15899 NCBITaxon:7737 denotes metapneumovirus
T404 15901-15918 NCBITaxon:11588 denotes Rift Valley fever
T405 15919-15924 NCBITaxon:10239 denotes virus
T406 16150-16158 SP_10 denotes SARS-CoV
T407 16160-16168 SP_9 denotes MERS-CoV
T408 16287-16294 CHEBI:4781;CHEBI:4781 denotes emetine
T409 16336-16346 SP_7 denotes SARS-CoV-2
T410 16347-16352 NCBITaxon:10239 denotes virus
T411 16353-16364 GO:0006260 denotes replication
T412 16404-16410 UBERON:0001969 denotes plasma
T413 16428-16435 CHEBI:4781;CHEBI:4781 denotes emetine
T414 16527-16537 SP_7 denotes SARS-CoV-2
T415 16538-16543 NCBITaxon:10239 denotes virus
T416 16564-16570 UBERON:0001969 denotes plasma
T417 16686-16694 CHEBI:36357;CHEBI:36357 denotes compound
T418 16725-16731 UBERON:0001969 denotes plasma
T419 16787-16797 DG_28 denotes remdesivir
T420 16802-16809 CHEBI:4781;CHEBI:4781 denotes emetine
T421 16820-16824 CHEBI:23888;CHEBI:23888 denotes Drug
T422 16909-16919 DG_28 denotes remdesivir
T423 16934-16941 CHEBI:4781;CHEBI:4781 denotes emetine
T424 16971-16981 DG_28 denotes Remdesivir
T425 17013-17020 CHEBI:4781;CHEBI:4781 denotes emetine
T426 17065-17070 NCBITaxon:10239 denotes viral
T427 17256-17265 CHEBI:36357;CHEBI:36357 denotes compounds
T428 17311-17321 DG_28 denotes Remdesivir
T429 17476-17486 DG_28 denotes remdesivir
T430 17491-17498 CHEBI:4781;CHEBI:4781 denotes emetine
T431 17499-17514 CHEBI:50488;CHEBI:50488 denotes dihydrochloride
T432 17523-17533 SP_7 denotes SARS-CoV-2
T433 17534-17539 NCBITaxon:10239 denotes virus
T434 17602-17612 DG_28 denotes remdesivir
T435 17627-17634 CHEBI:4781;CHEBI:4781 denotes emetine
T436 17651-17655 CL_6 denotes Vero
T437 17684-17689 NCBITaxon:10239 denotes viral
T438 17725-17730 NCBITaxon:10239 denotes viral
T439 17795-17800 NCBITaxon:10239 denotes viral
T440 17820-17824 CHEBI:23888;CHEBI:23888 denotes drug
T441 17898-17908 DG_28 denotes remdesivir
T442 17976-17986 DG_28 denotes remdesivir
T443 18215-18220 CHEBI:23888;CHEBI:23888 denotes drugs
T459 18264-18273 CHEBI:36357;CHEBI:36357 denotes compounds
T460 18315-18326 NCBITaxon:11118 denotes coronavirus
T461 18330-18340 SP_7 denotes SARS-CoV-2
T462 18341-18352 GO:0006260 denotes replication
T463 18465-18475 SP_7 denotes SARS-CoV-2
T464 18506-18512 UBERON:0001969 denotes plasma
T465 18611-18620 CHEBI:36357;CHEBI:36357 denotes compounds
T466 18633-18643 SP_7 denotes SARS-CoV-2
T467 18644-18649 NCBITaxon:10239 denotes virus
T74695 0-10 DG_28 denotes Remdesivir
T29884 12-21 DG_23 denotes lopinavir
T21599 23-30 CHEBI:4781;CHEBI:4781 denotes emetine
T62330 62-72 SP_7 denotes SARS-CoV-2
T38282 73-84 GO:0006260 denotes replication
T1741 140-150 SP_7 denotes SARS-CoV-2
T82064 151-156 NCBITaxon:10239 denotes virus
T24338 285-294 CHEBI:36357;CHEBI:36357 denotes compounds
T2435 336-347 NCBITaxon:11118 denotes coronavirus
T41112 348-359 GO:0006260 denotes replication
T93186 364-373 CHEBI:36357;CHEBI:36357 denotes compounds
T5199 433-443 SP_7 denotes SARS-CoV-2
T32162 488-498 DG_28 denotes remdesivir
T17541 500-509 DG_23;NCBITaxon:11646 denotes lopinavir
T621 548-558 SP_7 denotes SARS-CoV-2
T88473 559-564 NCBITaxon:10239 denotes virus
T95408 568-572 CL_6 denotes Vero
T26758 687-696 CHEBI:85129;DG_29;CHEBI:85129 denotes Ribavirin
T58960 700-711 DG_17;NCBITaxon:31032 denotes favipiravir
T59518 811-821 DG_28 denotes remdesivir
T89769 852-862 DG_28 denotes remdesivir
T93617 894-901 CHEBI:6121;CHEBI:6121 denotes emetine
T92936 946-951 NCBITaxon:10239 denotes viral
T65617 1031-1040 CHEBI:36357;CHEBI:36357 denotes compounds
T6727 1063-1069 UBERON:0001969 denotes plasma
T54351 1138-1148 DG_28 denotes Remdesivir
T83036 1158-1168 SP_7 denotes SARS-CoV-2
T96493 1169-1180 GO:0006260 denotes replication
T85588 1184-1188 CL_6 denotes Vero
T81617 1224-1233 DG_23 denotes Lopinavir
T3856 1242-1251 DG_30 denotes ritonavir
T86607 1261-1271 SP_7 denotes SARS-CoV-2
T41304 1272-1283 GO:0006260 denotes replication
T99181 1332-1339 CHEBI:4781;CHEBI:4781 denotes emetine
T64373 1349-1359 SP_7 denotes SARS-CoV-2
T23356 1360-1371 GO:0006260 denotes replication
T43637 1435-1445 DG_28 denotes remdesivir
T39 6336-6346 SP_7 denotes SARS-CoV-2
T40 6347-6358 GO:0006260 denotes replication
T41 6362-6366 CL_6 denotes Vero
T42 12223-12232 DG_23 denotes Lopinavir
T43 12241-12250 DG_30 denotes ritonavir
T44 18330-18340 SP_7 denotes SARS-CoV-2
T45 18341-18352 GO:0006260 denotes replication
T14343 18633-18643 SP_7 denotes SARS-CoV-2
T5529 18644-18649 NCBITaxon:10239 denotes virus
T54781 704-712 SO:0000704 denotes piravir
T98320 713-721 SO:0000853 denotes hat are
T62840 729-737 SP_10 denotes y evalua
T29138 766-769 SP_2 denotes wed
T71046 770-783 NCBITaxon:11118 denotes no inhibition
T96251 795-807 SP_8;NCBITaxon:694002 denotes Synergy betw
T18362 844-853 CHEBI:36357;CHEBI:36357 denotes ed, and r
T72305 897-905 SP_10 denotes tine at
T20473 915-930 NCBITaxon:11118 denotes ay achieve 64.9
T86134 956-966 SP_7 denotes d. Combina
T83525 1080-1090 DG_28 denotes ions and p
T59770 1092-1099 DG_28 denotes vide be
T32737 1104-1111 CHEBI:50266;CHEBI:50266 denotes clinica
T67513 1115-1125 CHEBI:22260;CHEBI:22260 denotes nefits. H
T44435 1183-1194 NCBITaxon:4894 denotes Vero-E6 ce
T45810 1196-1211 NCBITaxon:7656 denotes s with EC50 at
T98605 1217-1232 NCBITaxon:11118 denotes μM. • Lopinavi
T55493 1333-1342 SP_7 denotes metine in
T90449 1415-1427 NCBITaxon:11118 denotes . • Combina
T80182 1598-1606 DG_23 denotes e world
T75122 1607-1616 DG_30 denotes s facing
T84020 1618-1627 DG_29 denotes escalati
T74170 1648-1656 DG_23 denotes have si
T91085 1657-1666 DG_30 denotes nificant
T89871 1668-1679 DG_10;CHEBI:3638;CHEBI:3638 denotes pacts on gl
T45243 1694-1701 DG_49 denotes tems an
T94669 1797-1807 DG_28 denotes nical pres
T8145 1834-1844 CHEBI:35660;CHEBI:35660 denotes infection
T98341 1846-1854 DG_23 denotes n 1% of
T22220 1855-1864 DG_30 denotes aboratory
T81180 1872-1881 DG_30 denotes ed cases
T59274 1883-1892 DG_13 denotes mild, se
T46476 1917-1926 CHEBI:35222;CHEBI:35222 denotes ions in 8
T84108 1954-1963 CHEBI:36357;CHEBI:36357 denotes ic cases,
T65087 1999-2007 GO:0042571 denotes ). The e
T38314 2018-2022 PR:000001919 denotes mpto
T59535 2041-2045 PR:000001393 denotes ris
T5723 2047-2058 DG_35 denotes (sCFR) amon
T21023 2109-2119 SP_7 denotes were 5.1 t
T4369 2130-2139 CHEBI:36357;CHEBI:36357 denotes ikely to
T28534 2231-2240 CHEBI:36357;CHEBI:36357 denotes productiv
T42817 2278-2289 NCBITaxon:11118 denotes et al., 202
T7914 2290-2301 GO:0006260 denotes ), the viru
T4162 2372-2383 NCBITaxon:11118 denotes time if no
T10674 2393-2401 SP_7 denotes vaccine
T47920 2404-2414 SP_7 denotes developed
T99982 2415-2420 NCBITaxon:10239 denotes Fine
T41515 2476-2487 UBERON:0001728 denotes compound l
T87073 2500-2506 UBERON:0000341 denotes he tre
T29645 2527-2535 SP_7 denotes coronavi
T52826 2563-2567 CL_6 denotes S-Co
T12546 2600-2605 NCBITaxon:10239 denotes molog
T43018 2669-2673 CL_6 denotes with
T73353 2738-2747 CHEBI:17634;CHEBI:17634 denotes unds prev
T71214 2758-2773 CHEBI:50144;CHEBI:50144 denotes rted to show ef
T87029 2795-2805 CHEBI:17334;CHEBI:17334 denotes or other c
T21525 2806-2818 CHEBI:17076;CHEBI:17076 denotes ronaviruses
T2533 2830-2835 CHEBI:46756;CHEBI:46756 denotes tive
T79534 2929-2933 CHEBI:51231;CHEBI:51231 denotes 2019
T15231 2941-2951 DG_28 denotes al., 2015
T67564 2960-2970 CHEBI:119915;CHEBI:119915;DG_17;NCBITaxon:31032 denotes ition, rem
T87782 2992-3001 CHEBI:50694;CHEBI:50694 denotes rodrug of
T16835 3009-3030 CHEBI:63599;CHEBI:63599 denotes ne analog with a broa
T9266 3038-3047 CHEBI:3213;CHEBI:3213;NCBITaxon:10442 denotes um antivi
T56626 3055-3083 CHEBI:3649;CHEBI:3649 denotes vity against filoviruses, pa
T4831 3090-3101 CHEBI:82721;CHEBI:82721 denotes iruses, and
T84456 3102-3115 CHEBI:36807;CHEBI:36807 denotes coronaviruses
T39900 3148-3156 CHEBI:31781;CHEBI:31781;DG_23 denotes al., 201
T49983 3164-3173 CHEBI:45409;CHEBI:45409;DG_30 denotes t et al.,
T31126 3183-3188 CHEBI:15377;CHEBI:15377 denotes s rec
T62767 3195-3202 CHEBI:4781;CHEBI:4781 denotes onfirme
T11480 3203-3218 CHEBI:50488;CHEBI:50488 denotes to inhibit 201
T91872 3226-3237 DG_19 denotes n vitro (Wa
T98412 3238-3251 CHEBI:36807;CHEBI:36807 denotes g et al., 202
T83890 3259-3268 CHEBI:63580;CHEBI:63580;DG_29 denotes rding to
T62592 3277-3288 CHEBI:82699;CHEBI:82699 denotes dition of t
T85596 3303-3314 CHEBI:7798;CHEBI:7798 denotes virus diagn
T74260 3337-3342 CHEBI:15377;CHEBI:15377 denotes issu
T85934 3393-3402 CHEBI:36357;CHEBI:36357 denotes s Republi
T39633 3415-3419 CL_6 denotes ptio
T59384 3451-3460 CHEBI:36357;CHEBI:36357 denotes aerosoli
T19980 3519-3529 SP_7 denotes tion with
T78162 3530-3536 NCBITaxon:10239 denotes opinav
T7780 3562-3571 CHEBI:36357;CHEBI:36357 denotes phosphate
T65969 3599-3604 NCBITaxon:10239 denotes Heal
T2935 3760-3769 CHEBI:36357;CHEBI:36357 denotes onavir, d
T20478 3843-3848 NCBITaxon:10239 denotes ounds
T47394 3938-3941 CHEBI:60004;CHEBI:60004 denotes zum
T41045 4152-4161 CHEBI:36357;CHEBI:36357 denotes to inhib
T16106 4175-4180 NCBITaxon:10239;GO:0006260 denotes repl
T24693 4181-4192 GO:0006260 denotes cation in v
T95528 4217-4226 CHEBI:36357;CHEBI:36357 denotes ted in cl
T61235 4244-4248 CL_6 denotes atie
T51394 4339-4348 CHEBI:36357;CHEBI:36357 denotes 0, was is
T4039 4360-4370 DG_28 denotes the nasoph
T15138 4372-4381 CHEBI:31781;CHEBI:31781;DG_23 denotes ynx aspir
T51669 4406-4413 CHEBI:4781;CHEBI:4781 denotes confirm
T58177 4414-4429 CHEBI:50488;CHEBI:50488 denotes d COVID-19 pati
T19301 4452-4462 SP_7 denotes Vero E6 ce
T37435 4463-4474 GO:0006260 denotes ls (ATCC CR
T65481 4478-4482 CL_6 denotes 86).
T20928 4569-4578 CHEBI:36357;CHEBI:36357 denotes ls in inf
T40645 4624-4633 CHEBI:63580;CHEBI:63580;DG_29 denotes -glucose,
T63738 4635-4645 CHEBI:119915;CHEBI:119915;DG_17;NCBITaxon:31032 denotes 00 mg/L so
T87956 4647-4658 CHEBI:7798;CHEBI:7798 denotes um pyruvate
T21919 4663-4672 CHEBI:3213;CHEBI:3213;NCBITaxon:10442 denotes FBS, 100,
T55558 4721-4731 SP_7 denotes . Compound
T14223 4732-4737 NCBITaxon:10239 denotes were
T47691 4793-4803 DG_28 denotes tocks were
T481 4810-4811 CHEBI:17865;CHEBI:17865 denotes e
T933 4811-4812 CHEBI:50217;CHEBI:50217 denotes d
T48640 4812-4817 CHEBI:48819;CHEBI:48819 denotes with
T76259 4830-4839 CHEBI:22260;CHEBI:22260;NCBITaxon:10508 denotes remdesivi
T96701 4881-4886 SP_6;NCBITaxon:9606 denotes teno
T77315 4887-4900 NCBITaxon:11118 denotes ovir, 10 mM f
T62577 4902-4906 NCBITaxon:10359 denotes dara
T40572 4916-4920 NCBITaxon:10359 denotes hate
T50277 4927-4935 SP_10 denotes baloxav
T73620 4937-4945 SP_9 denotes , 10 mM
T4950 4951-4961 SP_7 denotes romazine h
T80102 5085-5095 SP_7 denotes emetine d
T5072 5119-5124 NCBITaxon:10239 denotes lides
T15145 5216-5226 DG_28 denotes e (10 mM i
T10448 5249-5259 SP_7 denotes y Roche. T
T83644 5260-5265 NCBITaxon:10239 denotes eval
T64090 5308-5313 NCBITaxon:10239 denotes E6 c
T4487 5364-5369 NCBITaxon:10239 denotes ectio
T17071 5418-5428 DG_28 denotes virus at M
T96477 5579-5584 PR:000000125 denotes the
T1195 5590-5595 NCBITaxon:39107 denotes were
T40045 5596-5605 NCBITaxon:9606 denotes verlaid w
T96720 5606-5611 NCBITaxon:10239 denotes th in
T66189 5666-5676 DG_28 denotes incubation
T25830 5808-5818 SP_7 denotes 1-Step Mas
T29703 5912-5922 DG_28 denotes n (GraphPa
T57743 5930-5939 CHEBI:22260;CHEBI:22260 denotes was used
T34401 5951-5962 DG_19 denotes dose-respon
T4604 5978-5999 CHEBI:63599;CHEBI:63599 denotes termined the 50% effe
T17962 6004-6013 CHEBI:60783;CHEBI:60783 denotes concentr
T44260 6025-6035 DG_17;NCBITaxon:31032 denotes ) of the c
T87537 6037-6046 DG_29 denotes pounds th
T38687 6072-6077 NCBITaxon:10239;GO:0006260 denotes on. C
T88567 6078-6090 GO:0006260 denotes totoxicty of
T50657 6124-6133 CHEBI:60783;CHEBI:60783 denotes in Vero E
T13669 6152-6159 GO:0008152 denotes ellTite
T43497 6222-6231 CHEBI:23447;CHEBI:23447 denotes compound
T36702 6313-6322 CHEBI:23447;CHEBI:23447 denotes were fou
T66276 6344-6349 SP_6;NCBITaxon:9606 denotes -2 re
T86414 6350-6356 CL:0002368;UBERON:0001005 denotes licati
T74533 6357-6366 UBERON:0000483;CL:0002368 denotes n in Vero
T88530 6367-6372 CL:0002368 denotes E6 ce
T215 6454-6463 CHEBI:36357;CHEBI:36357 denotes ompounds
T216 6472-6482 SP_7 denotes undergoin
T217 6486-6490 CL_6 denotes inic
T218 6531-6541 SP_7 denotes oseltamiv
T219 6644-6650 NCBITaxon:10376 denotes tions
T220 6670-6675 NCBITaxon:10239 denotes 1). R
T221 6752-6757 NCBITaxon:10376 denotes inhi
T222 6761-6769 SP_10 denotes human co
T223 7071-7077 NCBITaxon:11089 denotes asing
T224 7084-7089 NCBITaxon:10239 denotes ratio
T225 7178-7184 NCBITaxon:10633 denotes e fitt
T226 7185-7190 NCBITaxon:10239 denotes d vir
T227 7325-7336 CHEBI:31624;CHEBI:31624 denotes C50 at 23.1
T228 7394-7401 CL:0000236 denotes o mutat
T229 7410-7421 CL:0000542 denotes 6L and V553
T230 7549-7564 DG_30 denotes emdesivir (Agos
T231 7742-7759 CHEBI:17883;CHEBI:17883 denotes the experiments,
T232 7944-7958 NCBITaxon:1239 denotes not inhibit vi
T233 7979-7990 CHEBI:82721;CHEBI:82721 denotes 100 μM (Ta
T234 7991-8019 CHEBI:17883;CHEBI:17883 denotes le 1). However, nucleoside a
T235 8084-8099 NCBITaxon:2 denotes ms by host cell
T236 8184-8191 CL:0000763 denotes effect
T237 8497-8520 CHEBI:17883;CHEBI:17883 denotes inhibitionb Reduction i
T238 8525-8538 GO:0098794 denotes ectious virus
T239 8673-8682 CHEBI:36357;CHEBI:36357 denotes 37-3 >100
T240 8686-8690 CL_6 denotes 23.1
T241 8857-8866 CHEBI:28201;CHEBI:28201;DG_29 denotes pproved f
T242 8924-8934 SP_7 denotes 100 500 >5
T243 8935-8940 NCBITaxon:10239 denotes 0 >50
T244 8944-8948 NCBITaxon:10633;CL_6 denotes lide
T245 8996-9005 CHEBI:36357;CHEBI:36357 denotes w fever v
T246 9076-9084 CHEBI:36357;CHEBI:36357 denotes hase 2 t
T247 9211-9216 NCBITaxon:10239 denotes tment
T248 9306-9311 NCBITaxon:10239 denotes FDA
T249 9423-9433 DG_28 denotes inhibitor
T250 9439-9447 DG_23;CHEBI:31781;CHEBI:31781 denotes proved f
T251 9477-9484 CHEBI:4781;CHEBI:4781 denotes n in co
T252 9485-9500 CHEBI:50488;CHEBI:50488 denotes bination with r
T253 9513-9523 SP_7 denotes 25-17-0 49
T254 9524-9529 NCBITaxon:10239 denotes 75 25
T255 9551-9556 NCBITaxon:10239 denotes prot
T256 9641-9645 CL_6 denotes r an
T257 9736-9745 CHEBI:36357;CHEBI:36357 denotes pproved i
T71435 9798-9807 CHEBI:36357;CHEBI:36357 denotes 1.5625 0
T63695 9816-9826 SP_7 denotes Oritavanci
T53400 9830-9834 CL_6 denotes phos
T59680 9910-9919 CHEBI:36357;CHEBI:36357 denotes ositive b
T44493 9923-9927 CL_6 denotes ria
T11771 10093-10102 CHEBI:63580;DG_29;CHEBI:63580 denotes 0 N.D. N.
T48987 10160-10170 SP_7 denotes r chronic
T34879 10171-10176 NCBITaxon:10239 denotes yeloi
T1975 10180-10184 NCBITaxon:10633;CL_6 denotes ukem
T59560 10232-10241 CHEBI:36357;CHEBI:36357 denotes carboxyla
T1290 10312-10320 CHEBI:36357;CHEBI:36357 denotes nza infe
T5891 10451-10456 NCBITaxon:10239 denotes on 19
T75776 10548-10553 NCBITaxon:10239 denotes cepto
T252 10668-10678 DG_28 denotes with seri
T51904 10684-10692 DG_23 denotes iluted c
T66827 10722-10729 CHEBI:4781;CHEBI:4781 denotes 8 h pos
T38909 10730-10745 CHEBI:50488;CHEBI:50488 denotes -incubation usi
T99460 10758-10768 SP_7 denotes Glow Lumin
T66727 10769-10774 NCBITaxon:10239 denotes scent
T75234 10796-10805 NCBITaxon:10239 denotes (Promega)
T84655 10890-10894 CL_6 denotes ich
T72639 10985-10994 CHEBI:36357;CHEBI:36357 denotes increasin
T69729 11006-11014 CHEBI:31781;DG_23;CHEBI:31781 denotes ion of t
T75921 11035-11044 DG_30 denotes erved at
T18501 11077-11087 CHEBI:37670;CHEBI:37670 denotes oncentrati
T82311 11089-11097 CHEBI:31781;DG_23;CHEBI:31781 denotes of the
T83691 11139-11148 CHEBI:45409;DG_30;CHEBI:45409 denotes ibiting c
T88030 11199-11208 DG_30 denotes d. c EC50
T44757 11262-11272 CHEBI:38559;CHEBI:38559 denotes natant at
T36744 11273-11281 PR:000006130 denotes 8h post-
T52028 11294-11303 GO:0008152 denotes g10 TCID5
T54687 11304-11312 DG_23;CHEBI:31781;CHEBI:31781 denotes /mL). d
T76649 11335-11343 CHEBI:31781;DG_23;CHEBI:31781 denotes l RNA co
T97780 11344-11354 CHEBI:45409;DG_30;CHEBI:45409 denotes y numbers
T87785 11398-11406 CHEBI:31781;DG_23;CHEBI:31781 denotes (log10
T11110 11437-11445 DG_23 denotes l activi
T63922 11454-11463 DG_30 denotes desivir (
T16185 11497-11505 SP_10 denotes (C) and
T78721 11507-11515 SP_9 denotes metine d
T53151 11521-11525 NCBITaxon:10359 denotes chlo
T2474 11608-11616 DG_23 denotes left Y a
T57449 11618-11627 DG_30 denotes s) and vi
T12773 11648-11657 DG_29 denotes o the ATP
T33252 11688-11696 SP_10 denotes ubated w
T78439 11750-11754 SP_10 denotes f th
T936 11787-11793 GO:0016265 denotes Lopina
T68161 11829-11837 CHEBI:31781;DG_23;CHEBI:31781 denotes e FDA ap
T86117 11838-11847 DG_30 denotes roved HIV
T54426 11853-11862 CHEBI:28201;DG_29;CHEBI:28201 denotes tease inh
T37907 11902-11911 CHEBI:63580;DG_29;CHEBI:63580 denotes hibiting
T37066 11916-11931 CHEBI:50858;CHEBI:50858 denotes than ritonavir
T44440 11964-11972 CHEBI:31781;DG_23;CHEBI:31781 denotes lability
T37156 11973-11982 DG_30 denotes in vivo.
T44801 11999-12008 CHEBI:28201;DG_29;CHEBI:28201 denotes s not onl
T73155 12035-12045 SP_7 denotes he host's
T30112 12160-12168 CHEBI:31781;DG_23;CHEBI:31781 denotes ongs bio
T8788 12196-12205 DG_30 denotes vivo (Sh
T45388 12214-12224 SP_7 denotes , 1998). L
T60664 12296-12304 CHEBI:31781;DG_23;CHEBI:31781 denotes S-CoV, a
T66975 12319-12328 CHEBI:45409;DG_30;CHEBI:45409 denotes vitro, w
T58590 12363-12371 CHEBI:31781;DG_23;CHEBI:31781 denotes .1 μM (d
T44981 12372-12377 UBERON:0001977 denotes Wild
T26291 12454-12464 SP_7 denotes previously
T68715 12465-12470 NCBITaxon:10239 denotes to tr
T54255 12520-12528 CHEBI:31781;DG_23;CHEBI:31781 denotes cal tria
T75595 12529-12538 DG_30 denotes . Less SA
T61562 12583-12592 CHEBI:63580;DG_29;CHEBI:63580 denotes r receivi
T11964 12645-12653 SP_7 denotes rin than
T28138 12780-12788 DG_23 denotes hout rib
T48763 12789-12798 DG_30 denotes virin is
T39148 12814-12824 SP_7 denotes ted in SAR
T64325 12917-12922 NCBITaxon:10239 denotes rved
T55281 13037-13045 CHEBI:31781;DG_23;CHEBI:31781 denotes . HIV-1
T96841 13071-13081 CHEBI:36357;CHEBI:36357 denotes mg of lopi
T99060 13090-13100 SP_7 denotes 100 mg of
T88152 13101-13106 NCBITaxon:10239 denotes riton
T44182 13172-13180 CHEBI:31781;DG_23;CHEBI:31781 denotes on at 9.
T72471 13205-13210 NCBITaxon:3193 denotes hich
T64745 13211-13219 CHEBI:22315;CHEBI:22315 denotes s below
T26611 13233-13245 NCBITaxon:6073 denotes st SARS-CoV-
T1434 13307-13316 GO:0005840 denotes avir/rito
T32411 13343-13354 GO:0006412 denotes daily with
T6794 13411-13414 PR:000010240 denotes nt
T48388 13515-13523 CHEBI:25675;CHEBI:25675 denotes control
T38213 13615-13622 CL:0000763 denotes ients t
T13587 13697-13702 NCBITaxon:10239 denotes s, an
T15277 13720-13733 NCBITaxon:10376 denotes arious time p
T1610 13735-13744 NCBITaxon:10633 denotes nts were
T77817 13745-13751 NCBITaxon:7955 denotes ompara
T86923 13752-13757 NCBITaxon:10239 denotes le be
T67515 13759-13765 NCBITaxon:10376 denotes een th
T10202 13766-13779 NCBITaxon:10633 denotes two groups (
T94139 13779-13780 NCBITaxon:10376 denotes C
T48203 13783-13795 NCBITaxon:9258 denotes et al., 2020
T79664 13796-13801 NCBITaxon:10239 denotes . Com
T9654 13804-13817 NCBITaxon:11118 denotes ational thera
T35744 13819-13827 NCBITaxon:9258 denotes of lopi
T65756 13828-13844 NCBITaxon:28295 denotes avir with the ot
T24083 13845-13850 NCBITaxon:10239 denotes er ef
T54918 13855-13860 NCBITaxon:39107 denotes ve co
T96000 13861-13870 NCBITaxon:5690 denotes pounds ag
T39412 13871-13876 NCBITaxon:10376 denotes inst
T8595 13879-13892 NCBITaxon:7729 denotes S-CoV-2 virus
T92308 13894-13897 NCBITaxon:10298 denotes ay
T21045 13902-13908 NCBITaxon:9654 denotes ase sy
T91166 13909-13914 NCBITaxon:10376 denotes ergy
T40885 13927-13934 NCBITaxon:10239 denotes e inhib
T66636 13936-13945 NCBITaxon:5690 denotes ory conce
T31768 13946-13953 NCBITaxon:10376 denotes tration
T37390 13955-13965 NCBITaxon:6231 denotes f lopinavi
T2663 13966-13973 NCBITaxon:10376 denotes . Homoh
T77556 13974-13979 NCBITaxon:10239 denotes rring
T29223 13985-13994 NCBITaxon:33758 denotes is a pla
T31283 14087-14097 SP_7 denotes the ribos
T93027 14219-14227 CHEBI:25675;CHEBI:25675 denotes romote t
T87372 14286-14292 UBERON:0001969 denotes ng, 20
T51725 14452-14462 SP_7 denotes rted to ex
T24739 14463-14468 NCBITaxon:10239 denotes ibit
T90567 14492-14509 GO:0006412 denotes ty against herpes
T93899 14510-14519 CHEBI:48001;CHEBI:48001 denotes iruses (v
T72886 14542-14551 NCBITaxon:33317 denotes herpes si
T45099 14578-14588 NCBITaxon:5774 denotes virus), c
T23080 14634-14644 GO:0005840 denotes and murine
T62379 14655-14676 NCBITaxon:5833 denotes virus), rhabdoviruses
T45335 14884-14891 NCBITaxon:10376 denotes h EC50
T16969 14903-14907 NCBITaxon:7955 denotes Fig.
T42624 14908-14913 NCBITaxon:10376 denotes 1C an
T19146 14915-14925 NCBITaxon:10376 denotes Table 1).
T1785 14927-14938 NCBITaxon:6073 denotes evious phar
T71027 14940-14946 NCBITaxon:9654 denotes cokine
T80641 14947-14952 NCBITaxon:10376 denotes ic st
T1065 14961-14970 NCBITaxon:33758 denotes d that pa
T80588 14974-14981 NCBITaxon:9940 denotes ts trea
T69278 14982-14990 NCBITaxon:9258 denotes ed with
T72172 14992-14998 NCBITaxon:27592 denotes 25 mg/
T2968 14999-15013 NCBITaxon:5690 denotes 2 omacetaxine
T54511 15017-15022 NCBITaxon:9258 denotes y 12 
T78740 15027-15033 NCBITaxon:7656 denotes subcut
T6403 15034-15043 NCBITaxon:7729 denotes neous inj
T46358 15044-15049 NCBITaxon:10239 denotes ction
T13633 15051-15060 NCBITaxon:6231 denotes ay reach
T23133 15061-15075 NCBITaxon:10376 denotes he maximal pla
T36362 15077-15083 NCBITaxon:5690 denotes a conc
T95862 15084-15091 NCBITaxon:10633 denotes ntratio
T61572 15092-15097 NCBITaxon:10376 denotes at 2
T32709 15101-15114 NCBITaxon:7737 denotes ng/mL (0.046 
T13406 15116-15133 NCBITaxon:11588 denotes ) and 36.2 ng/mL
T29449 15134-15139 NCBITaxon:10239 denotes 0.066
T45591 15365-15373 SP_10 denotes obiasis;
T43407 15375-15383 SP_9 denotes t also i
T82680 15502-15509 CHEBI:4781;CHEBI:4781 denotes r, its
T37276 15552-15562 SP_7 denotes clinical
T28279 15563-15568 NCBITaxon:10239 denotes se in
T59877 15569-15580 GO:0006260 denotes the recent
T7884 15620-15626 UBERON:0001969 denotes activ
T97991 15644-15651 CHEBI:4781;CHEBI:4781 denotes d range
T95218 15747-15757 SP_7 denotes echovirus
T76476 15758-15763 NCBITaxon:10239 denotes 1, bu
T57941 15783-15789 UBERON:0001969 denotes ne her
T32842 15907-15915 CHEBI:36357;CHEBI:36357 denotes alley fe
T64232 15945-15951 UBERON:0001969 denotes rsen e
T31675 16007-16017 DG_28 denotes al., 2017;
T22483 16022-16029 CHEBI:4781;CHEBI:4781 denotes ibeny e
T81362 16040-16045 CHEBI:23888;CHEBI:23888 denotes ; Muk
T76761 16130-16140 DG_28 denotes oV-OC43, h
T68144 16155-16162 CHEBI:4781;CHEBI:4781 denotes CoV, ME
T55688 16192-16202 DG_28 denotes ith EC50 r
T44310 16234-16241 CHEBI:4781;CHEBI:4781 denotes (Dyall
T92471 16284-16289 NCBITaxon:10239 denotes ed em
T25817 16475-16484 CHEBI:36357;CHEBI:36357 denotes thal et a
T16528 16530-16540 DG_28 denotes S-CoV-2 vi
T77622 16694-16704 DG_28 denotes below the
T59146 16710-16717 CHEBI:4781;CHEBI:4781 denotes al ther
T84817 16718-16733 CHEBI:50488;CHEBI:50488 denotes peutic plasma c
T56857 16742-16752 SP_7 denotes ion, we ex
T93581 16753-16758 NCBITaxon:10239 denotes lored
T68962 16821-16831 DG_28 denotes rug intera
T2472 16846-16853 CHEBI:4781;CHEBI:4781 denotes ated us
T25544 16870-16874 CL_6 denotes ard
T44109 16903-16908 NCBITaxon:10239 denotes luted
T41082 16944-16949 NCBITaxon:10239 denotes –0.78
T33301 17012-17017 NCBITaxon:10239 denotes emet
T56781 17036-17042 CHEBI:23888;CHEBI:23888 denotes achie
T71099 17115-17125 DG_28 denotes Fig. 2 A).
T5687 17193-17203 DG_28 denotes et al., 2
T6946 17432-17437 CHEBI:23888;CHEBI:23888 denotes 4 (Fi
T444 17476-17486 DG_28 denotes remdesivir
T445 17491-17498 CHEBI:4781;CHEBI:4781 denotes emetine
T446 17499-17514 CHEBI:50488;CHEBI:50488 denotes dihydrochloride
T447 17523-17533 SP_7 denotes SARS-CoV-2
T448 17534-17539 NCBITaxon:10239 denotes virus
T449 17602-17612 DG_28 denotes remdesivir
T450 17627-17634 CHEBI:4781;CHEBI:4781 denotes emetine
T451 17651-17655 CL_6 denotes Vero
T452 17684-17689 NCBITaxon:10239 denotes viral
T453 17725-17730 NCBITaxon:10239 denotes viral
T454 17795-17800 NCBITaxon:10239 denotes viral
T455 17820-17824 CHEBI:23888;CHEBI:23888 denotes drug
T456 17898-17908 DG_28 denotes remdesivir
T457 17976-17986 DG_28 denotes remdesivir
T458 18215-18220 CHEBI:23888;CHEBI:23888 denotes drugs
T78166 18264-18273 CHEBI:36357;CHEBI:36357 denotes compounds
T49692 18315-18326 NCBITaxon:11118 denotes coronavirus
T59746 18330-18340 SP_7 denotes SARS-CoV-2
T93809 18341-18352 GO:0006260 denotes replication
T69492 18465-18475 SP_7 denotes SARS-CoV-2
T50491 18506-18512 UBERON:0001969 denotes plasma
T88361 18611-18620 CHEBI:36357;CHEBI:36357 denotes compounds
T75940 18633-18643 SP_7 denotes SARS-CoV-2
T33160 18644-18649 NCBITaxon:10239 denotes virus