PMC:7108609 / 21513-22613 JSONTXT

{"project":"2_test","denotations":[{"id":"18818423-16166518-45167064","span":{"begin":149,"end":153},"obj":"16166518"},{"id":"18818423-17715238-45167065","span":{"begin":166,"end":170},"obj":"17715238"},{"id":"18818423-17428553-45167066","span":{"begin":489,"end":493},"obj":"17428553"},{"id":"18818423-15728127-45167067","span":{"begin":773,"end":777},"obj":"15728127"},{"id":"18818423-14502281-45167068","span":{"begin":931,"end":935},"obj":"14502281"},{"id":"18818423-17407191-45167069","span":{"begin":953,"end":957},"obj":"17407191"},{"id":"T14822","span":{"begin":149,"end":153},"obj":"16166518"},{"id":"T44287","span":{"begin":166,"end":170},"obj":"17715238"},{"id":"T6466","span":{"begin":489,"end":493},"obj":"17428553"},{"id":"T33803","span":{"begin":773,"end":777},"obj":"15728127"},{"id":"T27375","span":{"begin":931,"end":935},"obj":"14502281"},{"id":"T53840","span":{"begin":953,"end":957},"obj":"17407191"}],"text":"Although the RBM of the SARS-CoV S protein does not involve any glycan chain, clusters of glycosylation sites are located in its vicinity (Li et al. 2005; Han et al. 2007). Large molecules such as lectins or antibodies binding to these glycans are thus expected to interfere with the S protein/ACE2 interaction. This has already been observed with mannose-specific lectins which have shown anti-viral activity against SARS-CoV by blocking virus attachment to its receptor (Keyaerts et al. 2007). Our data indicate that natural anticarbohydrate antibodies could have a similar effect. In addition to the blocking of virus attachment to its receptor, natural antibodies could block entry or opsonize viral particles leading to complement-mediated neutralization (Neil et al. 2005). Moreover, it was recently shown that natural antibodies can contribute to help the generation of cytotoxic T cells against the pathogen (Stäger et al. 2003; Dürrbach et al. 2007). These additional mechanisms of protection may also have participated to the protection of blood group O individual during the SARS outbreak."}