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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4 67-72 Gene denotes furin Gene:5045
5 30-45 Species denotes new coronavirus Tax:2697049
6 46-55 Species denotes 2019-nCoV Tax:2697049
7 102-105 Species denotes CoV Tax:11118
17 436-441 Gene denotes Spike Gene:43740568
18 404-409 Gene denotes furin Gene:5045
19 145-160 Species denotes new coronavirus Tax:2697049
20 162-171 Species denotes 2019-nCoV Tax:2697049
21 183-189 Species denotes Humans Tax:9606
22 350-358 Species denotes SARS-CoV Tax:694009
23 373-377 Species denotes CoVs Tax:11118
24 457-466 Species denotes 2019-nCoV Tax:2697049
25 499-503 Species denotes CoVs Tax:11118
28 729-738 Species denotes 2019-nCoV Tax:2697049
29 778-795 Species denotes betacoronaviruses Tax:694002
35 823-832 Gene denotes S-protein Gene:43740568
36 857-862 Gene denotes furin Gene:5045
37 813-822 Species denotes 2019-nCoV Tax:2697049
38 902-905 Species denotes CoV Tax:11118
39 916-924 Species denotes SARS-CoV Tax:694009
43 943-948 Gene denotes furin Gene:5045
44 975-984 Gene denotes S-protein Gene:43740568
45 988-997 Species denotes 2019-nCoV Tax:2697049
48 1149-1154 Gene denotes furin Gene:5045
49 1093-1102 Species denotes 2019-nCoV Tax:2697049
75 3626-3632 Gene denotes Orf1ab Gene:43740578
76 3857-3866 Gene denotes S-protein Gene:43740568
77 3985-3994 Gene denotes S-protein Gene:43740568
78 3171-3180 Gene denotes S-protein Gene:43740568
79 3114-3118 Species denotes nCoV Tax:2697049
80 3210-3213 Species denotes CoV Tax:11118
81 3249-3262 Species denotes coronaviruses Tax:11118
82 3295-3298 Species denotes Cov Tax:11118
83 3304-3319 Species denotes betacoronavirus Tax:694002
84 3321-3326 Species denotes β-CoV Tax:694002
85 3353-3362 Species denotes 2019-nCoV Tax:2697049
86 3378-3381 Species denotes CoV Tax:11118
87 3400-3408 Species denotes SARS-CoV Tax:694009
88 3453-3462 Species denotes HCoV-OC43 Tax:31631
89 3494-3503 Species denotes HCoV-NL63 Tax:277944
90 3518-3526 Species denotes HCoV229E Tax:11137
91 3541-3549 Species denotes MERS-CoV Tax:1335626
92 3872-3875 Species denotes CoV Tax:11118
93 3886-3895 Species denotes 2019-nCoV Tax:2697049
94 3919-3928 Species denotes 2019-nCoV Tax:2697049
95 3975-3978 Species denotes CoV Tax:11118
96 4059-4076 Species denotes betacoronaviruses Tax:694002
97 4119-4128 Species denotes 2019-nCoV Tax:2697049
98 3564-3568 Species denotes HKU1 Tax:290028
99 3760-3765 Gene denotes furin Gene:5045
131 2770-2775 Gene denotes Spike Gene:43740568
132 2777-2778 Gene denotes S Gene:43740568
133 1168-1173 Species denotes Human Tax:9606
134 1174-1187 Species denotes coronaviruses Tax:11118
135 1189-1192 Species denotes CoV Tax:11118
136 1366-1374 Species denotes SARS-CoV Tax:694009
137 1379-1387 Species denotes MERS-CoV Tax:1335626
138 1464-1469 Species denotes human Tax:9606
139 1619-1626 Species denotes new CoV Tax:2697049
140 1628-1637 Species denotes 2019-nCoV Tax:2697049
141 1740-1745 Species denotes human Tax:9606
142 1903-1909 Species denotes humans Tax:9606
143 1951-1956 Species denotes human Tax:9606
144 1960-1965 Species denotes human Tax:9606
145 2060-2065 Species denotes human Tax:9606
146 2542-2551 Species denotes 2019-nCoV Tax:2697049
147 2628-2636 Species denotes SARS-CoV Tax:694009
148 2645-2648 Species denotes CoV Tax:11118
149 2671-2674 Species denotes CoV Tax:11118
150 2701-2710 Species denotes 2019-nCoV Tax:2697049
151 2712-2721 Species denotes 2019-nCoV Tax:2697049
152 2802-2810 Species denotes SARS-CoV Tax:694009
153 2824-2827 Species denotes CoV Tax:11118
154 1343-1353 Disease denotes infections MESH:D007239
155 1496-1505 Disease denotes pneumonia MESH:D011014
156 1510-1523 Disease denotes bronchiolitis MESH:D001988
157 1534-1544 Disease denotes meningitis MESH:D008581
158 1697-1712 Disease denotes viral infection MESH:D001102
159 1746-1765 Disease denotes respiratory disease MESH:D012140
160 2066-2076 Disease denotes infections MESH:D007239
161 2093-2099 Disease denotes deaths MESH:D003643
163 6203-6216 Species denotes coronaviruses Tax:11118
174 7116-7121 Gene denotes furin Gene:5045
175 6357-6366 Gene denotes S-protein Gene:43740568
176 7030-7039 Gene denotes S-protein Gene:43740568
177 6341-6346 Species denotes human Tax:9606
178 6347-6356 Species denotes 2019-nCoV Tax:2697049
179 6459-6467 Species denotes SARS-CoV Tax:694009
180 6472-6480 Species denotes MERS-CoV Tax:1335626
181 6761-6764 Species denotes CoV Tax:11118
182 7021-7029 Species denotes SARS-CoV Tax:694009
183 7224-7229 Gene denotes furin Gene:5045
204 5012-5017 Gene denotes furin Gene:5045
209 5255-5260 Species denotes human Tax:9606
210 5271-5284 Species denotes coronaviruses Tax:11118
211 5293-5302 Species denotes HCoV-OC43 Tax:31631
212 13343-13351 Species denotes MERS-CoV Tax:1335626
216 4670-4680 Species denotes infectious Tax:11120
220 4335-4341 Chemical denotes serine MESH:D012694
221 4794-4811 Chemical denotes basic amino acids MESH:D024361
222 5043-5059 Disease denotes viral infections MESH:D001102
234 7871-7876 Gene denotes furin Gene:5045
235 8448-8453 Gene denotes furin Gene:5045
236 7795-7800 Gene denotes furin Gene:5045
237 7426-7441 Species denotes influenza virus Tax:11309
238 7470-7485 Species denotes influenza virus Tax:11309
239 8071-8075 Species denotes H5N1 Tax:102793
240 7778-7787 Species denotes influenza Tax:11309
241 8257-8260 Chemical denotes Arg MESH:D001120
242 8338-8341 Chemical denotes Leu MESH:D007930
243 7660-7670 Disease denotes infections MESH:D007239
293 8562-8571 Gene denotes S-protein Gene:43740568
294 8736-8745 Gene denotes S-protein Gene:43740568
295 9392-9423 Gene denotes angiotensin-converting enzyme 2 Gene:59272
296 9425-9429 Gene denotes ACE2 Gene:59272
297 9598-9602 Gene denotes ACE2 Gene:59272
298 9752-9756 Gene denotes ACE2 Gene:59272
299 10342-10351 Gene denotes S-protein Gene:43740568
300 10817-10822 Gene denotes furin Gene:5045
301 11017-11022 Gene denotes furin Gene:5045
302 11277-11286 Gene denotes S-protein Gene:43740568
303 11461-11466 Gene denotes furin Gene:5045
304 12104-12109 Gene denotes furin Gene:5045
305 12154-12163 Gene denotes S-protein Gene:43740568
306 12263-12268 Gene denotes furin Gene:5045
307 12365-12374 Gene denotes S-protein Gene:43740568
308 12499-12510 Gene denotes cathepsin L Gene:1514
309 12514-12521 Gene denotes TMPRSS2 Gene:7113
310 12922-12927 Gene denotes furin Gene:5045
311 10433-10438 Gene denotes furin Gene:5045
312 12824-12833 Gene denotes S-protein Gene:43740568
313 12018-12027 Gene denotes S-protein Gene:43740568
314 8985-8994 Gene denotes S-protein Gene:43740568
315 8550-8561 Species denotes coronavirus Tax:11118
316 8642-8645 Species denotes CoV Tax:11118
317 8693-8704 Species denotes coronavirus Tax:11118
318 9299-9307 Species denotes SARS-CoV Tax:694009
319 9454-9462 Species denotes SARS-CoV Tax:694009
320 9485-9490 Species denotes human Tax:9606
321 9633-9641 Species denotes SARS-CoV Tax:694009
322 9710-9719 Species denotes 2019-nCoV Tax:2697049
323 9799-9803 Species denotes nCoV Tax:2697049
324 10056-10065 Species denotes 2019-nCoV Tax:2697049
325 10070-10078 Species denotes SARS-CoV Tax:694009
326 10599-10608 Species denotes 2019-nCoV Tax:2697049
327 10613-10621 Species denotes SARS-CoV Tax:694009
328 10639-10647 Species denotes MERS-CoV Tax:1335626
329 10652-10661 Species denotes HCoV-OC43 Tax:31631
330 10874-10879 Species denotes human Tax:9606
331 10880-10883 Species denotes CoV Tax:11118
332 11205-11214 Species denotes 2019-nCoV Tax:2697049
333 11385-11394 Species denotes 2019-nCoV Tax:2697049
334 11654-11658 Species denotes CoVs Tax:11118
335 11750-11763 Species denotes coronaviruses Tax:11118
336 12009-12017 Species denotes MERS-CoV Tax:1335626
337 12167-12175 Species denotes SARS-CoV Tax:694009
338 12814-12823 Species denotes 2019-nCoV Tax:2697049
339 10523-10526 Chemical denotes Phe MESH:D010649
340 10739-10742 Chemical denotes Ala
341 9066-9075 Disease denotes infection MESH:D007239
363 12967-12972 Gene denotes furin Gene:5045
364 13373-13378 Gene denotes furin Gene:5045
365 13408-13417 Gene denotes S-protein Gene:43740568
366 13880-13885 Gene denotes furin Gene:5045
367 13984-13993 Gene denotes S-protein Gene:43740568
368 14282-14291 Gene denotes S-protein Gene:43740568
369 13473-13478 Gene denotes furin Gene:5045
370 13575-13584 Gene denotes S-protein Gene:43740568
371 13206-13215 Species denotes 2019-nCoV Tax:2697049
372 13277-13294 Species denotes betacoronaviruses Tax:694002
373 13327-13330 Species denotes CoV Tax:11118
374 13332-13341 Species denotes HCoV-OC43 Tax:31631
376 13565-13574 Species denotes 2019-nCoV Tax:2697049
377 14046-14055 Species denotes 2019-nCoV Tax:2697049
378 14087-14092 Species denotes human Tax:9606
379 14132-14149 Species denotes betacoronaviruses Tax:694002
380 14226-14230 Species denotes CoVs Tax:11118
381 14374-14382 Species denotes SARS-CoV Tax:694009
382 13784-13789 Gene denotes furin Gene:5045
383 13652-13655 Chemical denotes Arg MESH:D001120
393 14753-14758 Gene denotes furin Gene:5045
394 14854-14883 Gene denotes protease activated receptor 1 Gene:2149
395 14885-14889 Gene denotes PAR1 Gene:2149
396 15015-15020 Gene denotes furin Gene:5045
397 15049-15053 Gene denotes PAR1 Gene:2149
398 15203-15208 Gene denotes furin Gene:5045
399 14615-14631 Disease denotes viral infections MESH:D001102
400 14653-14661 Disease denotes infected MESH:D007239
401 14803-14816 Disease denotes HIV infection MESH:D015658
423 15324-15329 Gene denotes furin Gene:5045
424 15569-15574 Gene denotes furin Gene:5045
425 15612-15615 Gene denotes Env Gene:100616444
426 15867-15872 Gene denotes furin Gene:5045
427 15874-15877 Gene denotes PC7 Gene:9159
428 15879-15882 Gene denotes PC5 Gene:5125
429 15884-15889 Gene denotes PACE4 Gene:5046
430 15894-15897 Gene denotes PC7 Gene:9159
431 15996-16001 Gene denotes furin Gene:5045
432 16129-16134 Gene denotes furin Gene:5045
433 15502-15507 Gene denotes furin Gene:5045
434 15606-15611 Species denotes HIV-1 Tax:11676
435 16615-16624 Species denotes 2019-nCoV Tax:2697049
436 16504-16509 Gene denotes furin Gene:5045
437 16160-16165 Gene denotes furin Gene:5045
438 15437-15443 Chemical denotes serine MESH:D012694
439 15659-15677 Chemical denotes chloromethylketone
440 16030-16052 Chemical denotes 2,5-dideoxystreptamine MESH:C516923
441 15348-15354 Disease denotes tumour MESH:D009369
442 15373-15392 Disease denotes bacterial infection MESH:D001424
443 16312-16320 Disease denotes toxicity MESH:D064420

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 10-22 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T2 223-229 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T3 331-337 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T4 442-449 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T5 825-832 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T6 977-984 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T7 1226-1229 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T8 1327-1342 Body_part denotes digestive tract http://purl.org/sig/ont/fma/fma317863
T9 1510-1523 Body_part denotes bronchiolitis http://purl.org/sig/ont/fma/fma76497
T10 2525-2531 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T11 2734-2744 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T12 2780-2787 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T13 2999-3006 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 3173-3180 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 3633-3643 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T16 3829-3839 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T17 3859-3866 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 3987-3994 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T19 4335-4341 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T20 4551-4559 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T21 4585-4593 Body_part denotes hormones http://purl.org/sig/ont/fma/fma12278
T22 4640-4652 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T23 4640-4644 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T24 4653-4666 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T25 4756-4764 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T26 4800-4811 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T27 4813-4815 Body_part denotes aa http://purl.org/sig/ont/fma/fma82739
T28 4885-4887 Body_part denotes aa http://purl.org/sig/ont/fma/fma82739
T29 4974-4986 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T30 4974-4978 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T31 4987-4995 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T32 5123-5136 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T33 5179-5193 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T34 5179-5183 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T35 5409-5416 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T36 5686-5698 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T37 5890-5897 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 6005-6012 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T39 6175-6182 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T40 6238-6241 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T41 6359-6366 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T42 7032-7039 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T43 7590-7596 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T44 7697-7707 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T45 7919-7923 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T46 7957-7961 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T47 8564-8571 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 8590-8597 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T49 8728-8730 Body_part denotes aa http://purl.org/sig/ont/fma/fma82739
T50 8738-8745 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 8778-8786 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T52 8810-8814 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T53 8833-8839 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T54 8987-8994 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T55 9043-9047 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T56 9124-9131 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T57 9202-9214 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T58 9202-9206 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T59 9262-9269 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T60 9311-9318 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T61 9491-9496 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T62 9617-9619 Body_part denotes aa http://purl.org/sig/ont/fma/fma82739
T63 9831-9838 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 10198-10202 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T65 10344-10351 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T66 11165-11170 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T67 11279-11286 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T68 11924-11928 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T69 12020-12027 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T70 12156-12163 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T71 12367-12374 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T72 12428-12430 Body_part denotes aa http://purl.org/sig/ont/fma/fma82739
T73 12464-12469 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T74 12732-12737 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75 12826-12833 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 12996-13001 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T77 13039-13056 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T78 13122-13134 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T79 13410-13417 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T80 13577-13584 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T81 13617-13628 Body_part denotes nucleotides http://purl.org/sig/ont/fma/fma82740
T82 13986-13993 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T83 14284-14291 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T84 14638-14643 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T85 14803-14806 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T86 14931-14939 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T87 15028-15047 Body_part denotes trans Golgi network http://purl.org/sig/ont/fma/fma61756
T88 15034-15047 Body_part denotes Golgi network http://purl.org/sig/ont/fma/fma67108
T89 15073-15085 Body_part denotes compartments http://purl.org/sig/ont/fma/fma76577
T90 15437-15443 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T91 15606-15609 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T92 15788-15792 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T93 16627-16635 Body_part denotes Appendix http://purl.org/sig/ont/fma/fma14542
T94 17062-17070 Body_part denotes Appendix http://purl.org/sig/ont/fma/fma14542

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1327-1342 Body_part denotes digestive tract http://purl.obolibrary.org/obo/UBERON_0001555
T2 7590-7596 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 7708-7714 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T4 8833-8839 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T5 13039-13056 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p68886s12 5146-5155 PosReg denotes enhancing
p68905s20 8138-8143 PosReg denotes hyper
p68924s39 10342-10343 Protein denotes S
p68936s2 12154-12163 Protein denotes S-protein

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 350-358 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 363-367 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T3 489-493 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T4 916-924 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 1343-1353 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T6 1366-1374 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 1496-1505 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T8 1510-1523 Disease denotes bronchiolitis http://purl.obolibrary.org/obo/MONDO_0002465
T9 1534-1544 Disease denotes meningitis http://purl.obolibrary.org/obo/MONDO_0004796|http://purl.obolibrary.org/obo/MONDO_0021108
T11 1697-1712 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T12 1703-1712 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T13 1746-1765 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T14 2066-2076 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T15 2628-2636 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 2706-2716 Disease denotes nCoV. 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T17 2802-2810 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 3200-3204 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T19 3400-3408 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 3424-3428 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T21 4670-4680 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T22 5043-5059 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T23 5969-5979 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T24 5980-5990 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T25 6459-6467 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 6522-6525 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T28 7021-7029 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 7426-7435 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T30 7470-7479 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T31 7660-7689 Disease denotes infections to the respiratory http://purl.obolibrary.org/obo/MONDO_0024355
T32 7778-7787 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T33 9066-9075 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 9299-9307 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 9454-9462 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 9633-9641 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 10070-10078 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 10613-10621 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 10935-10945 Disease denotes S sequence http://purl.obolibrary.org/obo/MONDO_0007821
T40 12167-12175 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 13027-13056 Disease denotes infects the respiratory tract http://purl.obolibrary.org/obo/MONDO_0024355
T42 14374-14382 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 14615-14631 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T44 14803-14816 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T45 14807-14816 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46 15373-15392 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T47 15383-15392 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 65-66 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 143-144 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 183-189 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Humans
T4 190-193 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T5 230-233 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T6 304-305 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 393-394 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 758-763 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 807-808 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T10 842-845 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T11 846-847 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 900-901 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T13 1168-1173 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T14 1230-1237 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T15 1327-1342 http://purl.obolibrary.org/obo/UBERON_0001555 denotes digestive tract
T16 1464-1469 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T17 1510-1523 http://purl.obolibrary.org/obo/UBERON_0002186 denotes bronchiolitis
T18 1617-1618 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 1639-1642 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T20 1740-1745 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T21 1771-1775 http://purl.obolibrary.org/obo/CLO_0001562 denotes a ~2
T22 1771-1775 http://purl.obolibrary.org/obo/CLO_0001563 denotes a ~2
T23 1794-1796 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T24 1794-1796 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T25 1816-1821 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26 1883-1889 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T27 1903-1909 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T28 1951-1956 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T29 1960-1965 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T30 1979-1982 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T31 2009-2010 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 2060-2065 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T33 2284-2285 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 2352-2353 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 2571-2572 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T36 2600-2601 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T37 2641-2644 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T38 2875-2880 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T39 2884-2885 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 3071-3076 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T41 3144-3146 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T42 3147-3149 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T43 3147-3149 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T44 3216-3217 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T45 3338-3339 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 3341-3342 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T47 3748-3749 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 3798-3799 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T49 3903-3905 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T50 3906-3908 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T51 3906-3908 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T52 4098-4099 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T53 4294-4299 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T54 4318-4319 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 4509-4519 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T56 4523-4524 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 4640-4644 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T58 4681-4688 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T59 4813-4815 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T60 4844-4851 http://purl.obolibrary.org/obo/CLO_0008195 denotes n-(R/K)
T61 4844-4851 http://purl.obolibrary.org/obo/CLO_0051425 denotes n-(R/K)
T62 4885-4887 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T63 4974-4978 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T64 5179-5183 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T65 5184-5193 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T66 5255-5260 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T67 5417-5420 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T68 5459-5461 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T69 5462-5464 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T70 5462-5464 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T71 5504-5506 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T72 5511-5513 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T73 5511-5513 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T74 5540-5547 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T75 5580-5587 http://purl.obolibrary.org/obo/CLO_0008195 denotes n-(R/K)
T76 5580-5587 http://purl.obolibrary.org/obo/CLO_0051425 denotes n-(R/K)
T77 5623-5626 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T78 5719-5720 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 5807-5810 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T80 5854-5855 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T81 5938-5939 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 5991-5996 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T83 6102-6110 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes chickens
T84 6242-6249 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T85 6341-6346 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T86 6372-6373 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 6374-6379 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T88 6482-6488 http://purl.obolibrary.org/obo/SO_0000418 denotes Signal
T89 6489-6496 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T90 6566-6573 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T91 6596-6603 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T92 6681-6683 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T93 6684-6686 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T94 6684-6686 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T95 6691-6693 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T96 6691-6693 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T97 6765-6767 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T98 6768-6770 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T99 6768-6770 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T100 6775-6777 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T101 6775-6777 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T102 7158-7159 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 7212-7213 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 7257-7259 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T105 7260-7262 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T106 7260-7262 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T107 7436-7441 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T108 7480-7485 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T109 7494-7495 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 7617-7627 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T111 7697-7707 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T112 7697-7707 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T113 7708-7714 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T114 7793-7794 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T115 7901-7902 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T116 7919-7929 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T117 7939-7940 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T118 7957-7961 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T119 7977-7982 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 8033-8034 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T121 8161-8166 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T122 8264-8266 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T123 8289-8291 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T124 8296-8298 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T125 8311-8313 http://purl.obolibrary.org/obo/CLO_0008339 denotes P6
T126 8345-8347 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T127 8446-8447 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T128 8728-8730 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T129 8810-8814 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T130 9015-9017 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T131 9018-9020 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T132 9018-9020 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T133 9043-9047 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T134 9162-9164 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T135 9192-9193 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T136 9202-9206 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T137 9228-9229 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 9241-9243 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T139 9241-9243 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T140 9244-9252 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T141 9308-9310 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T142 9328-9329 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 9432-9434 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T144 9432-9434 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T145 9477-9480 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T146 9485-9496 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T147 9506-9511 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T148 9528-9537 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T149 9528-9537 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T150 9595-9597 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T151 9617-9619 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T152 9627-9629 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T153 9643-9645 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T154 9643-9645 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T155 9828-9830 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T156 9828-9830 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T157 9859-9866 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T158 9873-9874 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T159 9900-9902 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T160 9900-9902 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T161 9937-9944 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T162 10137-10145 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T163 10198-10202 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T164 10383-10385 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T165 10386-10388 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T166 10386-10388 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T167 10393-10395 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T168 10393-10395 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T169 10416-10421 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T170 10444-10446 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T171 10444-10446 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T172 10476-10478 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T173 10483-10485 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T174 10505-10506 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T175 10507-10509 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T176 10666-10668 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T177 10669-10671 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T178 10669-10671 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T179 10706-10708 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T180 10713-10715 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T181 10762-10764 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T182 10778-10779 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T183 10874-10879 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T184 10889-10891 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T185 10889-10891 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T186 10921-10922 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T187 10933-10936 http://purl.obolibrary.org/obo/CLO_0008882 denotes R↓S
T188 10988-10990 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T189 10998-11000 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T190 11044-11045 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 11165-11170 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T192 11198-11200 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T193 11198-11200 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T194 11233-11234 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 11259-11269 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T196 11395-11397 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T197 11395-11397 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T198 11497-11499 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T199 11497-11499 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T200 11535-11537 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T201 11535-11537 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T202 11587-11589 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T203 11590-11592 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T204 11590-11592 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T205 11616-11619 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T206 11696-11698 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T207 11699-11701 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T208 11699-11701 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T209 11835-11836 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 11924-11928 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T211 11972-11974 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T212 11975-11977 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T213 11975-11977 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T214 12044-12045 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T215 12078-12083 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T216 12250-12251 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T217 12294-12296 http://purl.obolibrary.org/obo/CLO_0009141 denotes ST
T218 12294-12296 http://purl.obolibrary.org/obo/CLO_0050980 denotes ST
T219 12389-12390 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T220 12428-12430 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T221 12450-12452 http://purl.obolibrary.org/obo/CLO_0009141 denotes ST
T222 12450-12452 http://purl.obolibrary.org/obo/CLO_0050980 denotes ST
T223 12464-12469 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T224 12640-12645 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T225 12685-12695 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T226 12732-12737 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T227 12996-13001 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T228 13016-13021 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T229 13101-13109 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T230 13272-13273 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T231 13701-13702 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T232 13772-13773 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 13939-13944 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T234 14020-14021 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 14087-14092 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T236 14130-14131 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T237 14177-14178 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T238 14335-14340 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T239 14526-14527 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 14638-14643 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T241 14665-14666 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T242 14677-14684 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T243 14741-14749 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T244 14863-14872 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T245 15251-15256 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T246 15270-15271 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T247 15330-15338 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T248 15400-15401 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T249 15490-15491 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T250 15657-15658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T251 15679-15682 http://purl.obolibrary.org/obo/CLO_0002526 denotes CMK
T252 15712-15713 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T253 15743-15744 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 15788-15792 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T255 15815-15818 http://purl.obolibrary.org/obo/CLO_0002526 denotes cmk
T256 15855-15863 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T257 16028-16029 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 16114-16115 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T259 16195-16196 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T260 16413-16419 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T261 16474-16475 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T262 16567-16573 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T263 16636-16637 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T264 16781-16782 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T265 16821-16822 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T266 16912-16917 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T267 17071-17072 http://purl.obolibrary.org/obo/CLO_0001020 denotes A

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 10-22 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T2 442-449 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T3 678-688 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T4 825-832 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T5 977-984 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T6 1155-1165 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T7 1794-1796 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T8 2469-2478 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T9 2734-2744 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T10 2734-2739 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T11 2740-2744 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T12 2780-2787 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13 2999-3006 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 3147-3149 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T15 3173-3180 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T16 3633-3643 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T17 3633-3638 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T18 3639-3643 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T19 3829-3839 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T20 3829-3834 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T21 3835-3839 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T22 3859-3866 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T23 3906-3908 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T24 3987-3994 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 4335-4341 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T26 4551-4559 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T27 4585-4593 Chemical denotes hormones http://purl.obolibrary.org/obo/CHEBI_24621
T28 4618-4627 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T29 4653-4666 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T30 4756-4764 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T31 4800-4811 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T32 4800-4805 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T33 4806-4811 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T34 4813-4815 Chemical denotes aa http://purl.obolibrary.org/obo/CHEBI_33709
T35 4885-4887 Chemical denotes aa http://purl.obolibrary.org/obo/CHEBI_33709
T36 4987-4995 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T37 5123-5136 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T38 5409-5416 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T39 5462-5464 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T40 5511-5513 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T41 5686-5698 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T42 5890-5897 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 6005-6012 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T44 6175-6182 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45 6359-6366 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46 6489-6496 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T47 6498-6500 Chemical denotes SP http://purl.obolibrary.org/obo/CHEBI_74820
T48 6566-6573 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T49 6575-6577 Chemical denotes FP http://purl.obolibrary.org/obo/CHEBI_74750
T50 6596-6603 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T51 6668-6670 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T53 6677-6679 Chemical denotes SP http://purl.obolibrary.org/obo/CHEBI_74820
T54 6684-6686 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T55 6691-6693 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T56 6768-6770 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T57 6775-6777 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T58 7032-7039 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T59 7260-7262 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T60 8061-8063 Chemical denotes GL http://purl.obolibrary.org/obo/CHEBI_73514
T61 8090-8092 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T62 8257-8260 Chemical denotes Arg http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952
T64 8264-8266 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T65 8289-8291 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T66 8296-8298 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T67 8338-8341 Chemical denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T70 8345-8347 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T71 8564-8571 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T72 8590-8597 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T73 8618-8623 Chemical denotes crown http://purl.obolibrary.org/obo/CHEBI_37409
T74 8728-8730 Chemical denotes aa http://purl.obolibrary.org/obo/CHEBI_33709
T75 8738-8745 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T76 8778-8786 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T77 8866-8868 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T78 8987-8994 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79 9018-9020 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T80 9124-9131 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 9241-9243 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T82 9262-9269 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T83 9311-9318 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T84 9392-9403 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T85 9432-9434 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T86 9539-9541 Chemical denotes Ge http://purl.obolibrary.org/obo/CHEBI_30441
T87 9617-9619 Chemical denotes aa http://purl.obolibrary.org/obo/CHEBI_33709
T88 9643-9645 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T89 9828-9830 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T90 9831-9838 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T91 9859-9866 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T92 9868-9870 Chemical denotes FP http://purl.obolibrary.org/obo/CHEBI_74750
T93 9900-9902 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T94 9937-9944 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T95 10017-10019 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T97 10137-10145 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T98 10261-10263 Chemical denotes FP http://purl.obolibrary.org/obo/CHEBI_74750
T99 10312-10314 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T100 10344-10351 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T101 10386-10388 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T102 10393-10395 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T103 10444-10446 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T104 10465-10467 Chemical denotes KR http://purl.obolibrary.org/obo/CHEBI_74553
T105 10468-10470 Chemical denotes SF http://purl.obolibrary.org/obo/CHEBI_71029
T106 10476-10478 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T107 10483-10485 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T108 10507-10509 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T109 10523-10526 Chemical denotes Phe http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997
T111 10669-10671 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T112 10697-10699 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801
T116 10706-10708 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T117 10713-10715 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T118 10739-10742 Chemical denotes Ala http://purl.obolibrary.org/obo/CHEBI_16977|http://purl.obolibrary.org/obo/CHEBI_46217
T120 10762-10764 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T121 10889-10891 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T122 10988-10990 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T123 10998-11000 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T124 11198-11200 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T125 11279-11286 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T126 11395-11397 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T127 11497-11499 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T128 11509-11511 Chemical denotes KR http://purl.obolibrary.org/obo/CHEBI_74553
T129 11512-11514 Chemical denotes SF http://purl.obolibrary.org/obo/CHEBI_71029
T130 11535-11537 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T131 11583-11585 Chemical denotes FP http://purl.obolibrary.org/obo/CHEBI_74750
T132 11590-11592 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T133 11660-11662 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T134 11699-11701 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T135 11975-11977 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T136 12020-12027 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T137 12051-12053 Chemical denotes SV http://purl.obolibrary.org/obo/CHEBI_74823
T138 12156-12163 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T139 12294-12296 Chemical denotes ST http://purl.obolibrary.org/obo/CHEBI_141393
T140 12367-12374 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T141 12428-12430 Chemical denotes aa http://purl.obolibrary.org/obo/CHEBI_33709
T142 12450-12452 Chemical denotes ST http://purl.obolibrary.org/obo/CHEBI_141393
T143 12826-12833 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T144 13122-13134 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T145 13410-13417 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T146 13577-13584 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T147 13617-13628 Chemical denotes nucleotides http://purl.obolibrary.org/obo/CHEBI_36976
T148 13652-13655 Chemical denotes Arg http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29952
T150 13716-13723 Chemical denotes solvent http://purl.obolibrary.org/obo/CHEBI_46787
T151 13738-13740 Chemical denotes SV http://purl.obolibrary.org/obo/CHEBI_74823
T152 13986-13993 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T153 14284-14291 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T154 14538-14547 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T155 14696-14706 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T156 14931-14939 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T157 15189-15199 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T158 15437-15462 Chemical denotes serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64926
T159 15437-15443 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T160 15444-15462 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T162 15453-15462 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T163 15554-15557 Chemical denotes PDX http://purl.obolibrary.org/obo/CHEBI_138653
T164 15745-15759 Chemical denotes decanoyl group http://purl.obolibrary.org/obo/CHEBI_23574
T165 15754-15759 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T166 16061-16070 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T167 16082-16091 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T168 16099-16108 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T169 16364-16372 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T170 16373-16383 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T171 16590-16599 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1028-1044 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T2 1697-1712 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T3 4468-4479 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T4 4569-4575 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T5 5043-5059 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T6 5738-5745 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T7 5750-5762 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T8 5782-5794 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T9 7962-7969 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T10 8144-8153 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T11 8144-8153 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T12 8840-8847 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T13 8852-8864 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T14 12208-12220 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T15 12763-12770 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T16 12781-12793 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T17 14341-14352 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T18 14615-14631 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T19 15355-15361 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T20 16210-16228 http://purl.obolibrary.org/obo/GO_0009987 denotes cellular processes
T21 16859-16870 http://purl.obolibrary.org/obo/GO_0006508 denotes Proteolysis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
T2 125-133 Sentence denotes Abstract
T3 134-218 Sentence denotes In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China.
T4 219-295 Sentence denotes Its genome has been sequenced and the genomic information promptly released.
T5 296-504 Sentence denotes Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs.
T6 505-689 Sentence denotes In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
T7 691-701 Sentence denotes Highlights
T8 702-809 Sentence denotes • The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
T9 810-935 Sentence denotes • 2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
T10 936-1063 Sentence denotes • The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
T11 1064-1166 Sentence denotes • Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
T12 1168-1354 Sentence denotes Human coronaviruses (CoV) are enveloped positive-stranded RNA viruses belonging to the order Nidovirales, and are mostly responsible for upper respiratory and digestive tract infections.
T13 1355-1598 Sentence denotes Among them SARS-CoV and MERS-CoV that spread in 2002 and 2013 respectively, have been associated with severe human illnesses, such as severe pneumonia and bronchiolitis, and even meningitis in more vulnerable populations (de Wit et al., 2016).
T14 1599-1811 Sentence denotes In December 2019, a new CoV (2019-nCoV) has been detected in the city of Wuhan, and this emerging viral infection was associated with severe human respiratory disease with a ~2–3% fatality rate (Li et al., 2020).
T15 1812-1942 Sentence denotes The virus that was presumed to have initially been transmitted from an animal reservoir to humans possibly via an amplifying host.
T16 1943-2144 Sentence denotes However human-to-human transmission has been reported, leading to a sustained epidemic spread with >31,000 confirmed human infections, including >640 deaths, reported by the WHO in early February 2020.
T17 2145-2213 Sentence denotes The estimated effective reproductive number (R) value of ~2.90 (95%:
T18 2214-2316 Sentence denotes 2.32–3.63) at the beginning of the outbreak raises the possibility of a pandemics (Zhao et al., 2020).
T19 2317-2403 Sentence denotes This prompted WHO to declare it as a Public Health Emergency of International Concern.
T20 2404-2511 Sentence denotes This is especially relevant because so far there are no specific antiviral treatments available or vaccine.
T21 2512-2711 Sentence denotes Based on its genome sequence, 2019-nCoV belongs to lineage b of Betacoronavirus (Fig. 1 A), which also includes the SARS-CoV and bat CoV ZXC21, the latter and CoV ZC45 being the closest to 2019-nCoV.
T22 2712-2854 Sentence denotes 2019-nCoV shares ~76% amino acid sequence identity in the Spike (S)-protein sequence with SARS-CoV and 80% with CoV ZXC21 (Chan et al., 2020).
T23 2855-3083 Sentence denotes In this article, we focus on a specific furin-like protease recognition pattern present in the vicinity of one of the maturation sites of the S protein (Fig. 1B) that may have significant functional implications for virus entry.
T24 3084-3352 Sentence denotes Fig. 1 Characterization of an nCoV-peculiar sequence at the S1/S2 cleavage site in the S-protein sequence, compared SARS-like CoV. (A) Phylogenetic tree of selected coronaviruses from genera alphacoronavirus (α-Cov) and betacoronavirus (β-CoV), lineages a, b, c and d:
T25 3353-3583 Sentence denotes 2019-nCoV (NC_045512.2), CoV-ZXC21 (MG772934), SARS-CoV (NC_004718.3), SARS-like BM4821 (MG772934), HCoV-OC43 (AY391777), HKU9-1 (EF065513), HCoV-NL63 (KF530114.1), HCoV229E (KF514433.1), MERS-CoV (NC019843.3), HKU1 (NC_006577.2).
T26 3584-3708 Sentence denotes The phylogenetic tree was obtained on the Orf1ab amino acid sequence using the Maximum Likelihood method by Mega X software.
T27 3709-3914 Sentence denotes Red asterisks indicate the presence of a canonical furin-like cleavage motif at site 1; (B) Alignment of the coding and amino acid sequences of the S-protein from CoV-ZXC21 and 2019-nCoV at the S1/S2 site.
T28 3915-3958 Sentence denotes The 2019-nCoV-specific sequence is in bold.
T29 3959-4260 Sentence denotes The sequence of CoV-ZXC21 S-protein at this position is representative of the sequence of the other betacoronaviruses belonging to lineage b, except the one of 2019-nCoV. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
T30 4261-4464 Sentence denotes The proprotein convertases (PCs; genes PCSKs) constitute a family of nine serine secretory proteases that regulate various biological processes in both healthy and disease states (Seidah and Prat, 2012).
T31 4465-4728 Sentence denotes By proteolysis, PCs are responsible for the activation of a wide variety of precursor proteins, such as growth factors, hormones, receptors and adhesion molecules, as well as cell surface glycoproteins of infectious viruses (Seidah and Chretien, 1999) (Table 1 ).
T32 4729-4916 Sentence denotes Seven PCs cleave precursor proteins at specific single or paired basic amino acids (aa) within the motif (R/K)-(2X)n-(R/K)↓, where n = 0, 1, 2, or 3 spacer aa (Seidah and Chretien, 1999).
T33 4917-5060 Sentence denotes Because of their role in the processing of many critical cell surface proteins PCs, especially furin, have been implicated in viral infections.
T34 5061-5239 Sentence denotes They have the potential to cleave specifically viral envelope glycoproteins, thereby enhancing viral fusion with host cell membranes (Izaguirre, 2019; Moulard and Decroly, 2000).
T35 5240-5523 Sentence denotes In the case of human-infecting coronaviruses such as HCoV-OC43 (Le Coupanec et al., 2015), MERS-CoV (Millet and Whittaker, 2014), and HKU1 (Chan et al., 2008) the spike protein has been demonstrated to be cleaved at an S1/S2 cleavage site (Fig. 2 ) generating the S1 and S2 subunits.
T36 5524-5605 Sentence denotes The above three viruses display the canonical (R/K)-(2X)n-(R/K)↓ motif (Table 1).
T37 5606-5763 Sentence denotes Additionally, it has been demonstrated that variation around the viral envelope glycoprotein cleavage site plays a role in cellular tropism and pathogenesis.
T38 5764-5907 Sentence denotes For instance, the pathogenesis of some CoV has been previously related to the presence of a furin-like cleavage site in the S-protein sequence.
T39 5908-6132 Sentence denotes For example, the insertion of a similar cleavage site in the infectious bronchitis virus (IBV) S-protein results in higher pathogenicity, pronounced neural symptoms and neurotropism in infected chickens (Cheng et al., 2019).
T40 6133-6258 Sentence denotes Table 1 Comparative sequences of envelope protein cleavage site(s) in coronaviruses (above) and in other RNA viruses (below).
T41 6259-6301 Sentence denotes Empty boxes: no consensus motif detected..
T42 6302-6413 Sentence denotes Fig. 2 Schematic representation of the human 2019-nCoV S-protein with a focus on the putative maturation sites.
T43 6414-6481 Sentence denotes The domains were previously characterized in SARS-CoV and MERS-CoV:
T44 6482-6672 Sentence denotes Signal peptide (SP), N-terminal domain (NTD), receptor-binding domain (RBD), fusion peptide (FP), internal fusion peptide (IFP), heptad repeat 1/2 (HR1/2), and the transmembrane domain (TM).
T45 6673-6734 Sentence denotes The SP, S1↓S2 and S2′ cleavage sites are indicated by arrows.
T46 6735-7102 Sentence denotes The sequence of different CoV S1/S2 and S2′ cleavage sites were aligned using Multalin webserver (http://multalin.toulouse.inra.fr/multalin/) with manual adjustments and the figure prepared using ESPript 3 (http://espript.ibcp.fr/ESPript/ESPript/) presenting the secondary structure of SARS-CoV S-protein at the bottom of the alignment (PDB 5X58) (Yuan et al., 2017).
T47 7103-7172 Sentence denotes Insertion of furin like cleavage site is surrounded by a black frame.
T48 7173-7399 Sentence denotes Red asterisks indicate the presence of a canonical furin-like cleavage motif at the S1/S2 site. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
T49 7400-7734 Sentence denotes Similarly, in the case of influenza virus, low-pathogenicity forms of influenza virus contain a single basic residue at the cleavage site, which is cleaved by trypsin-like proteases and the tissue distribution of the activating protease(s) typically restricts infections to the respiratory and/or intestinal organs (Sun et al., 2010).
T50 7735-8003 Sentence denotes Conversely, the highly pathogenic forms of influenza have a furin-like cleavage site cleaved by different cellular proteases, including furin, which are expressed in a wide variety of cell types allowing a widening of the cell tropism of the virus (Kido et al., 2012).
T51 8004-8223 Sentence denotes Furthermore the insertion of a multibasic motif RERRRKKR↓GL at the H5N1 hemagglutinin HA cleavage site was likely associated with the hyper-virulence of the virus during the Hong Kong 1997 outbreak (Claas et al., 1998).
T52 8224-8545 Sentence denotes This motif exhibits the critical Arg at P1 and basic residues at P2 and P4, as well as P6 and P8 and an aliphatic Leu at P2’ positions (Table 1) (Schechter and Berger nomenclature (Schechter and Berger, 1968)), typical of a furin-like cleavage specificity (Braun and Sauter, 2019; Izaguirre, 2019; Seidah and Prat, 2012).
T53 8546-8717 Sentence denotes The coronavirus S-protein is the structural protein responsible for the crown-like shape of the CoV viral particles, from which the original name “coronavirus” was coined.
T54 8718-8911 Sentence denotes The ~1200 aa long S-protein belongs to class-I viral fusion proteins and contributes to the cell receptor binding, tissue tropism and pathogenesis (Lu et al., 2015; Millet and Whittaker, 2014).
T55 8912-8970 Sentence denotes It contains several conserved domains and motifs (Fig. 2).
T56 8971-9076 Sentence denotes The trimetric S-protein is processed at the S1/S2 cleavage site by host cell proteases, during infection.
T57 9077-9294 Sentence denotes Following cleavage, also known as priming, the protein is divided into an N-terminal S1-ectodomain that recognises a cognate cell surface receptor and a C-terminal S2-membrane-anchored protein involved in viral entry.
T58 9295-9449 Sentence denotes The SARS-CoV S1-protein contains a conserved Receptor Binding Domain (RBD), which recognises the angiotensin-converting enzyme 2 (ACE2) (Li et al., 2003).
T59 9450-9575 Sentence denotes The SARS-CoV binds to both bat and human cells, and the virus can infect both organisms (Ge et al., 2013; Kuhn et al., 2004).
T60 9576-9660 Sentence denotes The RBD surface of S1/ACE2 implicates 14 aa in the S1 of SARS-CoV (Li et al., 2005).
T61 9661-9823 Sentence denotes Among them, 8 residues are strictly conserved in 2019-nCoV, supporting the hypothesis that ACE2 is also the receptor of the newly emerged nCoV (Wan et al., 2020).
T62 9824-10030 Sentence denotes The S2-protein contains the fusion peptide (FP), a second proteolytic site (S2′), followed by an internal fusion peptide (IFP) and two heptad-repeat domains preceding the transmembrane domain (TM) (Fig. 2).
T63 10031-10155 Sentence denotes Notably, the IFPs of the 2019-nCoV and SARS-CoV are identical, displaying characteristics of viral fusion peptides (Fig. 2).
T64 10156-10428 Sentence denotes While the molecular mechanism involved in cell entry is not yet fully understood, it is likely that both FP and IFP participate in the viral entry process (Lu et al., 2015) and thus the S-protein must likely be cleaved at both S1/S2 and S2′ cleavage sites for virus entry.
T65 10429-10631 Sentence denotes The furin-like S2′ cleavage site at KR↓SF with P1 and P2 basic residues and a P2′ hydrophobic Phe (Seidah and Prat, 2012), downstream of the IFP is identical between the 2019-nCoV and SARS-CoV (Fig. 2).
T66 10632-10823 Sentence denotes In the MERS-CoV and HCoV-OC43 the S1/S2 site is replaced by RXXR↓SA, with P1 and P4 basic residues, and an Ala (not aliphatic) at P2′, suggesting a somewhat less favourable cleavage by furin.
T67 10824-11171 Sentence denotes However, in the other less pathogenic circulating human CoV, the S2′ cleavage site only exhibits a monobasic R↓S sequence (Fig. 2) with no basic residues at either P2 and/or P4 needed to allow furin cleavage, suggesting a less efficient cleavage or higher restriction at the entry step depending on the cognate proteases expressed by target cells.
T68 11172-11371 Sentence denotes Even though processing at S2′ in 2019-nCoV is expected to be a key event for the final activation of the S-protein, the protease(s) involved in this process have not yet been conclusively identified.
T69 11372-11515 Sentence denotes Based on the 2019-nCoV S2′ sequence and the above arguments, we propose that one or more furin-like enzymes would cleave the S2′ site at KR↓SF.
T70 11516-11677 Sentence denotes In contrast to the S2′, the first cleavage between the RBD and the FP (S1/S2 cleavage site, Fig. 2) has been extensively studied for many CoVs (Lu et al., 2015).
T71 11678-11851 Sentence denotes Interestingly the S1/S2 processing site exhibits different motifs among coronaviruses (Fig. 2, site 1 & site 2), with many of them displaying cleavage after a basic residue.
T72 11852-11992 Sentence denotes It is thus likely that the priming process is ensured by different host cell proteases depending on the sequence of the S1/S2 cleavage site.
T73 11993-12138 Sentence denotes Accordingly the MERS-CoV S-protein, which contains a RSVR↓SV motif is cleaved during virus egress, probably by furin (Mille and Whittaker, 2014).
T74 12139-12298 Sentence denotes Conversely the S-protein of SARS-CoV remains largely uncleaved after biosynthesis, possibly due to the lack of a favourable furin-like cleavage site (SLLR-ST).
T75 12299-12601 Sentence denotes In this case, it was reported that following receptor binding the S-protein is cleaved at a conserved sequence AYT↓M (located 10 aa downstream of SLLR-ST) by target cells’ proteases such as elastase, cathepsin L or TMPRSS2 (Bosch et al., 2008; Matsuyama et al., 2010, 2005; Millet and Whittaker, 2015).
T76 12602-12794 Sentence denotes As the priming event is essential for virus entry, the efficacy and extent of this activation step by the proteases of the target cells should regulate cellular tropism and viral pathogenesis.
T77 12795-12960 Sentence denotes In the case of the 2019-nCoV S-protein, the conserved site 2 sequence AYT↓M may still be cleaved, possibly after the preferred furin-cleavage at the site 1 (Fig. 2).
T78 12961-13177 Sentence denotes Since furin is highly expressed in lungs, an enveloped virus that infects the respiratory tract may successfully exploit this convertase to activate its surface glycoprotein (Bassi et al., 2017; Mbikay et al., 1997).
T79 13178-13295 Sentence denotes Before the emergence of the 2019-nCoV, this important feature was not observed in the lineage b of betacoronaviruses.
T80 13296-13548 Sentence denotes However, it is shared by other CoV (HCoV-OC43, MERS-CoV, MHV-A59) harbouring furin-like cleavage sites in their S-protein (Fig. 2; Table 1), which were shown to be processed by furin experimentally (Le Coupanec et al., 2015; Mille and Whittaker, 2014).
T81 13549-13874 Sentence denotes Strikingly, the 2019-nCoV S-protein sequence contains 12 additional nucleotides upstream of the single Arg↓ cleavage site 1 (Fig. 1, Fig. 2) leading to a predictively solvent-exposed PRRAR↓SV sequence, which corresponds to a canonical furin-like cleavage site (Braun and Sauter, 2019; Izaguirre, 2019; Seidah and Prat, 2012).
T82 13875-14150 Sentence denotes This furin-like cleavage site, is supposed to be cleaved during virus egress (Mille and Whittaker, 2014) for S-protein “priming” and may provide a gain-of-function to the 2019-nCoV for efficient spreading in the human population compared to other lineage b betacoronaviruses.
T83 14151-14231 Sentence denotes This possibly illustrates a convergent evolution pathway between unrelated CoVs.
T84 14232-14383 Sentence denotes Interestingly, if this site is not processed, the S-protein is expected to be cleaved at site 2 during virus endocytosis, as observed for the SARS-CoV.
T85 14384-14557 Sentence denotes Obviously much more work is needed to demonstrate experimentally our assertion, but the inhibition of such processing enzyme(s) may represent a potential antiviral strategy.
T86 14558-14772 Sentence denotes Indeed, it was recently shown that in an effort to limit viral infections, host cells that are infected by a number of viruses provoke an interferon response to inhibit the enzymatic activity of furin-like enzymes.
T87 14773-15144 Sentence denotes It was also demonstrated that HIV infection induces the expression of either the protease activated receptor 1 (PAR1) (Kim et al., 2015) or guanylate binding proteins 2 and 5 (GBP2,5) (Braun and Sauter, 2019) that restrict the trafficking of furin to the trans Golgi network (PAR1) or to early Golgi compartments (GBP2,5) where the proprotein convertase remains inactive.
T88 15145-15269 Sentence denotes Altogether, these observations suggest that inhibitors of furin-like enzymes may contribute to inhibiting virus propagation.
T89 15270-15393 Sentence denotes A variety of approaches have been proposed to inhibit furin activity to limit tumour growth, viral and bacterial infection.
T90 15394-15640 Sentence denotes Thus, a variant of the naturally occurring serine protease inhibitor α-1 antitrypsin harbouring a consensus furin cleavage, called α-1 antitrypsin Portland (α1-PDX), inhibits furin and prevents the processing of HIV-1 Env (Anderson et al., 1993).
T91 15641-15942 Sentence denotes The addition of a chloromethylketone (CMK) moiety to the C-terminus of a polybasic cleavage motif and a decanoyl group at the N-terminus to favour cell penetration (dec-RVKR-cmk) irreversibly blocked the enzymatic activity of furin, PC7, PC5, PACE4 and PC7 (Decroly et al., 1996, Garten et al., 1994).
T92 15943-16156 Sentence denotes Finally, the elucidation of the crystal structure of furin resulted in the design of a 2,5-dideoxystreptamine-derived inhibitor, where two molecules of the inhibitor form a complex with furin (Dahms et al., 2017).
T93 16157-16321 Sentence denotes As furin-like enzymes are involved in a multitude of cellular processes, one important issue would be to avoid systemic inhibition that may result in some toxicity.
T94 16322-16625 Sentence denotes Accordingly, it is likely that such small molecule inhibitors, or other more potent orally active ones, possibly delivered by inhalation and exhibiting a slow dissociation rate from furin to allow for sustained inhibition, deserve to be rapidly tested to assess their antiviral effect against 2019-nCoV.
T95 16627-16657 Sentence denotes Appendix A Supplementary data
T96 16658-16736 Sentence denotes The following is the Supplementary data to this article:Multimedia component 1
T97 16738-16753 Sentence denotes Acknowledgments
T98 16754-17061 Sentence denotes This work was supported by a CIHR Foundation grant # 148363 (NGS), a Canada Research Chairs in Precursor Proteolysis (NGS; # 950-231335), and by the European Virus Archive Global (BCo; EVA GLOBAL) funded by the European Union's Horizon 2020 research and innovation programme under grant agreement No 871029.
T99 17062-17180 Sentence denotes Appendix A Supplementary data to this article can be found online at https://doi.org/10.1016/j.antiviral.2020.104742.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1496-1505 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 1510-1523 Phenotype denotes bronchiolitis http://purl.obolibrary.org/obo/HP_0011950
T3 1534-1544 Phenotype denotes meningitis http://purl.obolibrary.org/obo/HP_0001287
T4 5980-5990 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T5 15348-15354 Phenotype denotes tumour http://purl.obolibrary.org/obo/HP_0002664