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PMC:7111504 / 16552-18751 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
260 101-110 Species denotes 2019-nCoV Tax:2697049
261 297-306 Species denotes 2019-nCoV Tax:2697049
262 413-421 Disease denotes infected MESH:D007239
263 652-661 Disease denotes infection MESH:D007239
268 716-733 Species denotes novel coronavirus Tax:2697049
269 925-934 Species denotes 2019-nCoV Tax:2697049
270 949-957 Species denotes SARS CoV Tax:694009
271 1089-1098 Species denotes 2019-nCoV Tax:2697049
277 2044-2047 Gene denotes TCR Gene:6962
278 1790-1799 Species denotes 2019-nCoV Tax:2697049
279 1887-1895 Species denotes SARS CoV Tax:694009
280 1949-1957 Species denotes SARS CoV Tax:694009
281 2020-2029 Chemical denotes NetMHCpan

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T180 75-86 CHEBI:60816;CHEBI:60816 denotes immunogenic
T181 101-110 SP_7 denotes 2019-nCoV
T182 276-282 UBERON:0002405 denotes immune
T183 297-306 SP_7 denotes 2019-nCoV
T184 587-595 CHEBI:75958;CHEBI:75958 denotes solution
T185 671-682 NCBITaxon:1 denotes individuals
T186 722-733 NCBITaxon:11118 denotes coronavirus
T187 925-934 SP_7 denotes 2019-nCoV
T188 949-957 SP_10 denotes SARS CoV
T189 958-969 CHEBI:60816;CHEBI:60816 denotes immunogenic
T190 1052-1063 CHEBI:60816;CHEBI:60816 denotes immunogenic
T191 1080-1084 SP_10 denotes SARS
T192 1089-1098 SP_7 denotes 2019-nCoV
T193 1706-1717 CHEBI:60816;CHEBI:60816 denotes immunogenic
T194 1764-1775 CHEBI:60816;CHEBI:60816 denotes immunogenic
T195 1790-1799 SP_7 denotes 2019-nCoV
T196 1852-1863 CHEBI:60816;CHEBI:60816 denotes immunogenic
T197 1887-1895 SP_10 denotes SARS CoV
T198 1937-1948 CHEBI:60816;CHEBI:60816 denotes immunogenic
T199 1949-1957 SP_10 denotes SARS CoV
T200 1990-2001 CHEBI:60816;CHEBI:60816 denotes immunogenic
T20287 75-86 CHEBI:60816;CHEBI:60816 denotes immunogenic
T62909 101-110 SP_7 denotes 2019-nCoV
T33026 276-282 UBERON:0002405 denotes immune
T14182 297-306 SP_7 denotes 2019-nCoV
T97785 587-595 CHEBI:75958;CHEBI:75958 denotes solution
T20380 671-682 NCBITaxon:1 denotes individuals
T88699 722-733 NCBITaxon:11118 denotes coronavirus
T36180 925-934 SP_7 denotes 2019-nCoV
T25512 949-957 SP_10 denotes SARS CoV
T97898 958-969 CHEBI:60816;CHEBI:60816 denotes immunogenic
T74245 1052-1063 CHEBI:60816;CHEBI:60816 denotes immunogenic
T63591 1080-1084 SP_10 denotes SARS
T88310 1089-1098 SP_7 denotes 2019-nCoV
T73381 1706-1717 CHEBI:60816;CHEBI:60816 denotes immunogenic
T75888 1764-1775 CHEBI:60816;CHEBI:60816 denotes immunogenic
T97602 1790-1799 SP_7 denotes 2019-nCoV
T82588 1852-1863 CHEBI:60816;CHEBI:60816 denotes immunogenic
T3215 1887-1895 SP_10 denotes SARS CoV
T41480 1937-1948 CHEBI:60816;CHEBI:60816 denotes immunogenic
T9465 1949-1957 SP_10 denotes SARS CoV
T57652 1990-2001 CHEBI:60816;CHEBI:60816 denotes immunogenic

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T97 1232-1236 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 1232-1236 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T20 652-661 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T21 949-953 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T22 1080-1084 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 1887-1891 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T24 1949-1953 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T214 36-37 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T215 87-95 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T216 243-244 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T217 516-528 http://purl.obolibrary.org/obo/OBI_0000968 denotes instrumental
T218 560-561 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 689-690 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T220 886-887 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T221 970-978 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T222 1064-1071 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T223 1144-1145 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T224 1366-1367 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T225 1718-1726 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T226 1776-1784 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T227 1958-1966 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T228 2133-2134 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T118 87-95 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T119 587-595 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T120 970-978 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T121 1064-1071 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T122 1718-1726 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T123 1776-1784 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T124 1958-1966 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T185 0-10 Sentence denotes Discussion
T186 11-172 Sentence denotes In this study we provide a profile of computationally predicted immunogenic peptides from 2019-nCoV for functional validation and potential vaccine developments.
T187 173-307 Sentence denotes We are fully aware that an effective vaccine development will require a very thorough investigation of immune correlates to 2019-nCoV.
T188 308-476 Sentence denotes However, due to the emergency and severity of the outbreak as well as the lack of access to samples from infected subjects, such approaches would not serve the urgency.
T189 477-683 Sentence denotes Therefore, computational prediction is instrumental for guiding biologists towards a quick and cost-effective solution to prevent the spread and ultimately help eliminate the infection from the individuals.
T190 684-824 Sentence denotes With a rising global concern of novel coronavirus outbreak, numerous research groups have started to investigate and publish their findings.
T191 825-981 Sentence denotes At the time of preparing this manuscript, we became aware of a similar study conducted in comparing 2019-nCoV proteome with SARS CoV immunogenic peptides 9.
T192 982-1218 Sentence denotes Our in silico approach takes the search beyond presenting only common immunogenic peptide between SARS and 2019-nCoV and provides the experimental community with a more comprehensive list including de novo and cross reactive candidates.
T193 1219-1420 Sentence denotes On the other hand, considering the fact that two studies have been accomplished independently with distinct approaches, this serves to demonstrate a high level of confidence in reproducing the results.
T194 1421-1571 Sentence denotes Reproducibility of computational prediction is always of high importance and becomes even more significant under urgent scenarios as of this outbreak.
T195 1572-1727 Sentence denotes Our study also suggests the need for further efforts to develop accurate predictive models and algorithms for the characterization of immunogenic peptides.
T196 1728-2075 Sentence denotes In this study, we provide potential immunogenic peptides from 2019-nCoV for vaccine targets that i) have been characterized immunogenic by previous studies on SARS CoV, ii) have high degree of similarity with immunogenic SARS CoV peptides and iii) are predicted immunogenic by combination of NetMHCpan and iPred/1G4 TCR positional weight matrices.
T197 2076-2199 Sentence denotes Given the limited time and resources, our work serves as a guide to save time and cost for further experimental validation.