PMC:7115396 / 29880-31095 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7115396","sourcedb":"PMC","sourceid":"7115396","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7115396","text":"Vaccines, particularly live-attenuated vaccines, remain the most effective means of protection against IBV challenge (e.g., the Mass serotype strains H120, H52, Ma5, and W93, which are still widely used in the poultry industry) [38], [39], [40]. However, due to the poor cross-protection provided between the different serotypes, these attenuated serotype-specific vaccines cannot provide complete protection, and the IB endemic in China cannot be controlled [22]. Genetic mutations and immune pressure during the replication process of the single stranded RNA virus often results in the emergence of IBV variants [41], [42]. To date, at least six genotypes of IBV strains have been identified in China, of which the QX-type (first isolated in 1999) remains the most prevalent genotype [10], [42], [43]. The poor relationship between the QX-type strains, which are abundant and display variable virulence in various parts of China, and the Mass-type vaccine strains could explain the failure of the Mass-type vaccination programs to control IBV in these flocks [19], [39]. Consequently, the development of novel vaccines against circulating IBV strains in China using local IBV strains is required [20], [43], 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