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PMC:7116472 / 187-2766 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
10 81-89 Species denotes patients Tax:9606
11 68-77 Disease denotes mortality MESH:D003643
12 116-140 Disease denotes coronavirus disease 2019 MESH:C000657245
13 142-150 Disease denotes covid-19 MESH:C000657245
18 403-414 Species denotes Coronavirus Tax:11118
19 561-569 Species denotes patients Tax:9606
20 664-672 Species denotes patients Tax:9606
21 262-272 Disease denotes Infections MESH:D007239
23 803-811 Disease denotes covid-19 MESH:C000657245
25 896-905 Disease denotes mortality MESH:D003643
38 1283-1301 Gene denotes C reactive protein Gene:1401
39 923-931 Species denotes patients Tax:9606
40 1621-1629 Species denotes Patients Tax:9606
41 1224-1230 Chemical denotes oxygen MESH:D010100
42 1267-1271 Chemical denotes urea MESH:D014508
43 973-982 Disease denotes mortality MESH:D003643
44 1033-1042 Disease denotes mortality MESH:D003643
45 1069-1078 Disease denotes Mortality MESH:D003643
46 1373-1382 Disease denotes mortality MESH:D003643
47 1682-1691 Disease denotes mortality MESH:D003643
48 1741-1750 Disease denotes mortality MESH:D003643
49 2023-2031 Disease denotes covid-19 MESH:C000657245
53 2376-2384 Species denotes patients Tax:9606
54 2242-2251 Disease denotes Mortality MESH:D003643
55 2411-2419 Disease denotes covid-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-9 Sentence denotes Objective
T4 10-152 Sentence denotes To develop and validate a pragmatic risk score to predict mortality in patients admitted to hospital with coronavirus disease 2019 (covid-19).
T5 154-160 Sentence denotes Design
T6 161-200 Sentence denotes Prospective observational cohort study.
T7 202-209 Sentence denotes Setting
T8 210-516 Sentence denotes International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study (performed by the ISARIC Coronavirus Clinical Characterisation Consortium—ISARIC-4C) in 260 hospitals across England, Scotland, and Wales.
T9 517-739 Sentence denotes Model training was performed on a cohort of patients recruited between 6 February and 20 May 2020, with validation conducted on a second cohort of patients recruited after model development between 21 May and 29 June 2020.
T10 741-753 Sentence denotes Participants
T11 754-861 Sentence denotes Adults (age ≥18 years) admitted to hospital with covid-19 at least four weeks before final data extraction.
T12 863-883 Sentence denotes Main Outcome Measure
T13 884-906 Sentence denotes In-hospital mortality.
T14 908-915 Sentence denotes Results
T15 916-1055 Sentence denotes 35 463 patients were included in the derivation dataset (mortality rate 32.2%) and 22 361 in the validation dataset (mortality rate 30.1%).
T16 1056-1328 Sentence denotes The final 4C Mortality Score included eight variables readily available at initial hospital assessment: age, sex, number of comorbidities, respiratory rate, peripheral oxygen saturation, level of consciousness, urea level, and C reactive protein (score range 0-21 points).
T17 1329-1520 Sentence denotes The 4C Score showed high discrimination for mortality (derivation cohort: area under the receiver operating characteristic curve 0.79, 95% confidence interval 0.78 to 0.79; validation cohort:
T18 1521-1620 Sentence denotes 0.77, 0.76 to 0.77) with excellent calibration (validation: calibration-in-the-large=0, slope=1.0).
T19 1621-1831 Sentence denotes Patients with a score of at least 15 (n=4158, 19%) had a 62% mortality (positive predictive value 62%) compared with 1% mortality for those with a score of 3 or less (n=1650, 7%; negative predictive value 99%).
T20 1832-2082 Sentence denotes Discriminatory performance was higher than 15 pre-existing risk stratification scores (area under the receiver operating characteristic curve range 0.61-0.76), with scores developed in other covid-19 cohorts often performing poorly (range 0.63-0.73).
T21 2084-2095 Sentence denotes Conclusions
T22 2096-2234 Sentence denotes An easy-to-use risk stratification score has been developed and validated based on commonly available parameters at hospital presentation.
T23 2235-2453 Sentence denotes The 4C Mortality Score outperformed existing scores, showed utility to directly inform clinical decision making, and can be used to stratify patients admitted to hospital with covid-19 into different management groups.
T24 2454-2544 Sentence denotes The score should be further validated to determine its applicability in other populations.
T25 2546-2564 Sentence denotes Study Registration
T26 2565-2579 Sentence denotes ISRCTN66726260