PMC:7121452 / 5160-5921 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"152","span":{"begin":8,"end":11},"obj":"Gene"},{"id":"153","span":{"begin":58,"end":72},"obj":"Gene"},{"id":"154","span":{"begin":99,"end":103},"obj":"Gene"},{"id":"155","span":{"begin":136,"end":140},"obj":"Gene"},{"id":"156","span":{"begin":239,"end":242},"obj":"Gene"},{"id":"157","span":{"begin":247,"end":251},"obj":"Gene"},{"id":"158","span":{"begin":306,"end":309},"obj":"Gene"},{"id":"159","span":{"begin":360,"end":364},"obj":"Gene"},{"id":"160","span":{"begin":461,"end":464},"obj":"Gene"},{"id":"161","span":{"begin":479,"end":483},"obj":"Gene"},{"id":"162","span":{"begin":614,"end":618},"obj":"Gene"},{"id":"163","span":{"begin":707,"end":711},"obj":"Gene"}],"attributes":[{"id":"A152","pred":"tao:has_database_id","subj":"152","obj":"Gene:1636"},{"id":"A153","pred":"tao:has_database_id","subj":"153","obj":"Gene:183"},{"id":"A154","pred":"tao:has_database_id","subj":"154","obj":"Gene:59272"},{"id":"A155","pred":"tao:has_database_id","subj":"155","obj":"Gene:59272"},{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"Gene:1636"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"Gene:59272"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"Gene:1636"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"Gene:59272"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"Gene:1636"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"Gene:59272"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"Gene:59272"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"Gene:59272"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Because ACE inhibitors and ARBs have different effects on angiotensin II, the primary substrate of ACE2, the effects of these agents on ACE2 levels and activity may be anticipated to differ. Despite substantial structural homology between ACE and ACE2, their enzyme active sites are distinct. As a result, ACE inhibitors in clinical use do not directly affect ACE2 activity.19 Experimental animal models have shown mixed findings with respect to the effects of ACE inhibitors on ACE2 levels or activity in tissue.20-25 Similarly, animal models have had inconsistent findings with respect to the effects of ARBs on ACE2, with some showing that ARBs may increase messenger RNA expression or protein levels of ACE2 in tissue21,26-34 and others showing no effect.23"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T12","span":{"begin":506,"end":512},"obj":"Body_part"},{"id":"T13","span":{"begin":661,"end":674},"obj":"Body_part"},{"id":"T14","span":{"begin":671,"end":674},"obj":"Body_part"},{"id":"T15","span":{"begin":689,"end":696},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Because ACE inhibitors and ARBs have different effects on angiotensin II, the primary substrate of ACE2, the effects of these agents on ACE2 levels and activity may be anticipated to differ. Despite substantial structural homology between ACE and ACE2, their enzyme active sites are distinct. As a result, ACE inhibitors in clinical use do not directly affect ACE2 activity.19 Experimental animal models have shown mixed findings with respect to the effects of ACE inhibitors on ACE2 levels or activity in tissue.20-25 Similarly, animal models have had inconsistent findings with respect to the effects of ARBs on ACE2, with some showing that ARBs may increase messenger RNA expression or protein levels of ACE2 in tissue21,26-34 and others showing no effect.23"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T7","span":{"begin":506,"end":512},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Because ACE inhibitors and ARBs have different effects on angiotensin II, the primary substrate of ACE2, the effects of these agents on ACE2 levels and activity may be anticipated to differ. Despite substantial structural homology between ACE and ACE2, their enzyme active sites are distinct. As a result, ACE inhibitors in clinical use do not directly affect ACE2 activity.19 Experimental animal models have shown mixed findings with respect to the effects of ACE inhibitors on ACE2 levels or activity in tissue.20-25 Similarly, animal models have had inconsistent findings with respect to the effects of ARBs on ACE2, with some showing that ARBs may increase messenger RNA expression or protein levels of ACE2 in tissue21,26-34 and others showing no effect.23"}

{"project":"LitCovid_AGAC","denotations":[{"id":"p78790s67","span":{"begin":652,"end":660},"obj":"PosReg"},{"id":"p78790s68","span":{"begin":661,"end":685},"obj":"MPA"},{"id":"p78790s72","span":{"begin":689,"end":703},"obj":"MPA"}],"text":"Because ACE inhibitors and ARBs have different effects on angiotensin II, the primary substrate of ACE2, the effects of these agents on ACE2 levels and activity may be anticipated to differ. Despite substantial structural homology between ACE and ACE2, their enzyme active sites are distinct. As a result, ACE inhibitors in clinical use do not directly affect ACE2 activity.19 Experimental animal models have shown mixed findings with respect to the effects of ACE inhibitors on ACE2 levels or activity in tissue.20-25 Similarly, animal models have had inconsistent findings with respect to the effects of ARBs on ACE2, with some showing that ARBs may increase messenger RNA expression or protein levels of ACE2 in tissue21,26-34 and others showing no effect.23"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T37","span":{"begin":152,"end":160},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T38","span":{"begin":266,"end":272},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T39","span":{"begin":296,"end":297},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T40","span":{"begin":365,"end":373},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T41","span":{"begin":390,"end":396},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T42","span":{"begin":494,"end":502},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T43","span":{"begin":530,"end":536},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T44","span":{"begin":727,"end":729},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"}],"text":"Because ACE inhibitors and ARBs have different effects on angiotensin II, the primary substrate of ACE2, the effects of these agents on ACE2 levels and activity may be anticipated to differ. Despite substantial structural homology between ACE and ACE2, their enzyme active sites are distinct. As a result, ACE inhibitors in clinical use do not directly affect ACE2 activity.19 Experimental animal models have shown mixed findings with respect to the effects of ACE inhibitors on ACE2 levels or activity in tissue.20-25 Similarly, animal models have had inconsistent findings with respect to the effects of ARBs on ACE2, with some showing that ARBs may increase messenger RNA expression or protein levels of ACE2 in tissue21,26-34 and others showing no effect.23"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T38","span":{"begin":8,"end":22},"obj":"Chemical"},{"id":"T39","span":{"begin":12,"end":22},"obj":"Chemical"},{"id":"T40","span":{"begin":58,"end":72},"obj":"Chemical"},{"id":"T43","span":{"begin":58,"end":69},"obj":"Chemical"},{"id":"T44","span":{"begin":70,"end":72},"obj":"Chemical"},{"id":"T45","span":{"begin":306,"end":320},"obj":"Chemical"},{"id":"T46","span":{"begin":310,"end":320},"obj":"Chemical"},{"id":"T47","span":{"begin":461,"end":475},"obj":"Chemical"},{"id":"T48","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T49","span":{"begin":661,"end":674},"obj":"Chemical"},{"id":"T50","span":{"begin":689,"end":696},"obj":"Chemical"}],"attributes":[{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_35457"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A41","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A42","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_35457"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_35457"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_33699"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Because ACE inhibitors and ARBs have different effects on angiotensin II, the primary substrate of ACE2, the effects of these agents on ACE2 levels and activity may be anticipated to differ. Despite substantial structural homology between ACE and ACE2, their enzyme active sites are distinct. As a result, ACE inhibitors in clinical use do not directly affect ACE2 activity.19 Experimental animal models have shown mixed findings with respect to the effects of ACE inhibitors on ACE2 levels or activity in tissue.20-25 Similarly, animal models have had inconsistent findings with respect to the effects of ARBs on ACE2, with some showing that ARBs may increase messenger RNA expression or protein levels of ACE2 in tissue21,26-34 and others showing no effect.23"}

{"project":"LitCovid-sentences","denotations":[{"id":"T22","span":{"begin":0,"end":190},"obj":"Sentence"},{"id":"T23","span":{"begin":191,"end":292},"obj":"Sentence"},{"id":"T24","span":{"begin":293,"end":761},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Because ACE inhibitors and ARBs have different effects on angiotensin II, the primary substrate of ACE2, the effects of these agents on ACE2 levels and activity may be anticipated to differ. Despite substantial structural homology between ACE and ACE2, their enzyme active sites are distinct. As a result, ACE inhibitors in clinical use do not directly affect ACE2 activity.19 Experimental animal models have shown mixed findings with respect to the effects of ACE inhibitors on ACE2 levels or activity in tissue.20-25 Similarly, animal models have had inconsistent findings with respect to the effects of ARBs on ACE2, with some showing that ARBs may increase messenger RNA expression or protein levels of ACE2 in tissue21,26-34 and others showing no effect.23"}

{"project":"2_test","denotations":[{"id":"32227760-15283675-75177416","span":{"begin":374,"end":376},"obj":"15283675"},{"id":"32227760-18192334-75177417","span":{"begin":516,"end":518},"obj":"18192334"},{"id":"32227760-15897343-75177418","span":{"begin":721,"end":723},"obj":"15897343"},{"id":"32227760-19004932-75177419","span":{"begin":727,"end":729},"obj":"19004932"},{"id":"32227760-22715807-75177420","span":{"begin":759,"end":761},"obj":"22715807"}],"text":"Because ACE inhibitors and ARBs have different effects on angiotensin II, the primary substrate of ACE2, the effects of these agents on ACE2 levels and activity may be anticipated to differ. Despite substantial structural homology between ACE and ACE2, their enzyme active sites are distinct. As a result, ACE inhibitors in clinical use do not directly affect ACE2 activity.19 Experimental animal models have shown mixed findings with respect to the effects of ACE inhibitors on ACE2 levels or activity in tissue.20-25 Similarly, animal models have had inconsistent findings with respect to the effects of ARBs on ACE2, with some showing that ARBs may increase messenger RNA expression or protein levels of ACE2 in tissue21,26-34 and others showing no effect.23"}