PMC:7108609 / 20820-21512 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7108609","sourcedb":"PMC","sourceid":"7108609","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7108609","text":"In order to determine if anti-HBGAs could block SARS-CoV entry into target cells, we used an experimental model of cell adhesion that has been developed with the aim of screening molecules that block the virus entry without using infectious particles. The model allowed us to show that either a monoclonal anti-A antibody or natural plasma anti-A specifically inhibited the SARS-CoV S protein/ACE2-dependent adhesion. This is in accordance with the hypothesis of the protective role of natural anti-HBGAs and strongly suggests that the low risk of infection of blood group O individuals during the Hong Kong hospital outbreak was due to the presence of these antibodies prior to the outbreak.","tracks":[]}