PMC:7116472 / 42324-45569 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"746","span":{"begin":91,"end":99},"obj":"Species"},{"id":"747","span":{"begin":126,"end":134},"obj":"Disease"},{"id":"762","span":{"begin":2989,"end":3007},"obj":"Gene"},{"id":"763","span":{"begin":195,"end":203},"obj":"Species"},{"id":"764","span":{"begin":245,"end":253},"obj":"Species"},{"id":"765","span":{"begin":2847,"end":2851},"obj":"Chemical"},{"id":"766","span":{"begin":2913,"end":2923},"obj":"Chemical"},{"id":"767","span":{"begin":288,"end":297},"obj":"Disease"},{"id":"768","span":{"begin":930,"end":945},"obj":"Disease"},{"id":"769","span":{"begin":1004,"end":1026},"obj":"Disease"},{"id":"770","span":{"begin":1083,"end":1101},"obj":"Disease"},{"id":"771","span":{"begin":1177,"end":1190},"obj":"Disease"},{"id":"772","span":{"begin":1327,"end":1352},"obj":"Disease"},{"id":"773","span":{"begin":1358,"end":1364},"obj":"Disease"},{"id":"774","span":{"begin":1422,"end":1430},"obj":"Disease"},{"id":"775","span":{"begin":2159,"end":2163},"obj":"Disease"},{"id":"777","span":{"begin":3082,"end":3106},"obj":"Disease"},{"id":"779","span":{"begin":3237,"end":3244},"obj":"Disease"}],"attributes":[{"id":"A746","pred":"tao:has_database_id","subj":"746","obj":"Tax:9606"},{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"MESH:C000657245"},{"id":"A762","pred":"tao:has_database_id","subj":"762","obj":"Gene:1401"},{"id":"A763","pred":"tao:has_database_id","subj":"763","obj":"Tax:9606"},{"id":"A764","pred":"tao:has_database_id","subj":"764","obj":"Tax:9606"},{"id":"A765","pred":"tao:has_database_id","subj":"765","obj":"MESH:D014508"},{"id":"A766","pred":"tao:has_database_id","subj":"766","obj":"MESH:D003404"},{"id":"A767","pred":"tao:has_database_id","subj":"767","obj":"MESH:D003643"},{"id":"A768","pred":"tao:has_database_id","subj":"768","obj":"MESH:D006331"},{"id":"A769","pred":"tao:has_database_id","subj":"769","obj":"MESH:D051436"},{"id":"A770","pred":"tao:has_database_id","subj":"770","obj":"MESH:D009369"},{"id":"A771","pred":"tao:has_database_id","subj":"771","obj":"MESH:D008107"},{"id":"A772","pred":"tao:has_database_id","subj":"772","obj":"MESH:D008171"},{"id":"A773","pred":"tao:has_database_id","subj":"773","obj":"MESH:D001249"},{"id":"A774","pred":"tao:has_database_id","subj":"774","obj":"MESH:D003920"},{"id":"A775","pred":"tao:has_database_id","subj":"775","obj":"MESH:D003128"},{"id":"A777","pred":"tao:has_database_id","subj":"777","obj":"MESH:C000657245"},{"id":"A779","pred":"tao:has_database_id","subj":"779","obj":"MESH:D009765"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 1 Demographic and clinical characteristics for derivation and validation cohorts of patients admitted to hospital with covid-19\ncharacteristics Derivation cohort validation cohort\nNo of patients (%) or median (iQR) Total No (%) No of patients (%) or median (iQR) total No (%)\nMortality in hospital 11 426 (32.2) 35 463 (100.0) 6729 (30.1) 22 361 (100.0)\nAge (years)\n    \u003c50 4876 (13.8) 35 277 (99.5) 2808 (12.6) 22 361 (100.0)\n    50-69 10 183 (28.9) — 5762 (25.8) —\n    70-79 8017 (22.7) — 4951 (22.1) —\n    ≥80 12 201 (34.6) — 8840 (39.5) —\nSex at birth\n    Female 14 741 (41.7) 35 356 (99.7) 10 178 (45.6) 22 319 (99.8)\nEthnicity\n    White 26 300 (82.2) 31 987 (90.2) 16 831 (84.9) 19 818 (88.6)\n    South Asian 1647 (5.1) — 811 (4.1) —\n    East Asian 271 (0.8) — 140 (0.7) —\n    Black 1256 (3.9) — 769 (3.9) —\n    Other ethnic minority 2513 (7.9) — 1267 (6.4) —\nChronic cardiac disease 10 513 (31.8) 33 090 (93.3) 7019 (34.0) 20 616 (92.2)\nChronic kidney disease 5653 (17.2) 32 834 (92.6) 3769 (18.4) 20 444 (91.4)\nMalignant neoplasm 3312 (10.2) 32 556 (91.8) 2187 (10.8) 20 297 (90.8)\nModerate or severe liver disease 604 (1.9) 32 538 (91.8) 434 (2.1) 20 218 (90.4)\nObesity (clinician defined) 3414 (11.4) 29 829 (84.1) 2234 (12.2) 18 304 (81.9)\nChronic pulmonary disease (not asthma) 5830 (17.7) 32 990 (93.0) 3737 (18.2) 20 502 (91.7)\nDiabetes (type 1 and 2) 8487 (26.0) 32 622 (92.0) 4275 (21.9) 19 511 (87.3)\nNo of comorbidities\n    0 8497 (24.0) 35 463 (100.0) 5098 (22.8) 22 361 (100.0)\n    1 9941 (28.0) — 6114 (27.3) —\n    ≥2 17 025 (48.0) — 11 149 (49.9) —\nRespiratory rate (breaths/min) 22.0 (9.0) 33 330 (94.0) 20.0 (8.0) 20 970 (93.8)\nOxygen saturation (%) 94.0 (6.0) 33 696 (95.0) 94.0 (5.0) 21 197 (94.8)\nSystolic blood pressure (mm Hg) 124.0 (33.0) 33 637 (94.9) 129.0 (33.0) 21 073 (94.2)\nDiastolic blood pressure (mm Hg) 70.0 (19.0) 33 568 (94.7) 73.0 (20.0) 21 026 (94.0)\nTemperature (°C) 37.3 (1.5) 33 467 (94.4) 37.1 (1.5) 21 139 (94.5)\nHeart rate (bpm) 90.0 (27.0) 33 405 (94.2) 90.0 (28.0) 20 991 (93.9)\nGlasgow coma scale score 15.0 (0.0) 30 819 (86.9) 15.0 (0.0) 20 015 (89.5)\nHaemoglobin (g/L) 129.0 (30.0) 29 924 (84.4) 127.0 (31.0) 18 480 (82.6)\nWhite blood cell count (109/L) 7.4 (5.1) 29 740 (83.9) 7.6 (5.3) 18 362 (82.1)\nNeutrophil count (109/L) 5.6 (4.6) 29 594 (83.5) 5.8 (4.9) 18 354 (82.1)\nLymphocyte count (109/L) 0.9 (0.7) 29 553 (83.3) 0.9 (0.7) 18 348 (82.1)\nPlatelet count (109/L) 216.0 (120.0) 29 582 (83.4) 223.0 (126.0) 18 281 (81.8)\nSodium (mmol/L) 137.0 (6.0) 29 522 (83.2) 137.0 (6.0) 18 409 (82.3)\nPotassium (mmol/L) 4.1 (0.8) 27 224 (76.8) 4.1 (0.8) 16 926 (75.7)\nTotal bilirubin (mg/dL) 10.0 (7.0) 24 446 (68.9) 10.0 (7.0) 15 404 (68.9)\nUrea (mmol/L) 7.0 (6.3) 26 122 (73.7) 7.3 (6.8) 16 863 (75.4)\nCreatinine (pmol/L) 86.0 (53.0) 29 439 (83.0) 86.0 (56.0) 18 225 (81.5)\nC reactive protein (mg/L) 84.9 (122.0) 27 856 (78.5) 78.0 (120.0) 17 119 (76.6)\nCovid-19=coronavirus disease 2019; IQR=interquartile range.\nComorbidities were defined using the Charlson comorbidity index, with the addition of clinician defined obesity."}

{"project":"LitCovid-sentences","denotations":[{"id":"T247","span":{"begin":0,"end":134},"obj":"Sentence"},{"id":"T248","span":{"begin":135,"end":188},"obj":"Sentence"},{"id":"T249","span":{"begin":189,"end":287},"obj":"Sentence"},{"id":"T250","span":{"begin":288,"end":369},"obj":"Sentence"},{"id":"T251","span":{"begin":370,"end":381},"obj":"Sentence"},{"id":"T252","span":{"begin":382,"end":446},"obj":"Sentence"},{"id":"T253","span":{"begin":447,"end":490},"obj":"Sentence"},{"id":"T254","span":{"begin":491,"end":532},"obj":"Sentence"},{"id":"T255","span":{"begin":533,"end":574},"obj":"Sentence"},{"id":"T256","span":{"begin":575,"end":587},"obj":"Sentence"},{"id":"T257","span":{"begin":588,"end":658},"obj":"Sentence"},{"id":"T258","span":{"begin":659,"end":668},"obj":"Sentence"},{"id":"T259","span":{"begin":669,"end":738},"obj":"Sentence"},{"id":"T260","span":{"begin":739,"end":783},"obj":"Sentence"},{"id":"T261","span":{"begin":784,"end":826},"obj":"Sentence"},{"id":"T262","span":{"begin":827,"end":865},"obj":"Sentence"},{"id":"T263","span":{"begin":866,"end":921},"obj":"Sentence"},{"id":"T264","span":{"begin":922,"end":1003},"obj":"Sentence"},{"id":"T265","span":{"begin":1004,"end":1082},"obj":"Sentence"},{"id":"T266","span":{"begin":1083,"end":1157},"obj":"Sentence"},{"id":"T267","span":{"begin":1158,"end":1242},"obj":"Sentence"},{"id":"T268","span":{"begin":1243,"end":1326},"obj":"Sentence"},{"id":"T269","span":{"begin":1327,"end":1421},"obj":"Sentence"},{"id":"T270","span":{"begin":1422,"end":1501},"obj":"Sentence"},{"id":"T271","span":{"begin":1502,"end":1521},"obj":"Sentence"},{"id":"T272","span":{"begin":1522,"end":1585},"obj":"Sentence"},{"id":"T273","span":{"begin":1586,"end":1623},"obj":"Sentence"},{"id":"T274","span":{"begin":1624,"end":1666},"obj":"Sentence"},{"id":"T275","span":{"begin":1667,"end":1751},"obj":"Sentence"},{"id":"T276","span":{"begin":1752,"end":1827},"obj":"Sentence"},{"id":"T277","span":{"begin":1828,"end":1917},"obj":"Sentence"},{"id":"T278","span":{"begin":1918,"end":2006},"obj":"Sentence"},{"id":"T279","span":{"begin":2007,"end":2077},"obj":"Sentence"},{"id":"T280","span":{"begin":2078,"end":2150},"obj":"Sentence"},{"id":"T281","span":{"begin":2151,"end":2229},"obj":"Sentence"},{"id":"T282","span":{"begin":2230,"end":2305},"obj":"Sentence"},{"id":"T283","span":{"begin":2306,"end":2388},"obj":"Sentence"},{"id":"T284","span":{"begin":2389,"end":2465},"obj":"Sentence"},{"id":"T285","span":{"begin":2466,"end":2542},"obj":"Sentence"},{"id":"T286","span":{"begin":2543,"end":2625},"obj":"Sentence"},{"id":"T287","span":{"begin":2626,"end":2697},"obj":"Sentence"},{"id":"T288","span":{"begin":2698,"end":2768},"obj":"Sentence"},{"id":"T289","span":{"begin":2769,"end":2846},"obj":"Sentence"},{"id":"T290","span":{"begin":2847,"end":2912},"obj":"Sentence"},{"id":"T291","span":{"begin":2913,"end":2988},"obj":"Sentence"},{"id":"T292","span":{"begin":2989,"end":3072},"obj":"Sentence"},{"id":"T293","span":{"begin":3073,"end":3132},"obj":"Sentence"},{"id":"T294","span":{"begin":3133,"end":3245},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 1 Demographic and clinical characteristics for derivation and validation cohorts of patients admitted to hospital with covid-19\ncharacteristics Derivation cohort validation cohort\nNo of patients (%) or median (iQR) Total No (%) No of patients (%) or median (iQR) total No (%)\nMortality in hospital 11 426 (32.2) 35 463 (100.0) 6729 (30.1) 22 361 (100.0)\nAge (years)\n    \u003c50 4876 (13.8) 35 277 (99.5) 2808 (12.6) 22 361 (100.0)\n    50-69 10 183 (28.9) — 5762 (25.8) —\n    70-79 8017 (22.7) — 4951 (22.1) —\n    ≥80 12 201 (34.6) — 8840 (39.5) —\nSex at birth\n    Female 14 741 (41.7) 35 356 (99.7) 10 178 (45.6) 22 319 (99.8)\nEthnicity\n    White 26 300 (82.2) 31 987 (90.2) 16 831 (84.9) 19 818 (88.6)\n    South Asian 1647 (5.1) — 811 (4.1) —\n    East Asian 271 (0.8) — 140 (0.7) —\n    Black 1256 (3.9) — 769 (3.9) —\n    Other ethnic minority 2513 (7.9) — 1267 (6.4) —\nChronic cardiac disease 10 513 (31.8) 33 090 (93.3) 7019 (34.0) 20 616 (92.2)\nChronic kidney disease 5653 (17.2) 32 834 (92.6) 3769 (18.4) 20 444 (91.4)\nMalignant neoplasm 3312 (10.2) 32 556 (91.8) 2187 (10.8) 20 297 (90.8)\nModerate or severe liver disease 604 (1.9) 32 538 (91.8) 434 (2.1) 20 218 (90.4)\nObesity (clinician defined) 3414 (11.4) 29 829 (84.1) 2234 (12.2) 18 304 (81.9)\nChronic pulmonary disease (not asthma) 5830 (17.7) 32 990 (93.0) 3737 (18.2) 20 502 (91.7)\nDiabetes (type 1 and 2) 8487 (26.0) 32 622 (92.0) 4275 (21.9) 19 511 (87.3)\nNo of comorbidities\n    0 8497 (24.0) 35 463 (100.0) 5098 (22.8) 22 361 (100.0)\n    1 9941 (28.0) — 6114 (27.3) —\n    ≥2 17 025 (48.0) — 11 149 (49.9) —\nRespiratory rate (breaths/min) 22.0 (9.0) 33 330 (94.0) 20.0 (8.0) 20 970 (93.8)\nOxygen saturation (%) 94.0 (6.0) 33 696 (95.0) 94.0 (5.0) 21 197 (94.8)\nSystolic blood pressure (mm Hg) 124.0 (33.0) 33 637 (94.9) 129.0 (33.0) 21 073 (94.2)\nDiastolic blood pressure (mm Hg) 70.0 (19.0) 33 568 (94.7) 73.0 (20.0) 21 026 (94.0)\nTemperature (°C) 37.3 (1.5) 33 467 (94.4) 37.1 (1.5) 21 139 (94.5)\nHeart rate (bpm) 90.0 (27.0) 33 405 (94.2) 90.0 (28.0) 20 991 (93.9)\nGlasgow coma scale score 15.0 (0.0) 30 819 (86.9) 15.0 (0.0) 20 015 (89.5)\nHaemoglobin (g/L) 129.0 (30.0) 29 924 (84.4) 127.0 (31.0) 18 480 (82.6)\nWhite blood cell count (109/L) 7.4 (5.1) 29 740 (83.9) 7.6 (5.3) 18 362 (82.1)\nNeutrophil count (109/L) 5.6 (4.6) 29 594 (83.5) 5.8 (4.9) 18 354 (82.1)\nLymphocyte count (109/L) 0.9 (0.7) 29 553 (83.3) 0.9 (0.7) 18 348 (82.1)\nPlatelet count (109/L) 216.0 (120.0) 29 582 (83.4) 223.0 (126.0) 18 281 (81.8)\nSodium (mmol/L) 137.0 (6.0) 29 522 (83.2) 137.0 (6.0) 18 409 (82.3)\nPotassium (mmol/L) 4.1 (0.8) 27 224 (76.8) 4.1 (0.8) 16 926 (75.7)\nTotal bilirubin (mg/dL) 10.0 (7.0) 24 446 (68.9) 10.0 (7.0) 15 404 (68.9)\nUrea (mmol/L) 7.0 (6.3) 26 122 (73.7) 7.3 (6.8) 16 863 (75.4)\nCreatinine (pmol/L) 86.0 (53.0) 29 439 (83.0) 86.0 (56.0) 18 225 (81.5)\nC reactive protein (mg/L) 84.9 (122.0) 27 856 (78.5) 78.0 (120.0) 17 119 (76.6)\nCovid-19=coronavirus disease 2019; IQR=interquartile range.\nComorbidities were defined using the Charlson comorbidity index, with the addition of clinician defined obesity."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T32","span":{"begin":1004,"end":1026},"obj":"Phenotype"},{"id":"T33","span":{"begin":1093,"end":1101},"obj":"Phenotype"},{"id":"T34","span":{"begin":1177,"end":1190},"obj":"Phenotype"},{"id":"T35","span":{"begin":1243,"end":1250},"obj":"Phenotype"},{"id":"T36","span":{"begin":1358,"end":1364},"obj":"Phenotype"},{"id":"T37","span":{"begin":2159,"end":2163},"obj":"Phenotype"},{"id":"T38","span":{"begin":3237,"end":3244},"obj":"Phenotype"}],"attributes":[{"id":"A32","pred":"hp_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/HP_0012622"},{"id":"A33","pred":"hp_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A34","pred":"hp_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/HP_0001392"},{"id":"A35","pred":"hp_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A36","pred":"hp_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0001259"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0001513"}],"text":"Table 1 Demographic and clinical characteristics for derivation and validation cohorts of patients admitted to hospital with covid-19\ncharacteristics Derivation cohort validation cohort\nNo of patients (%) or median (iQR) Total No (%) No of patients (%) or median (iQR) total No (%)\nMortality in hospital 11 426 (32.2) 35 463 (100.0) 6729 (30.1) 22 361 (100.0)\nAge (years)\n    \u003c50 4876 (13.8) 35 277 (99.5) 2808 (12.6) 22 361 (100.0)\n    50-69 10 183 (28.9) — 5762 (25.8) —\n    70-79 8017 (22.7) — 4951 (22.1) —\n    ≥80 12 201 (34.6) — 8840 (39.5) —\nSex at birth\n    Female 14 741 (41.7) 35 356 (99.7) 10 178 (45.6) 22 319 (99.8)\nEthnicity\n    White 26 300 (82.2) 31 987 (90.2) 16 831 (84.9) 19 818 (88.6)\n    South Asian 1647 (5.1) — 811 (4.1) —\n    East Asian 271 (0.8) — 140 (0.7) —\n    Black 1256 (3.9) — 769 (3.9) —\n    Other ethnic minority 2513 (7.9) — 1267 (6.4) —\nChronic cardiac disease 10 513 (31.8) 33 090 (93.3) 7019 (34.0) 20 616 (92.2)\nChronic kidney disease 5653 (17.2) 32 834 (92.6) 3769 (18.4) 20 444 (91.4)\nMalignant neoplasm 3312 (10.2) 32 556 (91.8) 2187 (10.8) 20 297 (90.8)\nModerate or severe liver disease 604 (1.9) 32 538 (91.8) 434 (2.1) 20 218 (90.4)\nObesity (clinician defined) 3414 (11.4) 29 829 (84.1) 2234 (12.2) 18 304 (81.9)\nChronic pulmonary disease (not asthma) 5830 (17.7) 32 990 (93.0) 3737 (18.2) 20 502 (91.7)\nDiabetes (type 1 and 2) 8487 (26.0) 32 622 (92.0) 4275 (21.9) 19 511 (87.3)\nNo of comorbidities\n    0 8497 (24.0) 35 463 (100.0) 5098 (22.8) 22 361 (100.0)\n    1 9941 (28.0) — 6114 (27.3) —\n    ≥2 17 025 (48.0) — 11 149 (49.9) —\nRespiratory rate (breaths/min) 22.0 (9.0) 33 330 (94.0) 20.0 (8.0) 20 970 (93.8)\nOxygen saturation (%) 94.0 (6.0) 33 696 (95.0) 94.0 (5.0) 21 197 (94.8)\nSystolic blood pressure (mm Hg) 124.0 (33.0) 33 637 (94.9) 129.0 (33.0) 21 073 (94.2)\nDiastolic blood pressure (mm Hg) 70.0 (19.0) 33 568 (94.7) 73.0 (20.0) 21 026 (94.0)\nTemperature (°C) 37.3 (1.5) 33 467 (94.4) 37.1 (1.5) 21 139 (94.5)\nHeart rate (bpm) 90.0 (27.0) 33 405 (94.2) 90.0 (28.0) 20 991 (93.9)\nGlasgow coma scale score 15.0 (0.0) 30 819 (86.9) 15.0 (0.0) 20 015 (89.5)\nHaemoglobin (g/L) 129.0 (30.0) 29 924 (84.4) 127.0 (31.0) 18 480 (82.6)\nWhite blood cell count (109/L) 7.4 (5.1) 29 740 (83.9) 7.6 (5.3) 18 362 (82.1)\nNeutrophil count (109/L) 5.6 (4.6) 29 594 (83.5) 5.8 (4.9) 18 354 (82.1)\nLymphocyte count (109/L) 0.9 (0.7) 29 553 (83.3) 0.9 (0.7) 18 348 (82.1)\nPlatelet count (109/L) 216.0 (120.0) 29 582 (83.4) 223.0 (126.0) 18 281 (81.8)\nSodium (mmol/L) 137.0 (6.0) 29 522 (83.2) 137.0 (6.0) 18 409 (82.3)\nPotassium (mmol/L) 4.1 (0.8) 27 224 (76.8) 4.1 (0.8) 16 926 (75.7)\nTotal bilirubin (mg/dL) 10.0 (7.0) 24 446 (68.9) 10.0 (7.0) 15 404 (68.9)\nUrea (mmol/L) 7.0 (6.3) 26 122 (73.7) 7.3 (6.8) 16 863 (75.4)\nCreatinine (pmol/L) 86.0 (53.0) 29 439 (83.0) 86.0 (56.0) 18 225 (81.5)\nC reactive protein (mg/L) 84.9 (122.0) 27 856 (78.5) 78.0 (120.0) 17 119 (76.6)\nCovid-19=coronavirus disease 2019; IQR=interquartile range.\nComorbidities were defined using the Charlson comorbidity index, with the addition of clinician defined obesity."}