PMC:7113610 / 10983-12504
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 389 | 777-781 | Gene | denotes | ACE2 | Gene:59272 |
| 390 | 1414-1418 | Gene | denotes | ACE2 | Gene:59272 |
| 391 | 1420-1451 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
| 392 | 896-904 | Gene | denotes | membrane | Gene:43740571 |
| 393 | 866-874 | Gene | denotes | envelope | Gene:43740570 |
| 394 | 838-839 | Gene | denotes | S | Gene:43740568 |
| 395 | 736-737 | Gene | denotes | S | Gene:43740568 |
| 396 | 683-693 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 397 | 941-951 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 410 | 60-65 | Gene | denotes | spike | Gene:43740568 |
| 411 | 291-296 | Gene | denotes | spike | Gene:43740568 |
| 412 | 524-528 | Gene | denotes | ACE2 | Gene:59272 |
| 413 | 133-141 | Gene | denotes | membrane | Gene:43740571 |
| 414 | 0-10 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 415 | 33-44 | Species | denotes | coronavirus | Tax:11118 |
| 416 | 308-318 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 417 | 452-462 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 418 | 518-523 | Species | denotes | human | Tax:9606 |
| 419 | 585-595 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 420 | 413-422 | Chemical | denotes | glutamine | MESH:D005973 |
| 421 | 493-499 | Chemical | denotes | lysine | MESH:D008239 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T22 | 66-73 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T23 | 142-150 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T24 | 160-163 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T25 | 238-250 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T26 | 266-274 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T27 | 297-304 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T28 | 413-422 | Body_part | denotes | glutamine | http://purl.org/sig/ont/fma/fma82752 |
| T29 | 493-499 | Body_part | denotes | lysine | http://purl.org/sig/ont/fma/fma82758 |
| T30 | 702-707 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T31 | 738-745 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T32 | 840-847 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T33 | 891-904 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T34 | 891-895 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T35 | 917-926 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T36 | 961-964 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T37 | 979-983 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T38 | 985-991 | Body_part | denotes | Genome | http://purl.org/sig/ont/fma/fma84116 |
| T39 | 992-995 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T40 | 1250-1258 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T41 | 1266-1274 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T42 | 1279-1285 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T43 | 1286-1289 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T44 | 1408-1412 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T45 | 1457-1478 | Body_part | denotes | endoplasmic reticulum | http://purl.org/sig/ont/fma/fma63842 |
| T46 | 1509-1520 | Body_part | denotes | compartment | http://purl.org/sig/ont/fma/fma76577 |
LitCovid_AGAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p68720s13 | 866-881 | MPA | denotes | envelope fusion |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T105 | 0-8 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T106 | 0-4 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T107 | 308-316 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T108 | 308-312 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T109 | 452-460 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T110 | 452-456 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T111 | 585-593 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T112 | 585-589 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T113 | 683-691 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T114 | 683-687 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T115 | 941-949 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T116 | 941-945 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T114 | 133-141 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T115 | 328-331 | http://purl.obolibrary.org/obo/CLO_0001577 | denotes | a 3 |
| T116 | 518-523 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T117 | 702-707 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T118 | 891-895 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T119 | 896-904 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T120 | 979-983 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T121 | 1147-1148 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T122 | 1408-1412 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T24 | 66-73 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T25 | 142-150 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T26 | 238-250 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T27 | 266-274 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T28 | 297-304 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T29 | 413-430 | Chemical | denotes | glutamine residue | http://purl.obolibrary.org/obo/CHEBI_32677 |
| T30 | 413-422 | Chemical | denotes | glutamine | http://purl.obolibrary.org/obo/CHEBI_28300 |
| T31 | 493-499 | Chemical | denotes | lysine | http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094 |
| T33 | 738-745 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T34 | 840-847 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T35 | 1250-1258 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T36 | 1266-1274 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T37 | 1420-1431 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 860-881 | http://purl.obolibrary.org/obo/GO_0098997 | denotes | viral envelope fusion |
| T10 | 860-881 | http://purl.obolibrary.org/obo/GO_0019064 | denotes | viral envelope fusion |
| T11 | 1110-1121 | http://purl.obolibrary.org/obo/GO_0004175 | denotes | proteinases |
| T12 | 1193-1206 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T13 | 1359-1370 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transported |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T86 | 0-286 | Sentence | denotes | SARS-CoV-2 possesses the typical coronavirus structure with spike protein and also expressed other polyproteins, nucleoproteins, and membrane proteins, such as RNA polymerase, 3-chymotrypsin-like protease, papain-like protease, helicase, glycoprotein, and accessory proteins [30], [31]. |
| T87 | 287-404 | Sentence | denotes | The spike protein of SARS-CoV-2 contains a 3-D structure in the RBD region to maintain the van der Waals forces [32]. |
| T88 | 405-543 | Sentence | denotes | The 394 glutamine residue in the RBD region of SARS-CoV-2 is recognized by the critical lysine 31 residue on the human ACE2 receptor [33]. |
| T89 | 544-657 | Sentence | denotes | The entire mechanism of pathogenicity of SARS-CoV-2, from attachment to replication is well mentioned in Fig. 3 . |
| T90 | 658-782 | Sentence | denotes | Fig. 3 The life cycle of SARS-CoV-2 in host cells; begins its life cycle when S protein binds to the cellular receptor ACE2. |
| T91 | 783-935 | Sentence | denotes | After receptor binding, the conformation change in the S protein facilitates viral envelope fusion with the cell membrane through the endosomal pathway. |
| T92 | 936-984 | Sentence | denotes | Then SARS-CoV-2 releases RNA into the host cell. |
| T93 | 985-1122 | Sentence | denotes | Genome RNA is translated into viral replicase polyproteins pp1a and 1ab, which are then cleaved into small products by viral proteinases. |
| T94 | 1123-1259 | Sentence | denotes | The polymerase produces a series of subgenomic mRNAs by discontinuous transcription and finally translated into relevant viral proteins. |
| T95 | 1260-1413 | Sentence | denotes | Viral proteins and genome RNA are subsequently assembled into virions in the ER and Golgi and then transported via vesicles and released out of the cell. |
| T96 | 1414-1521 | Sentence | denotes | ACE2, angiotensin-converting enzyme 2; ER, endoplasmic reticulum; ERGIC, ER–Golgi intermediate compartment. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T280 | 0-10 | SP_7 | denotes | SARS-CoV-2 |
| T281 | 33-44 | NCBITaxon:11118 | denotes | coronavirus |
| T282 | 83-92 | GO:0010467 | denotes | expressed |
| T283 | 133-141 | GO:0016020 | denotes | membrane |
| T284 | 238-250 | CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T285 | 308-318 | SP_7 | denotes | SARS-CoV-2 |
| T286 | 452-462 | SP_7 | denotes | SARS-CoV-2 |
| T287 | 518-523 | SP_6;NCBITaxon:9606;PG_10 | denotes | human |
| T288 | 524-528 | PG_10;PR:000003622 | denotes | ACE2 |
| T289 | 568-581 | BV_19 | denotes | pathogenicity |
| T290 | 585-595 | SP_7 | denotes | SARS-CoV-2 |
| T291 | 616-627 | GO:0006260 | denotes | replication |
| T292 | 683-693 | SP_7 | denotes | SARS-CoV-2 |
| T293 | 720-724 | UBERON:0000104 | denotes | life |
| T294 | 736-745 | PG_1 | denotes | S protein |
| T295 | 777-781 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T296 | 838-847 | PG_1 | denotes | S protein |
| T297 | 860-865 | NCBITaxon:10239;GO:0019031 | denotes | viral |
| T298 | 866-874 | GO:0019031;GO:0061025 | denotes | envelope |
| T299 | 875-886 | GO:0061025 | denotes | fusion with |
| T300 | 891-904 | GO:0005886 | denotes | cell membrane |
| T301 | 917-926 | GO:0005768 | denotes | endosomal |
| T302 | 941-951 | SP_7 | denotes | SARS-CoV-2 |
| T303 | 985-991 | SO:0001026 | denotes | Genome |
| T304 | 999-1009 | GO:0006412 | denotes | translated |
| T305 | 1015-1020 | NCBITaxon:10239 | denotes | viral |
| T306 | 1021-1030 | GO:0006260 | denotes | replicase |
| T307 | 1044-1048 | PG_16;PR:000003209 | denotes | pp1a |
| T308 | 1073-1080 | MOP:0000780 | denotes | cleaved |
| T309 | 1104-1109 | NCBITaxon:10239 | denotes | viral |
| T310 | 1159-1169 | SO:0001026 | denotes | subgenomic |
| T311 | 1219-1229 | GO:0006412 | denotes | translated |
| T312 | 1244-1249 | NCBITaxon:10239 | denotes | viral |
| T313 | 1279-1285 | SO:0001026 | denotes | genome |
| T314 | 1322-1329 | GO:0019012 | denotes | virions |
| T315 | 1337-1339 | GO:0005783 | denotes | ER |
| T316 | 1344-1349 | GO:0005801 | denotes | Golgi |
| T317 | 1375-1383 | GO:0031982 | denotes | vesicles |
| T318 | 1414-1418 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T319 | 1420-1451 | PG_10;PR:000003622 | denotes | angiotensin-converting enzyme 2 |
| T320 | 1453-1455 | GO:0005783 | denotes | ER |
| T321 | 1457-1478 | GO:0005783 | denotes | endoplasmic reticulum |
| T322 | 1480-1485 | GO:0005793 | denotes | ERGIC |
| T323 | 1487-1495 | GO:0005793 | denotes | ER–Golgi |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32257431-32009228-54950101 | 400-402 | 32009228 | denotes | 32 |