PMC:7105881 / 51466-52985
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1605 | 0-8 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1629 | 1076-1081 | Gene | denotes | hDPP4 | Gene:1803 |
| 1630 | 156-160 | Species | denotes | mice | Tax:10090 |
| 1631 | 196-204 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1632 | 242-246 | Species | denotes | mice | Tax:10090 |
| 1633 | 333-337 | Species | denotes | mice | Tax:10090 |
| 1634 | 397-405 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1635 | 481-489 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1636 | 594-603 | Species | denotes | dromedary | Tax:9838 |
| 1637 | 604-610 | Species | denotes | camels | Tax:9838 |
| 1638 | 657-665 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1639 | 719-726 | Species | denotes | alpacas | Tax:30538 |
| 1640 | 970-978 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1641 | 1093-1097 | Species | denotes | mice | Tax:10090 |
| 1642 | 1106-1114 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1643 | 1271-1279 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1644 | 1283-1290 | Species | denotes | rabbits | Tax:9986 |
| 1645 | 1500-1508 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1646 | 958-969 | Species | denotes | recombinant | Tax:575864 |
| 1647 | 251-269 | Chemical | denotes | aluminum phosphate | MESH:C012714 |
| 1648 | 517-522 | Chemical | denotes | Advax | MESH:C576871 |
| 1649 | 428-446 | Disease | denotes | MERS-CoV infection | MESH:D018352 |
| 1650 | 775-790 | Disease | denotes | viral infection | MESH:D001102 |
| 1651 | 827-840 | Disease | denotes | CoV infection | MESH:D018352 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T294 | 45-52 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
| T295 | 108-115 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T296 | 208-215 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T297 | 493-500 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T298 | 871-876 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T299 | 890-898 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T300 | 983-990 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T301 | 1037-1041 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T302 | 1511-1518 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T18 | 871-876 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T258 | 437-446 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T259 | 775-790 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T260 | 781-790 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T261 | 831-840 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T262 | 979-982 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T625 | 174-177 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T626 | 194-195 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T627 | 205-207 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T628 | 490-492 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T629 | 604-610 | http://purl.obolibrary.org/obo/NCBITaxon_9837 | denotes | camels |
| T630 | 956-957 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T631 | 1037-1041 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T632 | 1196-1204 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T633 | 1227-1228 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T634 | 1229-1231 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T635 | 1229-1231 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T636 | 1232-1239 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T637 | 1349-1356 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T80022 | 45-52 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
| T7311 | 108-115 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T57132 | 208-215 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T57819 | 251-259 | Chemical | denotes | aluminum | http://purl.obolibrary.org/obo/CHEBI_28984 |
| T80718 | 260-269 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T17955 | 281-289 | Chemical | denotes | adjuvant | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T31295 | 493-500 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T49139 | 983-990 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T12977 | 1229-1231 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T4610 | 1232-1239 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T3633 | 1349-1356 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T63120 | 1511-1518 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T105 | 636-650 | http://purl.obolibrary.org/obo/GO_0019076 | denotes | viral shedding |
| T106 | 755-769 | http://purl.obolibrary.org/obo/GO_0019076 | denotes | viral shedding |
| T107 | 775-790 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32265848-26218507-36511221 | 461-465 | 26218507 | denotes | 2015 |
| 32265848-30832356-36511222 | 921-925 | 30832356 | denotes | 2019 |
| 32265848-27899228-36511223 | 1142-1146 | 27899228 | denotes | 2017 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T280 | 0-62 | Sentence | denotes | MERS-CoV Subunit Vaccines Based on Non-RBD S Protein Fragments |
| T281 | 63-170 | Sentence | denotes | MERS vaccines targeting non-RBD regions of S protein have been developed and investigated in mice and NHPs. |
| T282 | 171-467 | Sentence | denotes | It has been shown that a MERS-CoV S1 protein formulated with Ribi (for mice) or aluminum phosphate (for NHPs) adjuvant elicited robust neutralizing antibodies in mice and NHPs against divergent strains of pseudotyped and live MERS-CoV, protecting NHPs from MERS-CoV infection (Wang et al., 2015). |
| T283 | 468-927 | Sentence | denotes | In addition, MERS-CoV S1 protein adjuvanted with Advax and Sigma Adjuvant System induced low-titer neutralizing antibodies in dromedary camels with reduced and delayed viral shedding after MERS-CoV challenge, but high-titer neutralizing antibodies in alpacas with complete protection of viral shedding from viral infection, indicating that protection of MERS-CoV infection is positively correlated with serum neutralizing antibody titers (Adney et al., 2019). |
| T284 | 928-1148 | Sentence | denotes | Moreover, immunization with a recombinant MERS-CoV NTD protein (rNTD) can induce neutralizing antibodies and cell-mediated responses, protecting Ad-hDPP4-transduced mice against MERS-CoV challenge (Jiaming et al., 2017). |
| T285 | 1149-1376 | Sentence | denotes | Notably, specific antibodies with neutralizing activity have been elicited by a S2 peptide sequence (residues 736–761) of MERS-CoV in rabbits (Yang et al., 2014a), but the protective efficacy of this peptide vaccine is unknown. |
| T286 | 1377-1519 | Sentence | denotes | The above reports demonstrate the potential for the development of MERS subunit vaccines based on the non-RBD fragments of MERS-CoV S protein. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T822 | 0-8 | SP_9 | denotes | MERS-CoV |
| T823 | 43-52 | PG_1 | denotes | S Protein |
| T824 | 63-67 | SP_9 | denotes | MERS |
| T825 | 106-115 | PG_1 | denotes | S protein |
| T826 | 156-160 | NCBITaxon:10088 | denotes | mice |
| T827 | 196-204 | SP_9 | denotes | MERS-CoV |
| T828 | 242-246 | NCBITaxon:10088 | denotes | mice |
| T829 | 260-269 | CHEBI:18367;CHEBI:18367 | denotes | phosphate |
| T830 | 281-289 | CHEBI:60809;CHEBI:60809 | denotes | adjuvant |
| T831 | 319-329 | GO:0042571 | denotes | antibodies |
| T832 | 333-337 | NCBITaxon:10088 | denotes | mice |
| T833 | 397-405 | SP_9 | denotes | MERS-CoV |
| T834 | 428-436 | SP_9 | denotes | MERS-CoV |
| T835 | 481-489 | SP_9 | denotes | MERS-CoV |
| T836 | 501-511 | CHEBI:60809;CHEBI:60809 | denotes | adjuvanted |
| T837 | 533-541 | CHEBI:60809;CHEBI:60809 | denotes | Adjuvant |
| T838 | 580-590 | GO:0042571 | denotes | antibodies |
| T839 | 594-603 | SP_3 | denotes | dromedary |
| T840 | 636-641 | NCBITaxon:10239 | denotes | viral |
| T841 | 657-665 | SP_9 | denotes | MERS-CoV |
| T842 | 705-715 | GO:0042571 | denotes | antibodies |
| T843 | 755-760 | NCBITaxon:10239 | denotes | viral |
| T844 | 775-780 | NCBITaxon:10239 | denotes | viral |
| T845 | 822-830 | SP_9 | denotes | MERS-CoV |
| T846 | 871-876 | UBERON:0001977 | denotes | serum |
| T847 | 890-898 | GO:0042571 | denotes | antibody |
| T848 | 970-978 | SP_9 | denotes | MERS-CoV |
| T849 | 1022-1032 | GO:0042571 | denotes | antibodies |
| T850 | 1076-1081 | PR:P27487 | denotes | hDPP4 |
| T851 | 1082-1092 | GO:0009293 | denotes | transduced |
| T852 | 1093-1097 | NCBITaxon:10088 | denotes | mice |
| T853 | 1106-1114 | SP_9 | denotes | MERS-CoV |
| T854 | 1167-1177 | GO:0042571 | denotes | antibodies |
| T855 | 1271-1279 | SP_9 | denotes | MERS-CoV |
| T856 | 1283-1290 | NCBITaxon:9986 | denotes | rabbits |
| T857 | 1444-1448 | SP_9 | denotes | MERS |
| T858 | 1500-1508 | SP_9 | denotes | MERS-CoV |
| T859 | 1509-1518 | PG_1 | denotes | S protein |
| T22870 | 0-8 | SP_9 | denotes | MERS-CoV |
| T19565 | 43-52 | PG_1 | denotes | S Protein |
| T62884 | 63-67 | SP_9 | denotes | MERS |
| T86511 | 106-115 | PG_1 | denotes | S protein |
| T41020 | 156-160 | NCBITaxon:10088 | denotes | mice |
| T40411 | 196-204 | SP_9 | denotes | MERS-CoV |
| T37210 | 242-246 | NCBITaxon:10088 | denotes | mice |
| T41168 | 260-269 | CHEBI:18367;CHEBI:18367 | denotes | phosphate |
| T70226 | 281-289 | CHEBI:60809;CHEBI:60809 | denotes | adjuvant |
| T92275 | 319-329 | GO:0042571 | denotes | antibodies |
| T79327 | 333-337 | NCBITaxon:10088 | denotes | mice |
| T83835 | 397-405 | SP_9 | denotes | MERS-CoV |
| T51357 | 428-436 | SP_9 | denotes | MERS-CoV |
| T49095 | 481-489 | SP_9 | denotes | MERS-CoV |
| T41407 | 501-511 | CHEBI:60809;CHEBI:60809 | denotes | adjuvanted |
| T73205 | 533-541 | CHEBI:60809;CHEBI:60809 | denotes | Adjuvant |
| T42217 | 580-590 | GO:0042571 | denotes | antibodies |
| T2952 | 594-603 | SP_3 | denotes | dromedary |
| T82649 | 636-641 | NCBITaxon:10239 | denotes | viral |
| T89000 | 657-665 | SP_9 | denotes | MERS-CoV |
| T40063 | 705-715 | GO:0042571 | denotes | antibodies |
| T61602 | 755-760 | NCBITaxon:10239 | denotes | viral |
| T77755 | 775-780 | NCBITaxon:10239 | denotes | viral |
| T3011 | 822-830 | SP_9 | denotes | MERS-CoV |
| T25491 | 871-876 | UBERON:0001977 | denotes | serum |
| T61243 | 890-898 | GO:0042571 | denotes | antibody |
| T77946 | 970-978 | SP_9 | denotes | MERS-CoV |
| T14492 | 1022-1032 | GO:0042571 | denotes | antibodies |
| T69971 | 1076-1081 | PR:P27487 | denotes | hDPP4 |
| T61320 | 1082-1092 | GO:0009293 | denotes | transduced |
| T91846 | 1093-1097 | NCBITaxon:10088 | denotes | mice |
| T23955 | 1106-1114 | SP_9 | denotes | MERS-CoV |
| T87243 | 1167-1177 | GO:0042571 | denotes | antibodies |
| T44539 | 1271-1279 | SP_9 | denotes | MERS-CoV |
| T16466 | 1283-1290 | NCBITaxon:9986 | denotes | rabbits |
| T51237 | 1444-1448 | SP_9 | denotes | MERS |
| T36049 | 1500-1508 | SP_9 | denotes | MERS-CoV |
| T16485 | 1509-1518 | PG_1 | denotes | S protein |