PMC:7113449 / 75-4905 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7113449","sourcedb":"PMC","sourceid":"7113449","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7113449","text":"The coronavirus disease 2019 (COVID-19) which started in Wuhan, China, and affected most of the country, is spreading rapidly throughout the world in spite of the concerted efforts from the governments and World Health Organization (WHO) to contain it. The virus spreads 1000 times faster than the other viral strains inside the body and causes various kind of illnesses [1]. Korea is also adversely affected by COVID-19 due to its geographical proximity to China. Considering the high attack rate and aggressive spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a concern that more serious diseases may develop due to a mutated type of the virus. Some treatment experiences in Korea suggest that steroids played an important role in the treatment of COVID-19. According to reports from China, although pneumonia was rare in the pediatric population, the risk of pneumonia increased with age and had a high mortality rate among the elderly in their 70s (8.0%) and 80s (14.8%) [2].\nClinical experiences in Korea (unpublished) and the data from Chinese COVID-19 reports indicate that\n1) Symptoms were mild and pneumonia was rare in the pediatric population. The elderly was more likely to suffer from severe rapidly progressing pneumonia. [2]\n2) Pneumonia was usually self-limited and resolved within a few weeks in people with normal immune status, but may result in varying degrees of pulmonary fibrosis.\n3) Usually responded well to steroid treatment (personal communications)\nRadiology and pathology examinations of patients with COVID-19 revealed inflammatory reactions in the lung that resembled what is observed in hypersensitivity pneumonitis rather than in other viral pneumonia [34].\nHypersensitivity pneumonitis (HP) has three variants, namely, 1) acute, 2) subacute, and 3) chronic. The pathophysiology of HP is determined by genetics, environment, age, and immune reactions (both innate and adaptive) [5].\nThe innate immunity is robust in the pediatric population while the complement system and adaptive immunity are not mature yet [6]. In contrast, the innate immunity is not effective while the complement system is increased in the elderly population. Adaptive immunity develops from childhood to adulthood, but declines with older age. Hence, a healthy adult who has been exposed to seasonal coronaviruses many times may suffer pneumonia due to immune enhancement, which resolves with mobilization of regulatory T cells [78]\nAcute HP is more common in the elderly. The defective innate immunity and the accelerated complement activation induced by SARS-CoV-2, similar to that by SARS CoV, leads to a severe rapidly progressing pneumonitis due to the triggering effect of the virus [910]. In contrast, a healthy adult with normal adaptive immunity controls the inflammatory reaction better through immune regulation and manifests as subacute HP. The innate immunity in the pediatric population appears to block the viral invasion at the mucosal level, and results in minimal to no symptoms.\nWe believe that there is an urgent need to establish a better sophisticated treatment strategy for COVID-19, because there may be a serious risk owing to the subtle mutations of the virus, which can lead to a more aggressive spread and more severe immunologic reaction in the host.\nHP has been reported in the literature for the past several decades, but its pathophysiology remains poorly understood. The possibility of obtaining the exact pathogenesis is less with the current knowledge and technology. Considering our current understanding of the pathophysiology and clinical features of HP, the treatment strategy for COVID-19 needs to be tailored according to the patient's age and immune status. Traditional HP treatment methods such as decreasing the antigen (virus) and controlling the abnormal immune response must be part of the strategy. SARS-CoV-2 is more likely to spread in the elderly and lead to severe pneumonia. Hence, COVID-19 patients would benefit from the administration of antiviral medications (nucleotide inhibitors, Human Immunodeficiency Virus (HIV) nucleoside reverse transcriptase inhibitor (NRTI), HIV non-nucleoside reverse transcriptase inhibitor (NNRTI), HIV protease inhibitor (PI), dextran sulfate, and combination therapy, etc.) that will limit the spread of less virulent virus both within the body and in the population. Prophylactic and therapeutic low dose steroid oral tablets/inhalers at the earlier stage of COVID-19 and high dose steroid treatment according to the severity of the disease can play important roles in decreasing the fatality and pulmonary fibrosis. Additionally, safer treatment options that control the complement cascade could be considered in cases of acute HP.\nGod Bless You and me… See the Sky with humble eyes and simple minds.","divisions":[{"label":"p","span":{"begin":0,"end":1011}},{"label":"p","span":{"begin":1012,"end":1112}},{"label":"p","span":{"begin":1113,"end":1271}},{"label":"p","span":{"begin":1272,"end":1435}},{"label":"p","span":{"begin":1436,"end":1508}},{"label":"p","span":{"begin":1509,"end":1722}},{"label":"p","span":{"begin":1723,"end":1947}},{"label":"p","span":{"begin":1948,"end":2471}},{"label":"p","span":{"begin":2472,"end":3036}},{"label":"p","span":{"begin":3037,"end":3318}},{"label":"p","span":{"begin":3319,"end":4761}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"14","span":{"begin":523,"end":570},"obj":"Species"},{"id":"15","span":{"begin":572,"end":582},"obj":"Species"},{"id":"16","span":{"begin":728,"end":736},"obj":"Chemical"},{"id":"17","span":{"begin":4,"end":28},"obj":"Disease"},{"id":"18","span":{"begin":30,"end":38},"obj":"Disease"},{"id":"19","span":{"begin":412,"end":420},"obj":"Disease"},{"id":"20","span":{"begin":782,"end":790},"obj":"Disease"},{"id":"21","span":{"begin":834,"end":843},"obj":"Disease"},{"id":"22","span":{"begin":894,"end":903},"obj":"Disease"},{"id":"23","span":{"begin":938,"end":947},"obj":"Disease"},{"id":"25","span":{"begin":1082,"end":1090},"obj":"Disease"},{"id":"28","span":{"begin":1139,"end":1148},"obj":"Disease"},{"id":"29","span":{"begin":1257,"end":1266},"obj":"Disease"},{"id":"33","span":{"begin":1345,"end":1351},"obj":"Species"},{"id":"34","span":{"begin":1275,"end":1284},"obj":"Disease"},{"id":"35","span":{"begin":1416,"end":1434},"obj":"Disease"},{"id":"37","span":{"begin":1465,"end":1472},"obj":"Chemical"},{"id":"42","span":{"begin":1549,"end":1557},"obj":"Species"},{"id":"43","span":{"begin":1563,"end":1571},"obj":"Disease"},{"id":"44","span":{"begin":1651,"end":1679},"obj":"Disease"},{"id":"45","span":{"begin":1701,"end":1716},"obj":"Disease"},{"id":"47","span":{"begin":1723,"end":1751},"obj":"Disease"},{"id":"50","span":{"begin":2339,"end":2352},"obj":"Species"},{"id":"51","span":{"begin":2375,"end":2384},"obj":"Disease"},{"id":"55","span":{"begin":2595,"end":2605},"obj":"Species"},{"id":"56","span":{"begin":2626,"end":2634},"obj":"Species"},{"id":"57","span":{"begin":2674,"end":2685},"obj":"Disease"},{"id":"59","span":{"begin":3136,"end":3144},"obj":"Disease"},{"id":"75","span":{"begin":3706,"end":3713},"obj":"Species"},{"id":"76","span":{"begin":3886,"end":3896},"obj":"Species"},{"id":"77","span":{"begin":3983,"end":3991},"obj":"Species"},{"id":"78","span":{"begin":4079,"end":4107},"obj":"Species"},{"id":"79","span":{"begin":4109,"end":4112},"obj":"Species"},{"id":"80","span":{"begin":4165,"end":4168},"obj":"Species"},{"id":"81","span":{"begin":4225,"end":4228},"obj":"Species"},{"id":"82","span":{"begin":4254,"end":4269},"obj":"Chemical"},{"id":"83","span":{"begin":4434,"end":4441},"obj":"Chemical"},{"id":"84","span":{"begin":4511,"end":4518},"obj":"Chemical"},{"id":"85","span":{"begin":3659,"end":3667},"obj":"Disease"},{"id":"86","span":{"begin":3956,"end":3965},"obj":"Disease"},{"id":"87","span":{"begin":3974,"end":3982},"obj":"Disease"},{"id":"88","span":{"begin":4488,"end":4496},"obj":"Disease"},{"id":"89","span":{"begin":4626,"end":4644},"obj":"Disease"}],"attributes":[{"id":"A14","pred":"tao:has_database_id","subj":"14","obj":"Tax:2697049"},{"id":"A15","pred":"tao:has_database_id","subj":"15","obj":"Tax:2697049"},{"id":"A16","pred":"tao:has_database_id","subj":"16","obj":"MESH:D013256"},{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"MESH:C000657245"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"MESH:C000657245"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"MESH:C000657245"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"MESH:C000657245"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"MESH:D011014"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"MESH:D011014"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"MESH:D003643"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:C000657245"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D011014"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D011014"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:9606"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D011014"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D011658"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D013256"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"Tax:9606"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:C000657245"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:D000542"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"MESH:D000542"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Tax:11118"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"MESH:D011014"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:2697049"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:694009"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"MESH:D011014"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"MESH:C000657245"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"Tax:9606"},{"id":"A76","pred":"tao:has_database_id","subj":"76","obj":"Tax:2697049"},{"id":"A77","pred":"tao:has_database_id","subj":"77","obj":"Tax:9606"},{"id":"A78","pred":"tao:has_database_id","subj":"78","obj":"Tax:12721"},{"id":"A79","pred":"tao:has_database_id","subj":"79","obj":"Tax:12721"},{"id":"A80","pred":"tao:has_database_id","subj":"80","obj":"Tax:12721"},{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"Tax:12721"},{"id":"A82","pred":"tao:has_database_id","subj":"82","obj":"MESH:D016264"},{"id":"A83","pred":"tao:has_database_id","subj":"83","obj":"MESH:D013256"},{"id":"A84","pred":"tao:has_database_id","subj":"84","obj":"MESH:D013256"},{"id":"A85","pred":"tao:has_database_id","subj":"85","obj":"MESH:C000657245"},{"id":"A86","pred":"tao:has_database_id","subj":"86","obj":"MESH:D011014"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"MESH:C000657245"},{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"MESH:C000657245"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"MESH:D011658"},{"subj":"14","pred":"source","obj":"LitCovid-PubTator"},{"subj":"15","pred":"source","obj":"LitCovid-PubTator"},{"subj":"16","pred":"source","obj":"LitCovid-PubTator"},{"subj":"17","pred":"source","obj":"LitCovid-PubTator"},{"subj":"18","pred":"source","obj":"LitCovid-PubTator"},{"subj":"19","pred":"source","obj":"LitCovid-PubTator"},{"subj":"20","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"},{"subj":"42","pred":"source","obj":"LitCovid-PubTator"},{"subj":"43","pred":"source","obj":"LitCovid-PubTator"},{"subj":"44","pred":"source","obj":"LitCovid-PubTator"},{"subj":"45","pred":"source","obj":"LitCovid-PubTator"},{"subj":"47","pred":"source","obj":"LitCovid-PubTator"},{"subj":"50","pred":"source","obj":"LitCovid-PubTator"},{"subj":"51","pred":"source","obj":"LitCovid-PubTator"},{"subj":"55","pred":"source","obj":"LitCovid-PubTator"},{"subj":"56","pred":"source","obj":"LitCovid-PubTator"},{"subj":"57","pred":"source","obj":"LitCovid-PubTator"},{"subj":"59","pred":"source","obj":"LitCovid-PubTator"},{"subj":"75","pred":"source","obj":"LitCovid-PubTator"},{"subj":"76","pred":"source","obj":"LitCovid-PubTator"},{"subj":"77","pred":"source","obj":"LitCovid-PubTator"},{"subj":"78","pred":"source","obj":"LitCovid-PubTator"},{"subj":"79","pred":"source","obj":"LitCovid-PubTator"},{"subj":"80","pred":"source","obj":"LitCovid-PubTator"},{"subj":"81","pred":"source","obj":"LitCovid-PubTator"},{"subj":"82","pred":"source","obj":"LitCovid-PubTator"},{"subj":"83","pred":"source","obj":"LitCovid-PubTator"},{"subj":"84","pred":"source","obj":"LitCovid-PubTator"},{"subj":"85","pred":"source","obj":"LitCovid-PubTator"},{"subj":"86","pred":"source","obj":"LitCovid-PubTator"},{"subj":"87","pred":"source","obj":"LitCovid-PubTator"},{"subj":"88","pred":"source","obj":"LitCovid-PubTator"},{"subj":"89","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":329,"end":333},"obj":"Body_part"},{"id":"T2","span":{"begin":1611,"end":1615},"obj":"Body_part"},{"id":"T3","span":{"begin":2448,"end":2466},"obj":"Body_part"},{"id":"T4","span":{"begin":2461,"end":2466},"obj":"Body_part"},{"id":"T5","span":{"begin":4056,"end":4066},"obj":"Body_part"},{"id":"T6","span":{"begin":4109,"end":4112},"obj":"Body_part"},{"id":"T7","span":{"begin":4165,"end":4168},"obj":"Body_part"},{"id":"T8","span":{"begin":4225,"end":4228},"obj":"Body_part"},{"id":"T9","span":{"begin":4368,"end":4372},"obj":"Body_part"},{"id":"T10","span":{"begin":4808,"end":4812},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma84070"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma54448"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":1611,"end":1615},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T6","span":{"begin":4,"end":28},"obj":"Disease"},{"id":"T7","span":{"begin":30,"end":38},"obj":"Disease"},{"id":"T8","span":{"begin":412,"end":420},"obj":"Disease"},{"id":"T9","span":{"begin":523,"end":570},"obj":"Disease"},{"id":"T10","span":{"begin":523,"end":556},"obj":"Disease"},{"id":"T11","span":{"begin":572,"end":580},"obj":"Disease"},{"id":"T12","span":{"begin":782,"end":790},"obj":"Disease"},{"id":"T13","span":{"begin":834,"end":843},"obj":"Disease"},{"id":"T14","span":{"begin":894,"end":903},"obj":"Disease"},{"id":"T15","span":{"begin":1082,"end":1090},"obj":"Disease"},{"id":"T16","span":{"begin":1139,"end":1148},"obj":"Disease"},{"id":"T17","span":{"begin":1257,"end":1266},"obj":"Disease"},{"id":"T18","span":{"begin":1275,"end":1284},"obj":"Disease"},{"id":"T19","span":{"begin":1416,"end":1434},"obj":"Disease"},{"id":"T20","span":{"begin":1563,"end":1571},"obj":"Disease"},{"id":"T21","span":{"begin":1651,"end":1679},"obj":"Disease"},{"id":"T23","span":{"begin":1651,"end":1667},"obj":"Disease"},{"id":"T25","span":{"begin":1668,"end":1679},"obj":"Disease"},{"id":"T26","span":{"begin":1701,"end":1716},"obj":"Disease"},{"id":"T27","span":{"begin":1707,"end":1716},"obj":"Disease"},{"id":"T28","span":{"begin":1723,"end":1751},"obj":"Disease"},{"id":"T30","span":{"begin":1740,"end":1751},"obj":"Disease"},{"id":"T31","span":{"begin":1753,"end":1755},"obj":"Disease"},{"id":"T32","span":{"begin":1847,"end":1849},"obj":"Disease"},{"id":"T33","span":{"begin":2375,"end":2384},"obj":"Disease"},{"id":"T34","span":{"begin":2478,"end":2480},"obj":"Disease"},{"id":"T35","span":{"begin":2595,"end":2603},"obj":"Disease"},{"id":"T36","span":{"begin":2626,"end":2630},"obj":"Disease"},{"id":"T37","span":{"begin":2674,"end":2685},"obj":"Disease"},{"id":"T38","span":{"begin":2888,"end":2890},"obj":"Disease"},{"id":"T39","span":{"begin":3136,"end":3144},"obj":"Disease"},{"id":"T40","span":{"begin":3319,"end":3321},"obj":"Disease"},{"id":"T41","span":{"begin":3628,"end":3630},"obj":"Disease"},{"id":"T42","span":{"begin":3659,"end":3667},"obj":"Disease"},{"id":"T43","span":{"begin":3751,"end":3753},"obj":"Disease"},{"id":"T44","span":{"begin":3886,"end":3894},"obj":"Disease"},{"id":"T45","span":{"begin":3956,"end":3965},"obj":"Disease"},{"id":"T46","span":{"begin":3974,"end":3982},"obj":"Disease"},{"id":"T47","span":{"begin":4085,"end":4101},"obj":"Disease"},{"id":"T48","span":{"begin":4488,"end":4496},"obj":"Disease"},{"id":"T49","span":{"begin":4626,"end":4644},"obj":"Disease"},{"id":"T50","span":{"begin":4758,"end":4760},"obj":"Disease"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0002771"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"id":"A22","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0017853"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0000605"},{"id":"A24","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0005271"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0043905"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0006012"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"id":"A29","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0017853"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0043905"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0043905"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0021094"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0002771"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0004553"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T2","span":{"begin":219,"end":231},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T3","span":{"begin":257,"end":262},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T4","span":{"begin":594,"end":595},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":650,"end":651},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":672,"end":677},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T7","span":{"begin":931,"end":932},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":1330,"end":1331},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9","span":{"begin":1611,"end":1615},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T10","span":{"begin":1611,"end":1615},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T11","span":{"begin":1718,"end":1720},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T12","span":{"begin":1753,"end":1755},"obj":"http://purl.obolibrary.org/obo/CLO_0003797"},{"id":"T13","span":{"begin":1753,"end":1755},"obj":"http://purl.obolibrary.org/obo/PR_000008725"},{"id":"T14","span":{"begin":1757,"end":1760},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T15","span":{"begin":1847,"end":1849},"obj":"http://purl.obolibrary.org/obo/CLO_0003797"},{"id":"T16","span":{"begin":1847,"end":1849},"obj":"http://purl.obolibrary.org/obo/PR_000008725"},{"id":"T17","span":{"begin":2290,"end":2291},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T18","span":{"begin":2310,"end":2313},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T19","span":{"begin":2448,"end":2466},"obj":"http://purl.obolibrary.org/obo/CL_0000815"},{"id":"T20","span":{"begin":2478,"end":2480},"obj":"http://purl.obolibrary.org/obo/CLO_0003797"},{"id":"T21","span":{"begin":2478,"end":2480},"obj":"http://purl.obolibrary.org/obo/PR_000008725"},{"id":"T22","span":{"begin":2573,"end":2583},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T23","span":{"begin":2645,"end":2646},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T24","span":{"begin":2722,"end":2727},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T25","span":{"begin":2748,"end":2749},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T26","span":{"begin":2888,"end":2890},"obj":"http://purl.obolibrary.org/obo/CLO_0003797"},{"id":"T27","span":{"begin":2888,"end":2890},"obj":"http://purl.obolibrary.org/obo/PR_000008725"},{"id":"T28","span":{"begin":3090,"end":3091},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T29","span":{"begin":3167,"end":3168},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T30","span":{"begin":3219,"end":3224},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T31","span":{"begin":3244,"end":3245},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T32","span":{"begin":3319,"end":3321},"obj":"http://purl.obolibrary.org/obo/CLO_0003797"},{"id":"T33","span":{"begin":3319,"end":3321},"obj":"http://purl.obolibrary.org/obo/PR_000008725"},{"id":"T34","span":{"begin":3322,"end":3325},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T35","span":{"begin":3628,"end":3630},"obj":"http://purl.obolibrary.org/obo/CLO_0003797"},{"id":"T36","span":{"begin":3628,"end":3630},"obj":"http://purl.obolibrary.org/obo/PR_000008725"},{"id":"T37","span":{"begin":3751,"end":3753},"obj":"http://purl.obolibrary.org/obo/CLO_0003797"},{"id":"T38","span":{"begin":3751,"end":3753},"obj":"http://purl.obolibrary.org/obo/PR_000008725"},{"id":"T39","span":{"begin":3804,"end":3809},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T40","span":{"begin":4079,"end":4084},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T41","span":{"begin":4102,"end":4107},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T42","span":{"begin":4346,"end":4351},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T43","span":{"begin":4758,"end":4760},"obj":"http://purl.obolibrary.org/obo/CLO_0003797"},{"id":"T44","span":{"begin":4758,"end":4760},"obj":"http://purl.obolibrary.org/obo/PR_000008725"},{"id":"T45","span":{"begin":4780,"end":4782},"obj":"http://purl.obolibrary.org/obo/CLO_0007653"},{"id":"T46","span":{"begin":4808,"end":4812},"obj":"http://www.ebi.ac.uk/efo/EFO_0000827"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":728,"end":736},"obj":"Chemical"},{"id":"T2","span":{"begin":1465,"end":1472},"obj":"Chemical"},{"id":"T3","span":{"begin":1753,"end":1755},"obj":"Chemical"},{"id":"T4","span":{"begin":1847,"end":1849},"obj":"Chemical"},{"id":"T5","span":{"begin":2478,"end":2480},"obj":"Chemical"},{"id":"T6","span":{"begin":2888,"end":2890},"obj":"Chemical"},{"id":"T7","span":{"begin":3319,"end":3321},"obj":"Chemical"},{"id":"T8","span":{"begin":3628,"end":3630},"obj":"Chemical"},{"id":"T9","span":{"begin":3751,"end":3753},"obj":"Chemical"},{"id":"T10","span":{"begin":3795,"end":3802},"obj":"Chemical"},{"id":"T11","span":{"begin":4033,"end":4042},"obj":"Chemical"},{"id":"T12","span":{"begin":4056,"end":4066},"obj":"Chemical"},{"id":"T13","span":{"begin":4067,"end":4077},"obj":"Chemical"},{"id":"T14","span":{"begin":4114,"end":4124},"obj":"Chemical"},{"id":"T15","span":{"begin":4125,"end":4156},"obj":"Chemical"},{"id":"T17","span":{"begin":4133,"end":4156},"obj":"Chemical"},{"id":"T18","span":{"begin":4147,"end":4156},"obj":"Chemical"},{"id":"T19","span":{"begin":4173,"end":4183},"obj":"Chemical"},{"id":"T20","span":{"begin":4184,"end":4215},"obj":"Chemical"},{"id":"T22","span":{"begin":4192,"end":4215},"obj":"Chemical"},{"id":"T23","span":{"begin":4206,"end":4215},"obj":"Chemical"},{"id":"T24","span":{"begin":4225,"end":4247},"obj":"Chemical"},{"id":"T25","span":{"begin":4229,"end":4247},"obj":"Chemical"},{"id":"T27","span":{"begin":4238,"end":4247},"obj":"Chemical"},{"id":"T28","span":{"begin":4249,"end":4251},"obj":"Chemical"},{"id":"T33","span":{"begin":4254,"end":4269},"obj":"Chemical"},{"id":"T34","span":{"begin":4254,"end":4261},"obj":"Chemical"},{"id":"T35","span":{"begin":4262,"end":4269},"obj":"Chemical"},{"id":"T36","span":{"begin":4434,"end":4441},"obj":"Chemical"},{"id":"T37","span":{"begin":4511,"end":4518},"obj":"Chemical"},{"id":"T38","span":{"begin":4758,"end":4760},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_74055"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_74055"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_74055"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_74055"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_74055"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_74055"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_74055"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_33838"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_53756"},{"id":"A16","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_59897"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_37416"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_33838"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_53756"},{"id":"A21","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_59897"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_37416"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_35660"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_37670"},{"id":"A26","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_60258"},{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_28874"},{"id":"A29","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_53806"},{"id":"A30","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_61484"},{"id":"A31","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_74790"},{"id":"A32","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_37670"},{"id":"A33","pred":"chebi_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_34674"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_52071"},{"id":"A35","pred":"chebi_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_74055"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":1651,"end":1667},"obj":"http://purl.obolibrary.org/obo/GO_0002524"},{"id":"T3","span":{"begin":1723,"end":1739},"obj":"http://purl.obolibrary.org/obo/GO_0002524"},{"id":"T4","span":{"begin":1952,"end":1967},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T5","span":{"begin":2097,"end":2112},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T6","span":{"begin":2526,"end":2541},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T7","span":{"begin":2562,"end":2583},"obj":"http://purl.obolibrary.org/obo/GO_0006956"},{"id":"T8","span":{"begin":2851,"end":2861},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T9","span":{"begin":2896,"end":2911},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T10","span":{"begin":3478,"end":3490},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T11","span":{"begin":3840,"end":3855},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T12","span":{"begin":4133,"end":4146},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T13","span":{"begin":4133,"end":4146},"obj":"http://purl.obolibrary.org/obo/GO_0003899"},{"id":"T14","span":{"begin":4192,"end":4205},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T15","span":{"begin":4192,"end":4205},"obj":"http://purl.obolibrary.org/obo/GO_0003899"},{"id":"T16","span":{"begin":4701,"end":4719},"obj":"http://purl.obolibrary.org/obo/GO_0006956"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T2","span":{"begin":0,"end":252},"obj":"Sentence"},{"id":"T3","span":{"begin":253,"end":375},"obj":"Sentence"},{"id":"T4","span":{"begin":376,"end":464},"obj":"Sentence"},{"id":"T5","span":{"begin":465,"end":678},"obj":"Sentence"},{"id":"T6","span":{"begin":679,"end":791},"obj":"Sentence"},{"id":"T7","span":{"begin":792,"end":1011},"obj":"Sentence"},{"id":"T8","span":{"begin":1012,"end":1112},"obj":"Sentence"},{"id":"T9","span":{"begin":1113,"end":1186},"obj":"Sentence"},{"id":"T10","span":{"begin":1187,"end":1271},"obj":"Sentence"},{"id":"T11","span":{"begin":1272,"end":1435},"obj":"Sentence"},{"id":"T12","span":{"begin":1436,"end":1508},"obj":"Sentence"},{"id":"T13","span":{"begin":1509,"end":1722},"obj":"Sentence"},{"id":"T14","span":{"begin":1723,"end":1823},"obj":"Sentence"},{"id":"T15","span":{"begin":1824,"end":1947},"obj":"Sentence"},{"id":"T16","span":{"begin":1948,"end":2079},"obj":"Sentence"},{"id":"T17","span":{"begin":2080,"end":2197},"obj":"Sentence"},{"id":"T18","span":{"begin":2198,"end":2282},"obj":"Sentence"},{"id":"T19","span":{"begin":2283,"end":2471},"obj":"Sentence"},{"id":"T20","span":{"begin":2472,"end":2511},"obj":"Sentence"},{"id":"T21","span":{"begin":2512,"end":2734},"obj":"Sentence"},{"id":"T22","span":{"begin":2735,"end":2891},"obj":"Sentence"},{"id":"T23","span":{"begin":2892,"end":3036},"obj":"Sentence"},{"id":"T24","span":{"begin":3037,"end":3318},"obj":"Sentence"},{"id":"T25","span":{"begin":3319,"end":3438},"obj":"Sentence"},{"id":"T26","span":{"begin":3439,"end":3541},"obj":"Sentence"},{"id":"T27","span":{"begin":3542,"end":3738},"obj":"Sentence"},{"id":"T28","span":{"begin":3739,"end":3885},"obj":"Sentence"},{"id":"T29","span":{"begin":3886,"end":3966},"obj":"Sentence"},{"id":"T30","span":{"begin":3967,"end":4395},"obj":"Sentence"},{"id":"T31","span":{"begin":4396,"end":4645},"obj":"Sentence"},{"id":"T32","span":{"begin":4646,"end":4761},"obj":"Sentence"},{"id":"T33","span":{"begin":4762,"end":4830},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"},{"subj":"T15","pred":"source","obj":"LitCovid-sentences"},{"subj":"T16","pred":"source","obj":"LitCovid-sentences"},{"subj":"T17","pred":"source","obj":"LitCovid-sentences"},{"subj":"T18","pred":"source","obj":"LitCovid-sentences"},{"subj":"T19","pred":"source","obj":"LitCovid-sentences"},{"subj":"T20","pred":"source","obj":"LitCovid-sentences"},{"subj":"T21","pred":"source","obj":"LitCovid-sentences"},{"subj":"T22","pred":"source","obj":"LitCovid-sentences"},{"subj":"T23","pred":"source","obj":"LitCovid-sentences"},{"subj":"T24","pred":"source","obj":"LitCovid-sentences"},{"subj":"T25","pred":"source","obj":"LitCovid-sentences"},{"subj":"T26","pred":"source","obj":"LitCovid-sentences"},{"subj":"T27","pred":"source","obj":"LitCovid-sentences"},{"subj":"T28","pred":"source","obj":"LitCovid-sentences"},{"subj":"T29","pred":"source","obj":"LitCovid-sentences"},{"subj":"T30","pred":"source","obj":"LitCovid-sentences"},{"subj":"T31","pred":"source","obj":"LitCovid-sentences"},{"subj":"T32","pred":"source","obj":"LitCovid-sentences"},{"subj":"T33","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T2","span":{"begin":834,"end":843},"obj":"Phenotype"},{"id":"T3","span":{"begin":894,"end":903},"obj":"Phenotype"},{"id":"T4","span":{"begin":1139,"end":1148},"obj":"Phenotype"},{"id":"T5","span":{"begin":1257,"end":1266},"obj":"Phenotype"},{"id":"T6","span":{"begin":1275,"end":1284},"obj":"Phenotype"},{"id":"T7","span":{"begin":1416,"end":1434},"obj":"Phenotype"},{"id":"T8","span":{"begin":1651,"end":1679},"obj":"Phenotype"},{"id":"T9","span":{"begin":1707,"end":1716},"obj":"Phenotype"},{"id":"T10","span":{"begin":1723,"end":1751},"obj":"Phenotype"},{"id":"T11","span":{"begin":1753,"end":1755},"obj":"Phenotype"},{"id":"T12","span":{"begin":1847,"end":1849},"obj":"Phenotype"},{"id":"T13","span":{"begin":2375,"end":2384},"obj":"Phenotype"},{"id":"T14","span":{"begin":2478,"end":2480},"obj":"Phenotype"},{"id":"T15","span":{"begin":2888,"end":2890},"obj":"Phenotype"},{"id":"T16","span":{"begin":3319,"end":3321},"obj":"Phenotype"},{"id":"T17","span":{"begin":3628,"end":3630},"obj":"Phenotype"},{"id":"T18","span":{"begin":3751,"end":3753},"obj":"Phenotype"},{"id":"T19","span":{"begin":3956,"end":3965},"obj":"Phenotype"},{"id":"T20","span":{"begin":4085,"end":4101},"obj":"Phenotype"},{"id":"T21","span":{"begin":4626,"end":4644},"obj":"Phenotype"},{"id":"T22","span":{"begin":4758,"end":4760},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002206"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0002721"},{"id":"A21","pred":"hp_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/HP_0002206"},{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0006516"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-HP"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93eca9","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9396"},{"id":"LitCovid-PD-UBERON","color":"#93b0ec"},{"id":"LitCovid-PD-MONDO","color":"#caec93"},{"id":"LitCovid-PD-CLO","color":"#ec93e4"},{"id":"LitCovid-PD-CHEBI","color":"#93ecd9"},{"id":"LitCovid-PD-GO-BP","color":"#ecbf93"},{"id":"LitCovid-sentences","color":"#a593ec"},{"id":"LitCovid-PD-HP","color":"#9aec93"}]}]}}