PMC:7113610 / 19156-20814 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7113610","sourcedb":"PMC","sourceid":"7113610","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7113610","text":"There is no available vaccine against COVID-19, while previous vaccines or strategies used to develop a vaccine against SARS-CoV can be effective. Recombinant protein from the Urbani (AY278741) strain of SARS-CoV was administered to mice and hamsters, resulted in the production of neutralizing antibodies and protection against SARS-CoV [56], [57]. The DNA fragment, inactivated whole virus or live-vectored strain of SARS-CoV (AY278741), significantly reduced the viral infection in various animal models [58], [59], [60], [61], [62], [63]. Different other strains of SARS-CoV were also used to produce inactivated or live-vectored vaccines which efficiently reduced the viral load in animal models. These strains include, Tor2 (AY274119) [64], [65], Utah (AY714217) [66], FRA (AY310120) [59], HKU-39849 (AY278491) [57], [67], BJ01 (AY278488) [68], [69], NS1 (AY508724) [70], ZJ01 (AY297028) [70], GD01 (AY278489) [69] and GZ50 (AY304495) [71]. However, there are few vaccines in the pipeline against SARS-CoV-2. The mRNA based vaccine prepared by the US National Institute of Allergy and Infectious Diseases against SARS-CoV-2 is under phase 1 trial [72]. INO-4800-DNA based vaccine will be soon available for human testing [73]. Chinese Centre for Disease Control and Prevention (CDC) working on the development of an inactivated virus vaccine [74], [75]. Soon mRNA based vaccine’s sample (prepared by Stermirna Therapeutics) will be available [76]. GeoVax-BravoVax is working to develop a Modified Vaccina Ankara (MVA) based vaccine [77]. While Clover Biopharmaceuticals is developing a recombinant 2019-nCoV S protein subunit-trimer based vaccine 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