PMC:7108609 / 3671-4715 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7108609","sourcedb":"PMC","sourceid":"7108609","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7108609","text":"Various genetic factors influencing the susceptibility to or the outcome of SARS have been described (Gu and Korteweg 2007). The ABO gene stands out among the genes involved since O blood group individuals were shown to have very low odds of infection compared to non-O individuals in a hospital outbreak that occurred in March 2003 in Hong Kong (Cheng et al. 2005). Histo-blood group antigens are present not only on erythrocytes but also on many epithelial cells, which are their main site of expression (Marionneau et al. 2001). Since SARS-CoV replicates in epithelial cells of the respiratory and digestive tracts that have the ability to synthesize ABH carbohydrate epitopes, we hypothesized that the S protein of virions produced by either A or B individuals could be decorated with A or B carbohydrate epitopes, respectively. Natural anti-A or -B antibodies from blood group O, B, and A individuals could bind to the S protein and block its interaction with ACE2, thereby preventing infection in accordance with the rules of transfusion.","tracks":[{"project":"2_test","denotations":[{"id":"18818423-17392154-45167052","span":{"begin":118,"end":122},"obj":"17392154"},{"id":"18818423-11522384-45167053","span":{"begin":525,"end":529},"obj":"11522384"},{"id":"T47094","span":{"begin":118,"end":122},"obj":"17392154"},{"id":"T8796","span":{"begin":525,"end":529},"obj":"11522384"}],"attributes":[{"subj":"18818423-17392154-45167052","pred":"source","obj":"2_test"},{"subj":"18818423-11522384-45167053","pred":"source","obj":"2_test"},{"subj":"T47094","pred":"source","obj":"2_test"},{"subj":"T8796","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#c793ec","default":true}]}]}}