PMC:7117554 / 3546-4680
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7117554","sourcedb":"PMC","sourceid":"7117554","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7117554","text":"The risk of transmitting SARS-CoV-2 can be mitigated through hospital infection control policies. We emphasize the importance of meticulous screening of patients and staff (including consideration of symptoms and travel history) before permitting entry into outpatient clinics together with the importance of engineering patient flow to minimize contact between patients. These strategies are also important for staff safety, to ensure maximal availability of both clinical and nonclinical staff. To reduce the number of clinic visits and the inherent risks, shorter radiotherapy fractionation and conversion of intravenous to oral systemic regimens can be considered. The opportunity exists for stopping or reducing frequency of selected maintenance treatments, or those with a long duration. For example, at our centre we will be moving from 2-weekly to 4-weekly administration of durvalumab as consolidation therapy for patients with non-small-cell lung cancer (reducing frequency), and recommending the consideration of treatment breaks for those receiving maintenance pemetrexed, or even forgoing maintenance pemetrexed entirely.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":947,"end":951},"obj":"Body_part"},{"id":"T2","span":{"begin":952,"end":956},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma7195"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":952,"end":956},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T46","span":{"begin":25,"end":33},"obj":"Disease"},{"id":"T47","span":{"begin":61,"end":79},"obj":"Disease"},{"id":"T48","span":{"begin":70,"end":79},"obj":"Disease"},{"id":"T49","span":{"begin":937,"end":963},"obj":"Disease"},{"id":"T50","span":{"begin":952,"end":963},"obj":"Disease"},{"id":"T51","span":{"begin":957,"end":963},"obj":"Disease"}],"attributes":[{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0043544"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005233"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0008903"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T12","span":{"begin":777,"end":778},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T13","span":{"begin":947,"end":951},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14","span":{"begin":952,"end":956},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T15","span":{"begin":952,"end":956},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"attributes":[{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":1073,"end":1083},"obj":"Chemical"},{"id":"T2","span":{"begin":1114,"end":1124},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_63616"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_63616"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T23","span":{"begin":937,"end":963},"obj":"Phenotype"}],"attributes":[{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0030358"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T28","span":{"begin":0,"end":97},"obj":"Sentence"},{"id":"T29","span":{"begin":98,"end":371},"obj":"Sentence"},{"id":"T30","span":{"begin":372,"end":496},"obj":"Sentence"},{"id":"T31","span":{"begin":497,"end":668},"obj":"Sentence"},{"id":"T32","span":{"begin":669,"end":793},"obj":"Sentence"},{"id":"T33","span":{"begin":794,"end":1134},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T28","pred":"source","obj":"LitCovid-sentences"},{"subj":"T29","pred":"source","obj":"LitCovid-sentences"},{"subj":"T30","pred":"source","obj":"LitCovid-sentences"},{"subj":"T31","pred":"source","obj":"LitCovid-sentences"},{"subj":"T32","pred":"source","obj":"LitCovid-sentences"},{"subj":"T33","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"135","span":{"begin":25,"end":35},"obj":"Species"},{"id":"136","span":{"begin":153,"end":161},"obj":"Species"},{"id":"137","span":{"begin":258,"end":268},"obj":"Species"},{"id":"138","span":{"begin":321,"end":328},"obj":"Species"},{"id":"139","span":{"begin":362,"end":370},"obj":"Species"},{"id":"140","span":{"begin":923,"end":931},"obj":"Species"},{"id":"141","span":{"begin":883,"end":893},"obj":"Chemical"},{"id":"142","span":{"begin":1073,"end":1083},"obj":"Chemical"},{"id":"143","span":{"begin":1114,"end":1124},"obj":"Chemical"},{"id":"144","span":{"begin":70,"end":79},"obj":"Disease"},{"id":"145","span":{"begin":937,"end":963},"obj":"Disease"}],"attributes":[{"id":"A135","pred":"tao:has_database_id","subj":"135","obj":"Tax:2697049"},{"id":"A136","pred":"tao:has_database_id","subj":"136","obj":"Tax:9606"},{"id":"A137","pred":"tao:has_database_id","subj":"137","obj":"Tax:9606"},{"id":"A138","pred":"tao:has_database_id","subj":"138","obj":"Tax:9606"},{"id":"A139","pred":"tao:has_database_id","subj":"139","obj":"Tax:9606"},{"id":"A140","pred":"tao:has_database_id","subj":"140","obj":"Tax:9606"},{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"MESH:C000613593"},{"id":"A142","pred":"tao:has_database_id","subj":"142","obj":"MESH:D000068437"},{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"MESH:D000068437"},{"id":"A144","pred":"tao:has_database_id","subj":"144","obj":"MESH:D007239"},{"id":"A145","pred":"tao:has_database_id","subj":"145","obj":"MESH:D002289"},{"subj":"135","pred":"source","obj":"LitCovid-PubTator"},{"subj":"136","pred":"source","obj":"LitCovid-PubTator"},{"subj":"137","pred":"source","obj":"LitCovid-PubTator"},{"subj":"138","pred":"source","obj":"LitCovid-PubTator"},{"subj":"139","pred":"source","obj":"LitCovid-PubTator"},{"subj":"140","pred":"source","obj":"LitCovid-PubTator"},{"subj":"141","pred":"source","obj":"LitCovid-PubTator"},{"subj":"142","pred":"source","obj":"LitCovid-PubTator"},{"subj":"143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"145","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93d2","default":true},{"id":"LitCovid-PD-UBERON","color":"#93ecec"},{"id":"LitCovid-PD-MONDO","color":"#ecd293"},{"id":"LitCovid-PD-CLO","color":"#b893ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ec9e"},{"id":"LitCovid-PD-HP","color":"#ec93a2"},{"id":"LitCovid-sentences","color":"#93bcec"},{"id":"LitCovid-PubTator","color":"#d6ec93"}]}]}}