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PMC:7115396 / 33527-38958 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1467-1478 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T173 10-17 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 48-56 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T175 158-162 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T176 251-258 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T177 394-399 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T178 421-425 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T179 551-555 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T180 693-700 Body_part denotes embryos http://purl.org/sig/ont/fma/fma296970
T181 819-835 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T182 830-835 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T183 859-866 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T184 890-896 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T185 910-915 Body_part denotes bursa http://purl.org/sig/ont/fma/fma9692
T186 992-999 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T187 1001-1005 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T188 1011-1017 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T189 1041-1047 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T190 1113-1117 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T191 1180-1184 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T192 1207-1214 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T193 1445-1450 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T194 1486-1498 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T195 1486-1490 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T196 1593-1597 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T197 1726-1732 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T198 1826-1833 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T199 1936-1943 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T200 2004-2009 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T201 2047-2052 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T202 2057-2064 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T203 2233-2239 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T204 2354-2360 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T205 2422-2430 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T206 2441-2445 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T207 2548-2555 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T208 2595-2602 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T209 2738-2745 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T210 2746-2762 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T211 2757-2762 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T212 3004-3010 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T213 3102-3110 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T214 3160-3168 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T215 3340-3347 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T216 3348-3358 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T217 3820-3828 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T218 3909-3917 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T219 3947-3950 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T220 3973-3978 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T221 3983-3990 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T222 4083-4087 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T223 4242-4249 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T224 4308-4315 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T225 4454-4472 Body_part denotes epithelial tissues http://purl.org/sig/ont/fma/fma9639
T226 4715-4718 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T227 5295-5301 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T61 890-896 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T62 992-999 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T63 1001-1005 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T64 1011-1017 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T65 1041-1047 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T66 1113-1117 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T67 1726-1732 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T68 1936-1943 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T69 2233-2239 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T70 2354-2360 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T71 2595-2602 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T72 2738-2745 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T73 3004-3010 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T74 3340-3347 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T75 3348-3358 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T76 3414-3420 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T77 5156-5159 Body_part denotes egg http://purl.obolibrary.org/obo/UBERON_0007379
T78 5295-5301 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T36 1145-1154 Disease denotes nephritis http://purl.obolibrary.org/obo/MONDO_0001166
T37 1266-1275 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T38 2620-2629 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39 2870-2879 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 4499-4508 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T41 4556-4569 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T42 4965-4974 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T482 158-162 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T483 240-250 http://purl.obolibrary.org/obo/CLO_0001410 denotes 52]. The S
T484 279-281 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T485 286-288 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T486 286-288 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T487 305-307 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T488 308-310 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T489 308-310 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T490 335-337 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T491 394-399 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T492 418-420 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T493 421-425 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T494 426-429 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T495 464-469 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T496 527-529 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T497 548-550 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T498 551-555 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T499 597-599 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T500 600-602 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T501 600-602 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T502 693-700 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T503 726-728 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T504 819-829 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T505 830-835 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T506 890-896 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T507 890-896 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T508 890-896 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T509 898-904 http://purl.obolibrary.org/obo/UBERON_0000991 denotes gonads
T510 1001-1005 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T511 1001-1005 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T512 1011-1017 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T513 1011-1017 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T514 1011-1017 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T515 1113-1117 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T516 1113-1117 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T517 1180-1184 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T518 1227-1235 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T519 1353-1363 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T520 1445-1450 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T521 1486-1490 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T522 1523-1525 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T523 1575-1580 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T524 1593-1597 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T525 1643-1645 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T526 1643-1645 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T527 1665-1673 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T528 1755-1757 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T529 1847-1849 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T530 1893-1895 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T531 2004-2009 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T532 2047-2052 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T533 2057-2064 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T534 2057-2064 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T535 2057-2064 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T536 2077-2089 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens, in
T537 2102-2110 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T538 2179-2181 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T539 2179-2181 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T540 2186-2188 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T541 2189-2194 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T542 2354-2360 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T543 2354-2360 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T544 2354-2360 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T545 2377-2379 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T546 2438-2440 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T547 2438-2440 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T548 2441-2445 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T549 2717-2722 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T550 2746-2756 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T551 2757-2762 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T552 3348-3358 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T553 3414-3420 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T554 3424-3432 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T555 3453-3455 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T556 3548-3556 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T557 3617-3619 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T558 3864-3866 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T559 3960-3962 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T560 3973-3978 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T561 3983-3990 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T562 3983-3990 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T563 3983-3990 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T564 4080-4082 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T565 4083-4087 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T566 4107-4112 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T567 4316-4319 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T568 4398-4400 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T569 4401-4406 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T570 4454-4472 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelial tissues
T571 4570-4577 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chicken
T572 4633-4634 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T573 4772-4780 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T574 4791-4793 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T575 4795-4797 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T576 4922-4924 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T577 5022-5025 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T578 5060-5065 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T579 5136-5138 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T580 5167-5175 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T581 5209-5210 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T582 5257-5262 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T583 5337-5344 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T584 5352-5354 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T585 5376-5377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T586 5422-5430 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T99 10-17 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T100 48-56 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T101 251-258 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T102 286-288 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T103 308-310 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T104 600-602 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T105 1467-1478 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T106 1474-1478 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T107 1643-1645 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T108 1862-1867 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T109 2179-2181 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T110 2438-2440 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T111 3102-3110 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T112 3160-3168 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T113 3247-3252 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T114 4242-4249 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T115 4282-4284 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T116 4308-4315 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T117 4928-4933 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T48 447-456 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T49 447-456 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T50 768-777 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T51 768-777 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T52 978-984 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T53 1094-1102 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T54 1094-1102 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T55 1094-1102 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T56 1094-1102 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T57 1631-1638 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T58 1665-1680 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T59 1733-1740 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T60 1962-1970 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T61 1962-1970 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T62 1962-1970 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T63 1962-1970 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T64 2240-2247 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T65 2322-2339 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T66 2322-2339 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T67 2971-2980 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T68 2971-2980 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T69 3024-3041 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T70 3024-3041 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T71 3311-3319 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T72 3311-3319 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T73 3311-3319 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T74 3311-3319 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T75 3666-3673 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T76 4444-4450 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T77 5156-5166 http://purl.obolibrary.org/obo/GO_0018991 denotes egg-laying
T78 5232-5241 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T79 5232-5241 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T229 0-132 Sentence denotes The spike protein is the coronavirus structural proteins, which plays an important role on pathogenicity in coronaviruses [6], [50].
T230 133-244 Sentence denotes However, replacing the S gene of Beaudette strain by the virulent strains does not make it virulent [51], [52].
T231 245-405 Sentence denotes The S protein can be cleaved into S1 and S2 subunits at the S1/S2 cleavage site [53], the S1 subunit is responsible for receptor binding to the host cells [54].
T232 406-481 Sentence denotes Whether the S1 gene has an effect on the virulence of the virus is unknown.
T233 482-701 Sentence denotes In this study, the recombinant strain, rH120-S1/YZ, expressed the S1 gene of the QX-like strain, which retains the S1/S2 cleavage site of H120, maintained the ability to replicate and exhibited pathogenicity in embryos.
T234 702-795 Sentence denotes However, providing IBYZ S1 sequences to H120 did not increase its virulence to that of rIBYZ.
T235 796-925 Sentence denotes IBVs replicate in many epithelial cells, including respiratory tissues, the alimentary canal, kidney, gonads, and bursa [2], [6].
T236 926-1055 Sentence denotes The QX-like rIBYZ strain is capable of considerable growth in the trachea, lung, and kidney, which leads to severe tissue damage.
T237 1056-1276 Sentence denotes In addition, this strain caused cilia necrosis and loss, lung congestion and hemorrhage, nephritis, as well as inflammatory cell infiltration in these tissues in infected chickens at different time points post-infection.
T238 1277-1550 Sentence denotes The ability of IBV to replicate within many respiratory, enteric, and other epithelial surfaces may be partially related to the fact that the attachment of IBV to host cells is dependent on sialic acid on the cell surface being recognized by the S1 subunit [6], [54], [55].
T239 1551-1686 Sentence denotes However, the binding of virus to the host cell is the first step in determining tropism and S2 is responsible for membrane fusion [56].
T240 1687-1868 Sentence denotes Thus, to further explore the different tissue tropism between rH120-S1/YZ and rIBYZ, we examined the viral loads and histopathology in the tissues of the rH120-S1/YZ-infected group.
T241 1869-2142 Sentence denotes It was found that rH120-S1/YZ remains moderately pathogenic in the trachea (e.g., some cilia necrosis and loss and decreased secretory cells) but no lesions were observed in the lungs and kidneys of infected chickens, in contrast to chickens infected with the rIBYZ strain.
T242 2143-2281 Sentence denotes This finding suggests that both the S2 and S1 genes might play an important role in viral tissue tropism as also suggested by others [57].
T243 2282-2477 Sentence denotes Another possibility is that the lack of viral replication and damage in kidney following rH120-S1/YZ is due to lower replication ability of backbone except S2 gene from its parental rH120 strain.
T244 2478-2826 Sentence denotes The viral load of the respiratory-type strain, rH120 in the different tissues indicated that the viral levels in the trachea, early following infection were significantly higher than those of rIBYZ, which indicates that the ability of the virus to attached to trachea epithelial cells of the rH120 strain was stronger than that of the rIBYZ strain.
T245 2827-3198 Sentence denotes However, during the later time points post-infection, the level of the rH120 strain was significantly lower than rIBYZ, which suggests that the virulence of IBV depends both on tissue invasion and viral replication ability, as well as other functions mediated by other viral proteins (e.g., non-structural, structural, and accessory proteins) [6], [29], [58], [59], [60].
T246 3199-3359 Sentence denotes The reduction of the viral load at 5 dpi in the group infected with the rIBYZ strain may be associated with the necrosis and shedding of the trachea epithelium.
T247 3360-3829 Sentence denotes Moreover, the ability to replication in the different organs of chickens infected with rH120-S1/YZ as reflected by viral loads at multiple time points was lower than that exhibited in the chickens infected with the rIBYZ strain, which demonstrated that the S1 subunit was not the only determinant of viral tropism that was consistent with results by others [57], [61], [62], and the significant difference in viral load was related to differences in the viral backbone.
T248 3830-4267 Sentence denotes However, when comparing the rH120-S1/YZ and rH120 strains which carry the same backbone, it was found that the viral RNA of rH120-S1/YZ in the lungs and kidneys was significantly lower than that of rH120, which may due to the replacement of the IBYZ S1 gene in the recombinant virus, whose structure on the surface contains some degree of changes, which we speculated that may affects the functionality of the S protein of coronaviruses.
T249 4268-4424 Sentence denotes Although cryo-EM structure of IBV spike protein has been determined, the relation between structure and function of different IBV S1 genes is unknown. [63].
T250 4425-4681 Sentence denotes In addition to the growth in epithelial tissues observed during the early infection period, IBV can establish long-term persistent infections in chicken flocks via oral and cloacal shedding, which represents a substantial challenge to IBV control [1], [6].
T251 4682-4827 Sentence denotes In this study, we detected viral RNA in the oral and cloacal swabs isolated from infected chickens at 7, 14, 18, 22, and 26 dpi by real-time PCR.
T252 4828-5003 Sentence denotes Compared with rH120 and rIBYZ, the viral load in both the oral and cloacal swabs of the rH120-S1/YZ group at different time points after infection was significantly decreased.
T253 5004-5205 Sentence denotes However, while it has been reported that the persistent virus will be re-excreted at the point of lay [1], the persistence of rH120-S1/YZ strain in the egg-laying chickens needs to be further verified.
T254 5206-5431 Sentence denotes In a word, due to its low virulence i presented in virus loading and lesion in different tissue, oral and cloacal shedding of host animals, rH120-S1/YZ can be considered a safe attenuated vaccine candidate for young chickens.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T21 1145-1154 Phenotype denotes nephritis http://purl.obolibrary.org/obo/HP_0000123

2_test

Id Subject Object Predicate Lexical cue
32057575-17296157-143294083 123-124 17296157 denotes 6
32057575-3010596-143294084 128-130 3010596 denotes 50
32057575-22179147-143294085 234-236 22179147 denotes 51
32057575-15564488-143294086 240-242 15564488 denotes 52
32057575-3010595-143294087 326-328 3010595 denotes 53
32057575-23896748-143294088 401-403 23896748 denotes 54
32057575-16537157-143294089 917-918 16537157 denotes 2
32057575-17296157-143294090 922-923 17296157 denotes 6
32057575-17296157-143294091 1535-1536 17296157 denotes 6
32057575-23896748-143294092 1540-1542 23896748 denotes 54
32057575-25451062-143294093 1546-1548 25451062 denotes 55
32057575-21697468-143294094 1682-1684 21697468 denotes 56
32057575-24041648-143294095 2277-2279 24041648 denotes 57
32057575-17296157-143294096 3171-3172 17296157 denotes 6
32057575-29366709-143294097 3176-3178 29366709 denotes 29
32057575-21047962-143294098 3188-3190 21047962 denotes 59
32057575-19816578-143294099 3194-3196 19816578 denotes 60
32057575-24041648-143294100 3718-3720 24041648 denotes 57
32057575-28899630-143294101 3724-3726 28899630 denotes 61
32057575-29684409-143294102 3730-3732 29684409 denotes 62
32057575-29684066-143294103 4420-4422 29684066 denotes 63
32057575-22702451-143294104 4673-4674 22702451 denotes 1
32057575-17296157-143294105 4678-4679 17296157 denotes 6
32057575-22702451-143294106 5107-5108 22702451 denotes 1

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
532 25-36 Species denotes coronavirus Tax:11118
533 108-121 Species denotes coronaviruses Tax:11118
534 1227-1235 Species denotes chickens Tax:9031
535 2077-2085 Species denotes chickens Tax:9031
536 2102-2110 Species denotes chickens Tax:9031
537 3424-3432 Species denotes chickens Tax:9031
538 3548-3556 Species denotes chickens Tax:9031
539 4253-4266 Species denotes coronaviruses Tax:11118
540 4570-4577 Species denotes chicken Tax:9031
541 4772-4780 Species denotes chickens Tax:9031
542 5167-5175 Species denotes chickens Tax:9031
543 5422-5430 Species denotes chickens Tax:9031
544 1292-1295 Species denotes IBV Tax:11120
545 1433-1436 Species denotes IBV Tax:11120
546 2984-2987 Species denotes IBV Tax:11120
547 4298-4301 Species denotes IBV Tax:11120
548 4394-4397 Species denotes IBV Tax:11120
549 4517-4520 Species denotes IBV Tax:11120
550 4660-4663 Species denotes IBV Tax:11120
551 1467-1478 Chemical denotes sialic acid MESH:D019158
552 3271-3276 Chemical denotes rIBYZ
553 1088-1102 Disease denotes cilia necrosis MESH:C536287
554 1133-1143 Disease denotes hemorrhage MESH:D006470
555 1145-1154 Disease denotes nephritis MESH:D009393
556 1218-1226 Disease denotes infected MESH:D007239
557 1266-1275 Disease denotes infection MESH:D007239
558 1853-1861 Disease denotes infected MESH:D007239
559 1956-1970 Disease denotes cilia necrosis MESH:C536287
560 2057-2076 Disease denotes kidneys of infected MESH:D007239
561 2111-2119 Disease denotes infected MESH:D007239
562 2620-2629 Disease denotes infection MESH:D007239
563 2870-2879 Disease denotes infection MESH:D007239
564 3253-3261 Disease denotes infected MESH:D007239
565 3311-3319 Disease denotes necrosis MESH:D009336
566 3433-3441 Disease denotes infected MESH:D007239
567 3557-3565 Disease denotes infected MESH:D007239
568 4499-4508 Disease denotes infection MESH:D007239
569 4556-4566 Disease denotes infections MESH:D007239
570 4763-4771 Disease denotes infected MESH:D007239
571 4965-4974 Disease denotes infection MESH:D007239