PMC:7105881 / 46526-47744 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
1513	670-674	Gene	denotes	DPP4	Gene:1803
1514	271-279	Species	denotes	MERS-CoV	Tax:1335626
1515	593-601	Species	denotes	MERS-CoV	Tax:1335626
1516	703-711	Species	denotes	MERS-CoV	Tax:1335626
1517	837-841	Species	denotes	mice	Tax:10090
1518	872-880	Species	denotes	MERS-CoV	Tax:1335626
1519	1071-1079	Species	denotes	MERS-CoV	Tax:1335626
1520	581-592	Species	denotes	recombinant	Tax:575864
1521	936-949	Disease	denotes	CoV infection	MESH:D018352

Id	Subject	Object	Predicate	Lexical cue	fma_id
T279	44-51	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T280	294-301	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T281	557-564	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T282	604-611	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T283	794-801	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T248	712-715	Disease	denotes	NTD	http://purl.obolibrary.org/obo/MONDO_0008449\|http://purl.obolibrary.org/obo/MONDO_0018075
T250	940-949	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550

Id	Subject	Object	Predicate	Lexical cue
T592	148-150	http://purl.obolibrary.org/obo/CLO_0008922	denotes	S2
T593	148-150	http://purl.obolibrary.org/obo/CLO_0050052	denotes	S2
T594	471-475	http://purl.obolibrary.org/obo/CLO_0001185	denotes	2018
T595	483-484	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T596	579-580	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T597	726-728	http://purl.obolibrary.org/obo/CLO_0008922	denotes	S2
T598	726-728	http://purl.obolibrary.org/obo/CLO_0050052	denotes	S2
T599	914-922	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activity

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T317	44-51	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T318	148-150	Chemical	denotes	S2	http://purl.obolibrary.org/obo/CHEBI_29387
T319	294-301	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T320	557-564	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T321	604-611	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T322	726-728	Chemical	denotes	S2	http://purl.obolibrary.org/obo/CHEBI_29387
T323	794-801	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080

Id	Subject	Object	Predicate	Lexical cue
T98	1201-1217	http://purl.obolibrary.org/obo/GO_0006955	denotes	immune responses

Id	Subject	Object	Predicate	Lexical cue
32265848-26218507-36511189	407-411	26218507	denotes	2015
32265848-27050368-36511190	429-433	27050368	denotes	2017
32265848-26678878-36511191	452-456	26678878	denotes	2016
32265848-30058403-36511192	471-475	30058403	denotes	2018
32265848-28807998-36511193	774-778	28807998	denotes	2017
32265848-28807998-36511194	979-983	28807998	denotes	2017

Id	Subject	Object	Predicate	Lexical cue
T261	0-253	Sentence	denotes	Subunit vaccines based on the full-length S protein cover both RBD and non-RBD neutralizing epitopes, some of which may be located in the conserved S2 subunit; thus this type of subunit vaccines are expected to induce high-titer neutralizing antibodies.
T262	254-565	Sentence	denotes	Although several MERS-CoV full-length S protein-based vaccines have been reported in other vaccine types, including viral vectors and DNAs (Wang et al., 2015; Wang C. et al., 2017; Haagmans et al., 2016; Zhou et al., 2018), only a few subunit vaccines have been developed that rely on the full-length S protein.
T263	566-780	Sentence	denotes	For example, a recombinant MERS-CoV S protein trimer (MERS S-2P) in prefusion conformation binds to the DPP4 receptor, as well as to the MERS-CoV NTD, RBD, and S2-specific neutralizing mAbs (Pallesen et al., 2017).
T264	781-985	Sentence	denotes	Whereas this protein induces neutralizing antibodies in mice against divergent pseudotyped MERS-CoV in vitro, its in vivo protective activity against MERS-CoV infection is unknown (Pallesen et al., 2017).
T265	986-1218	Sentence	denotes	Therefore, more studies are needed to elucidate the potential for the development of MERS-CoV full-length S-based subunit vaccines, including understanding their protective efficacy and identifying possible harmful immune responses.

Id	Subject	Object	Predicate	Lexical cue
T736	42-51	PG_1	denotes	S protein
T737	92-100	BV_9	denotes	epitopes
T738	242-252	GO:0042571	denotes	antibodies
T739	271-279	SP_9	denotes	MERS-CoV
T740	292-301	PG_1	denotes	S protein
T741	370-375	NCBITaxon:10239	denotes	viral
T742	376-383	SO:0000440	denotes	vectors
T743	555-564	PG_1	denotes	S protein
T744	593-601	SP_9	denotes	MERS-CoV
T745	602-611	PG_1	denotes	S protein
T746	620-624	SP_9	denotes	MERS
T747	670-674	PG_7;PR:000001341	denotes	DPP4
T748	703-711	SP_9	denotes	MERS-CoV
T749	823-833	GO:0042571	denotes	antibodies
T750	837-841	NCBITaxon:10088	denotes	mice
T751	872-880	SP_9	denotes	MERS-CoV
T752	931-939	SP_9	denotes	MERS-CoV
T753	1071-1079	SP_9	denotes	MERS-CoV
T754	1201-1207	UBERON:0002405;GO:0006955	denotes	immune
T755	1208-1217	GO:0006955	denotes	responses
T19245	42-51	PG_1	denotes	S protein
T10944	92-100	BV_9	denotes	epitopes
T3133	242-252	GO:0042571	denotes	antibodies
T39872	271-279	SP_9	denotes	MERS-CoV
T54197	292-301	PG_1	denotes	S protein
T63042	370-375	NCBITaxon:10239	denotes	viral
T96244	376-383	SO:0000440	denotes	vectors
T65220	555-564	PG_1	denotes	S protein
T14845	593-601	SP_9	denotes	MERS-CoV
T56322	602-611	PG_1	denotes	S protein
T60462	620-624	SP_9	denotes	MERS
T79215	670-674	PG_7;PR:000001341	denotes	DPP4
T25358	703-711	SP_9	denotes	MERS-CoV
T93063	823-833	GO:0042571	denotes	antibodies
T4667	837-841	NCBITaxon:10088	denotes	mice
T77387	872-880	SP_9	denotes	MERS-CoV
T24759	931-939	SP_9	denotes	MERS-CoV
T54709	1071-1079	SP_9	denotes	MERS-CoV
T26753	1201-1207	UBERON:0002405;GO:0006955	denotes	immune
T60154	1208-1217	GO:0006955	denotes	responses