PMC:7105881 / 936-1617 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7105881","sourcedb":"PMC","sourceid":"7105881","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7105881","text":"transmitting through intermediate hosts, leading to human infections. Nevertheless, the intermediate host for 2019-nCoV is still under investigation and the vaccines against this new CoV have not been available. Although a variety of vaccines have been developed against infections of SARS-CoV and MERS-CoV, none of them has been approved for use in humans. In this review, we have described the structure and function of key proteins of emerging human CoVs, overviewed the current vaccine types to be developed against SARS-CoV and MERS-CoV, and summarized recent advances in subunit vaccines against these two pathogenic human CoVs. These subunit vaccines are introduced on the b","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"52","span":{"begin":52,"end":57},"obj":"Species"},{"id":"53","span":{"begin":110,"end":119},"obj":"Species"},{"id":"54","span":{"begin":179,"end":186},"obj":"Species"},{"id":"55","span":{"begin":285,"end":293},"obj":"Species"},{"id":"56","span":{"begin":298,"end":306},"obj":"Species"},{"id":"57","span":{"begin":350,"end":356},"obj":"Species"},{"id":"58","span":{"begin":447,"end":452},"obj":"Species"},{"id":"59","span":{"begin":453,"end":457},"obj":"Species"},{"id":"60","span":{"begin":520,"end":528},"obj":"Species"},{"id":"61","span":{"begin":533,"end":541},"obj":"Species"},{"id":"62","span":{"begin":623,"end":628},"obj":"Species"},{"id":"63","span":{"begin":629,"end":633},"obj":"Species"},{"id":"72","span":{"begin":58,"end":68},"obj":"Disease"},{"id":"73","span":{"begin":271,"end":281},"obj":"Disease"}],"attributes":[{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Tax:9606"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:2697049"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:2697049"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:694009"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:1335626"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:9606"},{"id":"A58","pred":"tao:has_database_id","subj":"58","obj":"Tax:9606"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"Tax:11118"},{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"Tax:694009"},{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"Tax:1335626"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"Tax:9606"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Tax:11118"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"MESH:D007239"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:D007239"},{"subj":"52","pred":"source","obj":"LitCovid-PubTator"},{"subj":"53","pred":"source","obj":"LitCovid-PubTator"},{"subj":"54","pred":"source","obj":"LitCovid-PubTator"},{"subj":"55","pred":"source","obj":"LitCovid-PubTator"},{"subj":"56","pred":"source","obj":"LitCovid-PubTator"},{"subj":"57","pred":"source","obj":"LitCovid-PubTator"},{"subj":"58","pred":"source","obj":"LitCovid-PubTator"},{"subj":"59","pred":"source","obj":"LitCovid-PubTator"},{"subj":"60","pred":"source","obj":"LitCovid-PubTator"},{"subj":"61","pred":"source","obj":"LitCovid-PubTator"},{"subj":"62","pred":"source","obj":"LitCovid-PubTator"},{"subj":"63","pred":"source","obj":"LitCovid-PubTator"},{"subj":"72","pred":"source","obj":"LitCovid-PubTator"},{"subj":"73","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":426,"end":434},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T8","span":{"begin":58,"end":68},"obj":"Disease"},{"id":"T9","span":{"begin":271,"end":281},"obj":"Disease"},{"id":"T10","span":{"begin":285,"end":293},"obj":"Disease"},{"id":"T11","span":{"begin":520,"end":528},"obj":"Disease"}],"attributes":[{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T9","span":{"begin":52,"end":57},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T10","span":{"begin":221,"end":222},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T11","span":{"begin":321,"end":324},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T12","span":{"begin":350,"end":356},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T13","span":{"begin":447,"end":452},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T14","span":{"begin":623,"end":628},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"attributes":[{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":426,"end":434},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T8","span":{"begin":70,"end":211},"obj":"Sentence"},{"id":"T9","span":{"begin":212,"end":357},"obj":"Sentence"},{"id":"T10","span":{"begin":358,"end":634},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T25","span":{"begin":52,"end":57},"obj":"SP_6;NCBITaxon:9606"},{"id":"T26","span":{"begin":110,"end":119},"obj":"SP_7"},{"id":"T27","span":{"begin":285,"end":293},"obj":"SP_10"},{"id":"T28","span":{"begin":298,"end":306},"obj":"SP_9"},{"id":"T29","span":{"begin":350,"end":356},"obj":"NCBITaxon:9606"},{"id":"T30","span":{"begin":447,"end":452},"obj":"SP_6;NCBITaxon:9606"},{"id":"T31","span":{"begin":520,"end":528},"obj":"SP_10"},{"id":"T32","span":{"begin":533,"end":541},"obj":"SP_9"},{"id":"T33","span":{"begin":623,"end":628},"obj":"SP_6;NCBITaxon:9606"},{"id":"T95839","span":{"begin":52,"end":57},"obj":"SP_6;NCBITaxon:9606"},{"id":"T58242","span":{"begin":110,"end":119},"obj":"SP_7"},{"id":"T89984","span":{"begin":285,"end":293},"obj":"SP_10"},{"id":"T56264","span":{"begin":298,"end":306},"obj":"SP_9"},{"id":"T11552","span":{"begin":350,"end":356},"obj":"NCBITaxon:9606"},{"id":"T28582","span":{"begin":447,"end":452},"obj":"SP_6;NCBITaxon:9606"},{"id":"T48545","span":{"begin":520,"end":528},"obj":"SP_10"},{"id":"T62193","span":{"begin":533,"end":541},"obj":"SP_9"},{"id":"T56881","span":{"begin":623,"end":628},"obj":"SP_6;NCBITaxon:9606"}],"attributes":[{"subj":"T25","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T30","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T32","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T33","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T95839","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T58242","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T89984","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T56264","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T11552","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28582","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T48545","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T62193","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T56881","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec9397","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93b1ec"},{"id":"LitCovid-PD-MONDO","color":"#cbec93"},{"id":"LitCovid-PD-CLO","color":"#ec93e5"},{"id":"LitCovid-PD-CHEBI","color":"#93ecd8"},{"id":"LitCovid-sentences","color":"#ecbe93"},{"id":"LitCovid-PMC-OGER-BB","color":"#a493ec"}]}]}}