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PMC:7121452 / 75-17415 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
21 404-435 Gene denotes angiotensin-converting enzyme 2 Gene:59272
22 437-441 Gene denotes ACE2 Gene:59272
23 604-608 Gene denotes ACE2 Gene:59272
24 745-749 Gene denotes ACE2 Gene:59272
25 775-779 Gene denotes ACE2 Gene:59272
26 971-974 Gene denotes ACE Gene:1636
27 127-132 Species denotes human Tax:9606
28 145-190 Species denotes Severe acute respiratory syndrome coronavirus Tax:694009
29 194-202 Species denotes SARS-CoV Tax:694009
30 210-220 Species denotes SARS-CoV-2 Tax:2697049
31 22-33 Chemical denotes aldosterone MESH:D000450
32 312-336 Disease denotes coronavirus disease 2019 MESH:C000657245
33 338-346 Disease denotes Covid-19 MESH:C000657245
34 855-863 Disease denotes Covid-19 MESH:C000657245
35 1082-1090 Disease denotes Covid-19 MESH:C000657245
47 1116-1119 Gene denotes ACE Gene:1636
48 1410-1414 Gene denotes ACE2 Gene:59272
49 1492-1496 Gene denotes ACE2 Gene:59272
50 1189-1197 Species denotes patients Tax:9606
51 1268-1274 Species denotes humans Tax:9606
52 1438-1444 Species denotes humans Tax:9606
53 1538-1546 Species denotes patients Tax:9606
54 1673-1681 Species denotes patients Tax:9606
55 1203-1211 Disease denotes Covid-19 MESH:C000657245
56 1552-1563 Disease denotes lung injury MESH:D055370
57 1706-1714 Disease denotes Covid-19 MESH:C000657245
59 1717-1725 Disease denotes Covid-19 MESH:C000657245
68 1869-1877 Species denotes patients Tax:9606
69 2159-2167 Species denotes patients Tax:9606
70 1850-1862 Disease denotes hypertension MESH:D006973
71 1883-1891 Disease denotes Covid-19 MESH:C000657245
72 1977-1985 Disease denotes Covid-19 MESH:C000657245
73 2095-2107 Disease denotes hypertension MESH:D006973
74 2283-2295 Disease denotes hypertension MESH:D006973
75 2312-2328 Disease denotes viral infections MESH:D001102
85 2479-2487 Species denotes patients Tax:9606
86 2625-2633 Species denotes patients Tax:9606
87 2409-2421 Disease denotes hypertension MESH:D006973
88 2493-2501 Disease denotes Covid-19 MESH:C000657245
89 2609-2613 Disease denotes died MESH:D003643
90 2956-2964 Disease denotes Covid-19 MESH:C000657245
91 2973-2978 Disease denotes death MESH:D003643
92 3205-3217 Disease denotes hypertension MESH:D006973
93 3301-3309 Disease denotes Covid-19 MESH:C000657245
101 3528-3536 Species denotes patients Tax:9606
102 3694-3702 Species denotes patients Tax:9606
103 3750-3758 Species denotes patients Tax:9606
104 4018-4026 Species denotes patients Tax:9606
105 3555-3567 Disease denotes hypertension MESH:D006973
106 3764-3772 Disease denotes Covid-19 MESH:C000657245
107 4032-4040 Disease denotes Covid-19 MESH:C000657245
109 4094-4098 Gene denotes ACE2 Gene:59272
125 4260-4264 Gene denotes ACE2 Gene:59272
126 4313-4327 Gene denotes angiotensin II Gene:183
127 4444-4458 Gene denotes angiotensin II Gene:183
128 4487-4491 Gene denotes ACE2 Gene:59272
129 4518-4531 Gene denotes angiotensin I Gene:183
130 4677-4681 Gene denotes ACE2 Gene:59272
131 4916-4920 Gene denotes ACE2 Gene:59272
132 4956-4960 Gene denotes ACE2 Gene:59272
133 4623-4629 Species denotes humans Tax:9606
134 4785-4795 Species denotes SARS-CoV-2 Tax:2697049
135 4403-4409 Chemical denotes sodium MESH:D012964
136 4535-4552 Chemical denotes angiotensin-(1–9)
137 4597-4605 Chemical denotes peptides MESH:D010455
138 4425-4433 Disease denotes fibrosis MESH:D005355
139 4813-4828 Disease denotes dominant injury MESH:D014947
152 5093-5096 Gene denotes ACE Gene:1636
153 5143-5157 Gene denotes angiotensin II Gene:183
154 5184-5188 Gene denotes ACE2 Gene:59272
155 5221-5225 Gene denotes ACE2 Gene:59272
156 5324-5327 Gene denotes ACE Gene:1636
157 5332-5336 Gene denotes ACE2 Gene:59272
158 5391-5394 Gene denotes ACE Gene:1636
159 5445-5449 Gene denotes ACE2 Gene:59272
160 5546-5549 Gene denotes ACE Gene:1636
161 5564-5568 Gene denotes ACE2 Gene:59272
162 5699-5703 Gene denotes ACE2 Gene:59272
163 5792-5796 Gene denotes ACE2 Gene:59272
205 5963-5967 Gene denotes ACE2 Gene:59272
206 6028-6031 Gene denotes ACE Gene:1636
207 6175-6178 Gene denotes ACE Gene:1636
208 6217-6221 Gene denotes ACE2 Gene:59272
209 6407-6410 Gene denotes ACE Gene:1636
210 6591-6595 Gene denotes ACE2 Gene:59272
211 6616-6620 Gene denotes ACE2 Gene:59272
212 6848-6852 Gene denotes ACE2 Gene:59272
213 6908-6911 Gene denotes ACE Gene:1636
214 7048-7052 Gene denotes ACE2 Gene:59272
215 7230-7233 Gene denotes ACE Gene:1636
216 7352-7355 Gene denotes ACE Gene:1636
217 7432-7436 Gene denotes ACE2 Gene:59272
218 7591-7595 Gene denotes ACE2 Gene:59272
219 6231-6245 Gene denotes angiotensin II Gene:183
220 5912-5918 Species denotes humans Tax:9606
221 6046-6054 Species denotes patients Tax:9606
222 6295-6303 Species denotes patients Tax:9606
223 6631-6639 Species denotes patients Tax:9606
224 6737-6745 Species denotes patients Tax:9606
225 6883-6891 Species denotes patients Tax:9606
226 6952-6960 Species denotes patients Tax:9606
227 7012-7020 Species denotes patients Tax:9606
228 7078-7086 Species denotes patients Tax:9606
229 7173-7181 Species denotes patients Tax:9606
230 6421-6430 Chemical denotes captopril MESH:D002216
231 6458-6467 Chemical denotes captopril MESH:D002216
232 7133-7143 Chemical denotes olmesartan MESH:C437965
233 7234-7243 Chemical denotes inhibitor
234 7244-7253 Chemical denotes enalapril MESH:D004656
235 7274-7282 Chemical denotes losartan MESH:D019808
236 7284-7295 Chemical denotes candesartan MESH:C081643
237 7297-7306 Chemical denotes valsartan MESH:D000068756
238 7312-7323 Chemical denotes telmisartan MESH:D000077333
239 6060-6083 Disease denotes coronary artery disease MESH:D003324
240 6309-6321 Disease denotes hypertension MESH:D006973
241 6751-6764 Disease denotes heart failure MESH:D006333
242 6768-6787 Disease denotes atrial fibrillation MESH:D001281
243 6791-6806 Disease denotes aortic stenosis MESH:D001024
244 6814-6837 Disease denotes coronary artery disease MESH:D003324
245 7026-7038 Disease denotes hypertension MESH:D006973
259 7850-7854 Gene denotes ACE2 Gene:59272
260 8016-8020 Gene denotes ACE2 Gene:59272
261 8131-8135 Gene denotes ACE2 Gene:59272
262 8310-8314 Gene denotes ACE2 Gene:59272
263 8407-8410 Gene denotes ACE Gene:1636
264 8486-8490 Gene denotes ACE2 Gene:59272
265 8592-8596 Gene denotes ACE2 Gene:59272
266 8768-8773 Gene denotes spike Gene:43740568
267 7795-7800 Species denotes human Tax:9606
268 8528-8534 Species denotes humans Tax:9606
269 8757-8767 Species denotes SARS-CoV-2 Tax:2697049
270 8814-8820 Species denotes humans Tax:9606
271 8878-8888 Species denotes SARS-CoV-2 Tax:2697049
273 8971-8979 Disease denotes Covid-19 MESH:C000657245
306 9038-9042 Gene denotes ACE2 Gene:59272
307 9082-9086 Gene denotes ACE2 Gene:59272
308 9218-9232 Gene denotes angiotensin II Gene:183
309 9347-9352 Gene denotes spike Gene:43740568
310 9401-9405 Gene denotes ACE2 Gene:59272
311 9509-9513 Gene denotes ACE2 Gene:59272
312 9584-9588 Gene denotes ACE2 Gene:59272
313 9724-9738 Gene denotes angiotensin II Gene:183
314 9840-9845 Gene denotes spike Gene:43740568
315 9974-9978 Gene denotes ACE2 Gene:70008
316 10184-10198 Gene denotes angiotensin II Gene:183
317 10296-10300 Gene denotes ACE2 Gene:59272
318 10343-10347 Gene denotes ACE2 Gene:59272
319 10477-10491 Gene denotes angiotensin II Gene:183
320 8980-8990 Species denotes SARS-CoV-2 Tax:2697049
321 9336-9346 Species denotes SARS-CoV-2 Tax:2697049
322 9803-9808 Species denotes mouse Tax:10090
323 9829-9837 Species denotes SARS-CoV Tax:694009
324 9924-9929 Species denotes mouse Tax:10090
325 10069-10096 Species denotes respiratory syncytial virus Tax:12814
326 10118-10126 Species denotes patients Tax:9606
327 10568-10574 Species denotes humans Tax:9606
328 9273-9285 Disease denotes organ injury MESH:D009102
329 9289-9297 Disease denotes Covid-19 MESH:C000657245
330 9446-9461 Disease denotes viral infection MESH:D001102
331 9868-9879 Disease denotes lung injury MESH:D055370
332 9991-10008 Disease denotes acute lung injury MESH:D055371
333 10132-10140 Disease denotes Covid-19 MESH:C000657245
334 10266-10277 Disease denotes lung injury MESH:D055370
335 10385-10396 Disease denotes lung-injury MESH:D055370
336 10436-10452 Disease denotes viral infections MESH:D001102
337 10529-10564 Disease denotes acute respiratory distress syndrome MESH:D012128
362 10591-10595 Gene denotes ACE2 Gene:59272
363 11060-11064 Gene denotes ACE2 Gene:59272
364 11150-11154 Gene denotes ACE2 Gene:59272
365 11270-11284 Gene denotes angiotensin II Gene:183
366 11430-11434 Gene denotes ACE2 Gene:59272
367 11487-11491 Gene denotes ACE2 Gene:59272
368 11503-11517 Gene denotes angiotensin II Gene:183
369 11665-11669 Gene denotes ACE2 Gene:59272
370 11304-11312 Species denotes patients Tax:9606
371 11528-11533 Species denotes human Tax:9606
372 11912-11920 Species denotes patients Tax:9606
373 11849-11857 Chemical denotes losartan MESH:D019808
374 10731-10739 Disease denotes Covid-19 MESH:C000657245
375 10752-10769 Disease denotes myocardial injury MESH:D009202
376 10830-10838 Disease denotes Covid-19 MESH:C000657245
377 10907-10912 Disease denotes death MESH:D003643
378 10969-10980 Disease denotes myocarditis MESH:D009205
379 11001-11008 Disease denotes viremia MESH:D014766
380 11209-11231 Disease denotes ventricular remodeling MESH:D020257
381 11247-11259 Disease denotes acute injury MESH:D000208
382 11317-11321 Disease denotes died MESH:D003643
383 11556-11578 Disease denotes dilated cardiomyopathy MESH:D002311
384 11764-11776 Disease denotes organ injury MESH:D009102
385 11877-11885 Disease denotes Covid-19 MESH:C000657245
387 12119-12127 Disease denotes Covid-19 MESH:C000657245
399 12214-12218 Gene denotes ACE2 Gene:59272
400 12252-12262 Species denotes SARS-CoV-2 Tax:2697049
401 12346-12354 Species denotes patients Tax:9606
402 12421-12429 Species denotes patients Tax:9606
403 12493-12501 Species denotes patients Tax:9606
404 12770-12778 Species denotes patients Tax:9606
405 12386-12394 Disease denotes Covid-19 MESH:C000657245
406 12446-12469 Disease denotes cardiovascular diseases MESH:D002318
407 12510-12527 Disease denotes myocardial injury MESH:D009202
408 12540-12557 Disease denotes myocardial stress MESH:D000079225
409 12565-12579 Disease denotes cardiomyopathy MESH:D009202
428 12942-12950 Species denotes patients Tax:9606
429 13052-13060 Species denotes patients Tax:9606
430 13222-13230 Species denotes patients Tax:9606
431 13628-13636 Species denotes patients Tax:9606
432 13015-13024 Chemical denotes Quinapril MESH:D000077583
433 13115-13124 Chemical denotes quinapril MESH:D000077583
434 12798-12811 Disease denotes heart failure MESH:D006333
435 12907-12920 Disease denotes heart failure MESH:D006333
436 12927-12941 Disease denotes critically ill MESH:D016638
437 12956-12964 Disease denotes Covid-19 MESH:C000657245
438 13086-13099 Disease denotes heart failure MESH:D006333
439 13188-13195 Disease denotes TRED-HF
440 13236-13249 Disease denotes heart failure MESH:D006333
441 13399-13421 Disease denotes dilated cardiomyopathy MESH:D002311
442 13489-13510 Disease denotes myocardial infarction MESH:D009203
443 13609-13618 Disease denotes mortality MESH:D003643
444 13668-13685 Disease denotes myocardial injury MESH:D009202
445 13702-13710 Disease denotes Covid-19 MESH:C000657245
451 14162-14169 Species denotes patient Tax:9606
452 14357-14364 Species denotes patient Tax:9606
453 14580-14588 Species denotes patients Tax:9606
454 13861-13873 Disease denotes hypertension MESH:D006973
455 14594-14602 Disease denotes Covid-19 MESH:C000657245
466 14870-14878 Species denotes patients Tax:9606
467 14994-15002 Species denotes patients Tax:9606
468 15083-15091 Species denotes patients Tax:9606
469 15167-15175 Species denotes patients Tax:9606
470 15264-15272 Species denotes patients Tax:9606
471 14884-14906 Disease denotes chronic kidney disease MESH:D051436
472 14943-14957 Disease denotes kidney disease MESH:D007674
473 15008-15016 Disease denotes Covid-19 MESH:C000657245
474 15100-15114 Disease denotes critically ill MESH:D016638
475 15200-15219 Disease denotes acute kidney injury MESH:D058186
482 15596-15600 Gene denotes ACE2 Gene:59272
483 15730-15738 Species denotes patients Tax:9606
484 15988-15996 Species denotes patients Tax:9606
485 15681-15689 Disease denotes Covid-19 MESH:C000657245
486 15823-15831 Disease denotes Covid-19 MESH:C000657245
487 16002-16010 Disease denotes Covid-19 MESH:C000657245
490 16294-16305 Chemical denotes Aldosterone MESH:D000450
491 16259-16267 Disease denotes Covid-19 MESH:C000657245
495 16315-16319 Gene denotes ACE2 Gene:59272
496 16408-16418 Species denotes SARS-CoV-2 Tax:2697049
497 16450-16458 Disease denotes Covid-19 MESH:C000657245
501 16546-16550 Gene denotes ACE2 Gene:59272
502 16606-16614 Species denotes patients Tax:9606
503 16620-16628 Disease denotes Covid-19 MESH:C000657245
506 16724-16730 Species denotes humans Tax:9606
507 16796-16804 Disease denotes Covid-19 MESH:C000657245
512 16917-16921 Gene denotes ACE2 Gene:59272
513 16911-16916 Species denotes human Tax:9606
514 16934-16942 Chemical denotes losartan MESH:D019808
515 16946-16954 Disease denotes Covid-19 MESH:C000657245
519 17007-17015 Species denotes patients Tax:9606
520 17042-17055 Disease denotes heart failure MESH:D006333
521 17068-17089 Disease denotes myocardial infarction MESH:D009203
524 17243-17251 Species denotes patients Tax:9606
525 17332-17340 Disease denotes Covid-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1552-1556 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T2 2026-2034 Body_part denotes Appendix http://purl.org/sig/ont/fma/fma14542
T3 4109-4115 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T4 4631-4637 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T5 4721-4726 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T6 4731-4738 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T7 4775-4780 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T8 4835-4839 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T9 4840-4865 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T10 4860-4865 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T11 4968-4973 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T12 5591-5597 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T13 5746-5759 Body_part denotes messenger RNA http://purl.org/sig/ont/fma/fma67122
T14 5756-5759 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T15 5774-5781 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 6060-6075 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T17 6584-6590 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T18 6751-6756 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T19 6814-6829 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T20 6841-6847 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T21 7397-7407 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T22 7408-7421 Body_part denotes messenger RNA http://purl.org/sig/ont/fma/fma67122
T23 7418-7421 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T24 7563-7567 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T25 8009-8015 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T26 8337-8343 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T27 8458-8462 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T28 8636-8642 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T29 8774-8781 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 9273-9278 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T31 9353-9360 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T32 9419-9432 Body_part denotes cell surfaces http://purl.org/sig/ont/fma/fma67653
T33 9419-9423 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T34 9556-9561 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T35 9605-9610 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T36 9635-9645 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T37 9846-9853 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 9868-9872 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T39 9997-10001 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T40 10177-10183 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T41 10266-10270 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T42 10385-10389 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T43 11340-11345 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T44 11383-11386 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T45 11435-11442 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 11670-11677 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T47 11764-11769 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T48 12680-12686 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T49 12691-12701 Body_part denotes myocardium http://purl.org/sig/ont/fma/fma9462
T50 12798-12803 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T51 12907-12912 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T52 13025-13030 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088
T53 13086-13091 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T54 13236-13241 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T55 14230-14235 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T56 14414-14419 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T57 14706-14711 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T58 14892-14898 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T59 14943-14949 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T60 15206-15212 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T61 17042-17047 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1552-1556 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 4109-4115 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 4631-4637 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T4 4654-4660 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T5 4721-4726 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T6 4835-4839 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 5591-5597 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T8 6060-6075 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T9 6069-6075 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T10 6751-6756 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T11 6814-6829 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T12 6823-6829 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T13 7563-7567 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T14 8337-8343 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T15 8458-8462 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T16 8636-8642 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T17 9160-9166 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T18 9273-9278 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T19 9868-9872 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T20 9997-10001 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T21 10266-10270 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T22 10385-10389 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T23 11340-11345 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T24 11764-11769 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T25 12680-12686 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T26 12691-12701 Body_part denotes myocardium http://purl.obolibrary.org/obo/UBERON_0002349
T27 12798-12803 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T28 12907-12912 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T29 13025-13030 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T30 13086-13091 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T31 13236-13241 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T32 14230-14235 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T33 14414-14419 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T34 14706-14711 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T35 14892-14898 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T36 14943-14949 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T37 15206-15212 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T38 17042-17047 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p78790s67 5737-5745 PosReg denotes increase
p78790s68 5746-5770 MPA denotes messenger RNA expression
p78790s72 5774-5788 MPA denotes protein levels
p78796s8 7387-7396 PosReg denotes increased
p78796s9 7397-7407 CPA denotes intestinal
p78796s10 7408-7428 MPA denotes messenger RNA levels
p78808s39 9401-9405 Protein denotes ACE2
p78808s53 9492-9499 NegReg denotes reduced
p78808s56 9514-9524 MPA denotes expression
p78811s9 10158-10166 PosReg denotes elevated
p78811s14 10196-10198 MPA denotes II
p78816s27 11422-11429 NegReg denotes reduced
p78816s28 11430-11442 Protein denotes ACE2 protein
p78816s30 11443-11453 MPA denotes expression
p78841s8 16537-16545 PosReg denotes increase
p78841s9 16546-16550 Protein denotes ACE2
p78841s10 16551-16561 MPA denotes expression

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 145-178 Disease denotes Severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T2 194-202 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 210-218 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 258-262 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 312-336 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T6 542-546 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T7 587-591 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T8 1557-1563 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T9 1850-1862 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T10 2095-2107 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T11 2283-2295 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T12 2409-2421 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T13 3205-3217 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T14 3555-3567 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T15 4785-4793 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 4822-4828 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T17 6060-6083 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T18 6069-6083 Disease denotes artery disease http://purl.obolibrary.org/obo/MONDO_0000473
T19 6309-6321 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T20 6751-6764 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T21 6768-6787 Disease denotes atrial fibrillation http://purl.obolibrary.org/obo/MONDO_0004981
T22 6791-6806 Disease denotes aortic stenosis http://purl.obolibrary.org/obo/MONDO_0004978|http://purl.obolibrary.org/obo/MONDO_0042981
T24 6814-6837 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T25 6823-6837 Disease denotes artery disease http://purl.obolibrary.org/obo/MONDO_0000473
T26 7026-7038 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T27 7129-7132 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T28 8757-8765 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 8878-8886 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 8980-8988 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 9279-9285 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T32 9336-9344 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 9446-9461 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T34 9452-9461 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T35 9829-9837 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 9862-9879 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T38 9873-9879 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T39 9991-10008 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T41 10002-10008 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T42 10271-10277 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T43 10390-10396 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T44 10529-10564 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T45 10535-10564 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T46 10763-10769 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T47 10963-10980 Disease denotes viral myocarditis http://purl.obolibrary.org/obo/MONDO_0023161
T48 10969-10980 Disease denotes myocarditis http://purl.obolibrary.org/obo/MONDO_0004496
T49 11041-11051 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T50 11119-11125 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T51 11253-11259 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T52 11327-11331 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T53 11556-11578 Disease denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0005021
T54 11564-11578 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T55 11770-11776 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T56 12252-12260 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 12446-12469 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T58 12521-12527 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T59 12798-12811 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T60 12907-12920 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T61 13025-13038 Disease denotes Heart Failure http://purl.obolibrary.org/obo/MONDO_0005252
T62 13074-13099 Disease denotes symptomatic heart failure http://purl.obolibrary.org/obo/MONDO_0005254
T63 13086-13099 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T64 13236-13249 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T65 13399-13421 Disease denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0005021
T66 13407-13421 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T67 13489-13510 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T68 13679-13685 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T69 13861-13873 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T70 14217-14244 Disease denotes increases in blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T71 14884-14906 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T72 14892-14906 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T74 14935-14957 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T75 14943-14957 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T77 15200-15219 Disease denotes acute kidney injury http://purl.obolibrary.org/obo/MONDO_0002492
T78 15213-15219 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T79 16408-16416 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 16930-16933 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T81 17042-17055 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T82 17068-17089 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 84-92 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T2 127-132 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T3 489-499 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T4 522-523 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 547-554 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T6 592-599 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T7 609-612 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T8 630-631 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 1268-1274 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T10 1426-1434 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T11 1438-1444 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T12 1552-1556 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T13 1552-1556 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T14 2002-2004 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T15 3460-3462 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T16 3736-3737 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 4102-4108 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Humans
T18 4172-4173 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 4239-4247 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T20 4268-4269 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 4597-4605 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T22 4623-4629 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T23 4654-4660 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T24 4721-4726 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T25 4721-4726 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T26 4721-4726 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T27 4721-4726 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T28 4731-4738 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T29 4731-4738 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T30 4731-4738 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T31 4775-4780 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T32 4835-4839 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T33 4835-4839 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T34 4849-4859 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T35 4860-4865 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T36 4968-4973 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T37 5237-5245 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T38 5351-5357 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T39 5381-5382 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 5450-5458 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T41 5475-5481 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T42 5579-5587 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T43 5615-5621 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T44 5812-5814 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T45 5872-5878 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T46 5912-5918 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T47 6069-6075 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T48 6069-6075 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T49 6132-6133 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T50 6257-6259 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T51 6485-6486 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52 6542-6544 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T53 6584-6590 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T54 6596-6604 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T55 6751-6756 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T56 6751-6756 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T57 6751-6756 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T58 6751-6756 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T59 6791-6797 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T60 6823-6829 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T61 6823-6829 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T62 6841-6847 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T63 6853-6861 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T64 6965-6966 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 7325-7327 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T66 7397-7407 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T67 7397-7407 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T68 7563-7567 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T69 7563-7567 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T70 7795-7800 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T71 7954-7955 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 7973-7975 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T73 8009-8015 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T74 8038-8039 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 8066-8074 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T76 8094-8102 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T77 8153-8161 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T78 8163-8164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 8458-8462 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T80 8458-8462 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T81 8507-8513 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T82 8528-8534 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T83 8607-8615 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T84 8814-8820 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T85 9160-9166 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T86 9171-9174 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T87 9233-9241 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T88 9273-9278 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T89 9419-9423 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T90 9433-9435 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T91 9500-9508 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T92 9547-9561 http://purl.obolibrary.org/obo/CL_0000010 denotes cultured cells
T93 9589-9597 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T94 9605-9610 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T95 9767-9777 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T96 9803-9808 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T97 9868-9872 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T98 9868-9872 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T99 9915-9917 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T100 9924-9929 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T101 9997-10001 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T102 9997-10001 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T103 10091-10096 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T104 10103-10104 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T105 10177-10183 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T106 10266-10270 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T107 10266-10270 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T108 10385-10389 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T109 10385-10389 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T110 10502-10503 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T111 10568-10574 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T112 10921-10928 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T113 11025-11026 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T114 11065-11068 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T115 11069-11070 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T116 11167-11173 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T117 11333-11335 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T118 11340-11345 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T119 11340-11345 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T120 11340-11345 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T121 11340-11345 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T122 11528-11533 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T123 11544-11550 http://purl.obolibrary.org/obo/UBERON_0000948 denotes hearts
T124 11544-11550 http://purl.obolibrary.org/obo/UBERON_0007100 denotes hearts
T125 11544-11550 http://purl.obolibrary.org/obo/UBERON_0015228 denotes hearts
T126 11544-11550 http://www.ebi.ac.uk/efo/EFO_0000815 denotes hearts
T127 11623-11627 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T128 11764-11769 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T129 11861-11862 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 11969-11970 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 12503-12509 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T132 12680-12686 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T133 12680-12686 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T134 12680-12686 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T135 12691-12701 http://purl.obolibrary.org/obo/UBERON_0002349 denotes myocardium
T136 12798-12803 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T137 12798-12803 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T138 12798-12803 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T139 12798-12803 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T140 12907-12912 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T141 12907-12912 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T142 12907-12912 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T143 12907-12912 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T144 13025-13030 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T145 13025-13030 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T146 13025-13030 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T147 13025-13030 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T148 13086-13091 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T149 13086-13091 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T150 13086-13091 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T151 13086-13091 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T152 13137-13138 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T153 13236-13241 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T154 13236-13241 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T155 13236-13241 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T156 13236-13241 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T157 13458-13459 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T158 13578-13581 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T159 14086-14087 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T160 14142-14143 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T161 14230-14235 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T162 14230-14235 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T163 14414-14419 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T164 14414-14419 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T165 14447-14448 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T166 14631-14632 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T167 14647-14657 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T168 14706-14711 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T169 14706-14711 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T170 14892-14898 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T171 14892-14898 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T172 14892-14898 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T173 14943-14949 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T174 14943-14949 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T175 14943-14949 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T176 15043-15045 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T177 15206-15212 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T178 15206-15212 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T179 15206-15212 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T180 15848-15849 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T181 15912-15914 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T182 15912-15914 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T183 16366-16376 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T184 16424-16429 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T185 16724-16730 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T186 16840-16844 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T187 16911-16916 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T188 17042-17047 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T189 17042-17047 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T190 17042-17047 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T191 17042-17047 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T3 10-21 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T4 22-33 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T6 84-92 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T7 404-415 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T8 719-729 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T9 971-985 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T10 975-985 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T11 990-1001 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T12 1116-1130 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T13 1120-1130 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T14 1180-1185 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T15 1626-1636 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T16 2762-2772 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T17 3395-3405 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T18 3589-3605 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T19 3620-3630 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T20 3851-3861 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T21 3900-3910 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T22 4239-4247 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T23 4313-4327 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T26 4313-4324 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T27 4325-4327 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T28 4331-4342 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T29 4403-4409 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T30 4444-4458 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T33 4444-4455 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T34 4456-4458 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T35 4518-4529 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T36 4535-4546 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T37 4597-4605 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T38 5093-5107 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T39 5097-5107 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T40 5143-5157 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T43 5143-5154 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T44 5155-5157 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T45 5391-5405 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T46 5395-5405 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T47 5546-5560 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T48 5550-5560 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T49 5746-5759 Chemical denotes messenger RNA http://purl.obolibrary.org/obo/CHEBI_33699
T50 5774-5781 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T51 6028-6042 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T52 6032-6042 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T53 6102-6113 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T54 6175-6189 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T55 6179-6189 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T56 6231-6245 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T59 6231-6242 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T60 6243-6245 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T61 6323-6334 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T62 6407-6420 Chemical denotes ACE inhibitor http://purl.obolibrary.org/obo/CHEBI_35457
T63 6411-6420 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T64 6421-6430 Chemical denotes captopril http://purl.obolibrary.org/obo/CHEBI_3380
T65 6458-6467 Chemical denotes captopril http://purl.obolibrary.org/obo/CHEBI_3380
T66 6507-6518 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T67 6688-6698 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T68 6908-6922 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T69 6912-6922 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T70 7133-7143 Chemical denotes olmesartan http://purl.obolibrary.org/obo/CHEBI_48416
T71 7230-7243 Chemical denotes ACE inhibitor http://purl.obolibrary.org/obo/CHEBI_35457
T72 7234-7243 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T73 7244-7253 Chemical denotes enalapril http://purl.obolibrary.org/obo/CHEBI_4784
T74 7274-7282 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T75 7284-7295 Chemical denotes candesartan http://purl.obolibrary.org/obo/CHEBI_3347
T76 7297-7306 Chemical denotes valsartan http://purl.obolibrary.org/obo/CHEBI_9927
T77 7312-7323 Chemical denotes telmisartan http://purl.obolibrary.org/obo/CHEBI_9434
T78 7352-7366 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T79 7356-7366 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T80 7408-7421 Chemical denotes messenger RNA http://purl.obolibrary.org/obo/CHEBI_33699
T81 7549-7559 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T82 7903-7913 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T83 7962-7966 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T84 8049-8058 Chemical denotes indicator http://purl.obolibrary.org/obo/CHEBI_47867
T85 8230-8239 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T86 8407-8421 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T87 8411-8421 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T88 8444-8454 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T89 8574-8584 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T90 8774-8781 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T91 9218-9232 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T94 9218-9229 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T95 9230-9232 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T96 9353-9360 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T97 9724-9738 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T100 9724-9735 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T101 9736-9738 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T102 9846-9853 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T103 10184-10198 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T106 10184-10195 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T107 10196-10198 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T108 10477-10491 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T111 10477-10488 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T112 10489-10491 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T113 11270-11284 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T116 11270-11281 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T117 11282-11284 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T118 11435-11442 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T119 11503-11517 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T122 11503-11514 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T123 11515-11517 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T124 11670-11677 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T125 11849-11857 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T126 11976-11985 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T127 12332-12342 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T128 12625-12635 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T129 13015-13024 Chemical denotes Quinapril http://purl.obolibrary.org/obo/CHEBI_8713
T130 13115-13124 Chemical denotes quinapril http://purl.obolibrary.org/obo/CHEBI_8713
T131 13193-13195 Chemical denotes HF http://purl.obolibrary.org/obo/CHEBI_141438|http://purl.obolibrary.org/obo/CHEBI_29228
T133 13358-13368 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T134 13443-13453 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T135 13769-13779 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T136 13800-13810 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T137 13916-13926 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T138 14093-14102 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T139 14114-14130 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T140 14288-14304 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T141 14815-14825 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T142 15343-15353 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T143 15582-15592 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T144 15628-15633 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T145 15696-15706 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T146 15912-15914 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T147 16282-16293 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T148 16294-16305 Chemical denotes Aldosterone http://purl.obolibrary.org/obo/CHEBI_27584
T149 16522-16532 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T150 16782-16792 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T151 16934-16942 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T152 16983-16993 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T153 17209-17219 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 830-839 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T2 830-839 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T3 4385-4401 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstriction
T4 4410-4419 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T5 6246-6256 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T6 9387-9397 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7 9446-9461 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T8 9570-9580 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9 12200-12210 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1850-1862 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T2 2095-2107 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T3 2283-2295 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T4 2409-2421 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 3205-3217 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T6 3555-3567 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 6309-6321 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 6751-6764 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T9 6768-6787 Phenotype denotes atrial fibrillation http://purl.obolibrary.org/obo/HP_0005110
T10 6791-6806 Phenotype denotes aortic stenosis http://purl.obolibrary.org/obo/HP_0001650
T11 7026-7038 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T12 9862-9879 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T13 9991-10008 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T14 10535-10555 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T15 10969-10980 Phenotype denotes myocarditis http://purl.obolibrary.org/obo/HP_0012819
T16 11001-11008 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T17 11556-11578 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T18 12446-12469 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T19 12798-12811 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T20 12907-12920 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T21 13025-13038 Phenotype denotes Heart Failure http://purl.obolibrary.org/obo/HP_0001635
T22 13086-13099 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T23 13236-13249 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T24 13399-13421 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T25 13489-13510 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T26 13861-13873 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T27 14217-14244 Phenotype denotes increases in blood pressure http://purl.obolibrary.org/obo/HP_0032263
T28 14884-14906 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T29 14935-14957 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T30 15200-15219 Phenotype denotes acute kidney injury http://purl.obolibrary.org/obo/HP_0001919
T31 17042-17055 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T32 17068-17089 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T2 0-144 Sentence denotes The renin–angiotensin–aldosterone system (RAAS) is an elegant cascade of vasoactive peptides that orchestrate key processes in human physiology.
T3 145-1091 Sentence denotes Severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and SARS-CoV-2, which have been responsible for the SARS epidemic in 2002 to 2004 and for the more recent coronavirus disease 2019 (Covid-19) pandemic, respectively, interface with the RAAS through angiotensin-converting enzyme 2 (ACE2), an enzyme that physiologically counters RAAS activation but also functions as a receptor for both SARS viruses.1,2 The interaction between the SARS viruses and ACE2 has been proposed as a potential factor in their infectivity,3,4 and there are concerns about the use of RAAS inhibitors that may alter ACE2 and whether variation in ACE2 expression may be in part responsible for disease virulence in the ongoing Covid-19 pandemic.5-8 Indeed, some media sources and health systems have recently called for the discontinuation of ACE inhibitors and angiotensin-receptor blockers (ARBs), both prophylactically and in the context of suspected Covid-19.
T4 1092-1231 Sentence denotes Given the common use of ACE inhibitors and ARBs worldwide, guidance on the use of these drugs in patients with Covid-19 is urgently needed.
T5 1232-1342 Sentence denotes Here, we highlight that the data in humans are too limited to support or refute these hypotheses and concerns.
T6 1343-1564 Sentence denotes Specifically, we discuss the uncertain effects of RAAS blockers on ACE2 levels and activity in humans, and we propose an alternative hypothesis that ACE2 may be beneficial rather than harmful in patients with lung injury.
T7 1565-1715 Sentence denotes We also explicitly raise the concern that withdrawal of RAAS inhibitors may be harmful in certain high-risk patients with known or suspected Covid-19.
T8 1717-1769 Sentence denotes Covid-19 and Older Adults with Coexisting Conditions
T9 1770-1892 Sentence denotes Initial reports5-8 have called attention to the potential overrepresentation of hypertension among patients with Covid-19.
T10 1893-2375 Sentence denotes In the largest of several case series from China that have been released during the Covid-19 pandemic (Table S1 in the Supplementary Appendix, available with the full text of this article at NEJM.org), hypertension was the most frequent coexisting condition in 1099 patients, with an estimated prevalence of 15%9; however, this estimate appears to be lower than the estimated prevalence of hypertension seen with other viral infections10 and in the general population in China.11,12
T11 2376-2660 Sentence denotes Coexisting conditions, including hypertension, have consistently been reported to be more common among patients with Covid-19 who have had severe illness, been admitted to the intensive care unit, received mechanical ventilation, or died than among patients who have had mild illness.
T12 2661-2835 Sentence denotes There are concerns that medical management of these coexisting conditions, including the use of RAAS inhibitors, may have contributed to the adverse health outcomes observed.
T13 2836-3142 Sentence denotes However, these conditions appear to track closely with advancing age,13 which is emerging as the strongest predictor of Covid-19–related death.14 Unfortunately, reports to date have not rigorously accounted for age or other key factors that contribute to health as potential confounders in risk prediction.
T14 3143-3312 Sentence denotes With other infective illnesses, coexisting conditions such as hypertension have been key prognostic determinants,10 and this also appears to be the case with Covid-19.15
T15 3313-3464 Sentence denotes It is important to note that, despite inferences about the use of background RAAS inhibitors, specific details have been lacking in studies (Table S1).
T16 3465-3862 Sentence denotes Population-based studies have estimated that only 30 to 40% of patients in China who have hypertension are treated with any antihypertensive therapy; RAAS inhibitors are used alone or in combination in 25 to 30% of these treated patients.11,12 Given such estimates, only a fraction of patients with Covid-19, at least in China, are anticipated to have been previously treated with RAAS inhibitors.
T17 3863-4052 Sentence denotes Data showing patterns of use of RAAS inhibitors and associated health outcomes that rigorously account for treatment indication and illness severity among patients with Covid-19 are needed.
T18 4054-4108 Sentence denotes Uncertain Effects of RAAS Inhibitors on ACE2 in Humans
T19 4109-4259 Sentence denotes Tissue-specific and circulating components of the RAAS make up a complex intersecting network of regulatory and counterregulatory peptides (Figure 1).
T20 4260-4434 Sentence denotes ACE2 is a key counterregulatory enzyme that degrades angiotensin II to angiotensin-(1–7), thereby attenuating its effects on vasoconstriction, sodium retention, and fibrosis.
T21 4435-5084 Sentence denotes Although angiotensin II is the primary substrate of ACE2, that enzyme also cleaves angiotensin I to angiotensin-(1–9) and participates in the hydrolysis of other peptides.16 In studies in humans, tissue samples from 15 organs have shown that ACE2 is expressed broadly, including in the heart and kidneys, as well as on the principal target cells for SARS-CoV-2 (and the site of dominant injury), the lung alveolar epithelial cells.17 Of interest, the circulating levels of soluble ACE2 are low and the functional role of ACE2 in the lungs appears to be relatively minimal under normal conditions18 but may be up-regulated in certain clinical states.
T22 5085-5275 Sentence denotes Because ACE inhibitors and ARBs have different effects on angiotensin II, the primary substrate of ACE2, the effects of these agents on ACE2 levels and activity may be anticipated to differ.
T23 5276-5377 Sentence denotes Despite substantial structural homology between ACE and ACE2, their enzyme active sites are distinct.
T24 5378-5846 Sentence denotes As a result, ACE inhibitors in clinical use do not directly affect ACE2 activity.19 Experimental animal models have shown mixed findings with respect to the effects of ACE inhibitors on ACE2 levels or activity in tissue.20-25 Similarly, animal models have had inconsistent findings with respect to the effects of ARBs on ACE2, with some showing that ARBs may increase messenger RNA expression or protein levels of ACE2 in tissue21,26-34 and others showing no effect.23
T25 5847-5979 Sentence denotes In contrast to available animal models, there are few studies in humans regarding the effects of RAAS inhibition on ACE2 expression.
T26 5980-6699 Sentence denotes In one study, the intravenous administration of ACE inhibitors in patients with coronary artery disease did not influence angiotensin-(1–7) production, a finding that calls into question whether ACE inhibitors have any direct effects on ACE2-directed angiotensin II metabolism.35 Similarly, in another study, among patients with hypertension, angiotensin-(1–7) levels appeared to be unaffected after initial treatment with the ACE inhibitor captopril; however, with exposure to captopril monotherapy over a period of 6 months, angiotensin-(1–7) levels increased.36 Furthermore, few studies have examined plasma ACE2 activity or urinary ACE2 levels in patients who have received long-term treatment with RAAS inhibitors.
T27 6700-6961 Sentence denotes In cross-sectional studies involving patients with heart failure,37 atrial fibrillation,38 aortic stenosis,39 and coronary artery disease,40 plasma ACE2 activity was not higher among patients who were taking ACE inhibitors or ARBs than among untreated patients.
T28 6962-7596 Sentence denotes In a longitudinal cohort study involving Japanese patients with hypertension, urinary ACE2 levels were higher among patients who received long-term treatment with the ARB olmesartan than among untreated control patients, but that association was not observed with the ACE inhibitor enalapril or with other ARBs (losartan, candesartan, valsartan, and telmisartan).41 Previous treatment with ACE inhibitors was associated with increased intestinal messenger RNA levels of ACE2 in one study, but that association was not observed with ARBs25; data are lacking regarding the effects of RAAS inhibitors on lung-specific expression of ACE2.
T29 7597-7812 Sentence denotes These seemingly conflicting data indicate the complexity underlying RAAS responses to pathway modulators and reinforce the concept that findings from preclinical models may not readily translate to human physiology.
T30 7813-8363 Sentence denotes Such data do suggest that effects on ACE2 should not be assumed to be uniform across RAAS inhibitors or even in response to therapies within a given drug class.41 It is important to note that the plasma ACE2 level may not be a reliable indicator of the activity of the full-length membrane-bound form, in part because ACE2 is shed from the membrane, a process that appears to be separately regulated by an endogenous inhibitor.42 In addition to the degree of expression, the biologic relevance of ACE2 may vary according to tissue and clinical state.
T31 8364-8547 Sentence denotes Unfortunately, data showing the effects of ACE inhibitors, ARBs, and other RAAS inhibitors on lung-specific expression of ACE2 in experimental animal models and in humans are lacking.
T32 8548-8782 Sentence denotes Furthermore, even if RAAS inhibitors modify ACE2 levels or activity (or both) in target tissue beds, clinical data are lacking to indicate whether this would in turn facilitate greater engagement and entry of SARS-CoV-2 spike protein.
T33 8783-8910 Sentence denotes Further mechanistic studies in humans are needed to better define the unique interplay between SARS-CoV-2 and the RAAS network.
T34 8912-8979 Sentence denotes Potential for Benefit Rather Than Harm of RAAS Blockers in Covid-19
T35 8980-9167 Sentence denotes SARS-CoV-2 appears not only to gain initial entry through ACE2 but also to subsequently down-regulate ACE2 expression such that the enzyme is unable to exert protective effects in organs.
T36 9168-9778 Sentence denotes It has been postulated but unproven that unabated angiotensin II activity may be in part responsible for organ injury in Covid-19.43,44 After the initial engagement of SARS-CoV-2 spike protein, there is subsequent down-regulation of ACE2 abundance on cell surfaces.45 Continued viral infection and replication contribute to reduced membrane ACE2 expression, at least in vitro in cultured cells.46 Down-regulation of ACE2 activity in the lungs facilitates the initial neutrophil infiltration in response to bacterial endotoxin47 and may result in unopposed angiotensin II accumulation and local RAAS activation.
T37 9779-10577 Sentence denotes Indeed, in experimental mouse models, exposure to SARS-CoV-1 spike protein induced acute lung injury, which is limited by RAAS blockade.45 Other mouse models have suggested that dysregulation of ACE2 may mediate acute lung injury that is secondary to virulent strains of influenza48,49 and respiratory syncytial virus.50 In a small study, patients with Covid-19 appeared to have elevated levels of plasma angiotensin II, which were in turn correlated with total viral load and degree of lung injury.44 Restoration of ACE2 through the administration of recombinant ACE2 appeared to reverse this devastating lung-injury process in preclinical models of other viral infections49,50 and safely reduced angiotensin II levels in a phase 2 trial evaluating acute respiratory distress syndrome in humans.51
T38 10578-10740 Sentence denotes Dysregulated ACE2 may theoretically also attenuate cardioprotection in the context of myocardial involvement and abnormal pulmonary hemodynamics52,53 in Covid-19.
T39 10741-11059 Sentence denotes Markers of myocardial injury have been shown to be elevated during the disease course of Covid-1954 and to increase rapidly with clinical deterioration and preceding death.14 Many viruses are cardiotropic, and subclinical viral myocarditis is commonly seen in viremia associated with a wide range of infectious agents.
T40 11060-11818 Sentence denotes ACE2 has a well-recognized role in myocardial recovery and injury response; in one study, ACE2 knockout in animal models contributed to adverse left ventricular remodeling in response to acute injury driven by angiotensin II.55 In autopsies of patients who died from SARS, 35% of heart samples showed the presence of viral RNA, which in turn was associated with reduced ACE2 protein expression.56 Administration of recombinant ACE2 normalizes angiotensin II levels in human explanted hearts with dilated cardiomyopathy.57 These hypotheses have prompted trials to test whether the provision of recombinant ACE2 protein may be beneficial in restoring balance to the RAAS network and potentially preventing organ injury (ClinicalTrials.gov number, NCT04287686).
T41 11819-12062 Sentence denotes In addition, paired trials of losartan as a treatment for Covid-19 are being conducted among patients who have not previously received treatment with a RAAS inhibitor and are either hospitalized (NCT04312009) or not hospitalized (NCT04311177).
T42 12064-12127 Sentence denotes Maintenance of RAAS Inhibitors with Known or Suspected Covid-19
T43 12128-12385 Sentence denotes Despite these theoretical uncertainties regarding whether pharmacologic regulation of ACE2 may influence the infectivity of SARS-CoV-2, there is clear potential for harm related to the withdrawal of RAAS inhibitors in patients in otherwise stable condition.
T44 12386-12619 Sentence denotes Covid-19 is particularly severe in patients with underlying cardiovascular diseases,9 and in many of these patients, active myocardial injury,14,54,58-60 myocardial stress,59 and cardiomyopathy59 develop during the course of illness.
T45 12620-12779 Sentence denotes RAAS inhibitors have established benefits in protecting the kidney and myocardium, and their withdrawal may risk clinical decompensation in high-risk patients.
T46 12780-13780 Sentence denotes Although rates of heart failure have been infrequently reported in epidemiologic reports from China to date, the prevalence of heart failure among critically ill patients with Covid-19 in the United States may be high (>40%).59 In the Quinapril Heart Failure Trial, among patients with chronic symptomatic heart failure, withdrawal of quinapril resulted in a progressive decline in clinical status.61 In the TRED-HF trial, among asymptomatic patients with heart failure with recovered left ventricular ejection fraction, the phased withdrawal of medical therapy (including RAAS inhibitors) resulted in rapid relapse of dilated cardiomyopathy.62 In addition, RAAS inhibitors are a cornerstone of therapy after myocardial infarction: maintenance of therapy in the days to weeks after the index event has been shown to reduce early mortality.63 Among patients with unstable clinical status, myocardial injury associated with Covid-19 may pose even higher early risks after withdrawal of RAAS inhibitors.
T47 13781-14070 Sentence denotes Withdrawal of RAAS inhibitors that are being administered for the management of hypertension may be less risky than withdrawal of RAAS inhibitors that are being administered for conditions in which they are considered guideline-directed therapy but may be associated with other challenges.
T48 14071-14245 Sentence denotes Switching from a RAAS inhibitor to another antihypertensive therapy in a stable ambulatory patient may require careful follow-up to avoid rebound increases in blood pressure.
T49 14246-14375 Sentence denotes In addition, selection of dose-equivalent antihypertensive therapies may be challenging in practice and may be patient-dependent.
T50 14376-14782 Sentence denotes Even small and short-lived periods of blood pressure instability after a therapeutic change have been associated with excess cardiovascular risk.64-66 This may be an especially important consideration in patients with Covid-19, which appears to result in a state of RAAS activation,44 and in settings (e.g., China) where baseline blood-pressure control is infrequently reached at the population level.11,12
T51 14783-14907 Sentence denotes The effects of withdrawing RAAS inhibitors or switching treatments are uncertain among patients with chronic kidney disease.
T52 14908-15448 Sentence denotes Although reported rates of chronic kidney disease appear to be low among hospitalized patients with Covid-19 in China (1 to 3%) (Table S1), the prevalence may be higher among patients who are critically ill and among those in other geographic regions.59 Many patients have varying degrees of acute kidney injury during illness.14,67,68 For these high-risk patients, individualized treatment decisions regarding the maintenance of RAAS inhibitors that are guided by hemodynamic status, renal function, and clinical stability are recommended.
T53 15449-15916 Sentence denotes On the basis of the available evidence, we think that, despite the theoretical concerns and uncertainty regarding the effect of RAAS inhibitors on ACE2 and the way in which these drugs might affect the propensity for or severity of Covid-19, RAAS inhibitors should be continued in patients in otherwise stable condition who are at risk for, are being evaluated for, or have Covid-19 (see text box), a position now supported by multiple specialty societies (Table S2).
T54 15917-16214 Sentence denotes Although additional data may further inform the treatment of high-risk patients with Covid-19, clinicians need to be cognizant of the unintended consequences of prematurely discontinuing proven therapies in response to hypothetical concerns that may be based on incomplete experimental evidence.69
T55 16215-16312 Sentence denotes Key Points Related to the Interplay between Covid-19 and the Renin–Angiotensin–Aldosterone System
T56 16313-16467 Sentence denotes • ACE2, an enzyme that physiologically counters RAAS activation, is the functional receptor to SARS-CoV-2, the virus responsible for the Covid-19 pandemic
T57 16468-16628 Sentence denotes • Select preclinical studies have suggested that RAAS inhibitors may increase ACE2 expression, raising concerns regarding their safety in patients with Covid-19
T58 16629-16804 Sentence denotes • Insufficient data are available to determine whether these observations readily translate to humans, and no studies have evaluated the effects of RAAS inhibitors in Covid-19
T59 16805-16954 Sentence denotes • Clinical trials are under way to test the safety and efficacy of RAAS modulators, including recombinant human ACE2 and the ARB losartan in Covid-19
T60 16955-17153 Sentence denotes • Abrupt withdrawal of RAAS inhibitors in high-risk patients, including those who have heart failure or have had myocardial infarction, may result in clinical instability and adverse health outcomes
T61 17154-17340 Sentence denotes • Until further data are available, we think that RAAS inhibitors should be continued in patients in otherwise stable condition who are at risk for, being evaluated for, or with Covid-19

2_test

Id Subject Object Predicate Lexical cue
32227760-32171062-75177404 1787-1788 32171062 denotes 8
32227760-31333767-75177405 2328-2330 31333767 denotes 10
32227760-29449338-75177406 2370-2372 29449338 denotes 11
32227760-29102084-75177407 2373-2375 29102084 denotes 12
32227760-32171076-75177408 2979-2981 32171076 denotes 14
32227760-31333767-75177409 3256-3258 31333767 denotes 10
32227760-32173574-75177410 3310-3312 32173574 denotes 15
32227760-29449338-75177411 3703-3705 29449338 denotes 11
32227760-29102084-75177412 3706-3708 29102084 denotes 12
32227760-11815627-75177413 4606-4608 11815627 denotes 16
32227760-15141377-75177414 4866-4868 15141377 denotes 17
32227760-31786979-75177415 5030-5032 31786979 denotes 18
32227760-15283675-75177416 5459-5461 15283675 denotes 19
32227760-18192334-75177417 5601-5603 18192334 denotes 25
32227760-15897343-75177418 5806-5808 15897343 denotes 21
32227760-19004932-75177419 5812-5814 19004932 denotes 34
32227760-22715807-75177420 5844-5846 22715807 denotes 23
32227760-15361769-75177421 6257-6259 15361769 denotes 35
32227760-8793704-75177422 6542-6544 8793704 denotes 36
32227760-19700132-75177423 6765-6767 19700132 denotes 37
32227760-27738071-75177424 6788-6790 27738071 denotes 38
32227760-31607667-75177425 6807-6809 31607667 denotes 39
32227760-29897923-75177426 6838-6840 29897923 denotes 40
32227760-24842388-75177427 7325-7327 24842388 denotes 41
32227760-25534429-75177428 7498-7500 25534429 denotes 25
32227760-24842388-75177429 7973-7975 24842388 denotes 41
32227760-15983030-75177430 8240-8242 15983030 denotes 42
32227760-32129518-75177431 9298-9300 32129518 denotes 43
32227760-32048163-75177432 9301-9303 32048163 denotes 44
32227760-16007097-75177433 9433-9435 16007097 denotes 45
32227760-22718567-75177434 9562-9564 22718567 denotes 46
32227760-28935640-75177435 9693-9695 28935640 denotes 47
32227760-16007097-75177436 9915-9917 16007097 denotes 45
32227760-25391767-75177437 10059-10061 25391767 denotes 48
32227760-24800825-75177438 10062-10064 24800825 denotes 49
32227760-26813885-75177439 10097-10099 26813885 denotes 50
32227760-32048163-75177440 10278-10280 32048163 denotes 44
32227760-24800825-75177441 10452-10454 24800825 denotes 49
32227760-26813885-75177442 10455-10457 26813885 denotes 50
32227760-28877748-75177443 10575-10577 28877748 denotes 51
32227760-29903860-75177444 10722-10724 29903860 denotes 52
32227760-29288933-75177445 10725-10727 29288933 denotes 53
32227760-32211816-75177446 10836-10840 32211816 denotes 1954
32227760-32171076-75177447 10913-10915 32171076 denotes 14
32227760-19808375-75177448 11285-11287 19808375 denotes 55
32227760-19453650-75177449 11454-11456 19453650 denotes 56
32227760-28209222-75177450 11579-11581 28209222 denotes 57
32227760-32171076-75177451 12528-12530 32171076 denotes 14
32227760-32211816-75177452 12531-12533 32211816 denotes 54
32227760-32125452-75177453 12537-12539 32125452 denotes 60
32227760-32191259-75177454 12558-12560 32191259 denotes 59
32227760-32191259-75177455 12579-12581 32191259 denotes 59
32227760-32191259-75177456 13005-13007 32191259 denotes 59
32227760-8227822-75177457 13178-13180 8227822 denotes 61
32227760-30429050-75177458 13422-13424 30429050 denotes 62
32227760-9631869-75177459 13619-13621 9631869 denotes 63
32227760-15207952-75177460 14524-14526 15207952 denotes 66
32227760-32048163-75177461 14658-14660 32048163 denotes 44
32227760-29449338-75177462 14777-14779 29449338 denotes 11
32227760-29102084-75177463 14780-14782 29102084 denotes 12
32227760-32191259-75177464 15159-15161 32191259 denotes 59
32227760-32171076-75177465 15235-15237 32171076 denotes 14
32227760-32007143-75177466 15238-15240 32007143 denotes 67
32227760-32167524-75177467 15241-15243 32167524 denotes 68
32227760-26643266-75177468 16212-16214 26643266 denotes 69