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PMC:7118659 / 6648-8934 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T9 222-226 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T10 1202-1206 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 1202-1206 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T52 53-61 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 186-194 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 443-451 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 545-553 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T56 636-644 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T57 811-819 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 846-854 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T59 1427-1435 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 1593-1601 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 1604-1614 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T62 1654-1661 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T63 1785-1796 Disease denotes retinopathy http://purl.obolibrary.org/obo/MONDO_0005283
T64 1878-1892 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T65 1963-1971 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 2156-2164 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 2167-2180 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T68 2264-2272 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T70 112-119 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T71 222-226 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T72 275-277 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T73 297-298 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 312-313 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 455-456 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T76 606-611 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T77 775-776 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 1153-1154 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 1202-1206 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T80 1202-1206 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T81 1252-1253 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 1384-1387 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T83 1463-1464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 1733-1739 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T85 1836-1838 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T86 1896-1897 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 1951-1952 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T88 2181-2187 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T89 2209-2212 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T90 2233-2240 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T62 13-22 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T63 33-44 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T64 423-434 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T65 489-500 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T66 509-523 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T67 509-518 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T68 519-523 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T69 524-534 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T70 585-590 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T71 732-743 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T72 764-769 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T73 856-867 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T74 1129-1140 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T75 1398-1409 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T76 1473-1484 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T77 1507-1515 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T78 1646-1650 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T79 1703-1714 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T80 1930-1941 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T81 2015-2026 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T82 2069-2080 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T83 2241-2252 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T9 1177-1182 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T10 1586-1614 Phenotype denotes severe SARS-CoV-2 infections http://purl.obolibrary.org/obo/HP_0033141
T11 1785-1796 Phenotype denotes retinopathy http://purl.obolibrary.org/obo/HP_0000488
T12 1878-1892 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T13 2144-2177 Phenotype denotes severity of SARS-CoV-2 infections http://purl.obolibrary.org/obo/HP_0033141

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
253 33-44 Chemical denotes chloroquine MESH:D002738
265 136-149 Species denotes coronaviruses Tax:11118
266 186-194 Species denotes SARS-CoV Tax:694009
267 210-221 Species denotes coronavirus Tax:11118
268 443-453 Species denotes SARS-CoV-2 Tax:2697049
269 545-555 Species denotes SARS-CoV-2 Tax:2697049
270 606-611 Species denotes human Tax:9606
271 612-620 Species denotes patients Tax:9606
272 423-434 Chemical denotes chloroquine MESH:D002738
273 489-500 Chemical denotes chloroquine MESH:D002738
274 524-534 Chemical denotes remdesivir MESH:C000606551
275 636-644 Disease denotes COVID-19 MESH:C000657245
303 811-821 Species denotes SARS-CoV-2 Tax:2697049
304 822-833 Species denotes coronavirus Tax:11118
305 1107-1115 Species denotes patients Tax:9606
306 1427-1437 Species denotes SARS-CoV-2 Tax:2697049
307 1733-1739 Species denotes humans Tax:9606
308 1983-1991 Species denotes patients Tax:9606
309 2181-2187 Species denotes humans Tax:9606
310 732-743 Chemical denotes chloroquine MESH:D002738
311 856-867 Chemical denotes Chloroquine MESH:D002738
312 1129-1140 Chemical denotes chloroquine MESH:D002738
313 1398-1409 Chemical denotes chloroquine MESH:D002738
314 1473-1484 Chemical denotes chloroquine MESH:D002738
315 1703-1714 Chemical denotes chloroquine MESH:D002738
316 1930-1941 Chemical denotes chloroquine MESH:D002738
317 2015-2026 Chemical denotes chloroquine MESH:D002738
318 2069-2080 Chemical denotes chloroquine MESH:D002738
319 2241-2252 Chemical denotes chloroquine MESH:D002738
320 846-854 Disease denotes COVID-19 MESH:C000657245
321 1098-1106 Disease denotes infected MESH:D007239
322 1177-1182 Disease denotes fever MESH:D005334
323 1593-1614 Disease denotes SARS-CoV-2 infections MESH:C000657245
324 1654-1661 Disease denotes malaria MESH:D008288
325 1777-1796 Disease denotes macular retinopathy MESH:C562746
326 1878-1892 Disease denotes cardiomyopathy MESH:D009202
327 1963-1982 Disease denotes SARS-CoV-2-infected MESH:C000657245
328 2156-2177 Disease denotes SARS-CoV-2 infections MESH:C000657245
329 2264-2272 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T39 0-63 Sentence denotes 3 Potential antiviral effect of chloroquine against SARS-CoV-2
T40 64-454 Sentence denotes Because of its broad spectrum of action against viruses, including most coronaviruses and particularly its close relative SARS-CoV-1, and because coronavirus cell entry occurs through the endolysosomal pathway [48], it made sense in a situation of a public-health emergency and the absence of any known efficient therapy to investigate the possible effect of chloroquine against SARS-CoV-2.
T41 455-650 Sentence denotes A recent paper reported that both chloroquine and the antiviral drug remdesivir inhibited SARS-CoV-2 in vitro and suggested these drugs be assessed in human patients suffering from COVID-19 [49].
T42 651-855 Sentence denotes Recently, the China National Center for Biotechnology Development indicated that chloroquine is one of the three drugs with a promising profile against the new SARS-CoV-2 coronavirus that causes COVID-19.
T43 856-993 Sentence denotes Chloroquine repurposing was investigated in hospitals in Beijing, in central China's Hunan Province and South China's Guangdong Province.
T44 994-1459 Sentence denotes According to preliminary reports [50,51] from the Chinese authorities suggesting that approximately 100 infected patients treated with chloroquine experienced a more rapid decline in fever and improvement of lung computed tomography (CT) images and required a shorter time to recover compared with control groups, with no obvious serious adverse effects, the Chinese medical advisory board has suggested chloroquine inclusion in the SARS-CoV-2 treatment guidelines.
T45 1460-1615 Sentence denotes As a result, chloroquine is probably the first molecule to be used in China and abroad on the front line for the treatment of severe SARS-CoV-2 infections.
T46 1616-1950 Sentence denotes Although the long use of this drug in malaria therapy demonstrates the safety of acute chloroquine administration to humans, one cannot ignore the minor risk of macular retinopathy, which depends on the cumulative dose [52], and the existence of some reports on cardiomyopathy as a severe adverse effect caused by chloroquine [53,54].
T47 1951-2059 Sentence denotes A survey of SARS-CoV-2-infected patients for adverse effects of chloroquine therapy remains to be performed.
T48 2060-2188 Sentence denotes However, chloroquine is currently among the best available candidates to impact the severity of SARS-CoV-2 infections in humans.
T49 2189-2286 Sentence denotes Currently, at least ten clinical trials are testing chloroquine as an anti-COVID-19 therapy [55].

2_test

Id Subject Object Predicate Lexical cue
32171740-32020029-48148546 646-648 32020029 denotes 49
32171740-32075365-48148547 1031-1033 32075365 denotes 51
32171740-1952638-48148548 1836-1838 1952638 denotes 52
32171740-3796692-48148549 1943-1945 3796692 denotes 53
32171740-8518071-48148550 1946-1948 8518071 denotes 54
T59778 646-648 32020029 denotes 49
T46805 1031-1033 32075365 denotes 51
T26068 1836-1838 1952638 denotes 52
T25498 1943-1945 3796692 denotes 53
T96160 1946-1948 8518071 denotes 54