PMC:7114094 / 134-689 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"17","span":{"begin":302,"end":307},"obj":"Gene"},{"id":"18","span":{"begin":270,"end":275},"obj":"Gene"},{"id":"19","span":{"begin":11,"end":26},"obj":"Species"},{"id":"20","span":{"begin":28,"end":37},"obj":"Species"},{"id":"21","span":{"begin":49,"end":55},"obj":"Species"},{"id":"22","span":{"begin":216,"end":224},"obj":"Species"},{"id":"23","span":{"begin":239,"end":243},"obj":"Species"},{"id":"24","span":{"begin":323,"end":332},"obj":"Species"},{"id":"25","span":{"begin":365,"end":369},"obj":"Species"}],"attributes":[{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"Gene:43740568"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"Gene:5045"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"Tax:2697049"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"Tax:2697049"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Tax:9606"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Tax:694009"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:11118"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Tax:2697049"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Tax:11118"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":89,"end":95},"obj":"Body_part"},{"id":"T3","span":{"begin":197,"end":203},"obj":"Body_part"},{"id":"T4","span":{"begin":308,"end":315},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":216,"end":224},"obj":"Disease"},{"id":"T2","span":{"begin":229,"end":233},"obj":"Disease"},{"id":"T3","span":{"begin":355,"end":359},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T2","span":{"begin":9,"end":10},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":49,"end":55},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T4","span":{"begin":56,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T5","span":{"begin":96,"end":99},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T6","span":{"begin":170,"end":171},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":259,"end":260},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2","span":{"begin":308,"end":315},"obj":"Chemical"},{"id":"T3","span":{"begin":544,"end":554},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"}],"text":"In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals."}

{"project":"LitCovid-sentences","denotations":[{"id":"T3","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"T4","span":{"begin":85,"end":161},"obj":"Sentence"},{"id":"T5","span":{"begin":162,"end":370},"obj":"Sentence"},{"id":"T6","span":{"begin":371,"end":555},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals."}