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PMC:7121452 / 10653-12137 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
362 13-17 Gene denotes ACE2 Gene:59272
363 482-486 Gene denotes ACE2 Gene:59272
364 572-576 Gene denotes ACE2 Gene:59272
365 692-706 Gene denotes angiotensin II Gene:183
366 852-856 Gene denotes ACE2 Gene:59272
367 909-913 Gene denotes ACE2 Gene:59272
368 925-939 Gene denotes angiotensin II Gene:183
369 1087-1091 Gene denotes ACE2 Gene:59272
370 726-734 Species denotes patients Tax:9606
371 950-955 Species denotes human Tax:9606
372 1334-1342 Species denotes patients Tax:9606
373 1271-1279 Chemical denotes losartan MESH:D019808
374 153-161 Disease denotes Covid-19 MESH:C000657245
375 174-191 Disease denotes myocardial injury MESH:D009202
376 252-260 Disease denotes Covid-19 MESH:C000657245
377 329-334 Disease denotes death MESH:D003643
378 391-402 Disease denotes myocarditis MESH:D009205
379 423-430 Disease denotes viremia MESH:D014766
380 631-653 Disease denotes ventricular remodeling MESH:D020257
381 669-681 Disease denotes acute injury MESH:D000208
382 739-743 Disease denotes died MESH:D003643
383 978-1000 Disease denotes dilated cardiomyopathy MESH:D002311
384 1186-1198 Disease denotes organ injury MESH:D009102
385 1299-1307 Disease denotes Covid-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T43 762-767 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T44 805-808 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T45 857-864 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 1092-1099 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T47 1186-1191 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T23 762-767 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T24 1186-1191 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p78816s27 844-851 NegReg denotes reduced
p78816s28 852-864 Protein denotes ACE2 protein
p78816s30 865-875 MPA denotes expression

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T46 185-191 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T47 385-402 Disease denotes viral myocarditis http://purl.obolibrary.org/obo/MONDO_0023161
T48 391-402 Disease denotes myocarditis http://purl.obolibrary.org/obo/MONDO_0004496
T49 463-473 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T50 541-547 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T51 675-681 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T52 749-753 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T53 978-1000 Disease denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0005021
T54 986-1000 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T55 1192-1198 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T112 343-350 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T113 447-448 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T114 487-490 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T115 491-492 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T116 589-595 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T117 755-757 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T118 762-767 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T119 762-767 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T120 762-767 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T121 762-767 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T122 950-955 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T123 966-972 http://purl.obolibrary.org/obo/UBERON_0000948 denotes hearts
T124 966-972 http://purl.obolibrary.org/obo/UBERON_0007100 denotes hearts
T125 966-972 http://purl.obolibrary.org/obo/UBERON_0015228 denotes hearts
T126 966-972 http://www.ebi.ac.uk/efo/EFO_0000815 denotes hearts
T127 1045-1049 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T128 1186-1191 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T129 1283-1284 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 1391-1392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T113 692-706 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T116 692-703 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T117 704-706 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T118 857-864 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T119 925-939 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T122 925-936 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T123 937-939 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T124 1092-1099 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T125 1271-1279 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T126 1398-1407 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T15 391-402 Phenotype denotes myocarditis http://purl.obolibrary.org/obo/HP_0012819
T16 423-430 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T17 978-1000 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T38 0-162 Sentence denotes Dysregulated ACE2 may theoretically also attenuate cardioprotection in the context of myocardial involvement and abnormal pulmonary hemodynamics52,53 in Covid-19.
T39 163-481 Sentence denotes Markers of myocardial injury have been shown to be elevated during the disease course of Covid-1954 and to increase rapidly with clinical deterioration and preceding death.14 Many viruses are cardiotropic, and subclinical viral myocarditis is commonly seen in viremia associated with a wide range of infectious agents.
T40 482-1240 Sentence denotes ACE2 has a well-recognized role in myocardial recovery and injury response; in one study, ACE2 knockout in animal models contributed to adverse left ventricular remodeling in response to acute injury driven by angiotensin II.55 In autopsies of patients who died from SARS, 35% of heart samples showed the presence of viral RNA, which in turn was associated with reduced ACE2 protein expression.56 Administration of recombinant ACE2 normalizes angiotensin II levels in human explanted hearts with dilated cardiomyopathy.57 These hypotheses have prompted trials to test whether the provision of recombinant ACE2 protein may be beneficial in restoring balance to the RAAS network and potentially preventing organ injury (ClinicalTrials.gov number, NCT04287686).
T41 1241-1484 Sentence denotes In addition, paired trials of losartan as a treatment for Covid-19 are being conducted among patients who have not previously received treatment with a RAAS inhibitor and are either hospitalized (NCT04312009) or not hospitalized (NCT04311177).

2_test

Id Subject Object Predicate Lexical cue
32227760-29903860-75177444 144-146 29903860 denotes 52
32227760-29288933-75177445 147-149 29288933 denotes 53
32227760-32211816-75177446 258-262 32211816 denotes 1954
32227760-32171076-75177447 335-337 32171076 denotes 14
32227760-19808375-75177448 707-709 19808375 denotes 55
32227760-19453650-75177449 876-878 19453650 denotes 56
32227760-28209222-75177450 1001-1003 28209222 denotes 57