PMC:7127009 / 11252-12729 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"367","span":{"begin":25,"end":28},"obj":"Gene"},{"id":"368","span":{"begin":100,"end":105},"obj":"Gene"},{"id":"369","span":{"begin":150,"end":155},"obj":"Gene"},{"id":"370","span":{"begin":315,"end":320},"obj":"Gene"},{"id":"371","span":{"begin":524,"end":551},"obj":"Gene"},{"id":"372","span":{"begin":948,"end":979},"obj":"Gene"},{"id":"373","span":{"begin":981,"end":985},"obj":"Gene"},{"id":"374","span":{"begin":1022,"end":1026},"obj":"Gene"},{"id":"375","span":{"begin":1042,"end":1046},"obj":"Gene"},{"id":"376","span":{"begin":1362,"end":1366},"obj":"Gene"},{"id":"377","span":{"begin":759,"end":764},"obj":"Gene"},{"id":"378","span":{"begin":122,"end":130},"obj":"Species"},{"id":"379","span":{"begin":227,"end":236},"obj":"Species"},{"id":"380","span":{"begin":285,"end":293},"obj":"Species"},{"id":"381","span":{"begin":376,"end":385},"obj":"Species"},{"id":"382","span":{"begin":484,"end":492},"obj":"Species"},{"id":"383","span":{"begin":714,"end":723},"obj":"Species"},{"id":"384","span":{"begin":1467,"end":1475},"obj":"Species"},{"id":"385","span":{"begin":631,"end":634},"obj":"Gene"},{"id":"386","span":{"begin":423,"end":434},"obj":"Chemical"},{"id":"387","span":{"begin":988,"end":999},"obj":"Chemical"},{"id":"388","span":{"begin":1261,"end":1272},"obj":"Chemical"},{"id":"389","span":{"begin":237,"end":246},"obj":"Disease"},{"id":"390","span":{"begin":400,"end":419},"obj":"Disease"},{"id":"391","span":{"begin":463,"end":483},"obj":"Disease"},{"id":"392","span":{"begin":1427,"end":1439},"obj":"Disease"},{"id":"393","span":{"begin":1458,"end":1466},"obj":"Disease"}],"attributes":[{"id":"A367","pred":"tao:has_database_id","subj":"367","obj":"Gene:3552"},{"id":"A368","pred":"tao:has_database_id","subj":"368","obj":"Gene:114548"},{"id":"A369","pred":"tao:has_database_id","subj":"369","obj":"Gene:3552"},{"id":"A370","pred":"tao:has_database_id","subj":"370","obj":"Gene:3552"},{"id":"A371","pred":"tao:has_database_id","subj":"371","obj":"Gene:3716"},{"id":"A372","pred":"tao:has_database_id","subj":"372","obj":"Gene:22848"},{"id":"A373","pred":"tao:has_database_id","subj":"373","obj":"Gene:22848"},{"id":"A374","pred":"tao:has_database_id","subj":"374","obj":"Gene:22848"},{"id":"A375","pred":"tao:has_database_id","subj":"375","obj":"Gene:22848"},{"id":"A376","pred":"tao:has_database_id","subj":"376","obj":"Gene:22848"},{"id":"A377","pred":"tao:has_database_id","subj":"377","obj":"Gene:43740568"},{"id":"A378","pred":"tao:has_database_id","subj":"378","obj":"Tax:694009"},{"id":"A379","pred":"tao:has_database_id","subj":"379","obj":"Tax:2697049"},{"id":"A380","pred":"tao:has_database_id","subj":"380","obj":"Tax:9606"},{"id":"A381","pred":"tao:has_database_id","subj":"381","obj":"Tax:2697049"},{"id":"A382","pred":"tao:has_database_id","subj":"382","obj":"Tax:9606"},{"id":"A383","pred":"tao:has_database_id","subj":"383","obj":"Tax:2697049"},{"id":"A384","pred":"tao:has_database_id","subj":"384","obj":"Tax:9606"},{"id":"A385","pred":"tao:has_database_id","subj":"385","obj":"Gene:3439"},{"id":"A386","pred":"tao:has_database_id","subj":"386","obj":"MESH:C000596027"},{"id":"A387","pred":"tao:has_database_id","subj":"387","obj":"MESH:C000596027"},{"id":"A388","pred":"tao:has_database_id","subj":"388","obj":"MESH:C000596027"},{"id":"A389","pred":"tao:has_database_id","subj":"389","obj":"MESH:D007239"},{"id":"A390","pred":"tao:has_database_id","subj":"390","obj":"MESH:D012140"},{"id":"A391","pred":"tao:has_database_id","subj":"391","obj":"MESH:D001172"},{"id":"A392","pred":"tao:has_database_id","subj":"392","obj":"MESH:D007249"},{"id":"A393","pred":"tao:has_database_id","subj":"393","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T62","span":{"begin":26,"end":29},"obj":"Body_part"},{"id":"T63","span":{"begin":151,"end":155},"obj":"Body_part"},{"id":"T64","span":{"begin":151,"end":153},"obj":"Body_part"},{"id":"T65","span":{"begin":276,"end":281},"obj":"Body_part"},{"id":"T66","span":{"begin":310,"end":315},"obj":"Body_part"},{"id":"T67","span":{"begin":316,"end":320},"obj":"Body_part"},{"id":"T68","span":{"begin":316,"end":318},"obj":"Body_part"},{"id":"T69","span":{"begin":735,"end":742},"obj":"Body_part"},{"id":"T70","span":{"begin":805,"end":810},"obj":"Body_part"},{"id":"T71","span":{"begin":964,"end":971},"obj":"Body_part"},{"id":"T72","span":{"begin":1238,"end":1244},"obj":"Body_part"}],"attributes":[{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T9","span":{"begin":310,"end":315},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T98","span":{"begin":123,"end":131},"obj":"Disease"},{"id":"T99","span":{"begin":123,"end":127},"obj":"Disease"},{"id":"T100","span":{"begin":228,"end":232},"obj":"Disease"},{"id":"T101","span":{"begin":238,"end":247},"obj":"Disease"},{"id":"T102","span":{"begin":377,"end":381},"obj":"Disease"},{"id":"T103","span":{"begin":401,"end":420},"obj":"Disease"},{"id":"T104","span":{"begin":464,"end":484},"obj":"Disease"},{"id":"T105","span":{"begin":475,"end":484},"obj":"Disease"},{"id":"T106","span":{"begin":715,"end":719},"obj":"Disease"},{"id":"T107","span":{"begin":1428,"end":1440},"obj":"Disease"},{"id":"T108","span":{"begin":1459,"end":1467},"obj":"Disease"}],"attributes":[{"id":"A98","pred":"mondo_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A99","pred":"mondo_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A100","pred":"mondo_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A101","pred":"mondo_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A102","pred":"mondo_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0005087"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0008383"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0005578"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T97","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T98","span":{"begin":83,"end":93},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T99","span":{"begin":202,"end":212},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T100","span":{"begin":276,"end":281},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T101","span":{"begin":512,"end":513},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T102","span":{"begin":592,"end":601},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T103","span":{"begin":636,"end":645},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T104","span":{"begin":699,"end":706},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T105","span":{"begin":733,"end":734},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T106","span":{"begin":805,"end":810},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T107","span":{"begin":819,"end":820},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T108","span":{"begin":929,"end":930},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T109","span":{"begin":1001,"end":1004},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T110","span":{"begin":1147,"end":1152},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T111","span":{"begin":1212,"end":1217},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T112","span":{"begin":1238,"end":1244},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T68","span":{"begin":151,"end":153},"obj":"Chemical"},{"id":"T70","span":{"begin":316,"end":318},"obj":"Chemical"},{"id":"T72","span":{"begin":445,"end":449},"obj":"Chemical"},{"id":"T73","span":{"begin":629,"end":631},"obj":"Chemical"},{"id":"T74","span":{"begin":735,"end":742},"obj":"Chemical"},{"id":"T75","span":{"begin":964,"end":971},"obj":"Chemical"}],"attributes":[{"id":"A68","pred":"chebi_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A69","pred":"chebi_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A70","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A71","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T11","span":{"begin":138,"end":147},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T12","span":{"begin":592,"end":601},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T13","span":{"begin":636,"end":645},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T14","span":{"begin":834,"end":863},"obj":"http://purl.obolibrary.org/obo/GO_0006898"},{"id":"T15","span":{"begin":852,"end":863},"obj":"http://purl.obolibrary.org/obo/GO_0006897"},{"id":"T16","span":{"begin":882,"end":925},"obj":"http://purl.obolibrary.org/obo/GO_0048259"},{"id":"T17","span":{"begin":896,"end":925},"obj":"http://purl.obolibrary.org/obo/GO_0006898"},{"id":"T18","span":{"begin":914,"end":925},"obj":"http://purl.obolibrary.org/obo/GO_0006897"},{"id":"T19","span":{"begin":1072,"end":1109},"obj":"http://purl.obolibrary.org/obo/GO_0048261"},{"id":"T20","span":{"begin":1080,"end":1109},"obj":"http://purl.obolibrary.org/obo/GO_0006898"},{"id":"T21","span":{"begin":1098,"end":1109},"obj":"http://purl.obolibrary.org/obo/GO_0006897"},{"id":"T22","span":{"begin":1428,"end":1440},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T25","span":{"begin":464,"end":484},"obj":"Phenotype"}],"attributes":[{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0001370"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"LitCovid-sentences","denotations":[{"id":"T66","span":{"begin":0,"end":157},"obj":"Sentence"},{"id":"T67","span":{"begin":158,"end":327},"obj":"Sentence"},{"id":"T68","span":{"begin":328,"end":646},"obj":"Sentence"},{"id":"T69","span":{"begin":647,"end":864},"obj":"Sentence"},{"id":"T70","span":{"begin":865,"end":988},"obj":"Sentence"},{"id":"T71","span":{"begin":989,"end":1028},"obj":"Sentence"},{"id":"T72","span":{"begin":1029,"end":1233},"obj":"Sentence"},{"id":"T73","span":{"begin":1234,"end":1477},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T222","span":{"begin":101,"end":106},"obj":"PR:000011271"},{"id":"T223","span":{"begin":123,"end":131},"obj":"SP_10"},{"id":"T224","span":{"begin":189,"end":212},"obj":"GO:0002437"},{"id":"T225","span":{"begin":228,"end":237},"obj":"SP_7"},{"id":"T226","span":{"begin":267,"end":281},"obj":"CL:0000542"},{"id":"T227","span":{"begin":310,"end":315},"obj":"UBERON:0001977"},{"id":"T228","span":{"begin":316,"end":321},"obj":"PR:000001136"},{"id":"T229","span":{"begin":377,"end":386},"obj":"SP_7"},{"id":"T230","span":{"begin":401,"end":412},"obj":"UBERON:0001004"},{"id":"T231","span":{"begin":424,"end":435},"obj":"DG_41"},{"id":"T232","span":{"begin":440,"end":444},"obj":"UBERON:0000165"},{"id":"T233","span":{"begin":445,"end":449},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T234","span":{"begin":578,"end":591},"obj":"GO:0005622;GO:0035556"},{"id":"T235","span":{"begin":592,"end":601},"obj":"GO:0035556"},{"id":"T236","span":{"begin":632,"end":635},"obj":"GO:0035556"},{"id":"T237","span":{"begin":636,"end":645},"obj":"GO:0008543"},{"id":"T238","span":{"begin":699,"end":706},"obj":"NCBITaxon:10239"},{"id":"T239","span":{"begin":715,"end":724},"obj":"SP_7"},{"id":"T240","span":{"begin":743,"end":752},"obj":"GO:0010467"},{"id":"T241","span":{"begin":781,"end":785},"obj":"G_3;PG_10;PR:000003622"},{"id":"T242","span":{"begin":799,"end":810},"obj":"CL:0000584"},{"id":"T243","span":{"begin":852,"end":863},"obj":"GO:0006898"},{"id":"T244","span":{"begin":914,"end":925},"obj":"GO:0048259"},{"id":"T245","span":{"begin":949,"end":980},"obj":"PR:000003526"},{"id":"T246","span":{"begin":982,"end":986},"obj":"PR:000003526"},{"id":"T247","span":{"begin":989,"end":1000},"obj":"CHEBI:3213;DG_41;CHEBI:3213"},{"id":"T248","span":{"begin":1023,"end":1027},"obj":"PR:000003526"},{"id":"T249","span":{"begin":1043,"end":1047},"obj":"PR:000003526"},{"id":"T250","span":{"begin":1098,"end":1109},"obj":"GO:0006898"},{"id":"T251","span":{"begin":1120,"end":1133},"obj":"GO:0005622;GO:0035376"},{"id":"T252","span":{"begin":1134,"end":1139},"obj":"GO:0035376"},{"id":"T253","span":{"begin":1147,"end":1152},"obj":"NCBITaxon:10239"},{"id":"T254","span":{"begin":1186,"end":1199},"obj":"GO:0005622;GO:0046907"},{"id":"T255","span":{"begin":1200,"end":1208},"obj":"GO:0046907"},{"id":"T256","span":{"begin":1212,"end":1217},"obj":"NCBITaxon:10239"},{"id":"T257","span":{"begin":1238,"end":1244},"obj":"UBERON:0001969"},{"id":"T258","span":{"begin":1262,"end":1273},"obj":"DG_41"},{"id":"T259","span":{"begin":1363,"end":1367},"obj":"PR:000003526"},{"id":"T260","span":{"begin":1408,"end":1413},"obj":"NCBITaxon:10239;GO:0035376"},{"id":"T261","span":{"begin":1414,"end":1419},"obj":"GO:0035376"},{"id":"T262","span":{"begin":1459,"end":1467},"obj":"SP_7"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}

{"project":"2_test","denotations":[{"id":"32253068-32143990-55639823","span":{"begin":322,"end":324},"obj":"32143990"}],"text":"A potential role for anti-IL1 biologics could be hypothesized from data showing an activation of the NLRP3 inflammasome by SARS-CoV, with secretion of IL-1β. Studies have demonstrated that inflammasome activation also occurs in SARS-CoV2 infection, especially within lymphoid cells and patients have increased serum IL-1β [14]. Another potential treatment under evaluation for SARS-CoV2 related acute respiratory disease is baricitinib, an oral drug used to treat rheumatoid arthritis patients that functions as a blocker of Janus Kinases (JAK) 1 and 2, enzymes associated with intracellular signaling, including Type I and type II IFN signaling. One rationale for its use is based on the fact that viruses such as SARS-CoV2 utilize a protein expressed on its spike to bind to the ACE2 receptor and enter cells through a mechanism of receptor-mediated endocytosis. One of the known regulators of receptor mediated endocytosis is a kinase termed the AP2-associated protein kinase 1 (AAK1). Baricitinib has high affinity for AAK1. Inhibition of AAK1 is reasoned to not only inhibit receptor mediated endocytosis (blocking intracellular entry of the virus) but it may also function in the intracellular assembly of virus particles [15]. The plasma concentration of baricitinib at its current therapeutic dosage (2 or 4 mg orally once daily) is sufficient to inhibit AAK1, thus it may be able to reduce both the viral entry and the inflammation characteristic of CoViD-19 patients."}