PMC:7108637 / 58488-60367 JSONTXT

{"project":"2_test","denotations":[{"id":"29579213-7844558-45167865","span":{"begin":312,"end":316},"obj":"7844558"},{"id":"29579213-12502850-45167866","span":{"begin":329,"end":333},"obj":"12502850"},{"id":"29579213-12609975-45167867","span":{"begin":349,"end":353},"obj":"12609975"},{"id":"29579213-16051304-45167868","span":{"begin":371,"end":375},"obj":"16051304"},{"id":"29579213-17001080-45167869","span":{"begin":390,"end":394},"obj":"17001080"},{"id":"29579213-18266465-45167870","span":{"begin":410,"end":414},"obj":"18266465"},{"id":"29579213-24766301-45167871","span":{"begin":428,"end":432},"obj":"24766301"},{"id":"29579213-27223297-45167872","span":{"begin":449,"end":453},"obj":"27223297"},{"id":"29579213-26629951-45167873","span":{"begin":467,"end":471},"obj":"26629951"},{"id":"29579213-27999160-45167874","span":{"begin":609,"end":613},"obj":"27999160"},{"id":"29579213-9600268-45167875","span":{"begin":761,"end":765},"obj":"9600268"},{"id":"29579213-11278567-45167876","span":{"begin":783,"end":787},"obj":"11278567"},{"id":"29579213-22006924-45167877","span":{"begin":812,"end":816},"obj":"22006924"},{"id":"29579213-26083631-45167878","span":{"begin":834,"end":838},"obj":"26083631"},{"id":"29579213-23384254-45167879","span":{"begin":1001,"end":1005},"obj":"23384254"},{"id":"29579213-25499264-45167880","span":{"begin":1139,"end":1143},"obj":"25499264"},{"id":"29579213-26105052-45167881","span":{"begin":1327,"end":1331},"obj":"26105052"},{"id":"29579213-17229687-45167882","span":{"begin":1426,"end":1430},"obj":"17229687"},{"id":"29579213-25965797-45167883","span":{"begin":1517,"end":1521},"obj":"25965797"},{"id":"29579213-28028222-45167884","span":{"begin":1679,"end":1683},"obj":"28028222"},{"id":"29579213-15956584-45167885","span":{"begin":1831,"end":1835},"obj":"15956584"},{"id":"29579213-17507469-45167886","span":{"begin":1854,"end":1858},"obj":"17507469"},{"id":"29579213-20844034-45167887","span":{"begin":1873,"end":1877},"obj":"20844034"},{"id":"T87668","span":{"begin":312,"end":316},"obj":"7844558"},{"id":"T2215","span":{"begin":329,"end":333},"obj":"12502850"},{"id":"T62100","span":{"begin":349,"end":353},"obj":"12609975"},{"id":"T28219","span":{"begin":371,"end":375},"obj":"16051304"},{"id":"T88832","span":{"begin":390,"end":394},"obj":"17001080"},{"id":"T51221","span":{"begin":410,"end":414},"obj":"18266465"},{"id":"T93488","span":{"begin":428,"end":432},"obj":"24766301"},{"id":"T53858","span":{"begin":449,"end":453},"obj":"27223297"},{"id":"T93048","span":{"begin":467,"end":471},"obj":"26629951"},{"id":"T23878","span":{"begin":609,"end":613},"obj":"27999160"},{"id":"T83961","span":{"begin":761,"end":765},"obj":"9600268"},{"id":"T80140","span":{"begin":783,"end":787},"obj":"11278567"},{"id":"T70913","span":{"begin":812,"end":816},"obj":"22006924"},{"id":"T89149","span":{"begin":834,"end":838},"obj":"26083631"},{"id":"T15825","span":{"begin":1001,"end":1005},"obj":"23384254"},{"id":"T44399","span":{"begin":1139,"end":1143},"obj":"25499264"},{"id":"T50998","span":{"begin":1327,"end":1331},"obj":"26105052"},{"id":"T40185","span":{"begin":1426,"end":1430},"obj":"17229687"},{"id":"T14683","span":{"begin":1517,"end":1521},"obj":"25965797"},{"id":"T13016","span":{"begin":1679,"end":1683},"obj":"28028222"},{"id":"T73345","span":{"begin":1831,"end":1835},"obj":"15956584"},{"id":"T83314","span":{"begin":1854,"end":1858},"obj":"17507469"},{"id":"T96782","span":{"begin":1873,"end":1877},"obj":"20844034"}],"text":"A number of viruses, such as HCV, Dengue virus, Ebola virus, SARS coronavirus, West Nile virus, Rift Valley fever virus and Japanese encephalitis virus use N-linked glycans as attachment and entry receptors by interacting with cellular lectins DC-SIGN, L-SIGN, LSECtin, ASGP-R or mannose receptor (Becker et al. 1995; Lin et al. 2003; Lozach et al. 2003; Gramberg et al. 2005; Davis et al. 2006; Miller et al. 2008; Chen et al. 2014; Phoenix et al. 2016; Wang et al. 2016). Mature N-glycans have been suggested to influence Lassa virus binding to cell entry receptor α-dystroglycan (Shrivastava-Ranjan et al. 2016). In addition, specific N-glycans on HIV-1 have been shown to affect CD4 receptor binding on T cells or regulate coreceptor usage (Nakayama et al. 1998; Pollakis et al. 2001; Francois and Balzarini 2011; Lombardi et al. 2015). Systemic functional analysis of HIV-1 gp160 potential N-glycosylation sites has identified a number of additional glycosites affecting infectivity (Wang et al. 2013). In addition, a certain N-glycan on HIV-1 gp41 was shown to have a consistent effect in several viral strains (Mathys and Balzarini 2014). Specific sialylated N-glycans on VZV gB have been identified that are important for interaction with myelin-associated glycoprotein and crucial for cell–cell fusion (Suenaga et al. 2015), and sialylation of virions in general was shown to affect entry of HSV-1 (Teuton and Brandt 2007). Similarly, specific N-linked glycans on HSV-2 gB influenced viral entry (Luo et al. 2015). An N-glycosylation site on IAV HA has also been shown to affect viral entry indirectly by modulating the avidity and specificity for sialosides (Wu et al. 2017). Finally, distinct putative N-glycosylation site mutations on HCV E1 and E2 resulted in diminished entry and altered CD81 binding (Goffard et al. 2005; Falkowska et al. 2007; Helle et al. 2010)."}