PMC:7118659 / 11327-12647 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7118659","sourcedb":"PMC","sourceid":"7118659","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7118659","text":"Chloroquine can also interfere with the post-translational modification of viral proteins. These post-translational modifications, which involve proteases and glycosyltransferases, occur within the endoplasmic reticulum or the trans-Golgi network vesicles and may require a low pH. For HIV, the antiretroviral effect of chloroquine is attributable to a post-transcriptional inhibition of glycosylation of the gp120 envelope glycoprotein, and the neosynthesised virus particles are non-infectious [19,65]. Chloroquine also inhibits the replication Dengue-2 virus by affecting the normal proteolytic processing of the flavivirus prM protein to M protein [32]. As a result, viral infectivity is impaired. In the herpes simplex virus (HSV) model, chloroquine inhibited budding with accumulation of non-infectious HSV-1 particles in the trans-Golgi network [66]. Using non-human coronavirus, it was shown that the intracellular site of coronavirus budding is determined by the localisation of its membrane M proteins that accumulate in the Golgi complex beyond the site of virion budding [67], suggesting a possible action of chloroquine on SARS-CoV-2 at this step of the replication cycle. It was recently reported that the C-terminal domain of the MERS-CoV M protein contains a trans-Golgi network localisation signal [68].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T34","span":{"begin":81,"end":89},"obj":"Body_part"},{"id":"T35","span":{"begin":198,"end":219},"obj":"Body_part"},{"id":"T36","span":{"begin":227,"end":246},"obj":"Body_part"},{"id":"T37","span":{"begin":233,"end":246},"obj":"Body_part"},{"id":"T38","span":{"begin":286,"end":289},"obj":"Body_part"},{"id":"T39","span":{"begin":424,"end":436},"obj":"Body_part"},{"id":"T40","span":{"begin":631,"end":638},"obj":"Body_part"},{"id":"T41","span":{"begin":644,"end":651},"obj":"Body_part"},{"id":"T42","span":{"begin":832,"end":851},"obj":"Body_part"},{"id":"T43","span":{"begin":838,"end":851},"obj":"Body_part"},{"id":"T44","span":{"begin":1003,"end":1011},"obj":"Body_part"},{"id":"T45","span":{"begin":1035,"end":1048},"obj":"Body_part"},{"id":"T46","span":{"begin":1256,"end":1263},"obj":"Body_part"},{"id":"T47","span":{"begin":1275,"end":1294},"obj":"Body_part"},{"id":"T48","span":{"begin":1281,"end":1294},"obj":"Body_part"}],"attributes":[{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma63842"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma61756"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma67108"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A42","pred":"fma_id","subj":"T42","obj":"http://purl.org/sig/ont/fma/fma61756"},{"id":"A43","pred":"fma_id","subj":"T43","obj":"http://purl.org/sig/ont/fma/fma67108"},{"id":"A44","pred":"fma_id","subj":"T44","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A45","pred":"fma_id","subj":"T45","obj":"http://purl.org/sig/ont/fma/fma63843"},{"id":"A46","pred":"fma_id","subj":"T46","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma61756"},{"id":"A48","pred":"fma_id","subj":"T48","obj":"http://purl.org/sig/ont/fma/fma67108"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid_AGAC","denotations":[{"id":"p76535s4","span":{"begin":671,"end":688},"obj":"MPA"}],"attributes":[{"subj":"p76535s4","pred":"source","obj":"LitCovid_AGAC"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T78","span":{"begin":485,"end":495},"obj":"Disease"},{"id":"T79","span":{"begin":547,"end":553},"obj":"Disease"},{"id":"T80","span":{"begin":709,"end":723},"obj":"Disease"},{"id":"T81","span":{"begin":798,"end":808},"obj":"Disease"},{"id":"T82","span":{"begin":1136,"end":1144},"obj":"Disease"}],"attributes":[{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A79","pred":"mondo_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/MONDO_0005502"},{"id":"A80","pred":"mondo_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/MONDO_0004609"},{"id":"A81","pred":"mondo_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A82","pred":"mondo_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T125","span":{"begin":272,"end":273},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T126","span":{"begin":351,"end":352},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T127","span":{"begin":461,"end":466},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T128","span":{"begin":556,"end":561},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T129","span":{"begin":661,"end":662},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T130","span":{"begin":724,"end":729},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T131","span":{"begin":868,"end":873},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T132","span":{"begin":992,"end":1000},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T133","span":{"begin":1100,"end":1101},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T134","span":{"begin":1273,"end":1274},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T135","span":{"begin":1308,"end":1314},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"attributes":[{"subj":"T125","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T129","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T130","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T131","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T132","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T135","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T118","span":{"begin":0,"end":11},"obj":"Chemical"},{"id":"T119","span":{"begin":81,"end":89},"obj":"Chemical"},{"id":"T120","span":{"begin":320,"end":331},"obj":"Chemical"},{"id":"T121","span":{"begin":424,"end":436},"obj":"Chemical"},{"id":"T122","span":{"begin":505,"end":516},"obj":"Chemical"},{"id":"T123","span":{"begin":631,"end":638},"obj":"Chemical"},{"id":"T124","span":{"begin":644,"end":651},"obj":"Chemical"},{"id":"T125","span":{"begin":743,"end":754},"obj":"Chemical"},{"id":"T126","span":{"begin":1003,"end":1011},"obj":"Chemical"},{"id":"T127","span":{"begin":1121,"end":1132},"obj":"Chemical"},{"id":"T128","span":{"begin":1256,"end":1263},"obj":"Chemical"}],"attributes":[{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":40,"end":71},"obj":"http://purl.obolibrary.org/obo/GO_0043687"},{"id":"T8","span":{"begin":97,"end":129},"obj":"http://purl.obolibrary.org/obo/GO_0043687"},{"id":"T9","span":{"begin":358,"end":373},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T10","span":{"begin":388,"end":401},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T11","span":{"begin":765,"end":772},"obj":"http://purl.obolibrary.org/obo/GO_0007114"},{"id":"T12","span":{"begin":943,"end":950},"obj":"http://purl.obolibrary.org/obo/GO_0007114"},{"id":"T13","span":{"begin":972,"end":984},"obj":"http://purl.obolibrary.org/obo/GO_0051179"},{"id":"T14","span":{"begin":1068,"end":1082},"obj":"http://purl.obolibrary.org/obo/GO_0046755"},{"id":"T15","span":{"begin":1075,"end":1082},"obj":"http://purl.obolibrary.org/obo/GO_0007114"},{"id":"T16","span":{"begin":1295,"end":1307},"obj":"http://purl.obolibrary.org/obo/GO_0051179"}],"attributes":[{"subj":"T7","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"402","span":{"begin":547,"end":561},"obj":"Species"},{"id":"403","span":{"begin":809,"end":814},"obj":"Species"},{"id":"404","span":{"begin":868,"end":885},"obj":"Species"},{"id":"405","span":{"begin":931,"end":942},"obj":"Species"},{"id":"406","span":{"begin":1136,"end":1146},"obj":"Species"},{"id":"407","span":{"begin":1245,"end":1253},"obj":"Species"},{"id":"408","span":{"begin":286,"end":289},"obj":"Species"},{"id":"409","span":{"begin":0,"end":11},"obj":"Chemical"},{"id":"410","span":{"begin":320,"end":331},"obj":"Chemical"},{"id":"411","span":{"begin":505,"end":516},"obj":"Chemical"},{"id":"412","span":{"begin":743,"end":754},"obj":"Chemical"},{"id":"413","span":{"begin":1121,"end":1132},"obj":"Chemical"}],"attributes":[{"id":"A402","pred":"tao:has_database_id","subj":"402","obj":"Tax:11060"},{"id":"A403","pred":"tao:has_database_id","subj":"403","obj":"Tax:10298"},{"id":"A404","pred":"tao:has_database_id","subj":"404","obj":"Tax:694448"},{"id":"A405","pred":"tao:has_database_id","subj":"405","obj":"Tax:11118"},{"id":"A406","pred":"tao:has_database_id","subj":"406","obj":"Tax:2697049"},{"id":"A407","pred":"tao:has_database_id","subj":"407","obj":"Tax:1335626"},{"id":"A408","pred":"tao:has_database_id","subj":"408","obj":"Tax:12721"},{"id":"A409","pred":"tao:has_database_id","subj":"409","obj":"MESH:D002738"},{"id":"A410","pred":"tao:has_database_id","subj":"410","obj":"MESH:D002738"},{"id":"A411","pred":"tao:has_database_id","subj":"411","obj":"MESH:D002738"},{"id":"A412","pred":"tao:has_database_id","subj":"412","obj":"MESH:D002738"},{"id":"A413","pred":"tao:has_database_id","subj":"413","obj":"MESH:D002738"},{"subj":"402","pred":"source","obj":"LitCovid-PubTator"},{"subj":"403","pred":"source","obj":"LitCovid-PubTator"},{"subj":"404","pred":"source","obj":"LitCovid-PubTator"},{"subj":"405","pred":"source","obj":"LitCovid-PubTator"},{"subj":"406","pred":"source","obj":"LitCovid-PubTator"},{"subj":"407","pred":"source","obj":"LitCovid-PubTator"},{"subj":"408","pred":"source","obj":"LitCovid-PubTator"},{"subj":"409","pred":"source","obj":"LitCovid-PubTator"},{"subj":"410","pred":"source","obj":"LitCovid-PubTator"},{"subj":"411","pred":"source","obj":"LitCovid-PubTator"},{"subj":"412","pred":"source","obj":"LitCovid-PubTator"},{"subj":"413","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T64","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"T65","span":{"begin":91,"end":281},"obj":"Sentence"},{"id":"T66","span":{"begin":282,"end":504},"obj":"Sentence"},{"id":"T67","span":{"begin":505,"end":657},"obj":"Sentence"},{"id":"T68","span":{"begin":658,"end":701},"obj":"Sentence"},{"id":"T69","span":{"begin":702,"end":857},"obj":"Sentence"},{"id":"T70","span":{"begin":858,"end":1185},"obj":"Sentence"},{"id":"T71","span":{"begin":1186,"end":1320},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T64","pred":"source","obj":"LitCovid-sentences"},{"subj":"T65","pred":"source","obj":"LitCovid-sentences"},{"subj":"T66","pred":"source","obj":"LitCovid-sentences"},{"subj":"T67","pred":"source","obj":"LitCovid-sentences"},{"subj":"T68","pred":"source","obj":"LitCovid-sentences"},{"subj":"T69","pred":"source","obj":"LitCovid-sentences"},{"subj":"T70","pred":"source","obj":"LitCovid-sentences"},{"subj":"T71","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32171740-11166661-48148562","span":{"begin":497,"end":499},"obj":"11166661"},{"id":"32171740-2154882-48148563","span":{"begin":653,"end":655},"obj":"2154882"},{"id":"32171740-11152497-48148564","span":{"begin":853,"end":855},"obj":"11152497"},{"id":"32171740-8083990-48148565","span":{"begin":1084,"end":1086},"obj":"8083990"},{"id":"32171740-31399512-48148566","span":{"begin":1316,"end":1318},"obj":"31399512"},{"id":"T3708","span":{"begin":497,"end":499},"obj":"11166661"},{"id":"T15506","span":{"begin":653,"end":655},"obj":"2154882"},{"id":"T63134","span":{"begin":853,"end":855},"obj":"11152497"},{"id":"T94735","span":{"begin":1084,"end":1086},"obj":"8083990"},{"id":"T99293","span":{"begin":1316,"end":1318},"obj":"31399512"}],"attributes":[{"subj":"32171740-11166661-48148562","pred":"source","obj":"2_test"},{"subj":"32171740-2154882-48148563","pred":"source","obj":"2_test"},{"subj":"32171740-11152497-48148564","pred":"source","obj":"2_test"},{"subj":"32171740-8083990-48148565","pred":"source","obj":"2_test"},{"subj":"32171740-31399512-48148566","pred":"source","obj":"2_test"},{"subj":"T3708","pred":"source","obj":"2_test"},{"subj":"T15506","pred":"source","obj":"2_test"},{"subj":"T63134","pred":"source","obj":"2_test"},{"subj":"T94735","pred":"source","obj":"2_test"},{"subj":"T99293","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93a5ec","default":true},{"id":"LitCovid_AGAC","color":"#bfec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93d9"},{"id":"LitCovid-PD-CLO","color":"#93ece5"},{"id":"LitCovid-PD-CHEBI","color":"#ecca93"},{"id":"LitCovid-PD-GO-BP","color":"#b093ec"},{"id":"LitCovid-PubTator","color":"#93ec96"},{"id":"LitCovid-sentences","color":"#ec93a9"},{"id":"2_test","color":"#93c3ec"}]}]}}