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PMC:7121452 / 7672-8985 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
259 253-257 Gene denotes ACE2 Gene:59272
260 419-423 Gene denotes ACE2 Gene:59272
261 534-538 Gene denotes ACE2 Gene:59272
262 713-717 Gene denotes ACE2 Gene:59272
263 810-813 Gene denotes ACE Gene:1636
264 889-893 Gene denotes ACE2 Gene:59272
265 995-999 Gene denotes ACE2 Gene:59272
266 1171-1176 Gene denotes spike Gene:43740568
267 198-203 Species denotes human Tax:9606
268 931-937 Species denotes humans Tax:9606
269 1160-1170 Species denotes SARS-CoV-2 Tax:2697049
270 1217-1223 Species denotes humans Tax:9606
271 1281-1291 Species denotes SARS-CoV-2 Tax:2697049

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T25 412-418 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T26 740-746 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T27 861-865 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T28 1039-1045 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T29 1177-1184 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T14 740-746 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T15 861-865 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T16 1039-1045 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T28 1160-1168 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 1281-1289 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T70 198-203 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T71 357-358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 376-378 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T73 412-418 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T74 441-442 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 469-477 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T76 497-505 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T77 556-564 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T78 566-567 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 861-865 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T80 861-865 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T81 910-916 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T82 931-937 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T83 1010-1018 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T84 1217-1223 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T82 306-316 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T83 365-369 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T84 452-461 Chemical denotes indicator http://purl.obolibrary.org/obo/CHEBI_47867
T85 633-642 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T86 810-824 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T87 814-824 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T88 847-857 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T89 977-987 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T90 1177-1184 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T29 0-215 Sentence denotes These seemingly conflicting data indicate the complexity underlying RAAS responses to pathway modulators and reinforce the concept that findings from preclinical models may not readily translate to human physiology.
T30 216-766 Sentence denotes Such data do suggest that effects on ACE2 should not be assumed to be uniform across RAAS inhibitors or even in response to therapies within a given drug class.41 It is important to note that the plasma ACE2 level may not be a reliable indicator of the activity of the full-length membrane-bound form, in part because ACE2 is shed from the membrane, a process that appears to be separately regulated by an endogenous inhibitor.42 In addition to the degree of expression, the biologic relevance of ACE2 may vary according to tissue and clinical state.
T31 767-950 Sentence denotes Unfortunately, data showing the effects of ACE inhibitors, ARBs, and other RAAS inhibitors on lung-specific expression of ACE2 in experimental animal models and in humans are lacking.
T32 951-1185 Sentence denotes Furthermore, even if RAAS inhibitors modify ACE2 levels or activity (or both) in target tissue beds, clinical data are lacking to indicate whether this would in turn facilitate greater engagement and entry of SARS-CoV-2 spike protein.
T33 1186-1313 Sentence denotes Further mechanistic studies in humans are needed to better define the unique interplay between SARS-CoV-2 and the RAAS network.

2_test

Id Subject Object Predicate Lexical cue
32227760-24842388-75177429 376-378 24842388 denotes 41
32227760-15983030-75177430 643-645 15983030 denotes 42