PMC:7105881 / 55604-56425
Annnotations
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"1705","span":{"begin":597,"end":602},"obj":"Gene"},{"id":"1706","span":{"begin":704,"end":731},"obj":"Gene"},{"id":"1707","span":{"begin":733,"end":738},"obj":"Gene"},{"id":"1708","span":{"begin":744,"end":757},"obj":"Gene"},{"id":"1709","span":{"begin":759,"end":763},"obj":"Gene"},{"id":"1710","span":{"begin":206,"end":210},"obj":"Species"},{"id":"1711","span":{"begin":218,"end":226},"obj":"Species"},{"id":"1712","span":{"begin":670,"end":674},"obj":"Chemical"},{"id":"1713","span":{"begin":395,"end":413},"obj":"Disease"}],"attributes":[{"id":"A1705","pred":"tao:has_database_id","subj":"1705","obj":"Gene:3458"},{"id":"A1706","pred":"tao:has_database_id","subj":"1706","obj":"Gene:7124"},{"id":"A1707","pred":"tao:has_database_id","subj":"1707","obj":"Gene:7124"},{"id":"A1708","pred":"tao:has_database_id","subj":"1708","obj":"Gene:3565"},{"id":"A1709","pred":"tao:has_database_id","subj":"1709","obj":"Gene:3565"},{"id":"A1710","pred":"tao:has_database_id","subj":"1710","obj":"Tax:10090"},{"id":"A1711","pred":"tao:has_database_id","subj":"1711","obj":"Tax:1335626"},{"id":"A1712","pred":"tao:has_database_id","subj":"1712","obj":"MESH:C041524"},{"id":"A1713","pred":"tao:has_database_id","subj":"1713","obj":"MESH:D018352"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
LitCovid-PD-FMA-UBERON
{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T319","span":{"begin":159,"end":166},"obj":"Body_part"},{"id":"T320","span":{"begin":368,"end":376},"obj":"Body_part"},{"id":"T321","span":{"begin":546,"end":553},"obj":"Body_part"},{"id":"T322","span":{"begin":615,"end":620},"obj":"Body_part"},{"id":"T323","span":{"begin":646,"end":653},"obj":"Body_part"},{"id":"T324","span":{"begin":744,"end":757},"obj":"Body_part"},{"id":"T325","span":{"begin":744,"end":755},"obj":"Body_part"},{"id":"T326","span":{"begin":777,"end":782},"obj":"Body_part"}],"attributes":[{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A321","pred":"fma_id","subj":"T321","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A323","pred":"fma_id","subj":"T323","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A324","pred":"fma_id","subj":"T324","obj":"http://purl.org/sig/ont/fma/fma264831"},{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
LitCovid_AGAC
{"project":"LitCovid_AGAC","denotations":[{"id":"p63268s31","span":{"begin":341,"end":367},"obj":"MPA"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
LitCovid-PD-MONDO
{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T271","span":{"begin":404,"end":413},"obj":"Disease"},{"id":"T272","span":{"begin":704,"end":709},"obj":"Disease"}],"attributes":[{"id":"A271","pred":"mondo_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A272","pred":"mondo_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
LitCovid-PD-CLO
{"project":"LitCovid-PD-CLO","denotations":[{"id":"T651","span":{"begin":216,"end":217},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T652","span":{"begin":248,"end":250},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T653","span":{"begin":613,"end":620},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T654","span":{"begin":704,"end":731},"obj":"http://purl.obolibrary.org/obo/PR_000000134"},{"id":"T655","span":{"begin":775,"end":782},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
LitCovid-PD-CHEBI
{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T8227","span":{"begin":159,"end":166},"obj":"Chemical"},{"id":"T92382","span":{"begin":167,"end":175},"obj":"Chemical"},{"id":"T19118","span":{"begin":546,"end":553},"obj":"Chemical"},{"id":"T68288","span":{"begin":646,"end":653},"obj":"Chemical"},{"id":"T41397","span":{"begin":726,"end":731},"obj":"Chemical"},{"id":"T41514","span":{"begin":759,"end":761},"obj":"Chemical"}],"attributes":[{"id":"A5252","pred":"chebi_id","subj":"T8227","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A9434","pred":"chebi_id","subj":"T92382","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A51487","pred":"chebi_id","subj":"T19118","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A52343","pred":"chebi_id","subj":"T68288","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A28087","pred":"chebi_id","subj":"T41397","obj":"http://purl.obolibrary.org/obo/CHEBI_30216"},{"id":"A46474","pred":"chebi_id","subj":"T41514","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A64671","pred":"chebi_id","subj":"T41514","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
LitCovid-PD-HP
{"project":"LitCovid-PD-HP","denotations":[{"id":"T15","span":{"begin":704,"end":709},"obj":"Phenotype"}],"attributes":[{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
LitCovid-PD-GO-BP
{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T110","span":{"begin":57,"end":73},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T111","span":{"begin":130,"end":146},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T112","span":{"begin":302,"end":327},"obj":"http://purl.obolibrary.org/obo/GO_0002456"},{"id":"T113","span":{"begin":302,"end":327},"obj":"http://purl.obolibrary.org/obo/GO_0002449"},{"id":"T114","span":{"begin":302,"end":327},"obj":"http://purl.obolibrary.org/obo/GO_0002443"},{"id":"T115","span":{"begin":710,"end":718},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T116","span":{"begin":710,"end":718},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T117","span":{"begin":710,"end":718},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T118","span":{"begin":710,"end":718},"obj":"http://purl.obolibrary.org/obo/GO_0001906"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
2_test
{"project":"2_test","denotations":[{"id":"32265848-25405618-36511234","span":{"begin":815,"end":819},"obj":"25405618"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T298","span":{"begin":0,"end":176},"obj":"Sentence"},{"id":"T299","span":{"begin":177,"end":493},"obj":"Sentence"},{"id":"T300","span":{"begin":494,"end":821},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}
LitCovid-PMC-OGER-BB
{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T913","span":{"begin":57,"end":63},"obj":"UBERON:0002405;GO:0006955"},{"id":"T914","span":{"begin":64,"end":73},"obj":"GO:0006955"},{"id":"T915","span":{"begin":130,"end":136},"obj":"UBERON:0002405;GO:0006955"},{"id":"T916","span":{"begin":137,"end":146},"obj":"GO:0006955"},{"id":"T917","span":{"begin":167,"end":175},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T918","span":{"begin":206,"end":210},"obj":"NCBITaxon:10088"},{"id":"T919","span":{"begin":218,"end":226},"obj":"SP_9"},{"id":"T920","span":{"begin":302,"end":310},"obj":"GO:0051716"},{"id":"T921","span":{"begin":311,"end":317},"obj":"UBERON:0002405;GO:0006955"},{"id":"T922","span":{"begin":318,"end":327},"obj":"GO:0006955"},{"id":"T923","span":{"begin":347,"end":354},"obj":"UBERON:0000912"},{"id":"T924","span":{"begin":368,"end":376},"obj":"GO:0042571;GO:0016064"},{"id":"T925","span":{"begin":377,"end":386},"obj":"GO:0016064"},{"id":"T926","span":{"begin":395,"end":403},"obj":"SP_9"},{"id":"T927","span":{"begin":530,"end":540},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T928","span":{"begin":597,"end":602},"obj":"PR:000000017"},{"id":"T929","span":{"begin":613,"end":620},"obj":"CL:0000084"},{"id":"T930","span":{"begin":654,"end":664},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T931","span":{"begin":704,"end":731},"obj":"PR:000000134"},{"id":"T932","span":{"begin":733,"end":738},"obj":"PR:000000134"},{"id":"T933","span":{"begin":744,"end":757},"obj":"PR:000001391"},{"id":"T934","span":{"begin":759,"end":763},"obj":"PR:000001391"},{"id":"T935","span":{"begin":765,"end":774},"obj":"GO:0046903"},{"id":"T936","span":{"begin":775,"end":782},"obj":"CL:0000084"},{"id":"T92188","span":{"begin":57,"end":63},"obj":"UBERON:0002405;GO:0006955"},{"id":"T16517","span":{"begin":64,"end":73},"obj":"GO:0006955"},{"id":"T23739","span":{"begin":130,"end":136},"obj":"UBERON:0002405;GO:0006955"},{"id":"T55531","span":{"begin":137,"end":146},"obj":"GO:0006955"},{"id":"T26614","span":{"begin":167,"end":175},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T39837","span":{"begin":206,"end":210},"obj":"NCBITaxon:10088"},{"id":"T16700","span":{"begin":218,"end":226},"obj":"SP_9"},{"id":"T55053","span":{"begin":302,"end":310},"obj":"GO:0051716"},{"id":"T63741","span":{"begin":311,"end":317},"obj":"UBERON:0002405;GO:0006955"},{"id":"T6035","span":{"begin":318,"end":327},"obj":"GO:0006955"},{"id":"T53384","span":{"begin":347,"end":354},"obj":"UBERON:0000912"},{"id":"T48624","span":{"begin":368,"end":376},"obj":"GO:0042571;GO:0016064"},{"id":"T90753","span":{"begin":377,"end":386},"obj":"GO:0016064"},{"id":"T38294","span":{"begin":395,"end":403},"obj":"SP_9"},{"id":"T70153","span":{"begin":530,"end":540},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T63512","span":{"begin":597,"end":602},"obj":"PR:000000017"},{"id":"T80557","span":{"begin":613,"end":620},"obj":"CL:0000084"},{"id":"T8440","span":{"begin":654,"end":664},"obj":"CHEBI:60809;CHEBI:60809"},{"id":"T7666","span":{"begin":704,"end":731},"obj":"PR:000000134"},{"id":"T21120","span":{"begin":733,"end":738},"obj":"PR:000000134"},{"id":"T60795","span":{"begin":744,"end":757},"obj":"PR:000001391"},{"id":"T88872","span":{"begin":759,"end":763},"obj":"PR:000001391"},{"id":"T34423","span":{"begin":765,"end":774},"obj":"GO:0046903"},{"id":"T31231","span":{"begin":775,"end":782},"obj":"CL:0000084"}],"text":"Vaccination pathways are important in inducing efficient immune responses, and different immunization routes may elicit different immune responses to the same protein antigens. For example, immunization of mice with a MERS-CoV subunit vaccine (RBD-Fc) via the intranasal route induced higher levels of cellular immune responses and stronger local mucosal neutralizing antibody responses against MERS-CoV infection than those induced by the same vaccine via the S.C. pathway (Ma et al., 2014a). In addition, while Freund’s and CpG-adjuvanted rRBD protein elicited higher-level systematic and local IFN-γ-producing T cells via the S.C. route, this protein adjuvanted with Alum and CpG induced higher-level tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4)-secreting T cells via the I.M. route (Lan et al., 2014)."}