
PMC:7113610 / 17572-19130
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
603 | 41-49 | Disease | denotes | COVID-19 | MESH:C000657245 |
635 | 322-337 | Gene | denotes | interferon beta | Gene:3456 |
636 | 605-609 | Gene | denotes | AAK1 | Gene:22848 |
637 | 1341-1345 | Gene | denotes | ACE2 | Gene:59272 |
638 | 364-374 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
639 | 391-399 | Species | denotes | patients | Tax:9606 |
640 | 696-704 | Species | denotes | patients | Tax:9606 |
641 | 898-908 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
642 | 930-936 | Species | denotes | humans | Tax:9606 |
643 | 941-945 | Species | denotes | mice | Tax:10090 |
644 | 1034-1042 | Species | denotes | patients | Tax:9606 |
645 | 1087-1095 | Species | denotes | patients | Tax:9606 |
646 | 1249-1259 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
647 | 205-215 | Chemical | denotes | remdesivir | MESH:C000606551 |
648 | 267-277 | Chemical | denotes | Remdesivir | MESH:C000606551 |
649 | 307-318 | Chemical | denotes | chloroquine | MESH:D002738 |
650 | 531-541 | Chemical | denotes | Nafamostat | MESH:C032855 |
651 | 543-555 | Chemical | denotes | Nitazoxanide | MESH:C041747 |
652 | 557-566 | Chemical | denotes | Ribavirin | MESH:D012254 |
653 | 568-579 | Chemical | denotes | Penciclovir | MESH:C053539 |
654 | 581-592 | Chemical | denotes | Favipiravir | MESH:C462182 |
655 | 594-603 | Chemical | denotes | Ritonavir | MESH:D019438 |
656 | 611-622 | Chemical | denotes | Baricitinib | MESH:C000596027 |
657 | 628-635 | Chemical | denotes | Arbidol | MESH:C086979 |
658 | 1370-1376 | Chemical | denotes | CR3022 | |
659 | 520-529 | Disease | denotes | infection | MESH:D007239 |
660 | 683-692 | Disease | denotes | infection | MESH:D007239 |
661 | 917-926 | Disease | denotes | infection | MESH:D007239 |
662 | 1046-1054 | Disease | denotes | COVID-19 | MESH:C000657245 |
663 | 1078-1086 | Disease | denotes | infected | MESH:D007239 |
664 | 1534-1542 | Disease | denotes | COVID-19 | MESH:C000657245 |
665 | 1543-1552 | Disease | denotes | infection | MESH:D007239 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T78 | 995-1007 | Body_part | denotes | blood plasma | http://purl.org/sig/ont/fma/fma62970 |
T79 | 1203-1211 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T80 | 1287-1297 | Body_part | denotes | antibody’s | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T6 | 995-1007 | Body_part | denotes | blood plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
T7 | 995-1000 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T186 | 41-49 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T187 | 364-372 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T188 | 364-368 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T189 | 520-529 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T190 | 683-692 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T191 | 898-906 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T192 | 898-902 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T193 | 917-926 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T194 | 1046-1054 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T195 | 1249-1257 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T196 | 1249-1253 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T197 | 1534-1542 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T198 | 1543-1552 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T171 | 186-188 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
T172 | 216-219 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T173 | 255-260 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T174 | 451-453 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
T175 | 668-674 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T176 | 743-745 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
T177 | 755-757 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
T178 | 930-936 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
T179 | 995-1007 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | blood plasma |
T180 | 1153-1154 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T181 | 1377-1380 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T182 | 1414-1415 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T62 | 104-115 | Chemical | denotes | antibiotics | http://purl.obolibrary.org/obo/CHEBI_33281 |
T63 | 132-137 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T64 | 205-215 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
T65 | 307-318 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T66 | 322-332 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
T67 | 333-337 | Chemical | denotes | beta | http://purl.obolibrary.org/obo/CHEBI_10545 |
T68 | 810-819 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T69 | 823-834 | Chemical | denotes | antibiotics | http://purl.obolibrary.org/obo/CHEBI_33281 |
T70 | 1298-1305 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T131 | 0-49 | Sentence | denotes | Potential therapeutic strategies against COVID-19 |
T132 | 50-266 | Sentence | denotes | Initially, interferons-α nebulization, broad-spectrum antibiotics, and anti-viral drugs were used to reduce the viral load [49], [51], [52], however, only remdesivir has shown promising impact against the virus [53]. |
T133 | 267-455 | Sentence | denotes | Remdesivir only and in combination with chloroquine or interferon beta significantly blocked the SARS-CoV-2 replication and patients were declared as clinically recovered [46], [50], [52]. |
T134 | 456-530 | Sentence | denotes | Various other anti-virals are currently being evaluated against infection. |
T135 | 531-759 | Sentence | denotes | Nafamostat, Nitazoxanide, Ribavirin, Penciclovir, Favipiravir, Ritonavir, AAK1, Baricitinib, and Arbidol exhibited moderate results when tested against infection in patients and in-vitro clinical isolates [46], [48], [50], [52]. |
T136 | 760-951 | Sentence | denotes | Several other combinations, such as combining the antiviral or antibiotics with traditional Chinese medicines were also evaluated against SARS-CoV-2 induced infection in humans and mice [46]. |
T137 | 952-1149 | Sentence | denotes | Recently in Shanghai, doctors isolated the blood plasma from clinically recovered patients of COVID-19 and injected it in the infected patients who showed positive results with rapid recovery [54]. |
T138 | 1150-1260 | Sentence | denotes | In a recent study, it was identified that monoclonal antibody (CR3022) binds with the spike RBD of SARS-CoV-2. |
T139 | 1261-1369 | Sentence | denotes | This is likely due to the antibody’s epitope not overlapping with the divergent ACE2 receptor-binding motif. |
T140 | 1370-1558 | Sentence | denotes | CR3022 has the potential to be developed as a therapeutic candidate, alone or in combination with other neutralizing antibodies for the prevention and treatment of COVID-19 infection [55]. |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T542 | 41-49 | SP_7 | denotes | COVID-19 |
T543 | 104-115 | CHEBI:33282;CHEBI:33282 | denotes | antibiotics |
T544 | 126-131 | NCBITaxon:10239 | denotes | viral |
T545 | 132-137 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
T546 | 162-167 | NCBITaxon:10239 | denotes | viral |
T547 | 205-215 | DG_28 | denotes | remdesivir |
T548 | 255-260 | NCBITaxon:10239 | denotes | virus |
T549 | 267-277 | DG_28 | denotes | Remdesivir |
T550 | 307-318 | DG_10;CHEBI:3638;CHEBI:3638 | denotes | chloroquine |
T551 | 322-337 | PR:000024939 | denotes | interferon beta |
T552 | 364-374 | SP_7 | denotes | SARS-CoV-2 |
T553 | 375-386 | GO:0006260 | denotes | replication |
T554 | 475-481 | NCBITaxon:10239 | denotes | virals |
T555 | 543-555 | CHEBI:17154;CHEBI:17154 | denotes | Nitazoxanide |
T556 | 557-566 | CHEBI:63580;CHEBI:63580;DG_29 | denotes | Ribavirin |
T557 | 568-579 | CHEBI:7956;CHEBI:7956 | denotes | Penciclovir |
T558 | 581-592 | CHEBI:119915;CHEBI:119915;DG_17 | denotes | Favipiravir |
T559 | 594-603 | DG_30 | denotes | Ritonavir |
T560 | 605-609 | PR:000003526 | denotes | AAK1 |
T561 | 611-622 | DG_41 | denotes | Baricitinib |
T562 | 628-635 | DG_49 | denotes | Arbidol |
T563 | 823-834 | CHEBI:33282;CHEBI:33282 | denotes | antibiotics |
T564 | 898-908 | SP_7 | denotes | SARS-CoV-2 |
T565 | 930-936 | NCBITaxon:9606 | denotes | humans |
T566 | 941-945 | NCBITaxon:10088 | denotes | mice |
T567 | 995-1007 | UBERON:0001969 | denotes | blood plasma |
T568 | 1046-1054 | SP_7 | denotes | COVID-19 |
T569 | 1203-1211 | GO:0042571 | denotes | antibody |
T570 | 1249-1259 | SP_7 | denotes | SARS-CoV-2 |
T571 | 1287-1295 | GO:0042571 | denotes | antibody |
T572 | 1298-1305 | BV_9 | denotes | epitope |
T573 | 1341-1345 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T574 | 1487-1497 | GO:0042571 | denotes | antibodies |
T575 | 1534-1542 | SP_7 | denotes | COVID-19 |
T56322 | 41-49 | SP_7 | denotes | COVID-19 |
T27276 | 104-115 | CHEBI:33282;CHEBI:33282 | denotes | antibiotics |
T5576 | 126-131 | NCBITaxon:10239 | denotes | viral |
T78132 | 132-137 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
T34797 | 162-167 | NCBITaxon:10239 | denotes | viral |
T81336 | 205-215 | DG_28 | denotes | remdesivir |
T90544 | 255-260 | NCBITaxon:10239 | denotes | virus |
T7656 | 267-277 | DG_28 | denotes | Remdesivir |
T83331 | 307-318 | DG_10;CHEBI:3638;CHEBI:3638 | denotes | chloroquine |
T49799 | 322-337 | PR:000024939 | denotes | interferon beta |
T8847 | 364-374 | SP_7 | denotes | SARS-CoV-2 |
T97023 | 375-386 | GO:0006260 | denotes | replication |
T81907 | 475-481 | NCBITaxon:10239 | denotes | virals |
T18257 | 543-555 | CHEBI:17154;CHEBI:17154 | denotes | Nitazoxanide |
T52332 | 557-566 | CHEBI:63580;CHEBI:63580;DG_29 | denotes | Ribavirin |
T47704 | 568-579 | CHEBI:7956;CHEBI:7956 | denotes | Penciclovir |
T49574 | 581-592 | CHEBI:119915;CHEBI:119915;DG_17 | denotes | Favipiravir |
T61606 | 594-603 | DG_30 | denotes | Ritonavir |
T43613 | 605-609 | PR:000003526 | denotes | AAK1 |
T67569 | 611-622 | DG_41 | denotes | Baricitinib |
T1403 | 628-635 | DG_49 | denotes | Arbidol |
T10184 | 823-834 | CHEBI:33282;CHEBI:33282 | denotes | antibiotics |
T21946 | 898-908 | SP_7 | denotes | SARS-CoV-2 |
T46433 | 930-936 | NCBITaxon:9606 | denotes | humans |
T30825 | 941-945 | NCBITaxon:10088 | denotes | mice |
T64508 | 995-1007 | UBERON:0001969 | denotes | blood plasma |
T4651 | 1046-1054 | SP_7 | denotes | COVID-19 |
T50772 | 1203-1211 | GO:0042571 | denotes | antibody |
T19930 | 1249-1259 | SP_7 | denotes | SARS-CoV-2 |
T75033 | 1287-1295 | GO:0042571 | denotes | antibody |
T85523 | 1298-1305 | BV_9 | denotes | epitope |
T66326 | 1341-1345 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T61832 | 1487-1497 | GO:0042571 | denotes | antibodies |
T75491 | 1534-1542 | SP_7 | denotes | COVID-19 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32257431-31745213-54950110 | 174-176 | 31745213 | denotes | 49 |
32257431-29511076-54950111 | 262-264 | 29511076 | denotes | 53 |
32257431-31924756-54950112 | 439-441 | 31924756 | denotes | 46 |
32257431-31924756-54950113 | 737-739 | 31924756 | denotes | 46 |
32257431-31924756-54950114 | 947-949 | 31924756 | denotes | 46 |